ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons

Cell Death

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Apoptosis

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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis

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p53 Has a Direct Apoptogenic Role at the Mitochondria

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ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

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Subcellular Distribution of Superoxide Dismutases (SOD) in Rat Liver

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Intraneuronal Aβ42 Accumulation in Human Brain

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Positron Emission Tomography in Evaluation of Dementia

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The Ets family of transcription factors

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Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

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Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells

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In Situ Oxidative Catalysis by Neurofibrillary Tangles and Senile Plaques in Alzheimer’s Disease

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Longitudinal PET evaluation of cerebral metabolic decline in dementia: a potential outcome measure in Alzheimer’s disease treatment studies

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Oligomerization of Alzheimer's β-Amyloid within Processes and Synapses of Cultured Neurons and Brain

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Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses

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Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome

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Ets target genes: past, present and future

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The pathological association between down syndrome and Alzheimer disease

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The ets gene family

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Alzheimer's Presenilin 1 Mutations Impair Kinesin-Based Axonal Transport

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The neurobiologie consequences of down syndrome

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Elevation in the Ratio of Cu/Zn-Superoxide Dismutase to Glutathione Peroxidase Activity Induces Features of Cellular Senescence and This Effect Is Mediated by Hydrogen Peroxide

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The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.

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Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice

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Down syndrome and Alzheimer's disease: A link between development and aging

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Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

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Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins

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Presenilin-1 Mutations Reduce Cytoskeletal Association, Deregulate Neurite Growth, and Potentiate Neuronal Dystrophy and Tau Phosphorylation

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Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.

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ETS2 overexpression in transgenic models and in Down syndrome predisposes to apoptosis via the p53 pathway

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Caspase-cleaved amyloid precursor protein and activated caspase-3 are co-localized in the granules of granulovacuolar degeneration in Alzheimer's disease and Down's syndrome brain

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Apoptosis-associated proteins p53 and APO-1/Fas (CD95) in brains of adult patients with Down syndrome

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Temporal cortex hypermetabolism in Down syndrome prior to the onset of dementia

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GVS‐111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons

Pelsman, A., Hoyo‐Vadillo, C., Гудашева, Т. А., Середенин, С. Б., Ostrovskaya, R. U., & Busciglio, J. A. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00031-5 · Cited by 65 · see citing works

ETS1 and ETS2 in p53 regulation: spatial separation of ETS binding sites (EBS) modulate protein: DNA interaction.

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Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

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Neuronal cell death in Down’s syndrome

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Molecular abnormalities of the brain in Down Syndrome: relevance to Alzheimer’s neurodegeneration

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Stress, Aging, and Neurodegenerative Disorders: Molecular Mechanismsa

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Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome

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Analysis of p53 transactivation through high-affinity binding sites.

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β-Amyloid precursor protein, ETS-2 and collagen alpha 1 (VI) chain precursor, encoded on chromosome 21, are not overexpressed in fetal Down syndrome: further evidence against gene dosage effect

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β-Amyloid deposition and neurofibrillary tangle association with caspase activation in Down syndrome

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The role of antioxidants in the chemistry of oxidative stress: A review

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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

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Different Conformations of Amyloid β Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons

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Cognitive deficits and associated neurological complications in individuals with Down's syndrome

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Molecular genetic analysis of Down syndrome

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RESEARCH ARTICLE: Neurogenesis Impairment and Increased Cell Death Reduce Total Neuron Number in the Hippocampal Region of Fetuses with Down Syndrome

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Deficits in human trisomy 21 iPSCs and neurons

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Phosphorylation of Actin-Depolymerizing Factor/Cofilin by LIM-Kinase Mediates Amyloid -Induced Degeneration: A Potential Mechanism of Neuronal Dystrophy in Alzheimer's Disease

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Delays in Motor Development in Children with Down Syndrome

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Adaptive Downregulation of Mitochondrial Function in Down Syndrome

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γ-Tocotrienol does not substantially protect DS neurons from hydrogen peroxide-induced oxidative injury

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Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities

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On the Origin of Superoxide Dismutase: An Evolutionary Perspective of Superoxide-Mediated Redox Signaling

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Integration-Free Induced Pluripotent Stem Cells Model Genetic and Neural Developmental Features of Down Syndrome Etiology

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Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome

Guidi, S., Ciani, E., Bonasoni, P., Santini, D., & Bartesaghi, R. (2011) · Brain Pathology · doi:10.1111/j.1750-3639.2010.00459.x · Cited by 165 · see citing works

Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

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Down syndrome and dementia: A randomized, controlled trial of antioxidant supplementation

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A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

Garcia, O., Torres, M., Helguera, P., Coskun, P., & Busciglio, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014200 · Cited by 122 · see citing works

Internalization of β-Amyloid Peptide by Primary Neurons in the Absence of Apolipoprotein E

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Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome

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Neurogenesis impairment: An early developmental defect in Down syndrome

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Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease

Domenico, F. D., Pupo, G., Tramutola, A., Giorgi, A., Schininà, M. E., Coccia, R., Head, E., Butterfield, D. A., & Marzia Perluigi, A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.027 · Cited by 98 · see citing works

S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

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Down syndrome: Neurobiological alterations and therapeutic targets

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Down syndrome and Alzheimer's disease: common molecular traits beyond the amyloid precursor protein

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Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3βin vivo

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Antioxidants in Down syndrome

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Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

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MiR-1246: A new link of the p53 family with cancer and Down syndrome

Liao, J., Zhou, X. Y., Zhang, Y., & Lu, H. (2012) · Cell Cycle · doi:10.4161/cc.20809 · Cited by 73 · see citing works

Oxidative Stress and Mitochondrial Dysfunction in Down’s Syndrome: Relevance to Aging and Dementia

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Platycodin D induces apoptosis and decreases telomerase activity in human leukemia cells

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Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease

Viejo, L., Noori, A., Merrill, E., Das, S., Hyman, B. T., & Serrano‐Pozo, A. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12753 · Cited by 69 · see citing works

Age-Related Neurodegeneration and Memory Loss in Down Syndrome

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Effects of voluntary physical exercise on adult hippocampal neurogenesis and behavior of Ts65Dn mice, a model of Down syndrome

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Transcriptional Dysregulation in Down Syndrome: Predictions for Altered Protein Complex Stoichiometries and Post-translational Modifications, and Consequences for Learning/Behavior Genes ELK, CREB, and the Estrogen and Glucocorticoid Receptors

Gardiner, K. (2006) · Behavior Genetics · doi:10.1007/s10519-006-9051-1 · Cited by 63 · see citing works

High incidence of acute lung injury in children with Down syndrome

Bruijn, M., van der Aa, L. B., van Rijn, R. R., Bos, A. P., & van Woensel, J. B. M. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0803-z · Cited by 61 · see citing works

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

Zamponi, E., Zamponi, N., Coskun, P., Quassollo, G., Lorenzo, A., Cannas, S., Pigino, G., Chialvo, D., Gardiner, K., Busciglio, J., et al. (2018) · Aging Cell · doi:10.1111/acel.12812 · Cited by 59 · see citing works

Proteomic approach to ETV5 during endometrial carcinoma invasion reveals a link to oxidative stress

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Mitochondrial alterations and tendency to apoptosis in peripheral blood cells from children with Down syndrome

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Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology

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Dissecting Alzheimer disease in Down syndrome using mouse models

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The Impact of Oxidative Stress on Pediatrics Syndromes

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Activation of Ets‐2 by oxidative stress induces Bcl‐xL expression and accounts for glial survival in amyotrophic lateral sclerosis

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Activation of p53 in Down Syndrome and in the Ts65Dn mouse brain is associated with a pro-apoptotic phenotype

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Plasma metabolites related to cellular energy metabolism are altered in adults with Down syndrome and Alzheimer's disease

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Antioxidants in Down Syndrome: From Preclinical Studies to Clinical Trials

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New Perspectives for the Rescue of Cognitive Disability in Down Syndrome

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Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress

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Apoptosis in Down’s syndrome: lessons from studies of human and mouse models

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ETS2 Regulating Neurodegenerative Signaling Pathway of Human Neuronal (SH-SY5Y) Cells Exposed to Single and Repeated Low-Dose Sarin (GB)

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Protein Kinase C-Regulated Aβ Production and Clearance

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Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer’s Disease in Subjects with Down Syndrome

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Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome

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Oxidative Stress in Down and Williams-Beuren Syndromes: An Overview

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The Shape of Mitochondrial Dysfunction in Down Syndrome

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Overexpression screen of chromosome 21 genes reveals modulators of Sonic hedgehog signaling relevant to Down syndrome

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A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction

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Opportunities and Limitations of Modelling Alzheimer’s Disease with Induced Pluripotent Stem Cells

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Expression pattern of matrix metalloproteinase and TIMP genes in fibroblasts derived from Ets-1 knock-out mice compared to wild-type mouse fibroblasts

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Untangle the mystery behind DS-associated AD – Is APP the main protagonist?

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The Ts65Dn mouse model of Down syndrome shows reduced expression of the Bcl‐XL antiapoptotic protein in the hippocampus not accompanied by changes in molecular or cellular markers of cell death

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Okadaic acid induces apoptosis in Down syndrome fibroblasts

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Early increased density of cyclooxygenase-2 (COX-2) immunoreactive neurons in Down syndrome

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Translocation of cytochrome c during cerebellar degeneration in Lurcher and weaver mutant mice

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Intricacies of aging and Down syndrome

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Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?

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Deciphering ETS2: An indispensable conduit to cancer

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Development of Alzheimer’s disease in Down syndrome

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Single-cell transcriptomic reconstruction of the human hair cycle: Capturing the temporal dynamics of skin tissue remodeling

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Extensive Natural Variation for Cellular Hydrogen Peroxide Release Is Genetically Controlled

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Telomerase activity and apoptosis genes as parameters of lymphocyte aging in Down syndrome patients

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Combinatorial Gene Effects on the Neural Progenitor Pool in Down Syndrome

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Mitochondrial Abnormalities in Down Syndrome: Pathogenesis, Effects and Therapeutic Approaches

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All-Optical Wavelength-Selective Switch by Intensity Control in Cascaded Interferometers

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High throughput gene complementation screening permits identification of a mammalian mitochondrial protein synthesis (ρ − ) mutant

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Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions

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Bio-Metal Dyshomeostasis-Associated Acceleration of Aging and Cognitive Decline in Down Syndrome

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SARS-CoV-2 infection of human cortical cells is influenced by the interaction between aneuploidy and biological sex: insights from a Down syndrome in vitro model

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Fluid biomarkers for Alzheimer's disease in Down syndrome: Current status and novel trends

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Lamivudine modulates the expression of neurological impairment-related genes and LINE-1 retrotransposons in brain tissues of a Down syndrome mouse model

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Cancer and Post‐Therapy Cardiotoxicity Risk in Adolescents, Young Adults, and Adults With Down Syndrome

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Apoptosis in Nervous Cells

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The accumulation of copper in the brain of Down syndrome promotes oxidative stress: possible mechanism underlying cognitive impairment

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Análise de polimorfismos da família p53 e sua via regulatória como fatores de risco para aneuploidia

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A closer look into down syndrome: unlocking the mystery of alzheimer’s disease

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Congenital Anomalies

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A role for the transcription factor ets‐2 in Down's syndrome neuropathology

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Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

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O4–02–07: Mitochondrial dysfunction and Alzheimer's disease in Down's Syndrome

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Neuronal cell death in Down’s syndrome

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Ets-2 Is Induced by Oxidative Stress and Sensitizes Cells to H2O2-Induced Apoptosis: Implications for Down's Syndrome

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