MCART1/SLC25A51 is required for mitochondrial NAD transport
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transporter, can functionally complement for each other. Thus, we propose that MCART1 is the long sought mitochondrial transporter for NAD in human cells.
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NADH is not efficiently transported across the inner mitochondrial membrane, necessitating electron shuttle pathways that transport reducing equivalents from the cytoplasm into the mitochondrial matrix for oxidation in the ETC.
“Notably, while NAD+ itself can be imported into mitochondria through SLC25A51–MCART1 (98, 99, 100), NADH is not efficiently transported.”
From Regulation and function of the mammalian tricarboxylic acid cycle (2023) · cites this paper as [99]
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- Authors
- Kory, N., uit de Bos, J., van der Rijt, S., Jankovic, N., Güra, M., Arp, N., Pena, I. A., Prakash, G., Chan, S. H., Kunchok, T., Lewis, C. A., & Sabatini, D. M.
- Affiliations
- Broad Institute (US)
- Whitehead Institute for Biomedical Research, 455 Main Street, Cambridge, MA 02142, USA.
- Whitehead Institute for Biomedical Research (US)
- Corresponding author
- Sabatini, David M.
- ORCID
- Venue
- Science Advances
- Published
- 2020-10-23
- Volume
- 6
- Issue
- 43
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC7577609
- OpenAlex
- W3084435846
- Cited by
- 205
- References
- 58
- Citations by year
- 2026: 29 · 2025: 39 · 2024: 31 · 2023: 44 · 2022: 31 · 2021: 29 · 2020: 2
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- U.S. Department of Defense (W81XWH-07-0448)
- Howard Hughes Medical Institute (HHMI investigator)
- National Cancer Institute (K99 CA241332, R01 CA103866, R01 CA129105, R37 AI47389)
- Damon Runyon Cancer Research Foundation (Postdoctoral Fellowship)
- St. Baldrick’s Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- mitochondrial transporters, NAD+, functional complementation
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