A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

Garcia, Octavio; Torres, Maria; Helguera, Pablo; Coskun, Pinar; Busciglio, Jorge

doi:10.1371/journal.pone.0014200

Cited by 122Down syndrome and intellectual disability researchNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

Open access

Garcia, Octavio, Torres, Maria, Helguera, Pablo, Coskun, Pinar, Busciglio, Jorge·2010·PLoS ONE

DOI 10.1371/journal.pone.0014200PMC PMC2996288

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Down's syndrome (DS) is the most common genetic cause of mental retardation. Reduced number and aberrant architecture of dendritic spines are common features of DS neuropathology. However, the mechanisms involved in DS spine alterations are not known. In addition to a relevant role in synapse formation and maintenance, astrocytes can regulate spine dynamics by releasing soluble factors or by physical contact with neurons. We have previously shown impaired mitochondrial function in DS astrocytes leading to metabolic alterations in protein processing and secretion. In this study, we investigated whether deficits in astrocyte function contribute to DS spine pathology. METHODOLOGY/PRINCIPAL FINDINGS: Using a human astrocyte/rat hippocampal neuron coculture, we found that DS astrocytes are directly involved in the development of spine malformations and reduced synaptic density. We also show that thrombospondin 1 (TSP-1), an astrocyte-secreted protein, possesses a potent modulatory effect on spine number and morphology, and that both DS brains and DS astrocytes exhibit marked deficits in TSP-1 protein expression. Depletion of TSP-1 from normal astrocytes resulted in dramatic changes in spine morphology, while restoration of TSP-1 levels prevented DS astrocyte-mediated spine and synaptic alterations. Astrocyte cultures derived from TSP-1 KO mice exhibited similar deficits to support spine formation and structure than DS astrocytes. CONCLUSIONS/SIGNIFICANCE: These results indicate that human astrocytes promote spine and synapse formation, identify astrocyte dysfunction as a significant factor of spine and synaptic pathology in the DS brain, and provide a mechanistic rationale for the exploration of TSP-1-based therapies to treat spine and synaptic pathology in DS and other neurological conditions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0014200

Cites

115 of 115 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Gene dysregulation and disrupted calcium signalling in glial cells contribute to the synaptic deficits in DS.
“Evidence suggests that gene dysregulation and disrupted calcium signalling in glial cells also contribute to the synaptic deficits131,134.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [134]
The Discussion (page unavailable) reports that Down’s syndrome astrocytes contribute to reduced synaptic density, and the Results link this effect to reduced astrocytic TSP-1 protein. The Discussion also notes elevated intracellular calcium in DS astrocytes, but does not establish that disrupted calcium signalling causes the synaptic deficits. It does not establish gene dysregulation as a cause either. (LLM, conf=0.83)
Experimental — accuracy not yet measured
Astrocytes and microglia have a role in the DS synaptic phenotype.
“Although the tools used to ensure accurate proportions of interneuron subtypes in a culture system have only recently been developed132, simple neuron–glia co-cultures have already provided evidence that astrocytes and microglia do have a role in the DS synaptic phenotype131,134,135.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [134]
The Introduction and Results report that neurons co-cultured with Down syndrome astrocytes developed abnormal spines and reduced synaptic density and activity. The paper supports an astrocyte role in the DS synaptic phenotype, but our copy does not establish the claimed role for microglia. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Rodent neurons cultured with astrocytes from DS fetal brain tissue have fewer synapses and abnormal spine morphology than neurons cultured with control astrocytes.
“Astrocytes isolated from DS fetal brain tissue produce less THBS1 than control astrocytes, and rodent neurons cultured with these astrocytes have fewer synapses and abnormal spine morphology than neurons cultured with control astrocytes134.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [134]
Astrocytes isolated from DS fetal brain tissue produce less THBS1 than control astrocytes.
“Astrocytes isolated from DS fetal brain tissue produce less THBS1 than control astrocytes, and rodent neurons cultured with these astrocytes have fewer synapses and abnormal spine morphology than neurons cultured with control astrocytes134.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [134]
Introduction of exogenous THBS1 into cultures rescues synaptic and spine deficits even when neurons are co-cultured with astrocytes from individuals with DS.
“The introduction of exogenous THBS1 into these cultures rescues synaptic and spine deficits, even when neurons are co-cultured with astrocytes from individuals with DS134.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [134]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.
Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works
Astrocytes, from brain glue to communication elements: the revolution continues
Volterra, A., & Meldolesi, J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1722 · Cited by 1,763 · see citing works
CNS synaptogenesis promoted by glia-derived cholesterol
Mauch, D. H., Nägler, K., Schumacher, S., Göritz, C., Müller, E.-C., Otto, A., & Pfrieger, F. W. (2001) · Science · doi:10.1126/science.294.5545.1354 · Cited by 1,711 · see citing works
Culturing hippocampal neurons
Kaech, S., & Banker, G. A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.356 · Cited by 1,705 · see citing works
Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis
Christopherson, K. S., Ullian, E. M., Stokes, C. C. A., Mullowney, C. E., Hell, J. W., Agah, A., Lawler, J., Mosher, D. F., Bornstein, P., & Barres, B. A. (2005) · Cell · doi:10.1016/j.cell.2004.12.020 · Cited by 1,688 · see citing works
The DNA sequence of human chromosome 21
Hattori, M., Fujiyama, A., Taylor, T. D., Watanabe, H., Yada, T., Park, H.-S., Toyoda, A., Ishii, K., Totoki, Y., Choi, D., et al. (2000) · Nature · doi:10.1038/35012518 · Cited by 1,475 · see citing works
Glia: listening and talking to the synapse
Haydon, P. G. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058528 · Cited by 1,410 · see citing works
Control of Synapse Number by Glia
Ullian, E. M., Sapperstein, S. K., Christopherson, K. S., & Barres, B. A. (2001) · Science · doi:10.1126/science.291.5504.657 · Cited by 1,380 · see citing works
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344 · see citing works
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A., Jessell, T. M., Wichterle, H., & Przedborski, S. (2007) · Nature Neuroscience · doi:10.1038/nn1876 · Cited by 1,220 · see citing works
Culturing hippocampal neurons.
Tanaka, H. (2002) · Folia Pharmacologica Japonica · doi:10.1254/fpj.119.163 · Cited by 1,141 · see citing works
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., Takahashi, R., Misawa, H., & Cleveland, D. W. (2008) · Nature Neuroscience · doi:10.1038/nn2047 · Cited by 1,140 · see citing works
Transient and persistent dendritic spines in the neocortex in vivo
Holtmaat, A. J. G. D., Trachtenberg, J. T., Wilbrecht, L., Shepherd, G. M., Zhang, X., Knott, G. W., & Svoboda, K. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.003 · Cited by 1,131 · see citing works
Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
Jiménez, B., Volpert, O. V., Crawford, S. E., Febbraio, M., Silverstein, R. L., & Bouck, N. (2000) · Nature Medicine · doi:10.1038/71517 · Cited by 1,014 · see citing works
Dentritic spines : structure, dynamics and regulation
Hering, H., & Sheng, M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35104061 · Cited by 961 · see citing works
Three-Dimensional Relationships between Hippocampal Synapses and Astrocytes
Ventura, R., & Harris, K. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-16-06897.1999 · Cited by 900 · see citing works
Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Eroglu, Ç., Allen, N. J., Susman, M. W., O'Rourke, N. A., Park, C. Y., Özkan, E., Chakraborty, C., Mulinyawe, S. B., Annis, D. S., Huberman, A. D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.025 · Cited by 893 · see citing works
Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation
Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 863 · see citing works
Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?
Fiala, J. C., Spacek, J., & Harris, K. M. (2002) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00158-3 · Cited by 811 · see citing works
An astrocytic basis of epilepsy
Tian, G.-F., Azmi, H., Takano, T., Xu, Q., Peng, W., Lin, J., Oberheim, N., Lou, N., Wang, X., Zielke, H. R., et al. (2005) · Nature Medicine · doi:10.1038/nm1277 · Cited by 806 · see citing works
Synaptic Efficacy Enhanced by Glial Cells in Vitro
Pfrieger, F. W., & Barres, B. A. (1997) · Science · doi:10.1126/science.277.5332.1684 · Cited by 793 · see citing works
Synaptic Islands Defined by the Territory of a Single Astrocyte
Halassa, M. M., Fellin, T., Takano, H., Dong, J.-H., & Haydon, P. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1419-07.2007 · Cited by 767 · see citing works
Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1
Fiala, J. C., Feinberg, M., Popov, V., & Harris, K. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08900.1998 · Cited by 758 · see citing works
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
Busciglio, J., & Yankner, B. A. (1995) · Nature · doi:10.1038/378776a0 · Cited by 741 · see citing works
Self-citation
Dendritic Anomalies in Disorders Associated with Mental Retardation
Kaufmann, W. E. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.10.981 · Cited by 733 · see citing works
Development of long-term dendritic spine stability in diverse regions of cerebral cortex
Zuo, Y., Lin, A., Chang, P., & Gan, W.-B. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.001 · Cited by 684 · see citing works
CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells
Dawson, D. W., Pearce, S. F. A., Zhong, R., Silverstein, R. L., Frazier, W. A., & Bouck, N. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.3.707 · Cited by 676 · see citing works
The Dynamics of Dendritic Structure in Developing Hippocampal Slices
Dailey, M. E., & Smith, S. J. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-09-02983.1996 · Cited by 611 · see citing works
Control of hippocampal dendritic spine morphology through ephrin-A3/EphA4 signaling
Murai, K. K., Nguyen, L. N., Irie, F., Yamaguchi, Y., & Pasquale, E. B. (2003) · Nature Neuroscience · doi:10.1038/nn994 · Cited by 516 · see citing works
Structure, development, and plasticity of dendritic spines
Harris, K. M. (1999) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)80050-6 · Cited by 515 · see citing works
Contribution of glial cells to the development of amyloid plaques in Alzheimer’s disease
Nagele, R. G., Węgiel, J., Venkataraman, V., Imaki, H., Wang, K.-C., & Wegiel, J. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.01.007 · Cited by 497 · see citing works
Different Conformations of Amyloid β Induce Neurotoxicity by Distinct Mechanisms in Human Cortical Neurons
Deshpande, A. M., Mina, E. W., Glabe, C. G., & Busciglio, J. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1189-06.2006 · Cited by 490 · see citing works
Self-citation
The Transcriptome and Metabolic Gene Signature of Protoplasmic Astrocytes in the Adult Murine Cortex
Lovatt, D., Sonnewald, U., Waagepetersen, H. S., Schousboe, A., He, W., Lin, J. H.-C., Han, X., Takano, T., Wang, S., Sim, F. J., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3404-07.2007 · Cited by 488 · see citing works
Non–cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology
Ballas, N., Lioy, D. T., Grunseich, C., & Mandel, G. (2009) · Nature Neuroscience · doi:10.1038/nn.2275 · Cited by 466 · see citing works
Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia.
Lawler, J., Sunday, M. E., Thibert, V., Duquette, M. A., George, E. L., Rayburn, H., & Hynes, R. O. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1684 · Cited by 456 · see citing works
The functions of thrombospondin-1 and-2
Lawler, J. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00143-5 · Cited by 441 · see citing works
Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
Nagele, R. G., D’Andrea, M. R., Lee, H., Venkataraman, V., & Wang, H.-Y. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02361-8 · Cited by 416 · see citing works
Cooperative Astrocyte and Dendritic Spine Dynamics at Hippocampal Excitatory Synapses
Haber, M., Zhou, L., & Murai, K. K. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1302-06.2006 · Cited by 413 · see citing works
The cell biology of thrombospondin-1
Chen, H., Herndon, M. E., & Lawler, J. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00107-4 · Cited by 393 · see citing works
Astrocytes in the Epileptic Brain
Wetherington, J. P., Serrano, G. E., & Dingledine, R. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.002 · Cited by 391 · see citing works
Altered Metabolism of the Amyloid β Precursor Protein Is Associated with Mitochondrial Dysfunction in Down's Syndrome
Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., & Yankner, B. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00604-9 · Cited by 387 · see citing works
Self-citation
Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons
Papa, M., Bundman, M. C., Greenberger, V., & Segal, M. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-01-00001.1995 · Cited by 330 · see citing works
Rapid formation and remodeling of postsynaptic densities in developing dendrites
Marrs, G. S., Green, S. H., & Dailey, M. E. (2001) · Nature Neuroscience · doi:10.1038/nn717 · Cited by 303 · see citing works
Loss of astrocytic domain organization in the epileptic brain
Oberheim, N. A., Tian, G.-F., Han, X., Peng, W., Takano, T., Ransom, B., & Nedergaard, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4980-07.2008 · Cited by 303 · see citing works
Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies
Isenberg, J. S., Martin‐Manso, G., Maxhimer, J. B., & Roberts, D. D. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2561 · Cited by 301 · see citing works
Synaptic structural abnormalities in the Ts65Dn mouse model of down syndrome
Belichenko, P. V., Masliah, E., Kleschevnikov, A. M., Villar, A. J., Epstein, C. J., Salehi, A., & Mobley, W. C. (2004) · Journal of Comparative Neurology · doi:10.1002/cne.20337 · Cited by 297 · see citing works
PKC signaling mediates global enhancement of excitatory synaptogenesis in neurons triggered by local contact with astrocytes.
Hama, H., Hara, C., Yamaguchi, K., & Miyawaki, A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00007-8 · Cited by 290 · see citing works
Structural abnormalities of the cerebral cortex in human chromosomal aberrations: a Golgi study
Marin-Padilla, M. (1972) · Brain Research · doi:10.1016/0006-8993(72)90324-1 · Cited by 290 · see citing works
Astrocytes and Ischemic Injury
Takano, T., Oberheim, N., Cotrina, M. L., & Nedergaard, M. (2008) · Stroke · doi:10.1161/strokeaha.108.533166 · Cited by 285 · see citing works
Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome. A Golgi study
Marin‐Padilla, M. (1976) · Journal of Comparative Neurology · doi:10.1002/cne.901670105 · Cited by 285 · see citing works
Rett Syndrome Astrocytes Are Abnormal and Spread MeCP2 Deficiency through Gap Junctions
Maezawa, I., Swanberg, S. E., Harvey, D. J., LaSalle, J. M., & Jin, L. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0324-09.2009 · Cited by 283 · see citing works
Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily
Crossin, K. L., & Krushel, L. A. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200006)218:2 · Cited by 283 · see citing works
Thrombospondins 1 and 2 are Necessary for Synaptic Plasticity and Functional Recovery after Stroke
Liauw, J. A., Hoang, S., Choi, M. Y., Eroğlu, Ç., Choi, M., Sun, G.-H., Percy, M., Wildman‐Tobriner, B., Bliss, T. M., Guzman, R. G., et al. (2008) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.65 · Cited by 263 · see citing works
Direct Astrocytic Contacts Regulate Local Maturation of Dendritic Spines
西田, 秀., & Okabe, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4466-06.2007 · Cited by 256 · see citing works
Parallels of craniofacial maldevelopment in down syndrome and Ts65Dn mice
Richtsmeier, J. T., Baxter, L. L., & Reeves, R. H. (2000) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(200002)217:2 · Cited by 255 · see citing works
A Role for Synaptic Zinc in Activity-Dependent Aβ Oligomer Formation and Accumulation at Excitatory Synapses
Deshpande, A., Kawai, H., Metherate, R., Glabe, C. G., & Busciglio, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5980-08.2009 · Cited by 232 · see citing works
Self-citation
Microtubules in Dendritic Spine Development
Gu, J., Firestein, B. L., & Zheng, J. Q. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2509-08.2008 · Cited by 221 · see citing works
Modulatory Role of Drebrin on the Cytoskeleton within Dendritic Spines in the Rat Cerebral Cortex
Hayashi, K., Ishikawa, R., Ye, L., He, X., Takata, K., Kohama, K., & Shirao, T. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-22-07161.1996 · Cited by 217 · see citing works
The Novel Roles of Glial Cells Revisited: The Contribution of Radial Glia and Astrocytes to Neurogenesis
Mori, T., Buffo, A., & Götz, M. (2005) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(05)69004-7 · Cited by 212 · see citing works
Synaptic and cognitive abnormalities in mouse models of down syndrome: Exploring genotype‐phenotype relationships
Belichenko, P. V., Kleschevnikov, A. M., Salehi, A., Epstein, C. J., & Mobley, W. C. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21433 · Cited by 202 · see citing works
Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus
Ferrer, I., & Gullotta, F. (1990) · Acta Neuropathologica · doi:10.1007/bf00294247 · Cited by 201 · see citing works
Thrombospondin 1 accelerates synaptogenesis in hippocampal neurons through neuroligin 1
Xu, J., Xiao, N., & Xia, J. (2009) · Nature Neuroscience · doi:10.1038/nn.2459 · Cited by 200 · see citing works
Dendritic pathology in mental retardation: from molecular genetics to neurobiology
Dierssen, M., & Ramakers, G. J. A. (2006) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2006.00224.x · Cited by 190 · see citing works
Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome: A quantitative golgi study
Suetsugu, M., & Mehraein, P. (1980) · Acta Neuropathologica · doi:10.1007/bf00688755 · Cited by 190 · see citing works
Astrocytes prevent abnormal neuronal development in the fragile X mouse.
Jacobs, S., & Doering, L. C. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5027-09.2010 · Cited by 170 · see citing works
Identification of integrin α3β1 as a neuronal thrombospondin receptor mediating neurite outgrowth
DeFreitas, M. F., Yoshida, C. K., Frazier, W. A., Mendrick, D. L., Kypta, R. M., & Reichard, L. F. (1995) · Neuron · doi:10.1016/0896-6273(95)90038-1 · Cited by 169 · see citing works
A Chromosome 21 Critical Region Does Not Cause Specific Down Syndrome Phenotypes
Olson, L. E., Richtsmeier, J., Leszl, J. M., & Reeves, R. H. (2004) · Science · doi:10.1126/science.1098992 · Cited by 153 · see citing works
Human Chromosome 21 Dosage: Effect on the Expression of the Interferon Induced Antiviral State
Tan, Y., Schneider, E. L., Tischfield, J. A., Epstein, C. J., & Ruddle, F. H. (1974) · Science · doi:10.1126/science.186.4158.61 · Cited by 144 · see citing works
Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis
Hughes, E. G., Elmariah, S. B., & Balice‐Gordon, R. J. (2009) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2009.10.004 · Cited by 143 · see citing works
Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome
Ayberk Kurt, M., Ilker Kafa, M., Dierssen, M., & Ceri Davies, D. (2004) · Brain Research · doi:10.1016/j.brainres.2004.06.075 · Cited by 126 · see citing works
Dendritic and histochemical development and ageing in patients with Down's syndrome
TAKASHIMA, S., IIDA, K., MITO, T., & ARIMA, M. (1994) · Journal of Intellectual Disability Research · doi:10.1111/j.1365-2788.1994.tb00394.x · Cited by 126 · see citing works
On dendrites in Down syndrome and DS murine models: a spiny way to learn
Benavides‐Piccione, R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.08.001 · Cited by 124 · see citing works
Rapid dendritic movements during synapse formation and rearrangement
Wong, W. T., & Wong, R. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(99)00059-8 · Cited by 121 · see citing works
Thrombospondin 1—a key astrocyte‐derived neurogenic factor
Lu, Z., & Kipnis, J. (2010) · The FASEB Journal · doi:10.1096/fj.09-150573 · Cited by 121 · see citing works
Glia maintain follower neuron survival during Drosophila CNS development
Booth, G. E., Kinrade, E. F. V., & Hidalgo, A. (2000) · Development · doi:10.1242/dev.127.2.237 · Cited by 120 · see citing works
Deposition and role of thrombospondin in the histogenesis of the cerebellar cortex.
O’Shea, K. S., Rheinheimer, J. S. T., & Dixit, V. M. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1275 · Cited by 117 · see citing works
Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome
Ebrahim, A. S., Shimohata, A., Akagi, T., Yu, W., Yamaguchi, M., Murayama, M., Chui, D., Takeuchi, T., Amano, K., Subramhanya, K. H., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl211 · Cited by 117 · see citing works
Thrombospondin and a 140 kd fragment promote adhesion and neurite outgrowth from embryonic central and peripheral neurons and from PC12 cells
O’Shea, K. S., Liu, L.-H. J., & Dixita, V. M. (1991) · Neuron · doi:10.1016/0896-6273(91)90261-w · Cited by 115 · see citing works
Increased Cortical Expression of Two Synaptogenic Thrombospondins in Human Brain Evolution
Cáceres, M., Suwyn, C. R., Maddox, M., Thomas, J. W., & Preuss, T. M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl140 · Cited by 114 · see citing works
Human brain glial cells synthesize thrombospondin.
Asch, A. S., Leung, L. L. K., Shapiro, J. R., & Nachman, R. L. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.9.2904 · Cited by 112 · see citing works
Identification of Astrocyte Secreted Proteins with a Combination of Shotgun Proteomics and Bioinformatics
Dowell, J. A., Johnson, J. A., & Li, L. (2009) · Journal of Proteome Research · doi:10.1021/pr900248y · Cited by 110 · see citing works
Thrombospondin‐1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
Blake, S. M., Strasser, V., Andrade, N., Duit, S., Hofbauer, R., Schneider, W. J., & Nimpf, J. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.223 · Cited by 107 · see citing works
Purinergic signaling induces thrombospondin-1 expression in astrocytes
Tran, M. D., & Neary, J. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603146103 · Cited by 100 · see citing works
Thrombospondin promotes process outgrowth in neurons from the peripheral and central nervous systems
Osterhout, D. J., Frazier, W. A., & Higgins, D. M. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90240-h · Cited by 99 · see citing works
Neuronal plasticity and astrocytic reaction in Down syndrome and Alzheimer disease
J�rgensen, O. S., Brooksbank, B. W. L., & Balázs, R. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90182-m · Cited by 98 · see citing works
Modulation of Neuritogenesis by Astrocyte Muscarinic Receptors
Guizzetti, M., Moore, N. H., Giordano, G., & Costa, L. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801316200 · Cited by 90 · see citing works
ets-2 Promotes the Activation of a Mitochondrial Death Pathway in Down's Syndrome Neurons
Helguera, P., Pelsman, A., Pigino, G., Wolvetang, E., Head, E., & Busciglio, J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.5107-04.2005 · Cited by 88 · see citing works
Self-citation
Shotgun proteomics implicates extracellular matrix proteins and protease systems in neuronal development induced by astrocyte cholinergic stimulation
Moore, N. H., Costa, L. G., Shaffer, S. A., Goodlett, D. R., & Guizzetti, M. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05836.x · Cited by 77 · see citing works
Mass spectrometric and computational analysis of cytokine‐induced alterations in the astrocyte secretome
Keene, S. D., Greco, T. M., Parastatidis, I., Lee, S. H., Hughes, E. G., Balice‐Gordon, R. J., Speicher, D. W., & Ischiropoulos, H. (2009) · PROTEOMICS · doi:10.1002/pmic.200800385 · Cited by 73 · see citing works
Interferon treatment inhibits glycosylation of a viral protein
Maheshwari, R. K., Banerjee, D. K., Waechter, C. J., Olden, K., & Friedman, R. M. (1980) · Nature · doi:10.1038/287454a0 · Cited by 72 · see citing works
Nitric Oxide and Its Gatekeeper Thrombospondin-1 in Tumor Angiogenesis
Roberts, D. D., Isenberg, J. S., Ridnour, L. A., & Wink, D. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1758 · Cited by 68 · see citing works
Tumor necrosis factor-alpha and IFN-gamma expression in human thymus. Localization and overexpression in Down syndrome (trisomy 21)
Murphy, M., Friend, D., Pike-Nobile, L., & Epstein, L. B. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.7.2506 · Cited by 67 · see citing works
GVS‐111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons
Pelsman, A., Hoyo‐Vadillo, C., Гудашева, Т. А., Середенин, С. Б., Ostrovskaya, R. U., & Busciglio, J. A. (2003) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(03)00031-5 · Cited by 65 · see citing works
Self-citation
Chromosome 21 and the cell growth inhibitory effect of human interferon preparations
Tan, Y. (1976) · Nature · doi:10.1038/260141a0 · Cited by 65 · see citing works
The actions of BDNF on dendritic spine density and morphology in organotypic slice cultures depend on the presence of serum in culture media
Chapleau, C. A., Carlo, M. E., Larimore, J. L., & Pozzo‐Miller, L. D. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.12.006 · Cited by 63 · see citing works
Thrombospondin Signaling of Focal Adhesion Disassembly Requires Activation of Phosphoinositide 3-Kinase
Greenwood, J. A., Pallero, M. A., Theibert, A. B., & Murphy-Ullrich, J. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1755 · Cited by 62 · see citing works
T Lymphocyte Maturation Is Impaired in Healthy Young Individuals Carrying Trisomy 21 (Down Syndrome)
Guazzarotti, L., Trabattoni, D., Castelletti, E., Boldrighini, B., Piacentini, L., Duca, P., Beretta, S., Pacei, M., Caprio, C., Vigan�, A., et al. (2009) · American Journal on Intellectual and Developmental Disabilities · doi:10.1352/2009.114.100-109 · Cited by 48 · see citing works
Stress, Aging, and Neurodegenerative Disorders: Molecular Mechanismsa
Busciglio, J. A., Andersen, J. K., Schipper, H. M., Gilad, G. M., McCarty, R. C., Marzatico, F., & Toussaint, O. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09021.x · Cited by 45 · see citing works
Self-citation
TSP-1 Secreted by Bone Marrow Stromal Cells Contributes to Retinal Ganglion Cell Neurite Outgrowth and Survival
Yu, K., Ge, J., Summers, J. B., Li, F., Liu, X., Ma, P., Kaminski, J., & Zhuang, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002470 · Cited by 44 · see citing works
Drebrin a content correlates with spine head size in the adult mouse cerebral cortex
Kobayashi, C., Aoki, C. J., Kojima, N., Yamazaki, H., & Shirao, T. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21408 · Cited by 43 · see citing works
Tau isoform expression and regulation in human cortical neurons
Deshpande, A. M., Win, K. M., & Busciglio, J. A. (2008) · The FASEB Journal · doi:10.1096/fj.07-096909 · Cited by 39 · see citing works
Self-citation
Inhibitory Effect of Gamma Interferon on Cultured Human Keratinocyte Thrombospondin Production, Distribution, and Biologic Activities
Nickoloff, B. J., Riser, B. L., Mitra, R. S., Dixit, V. M., & Varani, J. (1988) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12465005 · Cited by 33 · see citing works
Phosphatidylinositol 3-Kinase and Focal Adhesion Kinase Are Early Signals in the Growth Factor–Like Responses to Thrombospondin-1 Seen in Human Vascular Smooth Muscle
Lymn, J., Rao, S. J., Clunn, G. F., Gallagher, K. L., O’Neil, C., Thompson, N. T., & Hughes, A. D. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.9.2133 · Cited by 31 · see citing works
Evidence for an interferon-related inflammatory reaction in the trisomy 16 mouse brain leading to caspase-1-mediated neuronal apoptosis
Hallam, D. M., Capps, N. L., Travelstead, A. L., Brewer, G. J., & Maroun, L. E. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00289-7 · Cited by 28 · see citing works
Down's syndrome astrocytes have greater antioxidant capacity than euploid astrocytes
Sebastià, J., Cristòfol, R. M., Pertusa, M., Vı́lchez, D., Torán, N., Barambio, S., Rodrı́guez-Farré, E., & Sanfeliu, C. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03686.x · Cited by 26 · see citing works
Interferon-γ- and interleukin-4-producing T cells in Down's syndrome
Franciotta, D. M., Verri, A., Zardini, E., Andreoni, L., AMICI, M. D., Moratti, R., & Nespoli, L. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.048 · Cited by 25 · see citing works
Cerebral cortical astroglia from the trisomy 16 mouse, a model for Down syndrome, produce neuronal cholinergic deficits in cell culture
Nelson, P. G., Fitzgerald, S., Рапопорт, С. И., Neale, E. A., Galdzicki, Z., Dunlap, V., Bowers, L. M., & Ágoston, D. V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12644 · Cited by 24 · see citing works
Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome
Bambrick, L. L., Yarowsky, P., & Krueger, B. K. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10630 · Cited by 23 · see citing works
Influences of interferon-gamma on cell proliferation and interleukin-6 production in Down syndrome derived fibroblasts
Iwamoto, T., Yamada, A., Yuasa, K., Fukumoto, E., Nakamura, T., Fujiwara, T., & Fukumoto, S. (2009) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.07.009 · Cited by 23 · see citing works
Reduced Expression of Thrombospondins and Craniofacial Dysmorphism in Mice Overexpressing Fra1
Nishiwaki, T., Yamaguchi, T., Chen, Z., Amano, H., Hankenson, K. D., BORNSTEIN, P. K., Toyama, Y., & Matsuo, K. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.051216 · Cited by 20 · see citing works
Interferon Action and Chromosome 21 Trisomy (Down Syndrome): 15 Years Later
Maroun, L. E. (1996) · Journal of Theoretical Biology · doi:10.1006/jtbi.1996.0113 · Cited by 20 · see citing works
The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression
Giehl, K., Graneß, A., & Goppelt‐Struebe, M. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00093.2007 · Cited by 19 · see citing works
Anti-gamma interferon can prevent the premature death of trisomy 16 mouse cortical neurons in culture
Hallam, D. M., & Maroun, L. E. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00541-2 · Cited by 17 · see citing works
Down's syndrome, interferon sensitivity and the development of leukaemia
Zihni, L. (1994) · Leukemia Research · doi:10.1016/0145-2126(94)90002-7 · Cited by 9 · see citing works
Untitled work
(1997) · doi:10.1002/(sici)1098-1136(199704)19:4

Flagged first, then by citations

Research works printed but not linked: 2

[27]Adams JC Tucker RP 2000 The thrombospondin type 1 repeat (TSR) superfamily: diverse proteins with related roles in neuronal development. Dev Dyn 218 280 299 10842357
[55]Bambrick LL Golovina VA Blaustein MP Yarowsky PJ Krueger BK 1997 Abnormal calcium homeostasis in astrocytes from the trisomy 16 mouse. Glia 19 352 358 9097079

Sorted by citations

Cell Biology of Astrocyte-Synapse Interactions
Allen, N. J., & Eroğlu, Ç. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.056 · Cited by 1,031 · see citing works
Emerging roles of astrocytes in neural circuit development
Clarke, L. E., & Barres, B. A. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3484 · Cited by 975 · see citing works
Astrocytes Control Synapse Formation, Function, and Elimination
Chung, W.-S., Allen, N. J., & Eroglu, C. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020370 · Cited by 839 · see citing works
Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons
Diniz, L. P., Almeida, J. C., Tortelli, V., Lopes, C. V., Setti-Perdigão, P., Stipursky, J., Kahn, S. A., Romão, L. F., Miranda, J. D., Alves‐Leon, S. V., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.380824 · Cited by 237 · see citing works
Role of astrocyte–synapse interactions in CNS disorders
Blanco‐Suárez, E., Caldwell, A. L. M., & Allen, N. J. (2016) · The Journal of Physiology · doi:10.1113/jp270988 · Cited by 222 · see citing works
Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain
Kim, S. K., Hayashi, H., Ishikawa, T., Shibata, K., Shigetomi, E., Shinozaki, Y., Inada, H., Roh, S. E., Kim, S. J., Lee, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci82859 · Cited by 200 · see citing works
Thrombospondins as key regulators of synaptogenesis in the central nervous system
Risher, W. C., & Eroğlu, Ç. (2012) · Matrix Biology · doi:10.1016/j.matbio.2012.01.004 · Cited by 184 · see citing works
Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease
Price, B. R., Johnson, L. A., & Norris, C. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101335 · Cited by 174 · see citing works
The interplay between neurons and glia in synapse development and plasticity
Stogsdill, J. A., & Eroğlu, Ç. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.09.016 · Cited by 172 · see citing works
Astrocyte-Secreted Matricellular Proteins in CNS Remodelling during Development and Disease
Jones, E. V., & Bouvier, D. S. (2014) · Neural Plasticity · doi:10.1155/2014/321209 · Cited by 169 · see citing works
Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1
Risher, W. C., Kim, N., Koh, S., Choi, J.-E., Mitev, P., Spence, E. F., Pilaz, L., Wang, D., Feng, G., Silver, D. L., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201802057 · Cited by 158 · see citing works
Astrocytes and the TGF-β1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword
Diniz, L. P., Matias, I. C. P., Siqueira, M., Stipursky, J., & Gomes, F. C. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1396-y · Cited by 163 · see citing works
Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms
Oksanen, M., Lehtonen, Š., Jaronen, M., Goldsteins, G., Hämäläinen, R. H., & Koıstınaho, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03111-7 · Cited by 156 · see citing works
Morphological plasticity of astroglia: Understanding synaptic microenvironment
Heller, J. P., & Rusakov, D. A. (2015) · Glia · doi:10.1002/glia.22821 · Cited by 150 · see citing works
Fetal Alcohol Spectrum Disorders: An Overview from the Glia Perspective
Wilhelm, C., & Guizzetti, M. (2016) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2015.00065 · Cited by 128 · see citing works
A Lifespan Approach to Neuroinflammatory and Cognitive Disorders: A Critical Role for Glia
Bilbo, S. D., Smith, S. H., & Schwarz, J. M. (2011) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-011-9299-y · Cited by 127 · see citing works
The X-Linked Intellectual Disability Protein TSPAN7 Regulates Excitatory Synapse Development and AMPAR Trafficking
Bassani, S., Cingolani, L. A., Valnegri, P., Folci, A., Zapata, J., Gianfelice, A., Sala, C., Goda, Y., & Passafaro, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.021 · Cited by 113 · see citing works
Further understanding the connection between Alzheimer's disease and Down syndrome
Snyder, H. M., Bain, L. J., Brickman, A. M., Carrillo, M. C., Esbensen, A. J., Espinosa, J. M., Fernandez, F., Fortea, J., Hartley, S. L., Head, E., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12112 · Cited by 105 · see citing works
Glia and Neurodevelopment: Focus on Fetal Alcohol Spectrum Disorders
Guizzetti, M., Zhang, X., Goeke, C. M., & Gavin, D. P. (2014) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00123 · Cited by 102 · see citing works
Role of glia in developmental synapse formation
Allen, N. J. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.06.004 · Cited by 91 · see citing works
Down syndrome: Neurobiological alterations and therapeutic targets
Vacca, R. A., Bawari, S., Valenti, D., Tewari, D., Nabavi, S. F., Shirooie, S., Sah, A. N., Volpicella, M., Braidy, N., & Nabavi, S. M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.001 · Cited by 90 · see citing works
Aberrant astrocyte protein secretion contributes to altered neuronal development in multiple models of neurodevelopmental disorders.
Caldwell, A. L. M., Sancho, L., Deng, J., Bosworth, A., Miglietta, A., Diedrich, J. K., Shokhirev, M. N., & Allen, N. J. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01150-1 · Cited by 86 · see citing works
Astrocyte‐mediated synapse remodeling in the pathological brain
Kim, S. K., Nabekura, J., & Koizumi, S. (2017) · Glia · doi:10.1002/glia.23169 · Cited by 84 · see citing works
Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model.
Cheng, C., Lau, S. K. M., & Doering, L. C. (2016) · Molecular Brain · doi:10.1186/s13041-016-0256-9 · Cited by 84 · see citing works
Astrocytic control of neural circuit formation: Highlights on TGF-beta signaling
Diniz, L. P., Matias, I. C. P., Garcia, M. N., & Gomes, F. C. A. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.07.008 · Cited by 84 · see citing works
Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer’s disease model
Kim, D. H., Lim, H., Lee, D., Choi, S. J., Oh, W., Yang, Y. S., Oh, J. S., Hwang, H. H., & Jeon, H. B. (2018) · Scientific Reports · doi:10.1038/s41598-017-18542-0 · Cited by 76 · see citing works
Type I Interferon Receptor Signaling in Astrocytes Regulates Hippocampal Synaptic Plasticity and Cognitive Function of the Healthy CNS
Hosseini, S., Michaelsen‐Preusse, K., Grigoryan, G., Chhatbar, C., Kalinke, U., & Körte, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107666 · Cited by 71 · see citing works
Astrocyte Regulation of Synapse Formation, Maturation, and EliminationPreprint
Chung, W., Baldwin, K. T., & Allen, N. J. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041352 · Cited by 73 · see citing works
Functions of flavonoids in the central nervous system: Astrocytes as targets for natural compounds
Matias, I. C. P., Buosi, A. S., & Gomes, F. C. A. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.01.009 · Cited by 70 · see citing works
Thrombospondins: A Role in Cardiovascular Disease
Chistiakov, D. A., Melnichenko, A. А., Myasoedova, V. A., Grechko, A. V., & Orekhov, A. N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071540 · Cited by 69 · see citing works
Astrocytes in Neural Circuits: Key Factors in Synaptic Regulation and Potential Targets for Neurodevelopmental Disorders
Liu, X., Ying, J., Wang, X., Zheng, Q., Zhao, T., Yoon, S., Yu, W., Yang, D., Yang, F., & Hua, F. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.729273 · Cited by 70 · see citing works
Casting a net on dendritic spines: The extracellular matrix and its receptors
Dansie, L. E., & Ethell, I. M. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20963 · Cited by 66 · see citing works
Delayed transplantation of precursor cell‐derived astrocytes provides multiple benefits in a rat model of Parkinsons
Pröschel, C., Stripay, J. L., Shih, C., Munger, J. C., & Noble, M. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201302878 · Cited by 64 · see citing works
Decreased astrocytic thrombospondin‐1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studies
Jayakumar, A. R., Tong, X., Curtis, K. M., Ruiz‐Cordero, R., Shamaladevi, N., Abuzamel, M., Johnstone, J. T., Gaidosh, G., Rao, K. V. R., & Norenberg, M. D. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12810 · Cited by 61 · see citing works
Role of Matricellular Proteins in Disorders of the Central Nervous System
Jayakumar, A. R., Apeksha, A., & Norenberg, M. D. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2088-5 · Cited by 58 · see citing works
Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model
Mizuno, G. O., Wang, Y., Shi, G., Wang, Y., Sun, J., Papadopoulos, S., Broussard, G. J., Unger, E. K., Deng, W., Weick, J., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.06.033 · Cited by 58 · see citing works
Down Syndrome iPSC-Derived Astrocytes Impair Neuronal Synaptogenesis and the mTOR Pathway In Vitro
Araujo, B. H. S., Kaid, C., De Souza, J. S., Gomes da Silva, S., Goulart, E., Caires, L. C. J., Musso, C. M., Torres, L. B., Ferrasa, A., Herai, R., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0818-6 · Cited by 56 · see citing works
Defects in Motoneuron–Astrocyte Interactions in Spinal Muscular Atrophy
Zhou, C., Feng, Z., & Ko, C. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3534-15.2016 · Cited by 47 · see citing works
The Role of Astrocytes in the Development of the Cerebellum
Araújo, A. P. B., Carpi-Santos, R., & Gomes, F. C. A. (2019) · The Cerebellum · doi:10.1007/s12311-019-01046-0 · Cited by 53 · see citing works
Human iPSC-derived Down syndrome astrocytes display genome-wide perturbations in gene expression, an altered adhesion profile, and increased cellular dynamics
Ponroy Bally, B., Farmer, W. T., Jones, E. V., Jessa, S., Kacerovsky, J. B., Mayran, A., Peng, H., Lefebvre, J. L., Drouin, J., Hayer, A., et al. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa003 · Cited by 49 · see citing works
Do Astrocytes Play a Role in Intellectual Disabilities?
Cresto, N., Pillet, L., Billuart, P., & Rouach, N. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.05.011 · Cited by 49 · see citing works
Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome
Torres, M. D., Garcı́a, O., Tang, C. G., & Busciglio, J. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.025 · Cited by 48 · see citing works
Self-citation
Mitochondrial dysfunction and Down's syndrome: is there a role for coenzyme Q(10) ?
Tiano, L., & Busciglio, J. (2011) · Biofactors · doi:10.1002/biof.184 · Cited by 43 · see citing works
Self-citation
Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density
Diwakarla, S., Nylander, E., Grönbladh, A., Vanga, S. R., Shamsudin, Y., Gutiérrez‐de‐Terán, H., Ng, L., Pham, V., Sävmarker, J., Lundbäck, T., et al. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.102533 · Cited by 45 · see citing works
Beyond counts and shapes: Studying pathology of dendritic spines in the context of the surrounding neuropil through serial section electron microscopy
Kuwajima, M., Špaček, J., & Harris, K. M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.061 · Cited by 45 · see citing works
Amyloid-β Inhibits Thrombospondin 1 Release From Cultured Astrocytes: Effects on Synaptic Protein Expression
Rao, K. V. R., Curtis, K. M., Johnstone, J. T., & Norenberg, M. D. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31829bd082 · Cited by 42 · see citing works
SNAP25 Inhibits Glioma Progression by Regulating Synapse Plasticity via GLS-Mediated Glutaminolysis
Huang, Q., Lian, C., Dong, Y., Zeng, H., Liu, B., Xu, N., He, Z., & Guo, H. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.698835 · Cited by 40 · see citing works
Astrocytes in Down Syndrome Across the Lifespan
Ponroy Bally, B., & Murai, K. K. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.702685 · Cited by 35 · see citing works
Role of P2 receptors in normal brain development and in neurodevelopmental psychiatric disorders
Huang, L., Otrokocsi, L., & Sperlágh, B. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.030 · Cited by 34 · see citing works
Distribution of thrombospondins and their neuronal receptor α2δ1 in the rat retina
Huang, J., Zhou, L., Wang, H., Luo, J., Zeng, L., Xiong, K., & Chen, D. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.03.012 · Cited by 30 · see citing works
Electroconvulsive seizure induces thrombospondin-1 in the adult rat hippocampus
Okada‐Tsuchioka, M., Segawa, M., Kajitani, N., Hisaoka‐Nakashima, K., Shibasaki, C., Morinobu, S., & Takebayashi, M. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.001 · Cited by 30 · see citing works
Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte–Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine
Siemsen, B. M., Denton, A. R., Parrilla-Carrero, J., Hooker, K. N., Carpenter, E. A., Prescot, M. E., Brock, A. G., Westphal, A. M., Leath, M. N., McFaddin, J. A., et al. (2023) · Cells · doi:10.3390/cells12141812 · Cited by 29 · see citing works
Altered microtubule dynamics in Mecp2‐deficient astrocytes
Nectoux, J., Florian, C., Delepine, C., Bahi‐Buisson, N., Khelfaoui, M., Reibel, S., Chelly, J., & Bienvenu, T. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23001 · Cited by 29 · see citing works
Astrocytic CCAAT/Enhancer Binding Protein δ Regulates Neuronal Viability and Spatial Learning Ability via miR-135a
Chu, Y., Ko, C., Wang, W., Wang, S., Gean, P., Kuo, Y., & Wang, J. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9359-z · Cited by 29 · see citing works
Consequences of trisomy 21 for brain development in Down syndrome
Russo, M. L., Sousa, A. M. M., & Bhattacharyya, A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-024-00866-2 · Cited by 28 · see citing works
“Although the tools used to ensure accurate proportions of interneuron subtypes in a culture system have only recently been developed 132 , simple neuron–glia co-cultures have already provided evidence that astrocytes and microglia do have a role in the DS synaptic phenotype 131,134,135 .”
Influential
Astrocytes regulate neuronal network activity by mediating synapse remodeling
Kim, N., & Chung, W. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.09.007 · Cited by 28 · see citing works
Human Trisomic iPSCs from Down Syndrome Fibroblasts Manifest Mitochondrial Alterations Early during Neuronal Differentiation
Mollo, N., Esposito, M., Aurilia, M., Scognamiglio, R., Accarino, R., Bonfiglio, F., Cicatiello, R., Charalambous, M., Procaccini, C., Micillo, T., et al. (2021) · Biology · doi:10.3390/biology10070609 · Cited by 29 · see citing works
Astrocytes and developmental plasticity in fragile X.
Cheng, C., Sourial, M., & Doering, L. C. (2012) · Neural Plasticity · doi:10.1155/2012/197491 · Cited by 28 · see citing works
Alterations in neuronal cytoskeletal and astrocytic proteins content in the brain of the autistic-like mouse strain C58/J
Barón-Mendoza, I., Garcı́a, O., Calvo‐Ochoa, E., Rebollar-García, J. O., Garzón-Cortés, D., Haro, R., & González‐Arenas, A. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.06.004 · Cited by 27 · see citing works
Astroglial and microglial pathology in Down syndrome: Focus on Alzheimer's disease
Garcı́a, O., & Aguilar, L. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.987212 · Cited by 25 · see citing works
Challenges and Opportunities for Translation of Therapies to Improve Cognition in Down Syndrome
Lee, S. E., Duran-Martinez, M., Khantsis, S., Bianchi, D., & Guedj, F. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.10.001 · Cited by 23 · see citing works
Thrombospondins and synaptogenesis.
Wang, B., Guo, W., & Huang, Y. (2012) · PubMed Central · doi:10.3969/j.issn.1673-5374.2012.22.009 · Cited by 22 · see citing works
Simultaneous analysis of dendritic spine density, morphology and excitatory glutamate receptors during neuron maturation in vitro by quantitative immunocytochemistry
Nwabuisi‐Heath, E., LaDu, M. J., & Yu, C. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.04.003 · Cited by 22 · see citing works
Gene Expression Studies in Down Syndrome: What Do They Tell Us about Disease Phenotypes?
Chapman, L., Ramnarine, I. V. P., Zemke, D., Majid, A., & Bell, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052968 · Cited by 21 · see citing works
Is Autism a Member of a Family of Diseases Resulting from Genetic/Cultural Mismatches? Implications for Treatment and Prevention
Bilbo, S. D., Jones, J. P., & Parker, W. (2012) · Autism Research and Treatment · doi:10.1155/2012/910946 · Cited by 21 · see citing works
Genetics and Molecular Basis of Congenital Heart Defects in Down Syndrome: Role of Extracellular Matrix Regulation
Mollo, N., Scognamiglio, R., Conti, A. M. F., Paladino, S., Nitsch, L., & Izzo, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032918 · Cited by 24 · see citing works
Hippocampal neuronal subtypes develop abnormal dendritic arbors in the presence of Fragile X astrocytes
Jacobs, S. A., Cheng, C., & Doering, L. C. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.011 · Cited by 21 · see citing works
Defective synthesis and release of astrocytic thrombospondin‐1 mediates the neuronal TDP ‐43 proteinopathy, resulting in defects in neuronal integrity associated with chronic traumatic encephalopathy: in vitro studies
Jayakumar, A. R., Tong, X., Shamaladevi, N., Barcelona, S., Gaidosh, G., Agarwal, A. N., & Norenberg, M. D. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13867 · Cited by 21 · see citing works
Glial Cell Modulation of Dendritic Spine Structure and Synaptic Function
Rasia‐Filho, A. A., Calcagnotto, M. E., & Halbach, O. V. B. U. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-36159-3_6 · Cited by 21 · see citing works
Association of thrombospondin 1 gene with schizophrenia in Korean population
Park, H. J., Kim, S. K., Kim, J.-W., Kang, W. S., & Chung, J. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-1513-3 · Cited by 20 · see citing works
Rethinking intellectual disability from neuro- to astro-pathology.
Fernández-Blanco, Á., & Dierssen, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239039 · Cited by 19 · see citing works
Macroglia-derived thrombospondin 2 regulates alterations of presynaptic proteins of retinal neurons following elevated hydrostatic pressure
Wang, S.-C., Hu, T., Wang, Z., Li, N., Zhou, L.-H., Liao, L., Wang, M., Liao, L.-B., Wang, H., Zeng, L.-P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185388 · Cited by 17 · see citing works
Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells
Samari, N., de Saint‐Georges, L., Pani, G., Baatout, S., Leyns, L., & Benotmane, M. A. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1245 · Cited by 18 · see citing works
High glucose-induced defective thrombospondin-1 release from astrocytes via TLR9 activation contributes to the synaptic protein loss
Zhao, Y., Pu, D., Sun, Y., Chen, J., Luo, C., Wang, M., Zhou, J., Lv, A., Zhu, S., Liao, Z., et al. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.12.030 · Cited by 16 · see citing works
Acute and Chronic Mu Opioids Differentially Regulate Thrombospondins 1 and 2 Isoforms in Astrocytes
Phamduong, E., Rathore, M. K., Crews, N. R., D’Angelo, A. S., Leinweber, A. L., Kappera, P., Krenning, T. M., Rendell, V. R., Belcheva, M. M., & Coscia, C. J. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400172n · Cited by 16 · see citing works
Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome
Brandebura, A. N., Paumier, A., Asbell, Q. N., Tao, T., Micael, M. K. B., Sanchez, S., & Allen, N. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116300 · Cited by 17 · see citing works
Overexpression of the Hsa21 Transcription Factor RUNX1 Modulates the Extracellular Matrix in Trisomy 21 Cells
Mollo, N., Aurilia, M., Scognamiglio, R., Zerillo, L., Cicatiello, R., Bonfiglio, F., Pagano, P., Paladino, S., Conti, A. M. F., Nitsch, L., et al. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.824922 · Cited by 12 · see citing works
Molecular mechanisms that change synapse number
Mansilla, A., Jordán-Álvarez, S., Santana, E., Jarabo, P., Casas‐Tintó, S., & Ferrús, A. (2018) · Journal of Neurogenetics · doi:10.1080/01677063.2018.1506781 · Cited by 11 · see citing works
The role of astrocytes in attention-deficit hyperactivity disorder: An update
Dury, L. C., Ohki, C. M. Y., Lesch, K., Walitza, S., & Grünblatt, E. (2025) · Psychiatry Research · doi:10.1016/j.psychres.2025.116558 · Cited by 9 · see citing works
Modeling Neurodevelopmental and Neuropsychiatric Diseases with Astrocytes Derived from Human-Induced Pluripotent Stem Cells
Ren, B., & Dunaevsky, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041692 · Cited by 11 · see citing works
Chemogenetic manipulation of astrocyte activity at the synapse— a gateway to manage brain disease
Pereira, M. J., Ayana, R., Holt, M. G., & Arckens, L. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1193130 · Cited by 10 · see citing works
Single-nucleus RNA sequencing reveals cell type-specific transcriptome alterations of Down syndrome hippocampus using the Dp16 mouse model
Zhou, Z., Zhi, C., Chen, D., Cai, Z., & Jiang, X. (2023) · Genes & Genomics · doi:10.1007/s13258-023-01433-2 · Cited by 9 · see citing works
Astrocytic Alterations and Dysfunction in Down Syndrome: Focus on Neurogenesis, Synaptogenesis, and Neural Circuits Formation
Uguagliati, B., & Grilli, M. (2024) · Cells · doi:10.3390/cells13242037 · Cited by 8 · see citing works
DYRK1A in the physiology and pathology of the neuron-astrocyte axis
Cisternas, P., Kim, J.-Y., Ashfeld, B. L., & Zartman, J. J. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1626062 · Cited by 7 · see citing works
Astrocyte: A Foe or a Friend in Intellectual Disability-Related Diseases
Wang, B., Zou, L., Li, M., & Zhou, L. (2022) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2022.877928 · Cited by 7 · see citing works
Unraveling Molecular Pathways Altered in MeCP2-Related Syndromes, in the Search for New Potential Avenues for Therapy
Castells, A. A., Balada, R., Tristán‐Noguero, A., O’Callaghan, M., Cortès‐Saladelafont, E., Pascual‐Alonso, A., García‐Cazorla, À., Armstrong, J., & Alcántara, S. (2021) · Biomedicines · doi:10.3390/biomedicines9020148 · Cited by 6 · see citing works
Dendrites: A Key Structural Element of Neurons
Rollenhagen, A., & Lübke, J. H. R. (2012) · Springer eBooks · doi:10.1007/978-1-4614-1997-6_11 · Cited by 6 · see citing works
The Contributions of Thrombospondin-1 to Epilepsy Formation
Cheng, Y., Zhai, Y., Yuan, Y., Wang, Q., Li, S., & Sun, H. (2024) · Neuroscience Bulletin · doi:10.1007/s12264-024-01194-2 · Cited by 5 · see citing works
Development of Alzheimer’s disease in Down syndrome
García, O. A., Domínguez-de-la-Cruz, E., Luna-Martínez, I. G., Garnett-Carbajal, J. A., & Villegas-Piña, J. A. (2025) · Exploration of neuroscience · doi:10.37349/en.2025.1006104 · Cited by 4 · see citing works
Glial Control of Synaptogenesis
Allen, N. J. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199794591.003.0031 · Cited by 4 · see citing works
Dendritic Elaboration: Morphology and Chemistry
Rollenhagen, A., & Lübke, J. H. R. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_11 · Cited by 4 · see citing works
Circuit Reconstruction after Traumatic Spinal Cord Injury by Cellular and Pharmacological Approaches
Hosseini, S. M., Stecina, K., Nemati, S., Wang, R. R., Zhang, J. V., & Karimi‐Abdolrezaee, S. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0362-25.2025 · Cited by 3 · see citing works
Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes
Silva, A. L. T. E., de Oliveira, P. H. P., Yokota-Moreno, B. Y., Fausto, J. D. S., Avila, J. P., Nakaya, H. I., Sertie, A. L., & Zampieri, B. L. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02090-0 · Cited by 5 · see citing works
Special characteristics of human astrocytes and their roles in brain homeostasis
Kousa, I., Talvio, K., Peteri, U., & Castrén, M. L. (2026) · Neuroscience Applied · doi:10.1016/j.nsa.2026.107000 · Cited by 3 · see citing works
Neurodevelopmental Abnormalities in Down Syndrome: Assessing Structural and Functional Deficits
Robinson, J., Chawla, N., Patel, S., Spey, E., McNulty, O., & Kaur, G. (2024) · Cureus · doi:10.7759/cureus.76156 · Cited by 4 · see citing works
Physical training promotes remodeling of the skeletal muscle extracellular matrix: An ultrastructural study in a murine model of Down syndrome
Cisterna, B., Boschi, F., Lacavalla, M. A., Vattemi, G. N. A., Zancanaro, C., & Malatesta, M. (2023) · Microscopy Research and Technique · doi:10.1002/jemt.24379 · Cited by 3 · see citing works
Human Astrocytes Synchronize Neural Organoid NetworksPreprint
Patel, M. D., Lavekar, S. S., Jaisalmeria, R., Oji, S., Jayasi, J., Cvetkovic, C., & Krencik, R. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.17.618921 · Cited by 3 · see citing works
Modular Platform for Rapidly Investigating Long‐Distance Propagation of Human Neural Network Activity
Patel, M. D., Lavekar, S. S., Jaisalmeria, R., Oji, S., Jayasi, J., Cvetkovic, C., & Krencik, R. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502081 · Cited by 4 · see citing works
Down Syndrome
Torres, M. D., & Busciglio, J. A. (2014) · Springer eBooks · doi:10.1007/978-3-7091-0715-7_10 · Cited by 2 · see citing works
Self-citation
Conditioned Media Therapy in Alzheimer's Disease: Current Findings and Future Challenges
Firoozi, A., Shadi, M., Aghaei, Z., & Namavar, M. R. (2023) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x18666230523155659 · Cited by 2 · see citing works

Dendritic spine pathology and thrombospondin-1 deficits in Down syndrome
Torres, M. D., Garcı́a, O., Tang, C. G., & Busciglio, J. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.09.025 · Cited by 48 · see citing works
Self-citation
P4‐032: Spine pathology in down's syndrome and Alzheimer's disease
Torres, M., Garcı́a, O., & Busciglio, J. A. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.2052
Self-citation
Thrombospondin-1 (TSP-1) and Neuronal Plasticity: Implications in Down Syndrome
Garcia, O., Villegas-Piña, J. A., & Villegas-Piña, J. A. (2022) · Medical Research Archives · doi:10.18103/mra.v10i10.3168 · Cited by 2 · see citing works
Self-citation
Astrocytopathy Is Associated with CA1 Synaptic Dysfunction in a Mouse Model of Down Syndrome
Fernández‐Blanco, Á., González-Arias, C., Sierra, C., Zamora‐Moratalla, A., Perea, G., & Dierssen, M. (2025) · Cells · doi:10.3390/cells14171332 · Cited by 2 · see citing works
Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome
Brandebura, A. N., Paumier, A., Asbell, Q. N., Tao, T., Micael, M. K. B., Sanchez, S., & Allen, N. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116300 · Cited by 17 · see citing works

Authors: Garcia, O., Torres, M., Helguera, P., Coskun, P., & Busciglio, J.
Affiliations: University of California, Irvine (US)
Corresponding author: Busciglio, Jorge
ORCID: Helguera, Pablo
Coskun, Pinar
Busciglio, Jorge
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2010-12-02
Volume: 5
Issue: 12
Pages: e14200
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0014200
PMC: PMC2996288
OpenAlex: W2036755685
Cited by: 122
References: 115
Citations by year: 2026: 5 · 2025: 8 · 2024: 9 · 2023: 9 · 2022: 6 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 12 · 2015: 4 · 2014: 9 · 2013: 8 · 2012: 12
FWCI: 7.32
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: Larry L. Hillblom Foundation
National Institutes of Health (AG16573)
National Institute on Aging (AG 16573, P50AG016573)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-38466, R01HD038466)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Down syndrome and intellectual disability research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: Down syndrome, thrombospondin-1, astrocytes, dendritic spines, synaptic pathology, dendritic spine morphology, synaptic density, astrocyte-neuron co-culture, hippocampal neurons, intellectual disability, astrocyte dysfunction
MeSH terms: Animals, Astrocytes, Brain, Down Syndrome, Humans, Microscopy, Fluorescence, Neurons, Synapses, Gene Expression Regulation, Developmental, Coculture Techniques, Thrombospondin 1, Animals, Genetically Modified, Dendritic Spines, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A Role for Thrombospondin-1 Deficits in Astrocyte-Mediated Spine and Synaptic Pathology in Down's Syndrome

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks