Febbraio, Mark A.

Muscles, exercise and obesity: skeletal muscle as a secretory organ

Pedersen, B. K., & Febbraio, M. A. (2012) · Nature Reviews Endocrinology

Exercise and Physiological ResponsesMuscle Physiology and Disorders

Cited by 2,909

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

Pedersen, B. K., & Febbraio, M. A. (2008) · Physiological Reviews

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,388

Exerkines in health, resilience and disease

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 927

Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase

Carey, A. L., Steinberg, G. R., Macaulay, S. L., Thomas, W. G., Holmes, A. G., Ramm, G., Prelovsek, O., Hohnen-Behrens, C., Watt, M. J., James, D. E., et al. (2006) · Diabetes

Metabolism, Diabetes, and CancerAdipokines, Inflammation, and Metabolic Diseases

Cited by 898

Muscle‐derived interleukin‐6: mechanisms for activation and possible biological roles

FEBBRAIO, M. A., & PEDERSEN, B. K. (2002) · The FASEB Journal

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 875

Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans

Starkie, R., Ostrowski, S. R., Jauffred, S., Febbraio, M., & Pedersen, B. K. (2003) · The FASEB Journal

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 790

Interleukin-6 stimulates lipolysis and fat oxidation in humans

van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism

Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

Cited by 767

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology

Adipokines, Inflammation, and Metabolic DiseasesImmune cells in cancer

Cited by 727

Brain-derived neurotrophic factor is produced by skeletal muscle cells in response to contraction and enhances fat oxidation via activation of AMP-activated protein kinase

Matthews, V. B., Åström, M.-B., Chan, M. H. S., Bruce, C. R., Krabbe, K. S., Prelovsek, O., Åkerström, T., Yfanti, C., Broholm, C., Mortensen, O. H., et al. (2009) · Diabetologia

Muscle Physiology and DisordersMetabolism, Diabetes, and Cancer

Cited by 722

Reactive oxygen species enhance insulin sensitivity

Loh, K., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B. J., Skiba, B., Ooms, L. M., et al. (2009) · Cell Metabolism

Redox biology and oxidative stressMetabolism, Diabetes, and Cancer

Cited by 581

HSP72 protects against obesity-induced insulin resistance

Chung, J., Nguyen, A.-K., Henstridge, D. C., Holmes, A. G., Chan, M. H. S., Mesa, J. L., Lancaster, G. I., Southgate, R. J., Bruce, C. R., Duffy, S. J., et al. (2008) · Proceedings of the National Academy of Sciences

Heat shock proteins researchAdipokines, Inflammation, and Metabolic Diseases

Cited by 553

Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

Hevener, A. L., Olefsky, J. M., Reichart, D., Nguyen, M. T. A., Bandyopadyhay, G., Leung, H.-Y., Watt, M. J., Benner, C., Febbraio, M. A., Nguyen, A.-K., et al. (2007) · Journal of Clinical Investigation

Peroxisome Proliferator-Activated ReceptorsAdipokines, Inflammation, and Metabolic Diseases

Cited by 459

Interleukin-6 Is a Novel Factor Mediating Glucose Homeostasis During Skeletal Muscle Contraction

Febbraio, M. A., Hiscock, N., Sacchetti, M., Fischer, C. P., & Pedersen, B. K. (2004) · Diabetes

Exercise and Physiological ResponsesMetabolism, Diabetes, and Cancer

Cited by 455

High-Density Lipoprotein Modulates Glucose Metabolism in Patients With Type 2 Diabetes Mellitus

Drew, B. G., Duffy, S. J., Formosa, M. F., Natoli, A. K., Henstridge, D. C., Penfold, S. A., Thomas, W. G., Mukhamedova, N., de Courten, B., Forbes, J. M., et al. (2009) · Circulation

Diabetes, Cardiovascular Risks, and LipoproteinsMetabolism, Diabetes, and Cancer

Cited by 443

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

Turner, N., Kowalski, G. M., Leslie, S. J., Risis, S., Yang, C., Lee-Young, R. S., Babb, J. R., Meikle, P. J., Lancaster, G. I., Henstridge, D. C., et al. (2013) · Diabetologia

Diet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic Diseases

Cited by 430

IL-6 and TNF-α expression in, and release from, contracting human skeletal muscle

Steensberg, A., Keller, C., Starkie, R. L., Osada, T., Febbraio, M. A., & Pedersen, B. K. (2002) · American Journal of Physiology-Endocrinology and Metabolism

Exercise and Physiological ResponsesCardiovascular and exercise physiology

Cited by 410

Contraction-Induced Myokine Production and Release: Is Skeletal Muscle an Endocrine Organ?

Febbraio, M. A., & Pedersen, B. K. (2005) · Exercise and Sport Sciences Reviews

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 402

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet–induced insulin resistance

Bruce, C. R., Hoy, A. J., Turner, N., Watt, M. J., Allen, T. L., Carpenter, K., Cooney, G. J., Febbraio, M. A., & Kraegen, E. W. (2009) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 363

Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance

Matthews, V. B., Allen, T. L., Risis, S., Chan, M. H. S., Henstridge, D. C., Watson, N., Zaffino, L. A., Babb, J. R., Boon, J., Meikle, P. J., et al. (2010) · Diabetologia

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 334

Fructose stimulated de novo lipogenesis is promoted by inflammation

Todoric, J., Di Caro, G., Reibe, S., Henstridge, D. C., Green, C. R., Vrbanac, A., Ceteci, F., Conche, C., McNulty, R., Shalapour, S., et al. (2020) · Nature Metabolism

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 328

Intramuscular Heat Shock Protein 72 and Heme Oxygenase-1 mRNA Are Reduced in Patients With Type 2 Diabetes

Bruce, C. R., Carey, A. L., Hawley, J. A., & Febbraio, M. A. (2003) · Diabetes

Heat shock proteins researchHeme Oxygenase-1 and Carbon Monoxide

Cited by 318

Acute IL-6 Treatment Increases Fatty Acid Turnover in Elderly Humans in Vivo and in Tissue Culture in Vitro

Petersen, E. W., Carey, A. L., Sacchetti, M., Steinberg, G. R., Macaulay, S. L., Febbraio, M. A., & Pedersen, B. K. (2005) · American Journal of Physiology-Endocrinology and Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 311

The Ever-Expanding Myokinome: Discovery Challenges and Therapeutic Implications

Whitham, M., & Febbraio, M. A. (2016) · Nature Reviews Drug Discovery

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 279

From cytokine to myokine: The emerging role of interleukin-6 in metabolic regulation

Pal, M., Febbraio, M. A., & Whitham, M. (2014) · Immunology & Cell Biology

Adipokines, Inflammation, and Metabolic DiseasesExercise and Physiological Responses

Cited by 258