Busciglio, Jorge

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

Busciglio, J., & Yankner, B. A. (1995) · Nature

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 741

β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

Busciglio, J., Lorenzo, A., Yeh, J., & Yankner, B. A. (1995) · Neuron

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 595

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 569

Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., & Yankner, B. A. (2002) · Neuron

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 387

Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative

Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 373

Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease

Resende, R., Moreira, P. I., Proença, T., Deshpande, A., Busciglio, J., Pereira, C., & Oliveira, C. R. (2008) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsAntioxidant Activity and Oxidative Stress

Cited by 343

A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses

Deshpande, A., Kawai, H., Metherate, R., Glabe, C. G., & Busciglio, J. (2009) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroscience and Neuropharmacology Research

Cited by 232

Evolution of neuroinflammation across the lifespan of individuals with Down syndrome

Flores-Aguilar, L., Iulita, M. F., Kovecses, O., Torres, M. D., Levi, S. M., Zhang, Y., Askenazi, M., Wisniewski, T., Busciglio, J., & Cuello, A. C. (2020) · Brain

Neuroinflammation and Neurodegeneration MechanismsDown syndrome and intellectual disability research

Cited by 138

Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter

Yeo, M., Berglund, K., Hanna, M., Guo, J. U., Kittur, J., Torres, M. D., Abramowitz, J., Busciglio, J., Gao, Y., Birnbaumer, L., et al. (2013) · Proceedings of the National Academy of Sciences

Effects and risks of endocrine disrupting chemicalsEpigenetics and DNA Methylation

Cited by 124

A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

Garcia, O., Torres, M., Helguera, P., Coskun, P., & Busciglio, J. (2010) · PLoS ONE

Down syndrome and intellectual disability researchNeuroscience and Neuropharmacology Research

Cited by 122

Aberrant Activation of Focal Adhesion Proteins Mediates Fibrillar Amyloid β-Induced Neuronal Dystrophy

Grace, E. A., & Busciglio, J. (2003) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCell Adhesion Molecules Research

Cited by 113

ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons

Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., & Busciglio, J. (2005) · The Journal of Neuroscience

Down syndrome and intellectual disability researchCell death mechanisms and regulation

Cited by 88