Sabatini, David M.

Longer Lifespan in Male Mice Treated With a Weakly Estrogenic Agonist, an Antioxidant, an α-Glucosidase Inhibitor or a Nrf2-Inducer

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., et al. (2016) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

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APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

Sienski, G., Narayan, P., Bonner, J. M., Kory, N., Boland, S., Arczewska, A. A., Ralvenius, W. T., Akay, L., Lockshin, E., He, L., et al. (2021) · Science Translational Medicine

Alzheimer's disease research and treatmentsLipid metabolism and biosynthesis

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Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

Pentinmikko, N., Iqbal, S., Mana, M., Andersson, S., Cognetta, A. B., Suciu, R. M., Roper, J., Luopajärvi, K., Markelin, E., Gopalakrishnan, S., et al. (2019) · Nature

Wnt/β-catenin signaling in development and cancerDigestive system and related health

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Calorie restriction in humans inhibits the PI 3 K/AKT pathway and induces a younger transcription profile

Mercken, E. M., Crosby, S. D., Lamming, D. W., JeBailey, L., Krzysik‐Walker, S., Villareal, D. T., Capri, M., Franceschi, C., Zhang, Y., Becker, K., et al. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

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Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1 H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

Liu, Q., Chang, J. W., Wang, J., Kang, S. A., Thoreen, C. C., Markhard, A., Hur, W., Zhang, J., Sim, T., Sabatini, D. M., et al. (2010) · Journal of Medicinal Chemistry

PI3K/AKT/mTOR signaling in cancerHeterocyclic Compound Synthesis and Bioactivity

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Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex

Sarbassov, D. D., & Sabatini, D. M. (2005) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerRedox biology and oxidative stress

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Fumarate is a terminal electron acceptor in the mammalian electron transport chain

Spinelli, J. B., Rosen, P. C., Sprenger, H.-G., Puszynska, A. M., Mann, J. L., Roessler, J. M., Cangelosi, A. L., Henne, A., Condon, K. J., Zhang, T., et al. (2021) · Science

Mitochondrial Function and PathologyCancer, Hypoxia, and Metabolism

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MCART1/SLC25A51 is required for mitochondrial NAD transport

Kory, N., uit de Bos, J., van der Rijt, S., Jankovic, N., Güra, M., Arp, N., Pena, I. A., Prakash, G., Chan, S. H., Kunchok, T., et al. (2020) · Science Advances

Mitochondrial Function and PathologySirtuins and Resveratrol in Medicine

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RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

Heo, J.-M., Ordureau, A., Swarup, S., Paulo, J. A., Shen, K., Sabatini, D. M., & Harper, J. W. (2018) · Science Advances

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

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Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

Shen, K., Huang, R. K., Brignole, E. J., Condon, K. J., Valenstein, M. L., Chantranupong, L., Bomaliyamu, A., Choe, A., Hong, C., Yu, Z., et al. (2018) · Nature

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

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A CREB3–ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

Reiling, J. H., Olive, A. J., Sanyal, S., Carette, J. E., Brummelkamp, T. R., Ploegh, H. L., Starnbach, M. N., & Sabatini, D. M. (2013) · Nature Cell Biology

Cellular transport and secretionEndoplasmic Reticulum Stress and Disease

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ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

Chudnovsky, Y., Kim, D., Zheng, S., Whyte, W. A., Bansal, M., Bray, M.-A., Gopal, S., Theisen, M. A., Bilodeau, S., Thiru, P., et al. (2014) · Cell Reports

Glioma Diagnosis and TreatmentCancer Cells and Metastasis

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Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

Shen, K., Choe, A., & Sabatini, D. M. (2017) · Molecular Cell

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

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Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

Yu, Y., Gao, S. M., Guan, Y., Hu, P.-W., Zhang, Q., Liu, J., Jing, B., Zhao, Q., Sabatini, D. M., Abu-Remaileh, M., et al. (2022) · eLife

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

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Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity

Yu, Y., Gao, S. M., Guan, Y., Hu, P.-W., Zhang, Q., Liu, J., Jing, B., Zhao, Q., Sabatini, D. M., Abu-Remaileh, M., et al. (2024) · eLife

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

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