AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

Zong, Haihong; Ren, Jian Ming; Young, Lawrence H.; Pypaert, Marc; Mu, James; Birnbaum, Morris J.; Shulman, Gerald I.

doi:10.1073/pnas.252625599

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

Mitochondrial biogenesis is a critical adaptation to chronic energy deprivation, yet the signaling mechanisms responsible for this response are poorly understood. To examine the role of AMP-activated protein kinase (AMPK), an evolutionarily conserved fuel sensor, in mitochondrial biogenesis we st…