Pietrzik, Claus U.

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., et al. (2001) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,388

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

Storck, S. E., Meister, S., Nahrath, J., Meißner, J. N., Schubert, N., Di Spiezio, A., Baches, S., Vandenbroucke, R. E., Bouter, Y., Prikulis, I., et al. (2015) · Journal of Clinical Investigation

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 477

The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice

Ring, S., Weyer, S. W., Kilian, S. B., Waldron, E., Pietrzik, C. U., Filippov, M. A., Herms, J., Buchholz, C., Eckman, C. B., Korte, M., et al. (2007) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 390

Modulation of amyloid β-protein clearance and Alzheimer’s disease susceptibility by the LDL receptor–related protein pathway

Kang, D. E., Pietrzik, C. U., Baum, L., Chevallier, N., Merriam, D. E., Kounnas, M. Z., Wagner, S. L., Troncoso, J. C., Kawas, C. H., Katzman, R., et al. (2000) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 354

Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

Brandscheid, C., Schuck, F., Reinhardt, S., Schäfer, K.-H., Pietrzik, C. U., Grimm, M., Hartmann, T., Schwiertz, A., & Endres, K. (2017) · Journal of Alzheimer s Disease

Gut microbiota and healthAlzheimer's disease research and treatments

Cited by 318

The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

Pietrzik, C. U., Busse, T., Merriam, D. E., Weggen, S., & Koo, E. H. (2002) · The EMBO Journal

Alzheimer's disease research and treatmentsCellular transport and secretion

Cited by 198

The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM

Storck, S. E., Hartz, A. M. S., Bernard, J., Wolf, A., Kachlmeier, A., Mahringer, A., Weggen, S., Pahnke, J., & Pietrzik, C. U. (2018) · Brain, Behavior, and Immunity

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 143

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

Pflanzner, T., Janko, M. C., André-Dohmen, B., Reuss, S., Weggen, S., Roebroek, A. J. M., Kuhlmann, C. R. W., & Pietrzik, C. U. (2011) · Neurobiology of Aging

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 141

Mechanisms of C-Reactive Protein-Induced Blood–Brain Barrier Disruption

Kuhlmann, C. R. W., Librizzi, L., Closhen, D., Pflanzner, T., Lessmann, V., Pietrzik, C. U., de Curtis, M., & Luhmann, H. J. (2009) · Stroke

Barrier Structure and Function StudiesAcute Ischemic Stroke Management

Cited by 138

LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer’s Disease

Van Gool, B., Storck, S. E., Reekmans, S. M., Lechat, B., Gordts, P. L. S. M., Pradier, L., Pietrzik, C. U., & Roebroek, A. J. M. (2019) · Molecular Neurobiology

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 114

Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

Tamboli, I. Y., Prager, K., Thal, D. R., Thelen, K. M., Dewachter, I., Pietrzik, C. U., St. George-Hyslop, P., Sisodia, S. S., De Strooper, B., Heneka, M. T., et al. (2008) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 68

The metalloprotease ADAMTS4 generates N-truncated Aβ4–x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer’s disease

Walter, S., Jumpertz, T., Hüttenrauch, M., Ogorek, I., Gerber, H., Storck, S. E., Zampar, S., Dimitrov, M., Lehmann, S., Lepka, K., et al. (2019) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 65

Low‐density lipoprotein receptor‐related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation

Safina, D., Schlitt, F., Romeo, R., Pflanzner, T., Pietrzik, C. U., Narayanaswami, V., Edenhofer, F., & Faissner, A. (2016) · Glia

Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene Regulation

Cited by 54

PCSK9 acts as a key regulator of Aβ clearance across the blood–brain barrier

Mazura, A. D., Ohler, A., Storck, S. E., Kurtyka, M., Scharfenberg, F., Weggen, S., Becker-Pauly, C., & Pietrzik, C. U. (2022) · Cellular and Molecular Life Sciences

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 53

LRP1 is critical for the surface distribution and internalization of the NR2B NMDA receptor subtype

Maier, W., Bednorz, M., Meister, S., Roebroek, A., Weggen, S., Schmitt, U., & Pietrzik, C. U. (2013) · Molecular Neurodegeneration

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 50

Meprin β: A novel regulator of blood–brain barrier integrity

Gindorf, M., Storck, S. E., Ohler, A., Scharfenberg, F., Becker-Pauly, C., & Pietrzik, C. U. (2021) · Journal of Cerebral Blood Flow & Metabolism

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 21

Endocrine Regulation of Microvascular Receptor—Mediated Transcytosis and Its Therapeutic Opportunities: Insights by PCSK9—Mediated Regulation

Mazura, A. D., & Pietrzik, C. U. (2023) · Pharmaceutics

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 9