Nelson, Erik R.

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Baek, A. E., Yu, Y.-R. A., He, S., Wardell, S. E., Chang, C.-Y., Kwon, S., Pillai, R. V., McDowell, H. B., Thompson, J. W., Dubois, L. G., et al. (2017) · Nature Communications

Cancer, Lipids, and MetabolismImmune cells in cancer

Cited by 427

Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Michalek, R. D., Gerriets, V. A., Nichols, A. G., Inoue, M., Kazmin, D., Chang, C.-Y., Dwyer, M. A., Nelson, E. R., Pollizzi, K. N., Ilkayeva, O., et al. (2011) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 216

27-Hydroxycholesterol acts on myeloid immune cells to induce T cell dysfunction, promoting breast cancer progression

Ma, L., Wang, L., Nelson, A. T., Han, C., He, S., Henn, M. A., Menon, K., Chen, J. J., Baek, A. E., Vardanyan, A., et al. (2020) · Cancer Letters

Cancer, Lipids, and MetabolismImmune cells in cancer

Cited by 98

Our evolving understanding of how 27-hydroxycholesterol influences cancer

Ma, L., Cho, W., & Nelson, E. R. (2022) · Biochemical Pharmacology

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cited by 53

The Cholesterol Metabolite 27HC Increases Secretion of Extracellular Vesicles Which Promote Breast Cancer Progression

Baek, A. E., Krawczynska, N., Das Gupta, A., Dvoretskiy, S. V., You, S., Park, J., Deng, Y.-H., Sorrells, J. E., Smith, B. P., Ma, L., et al. (2021) · Endocrinology

Extracellular vesicles in diseaseCancer, Lipids, and Metabolism

Cited by 43

Nuclear receptors, cholesterol homeostasis and the immune system

Shahoei, S. H., & Nelson, E. R. (2019) · The Journal of Steroid Biochemistry and Molecular Biology

Cholesterol and Lipid MetabolismSteroid Chemistry and Biochemistry

Cited by 43

The Liver X Receptor Is Selectively Modulated to Differentially Alter Female Mammary Metastasis-associated Myeloid Cells

Ma, L., Vidana Gamage, H. E., Tiwari, S., Han, C., Henn, M. A., Krawczynska, N., Dibaeinia, P., Koelwyn, G. J., Das Gupta, A., Bautista Rivas, R. O., et al. (2022) · Endocrinology

Cholesterol and Lipid MetabolismCancer, Lipids, and Metabolism

Cited by 21

Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages

Shahoei, S. H., Kim, Y.-C., Cler, S. J., Ma, L., Anakk, S., Kemper, J. K., & Nelson, E. R. (2019) · Endocrinology

T-cell and B-cell ImmunologyProtein Tyrosine Phosphatases

Cited by 16

Development of NR0B2 as a therapeutic target for the re-education of tumor associated myeloid cells

Vidana Gamage, H. E., Albright, S. T., Smith, A. J., Farmer, R., Shahoei, S. H., Wang, Y., Fink, E. C., Jacquin, E., Weisser, E., Bautista, R. O., et al. (2024) · Cancer Letters

Cancer Immunotherapy and BiomarkersImmune cells in cancer

Cited by 13

27-Hydroxycholesterol Enhances Secretion of Extracellular Vesicles by ROS-Induced Dysregulation of Lysosomes

Das Gupta, A., Park, J., Sorrells, J. E., Kim, H., Krawczynska, N., Pradeep, D., Wang, Y., Vidana Gamage, H. E., Nelczyk, A. T., Boppart, S. A., et al. (2024) · Endocrinology

Extracellular vesicles in diseaseCellular transport and secretion

Cited by 10

NR0B2 re-educates myeloid immune cells to reduce regulatory T cell expansion and progression of breast and other solid tumors

Vidana Gamage, H. E., Shahoei, S. H., Wang, Y., Jacquin, E., Weisser, E., Bautista, R. O., Henn, M. A., Schane, C. P., Nelczyk, A. T., Ma, L., et al. (2024) · Cancer Letters

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 9

Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells

Bendre, S. V., Wang, Y., Hajyousif, B., K C, R., Bhogale, S. G., Pradeep, D., Krawczynska, N., Schane, C. P., Weisser, E., Singh, A., et al. (2026) · Science Advances

Immune cells in cancerCancer, Lipids, and Metabolism

Cited by 8

Role of Protein Regulators of Cholesterol Homeostasis in Immune Modulation and Cancer Pathophysiology

Wang, Y., Bendre, S. V., Krauklis, S. A., Steelman, A. J., & Nelson, E. R. (2025) · Endocrinology

Cancer, Lipids, and MetabolismCholesterol and Lipid Metabolism

Cited by 6