Cited by 205Mitochondrial Function and PathologySirtuins and Resveratrol in MedicineNuclear Structure and Function

MCART1/SLC25A51 is required for mitochondrial NAD transport

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Kory, Nora, uit de Bos, Jelmi, van der Rijt, Sanne, Jankovic, Nevena, Güra, Miriam, Arp, Nicholas, Pena, Izabella A., Prakash, Gyan +4 more·2020·Science Advances

Abstract

transporter, can functionally complement for each other. Thus, we propose that MCART1 is the long sought mitochondrial transporter for NAD in human cells.

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Crossref · 10.1126/sciadv.abe5310

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  • NADH is not efficiently transported across the inner mitochondrial membrane, necessitating electron shuttle pathways that transport reducing equivalents from the cytoplasm into the mitochondrial matrix for oxidation in the ETC.

    “Notably, while NAD+ itself can be imported into mitochondria through SLC25A51–MCART1 (98, 99, 100), NADH is not efficiently transported.”

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Authors
Kory, N., uit de Bos, J., van der Rijt, S., Jankovic, N., Güra, M., Arp, N., Pena, I. A., Prakash, G., Chan, S. H., Kunchok, T., Lewis, C. A., & Sabatini, D. M.
Affiliations
  • Broad Institute (US)
  • Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
  • Whitehead Institute for Biomedical Research (US)
Corresponding author
Sabatini, David M.
Venue
Science Advances
Published
2020-10-23
Volume
6
Issue
43
ISSN
2375-2548 (ISSN-L)
OpenAlex
W3084435846
Cited by
205
References
58
Citations by year
2026: 29 · 2025: 39 · 2024: 31 · 2023: 44 · 2022: 31 · 2021: 29 · 2020: 2
FWCI
8.60
Type
journal article
Language
en
Open access
Locations
  • Science Advances (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
Funders
  • U.S. Department of Defense (W81XWH-07-0448)
  • Howard Hughes Medical Institute (HHMI investigator)
  • National Cancer Institute (K99 CA241332, R01 CA103866, R01 CA129105, R37 AI47389)
  • Damon Runyon Cancer Research Foundation (Postdoctoral Fellowship)
  • St. Baldrick’s Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords
mitochondrial transporters, NAD+, functional complementation

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