Birnbaum, Morris J.

Regulation of neuronal survival by the serine-threonine protein kinase Akt

Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 2,436

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Minokoshi, Y., Alquier, T., Furukawa, N., Kim, Y.-B., Lee, A., Xue, B., Mu, J., Foufelle, F., Ferré, P., Birnbaum, M. J., et al. (2004) · Nature

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 1,637

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,619

Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation

Kohn, A. D., Summers, S. A., Birnbaum, M. J., & Roth, R. A. (1996) · Journal of Biological Chemistry

Metabolism, Diabetes, and CancerPI3K/AKT/mTOR signaling in cancer

Cited by 1,284

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism

Sphingolipid Metabolism and SignalingAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,232

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

Zong, H., Ren, J. M., Young, L. H., Pypaert, M., Mu, J., Birnbaum, M. J., & Shulman, G. I. (2002) · Proceedings of the National Academy of Sciences

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 1,036

Essential Regulation of Cell Bioenergetics by Constitutive InsP3 Receptor Ca2+ Transfer to Mitochondria

Cárdenas, C., Miller, R. A., Smith, I., Bui, T., Molgó, J., Müller, M., Vais, H., Cheung, K.-H., Yang, J., Parker, I., et al. (2010) · Cell

Mitochondrial Function and PathologyCalcium signaling and nucleotide metabolism

Cited by 1,026

A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle

Mu, J., Brozinick, J. T., Valladares, O., Bucan, M., & Birnbaum, M. J. (2001) · Molecular Cell

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

Cited by 924

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

Holland, W. L., Miller, R. A., Wang, Z. V., Sun, K., Barth, B. M., Bui, H. H., Davis, K. E., Bikman, B. T., Halberg, N., Rutkowski, J. M., et al. (2011) · Nature Medicine

Sphingolipid Metabolism and SignalingAdipokines, Inflammation, and Metabolic Diseases

Cited by 892

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., et al. (2014) · Immunity

T-cell and B-cell ImmunologyLipid metabolism and biosynthesis

Cited by 790

AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

Russell, R. R., Li, J., Coven, D. L., Pypaert, M., Zechner, C., Palmeri, M., Giordano, F. J., Mu, J., Birnbaum, M. J., & Young, L. H. (2004) · Journal of Clinical Investigation

Cardiac Ischemia and ReperfusionMetabolism, Diabetes, and Cancer

Cited by 738

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell

Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

Cited by 719

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

Jang, C., Hui, S., Lu, W., Cowan, A. J., Morscher, R. J., Lee, G., Liu, W., Tesz, G. J., Birnbaum, M. J., & Rabinowitz, J. D. (2018) · Cell Metabolism

Diet, Metabolism, and DiseaseMetabolism, Diabetes, and Cancer

Cited by 639

The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

Viollet, B., Andreelli, F., Jørgensen, S. B., Perrin, C., Geloen, A., Flamez, D., Mu, J., Lenzner, C., Baud, O., Bennoun, M., et al. (2003) · Journal of Clinical Investigation

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 499

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator

Li, X., Monks, B., Ge, Q., & Birnbaum, M. J. (2007) · Nature

Metabolism, Diabetes, and CancerPeroxisome Proliferator-Activated Receptors

Cited by 487

Regulation of Insulin-Stimulated Glucose Transporter GLUT4 Translocation and Akt Kinase Activity by Ceramide

Summers, S. A., Garza, L. A., Zhou, H., & Birnbaum, M. J. (1998) · Molecular and Cellular Biology

Sphingolipid Metabolism and SignalingMetabolism, Diabetes, and Cancer

Cited by 475

Exercise induces isoform-specific increase in 5'AMP-activated protein kinase activity in human skeletal muscle

Fujii, N., Hayashi, T., Hirshman, M. F., Smith, J. T., Habinowski, S. A., Kaijser, L., Mu, J., Ljungqvist, O., Birnbaum, M. J., Witters, L. A., et al. (2000) · Biochemical and Biophysical Research Communications

Metabolism, Diabetes, and CancerCardiovascular and exercise physiology

Cited by 351

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., et al. (2012) · Nature Medicine

Liver Disease Diagnosis and TreatmentLipid metabolism and biosynthesis

Cited by 335

The Regulation of AMP-Activated Protein Kinase by H2O2

Choi, S.-L., Kim, S.-J., Lee, K.-T., Kim, J., Mu, J., Birnbaum, M. J., Soo Kim, S., & Ha, J. (2001) · Biochemical and Biophysical Research Communications

Metabolism, Diabetes, and CancerRedox biology and oxidative stress

Cited by 294

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species

Juntilla, M. M., Patil, V. D., Calamito, M., Joshi, R. P., Birnbaum, M. J., & Koretzky, G. A. (2010) · Blood

Hematopoietic Stem Cell TransplantationRedox biology and oxidative stress

Cited by 284

Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models

Viollet, B., Andreelli, F., Jørgensen, S. B., Perrin, C., Flamez, D., Mu, J., Wojtaszewski, J. F. P., Schuit, F. C., Birnbaum, M., Richter, E., et al. (2003) · Biochemical Society Transactions

Metabolism, Diabetes, and CancerPancreatic function and diabetes

Cited by 241

Akt and CHIP coregulate tau degradation through coordinated interactions

Dickey, C. A., Koren, J., Zhang, Y.-J., Xu, Y.-F., Jinwal, U. K., Birnbaum, M. J., Monks, B., Sun, M., Cheng, J. Q., Patterson, C., et al. (2008) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsHeat shock proteins research

Cited by 226

Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake

Gao, S., Kinzig, K. P., Aja, S., Scott, K. A., Keung, W., Kelly, S., Strynadka, K., Chohnan, S., Smith, W. W., Tamashiro, K. L. K., et al. (2007) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 215

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo

Titchenell, P. M., Chu, Q., Monks, B. R., & Birnbaum, M. J. (2015) · Nature Communications

Metabolism, Diabetes, and CancerFOXO transcription factor regulation

Cited by 169