Altered Gut Microbiome Composition and Tryptic Activity of the 5xFAD Alzheimer’s Mouse Model

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Ingestion of <i>Lactobacillus</i> strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

Bravo, J. A., Forsythe, P., Chew, M. V., Escaravage, E., Savignac, H. M., Dinan, T. G., Bienenstock, J., & Cryan, J. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102999108 · Cited by 3,888 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · see citing works

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders

Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works

Normal gut microbiota modulates brain development and behavior

Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228 · see citing works

The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works

Gut–brain axis: How the microbiome influences anxiety and depression

Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · see citing works

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200 · see citing works

Human gut microbes impact host serum metabolome and insulin sensitivity

Pedersen, H. K., Gudmundsdottir, V., Nielsen, H. B., Hyotylainen, T., Nielsen, T., Jensen, B. A. H., Forslund, K., Hildebrand, F., Prifti, E., Falony, G., et al. (2016) · Nature · doi:10.1038/nature18646 · Cited by 2,116 · see citing works

Blood-brain barrier breakdown in the aging human hippocampus

Montagne, A., Barnes, S. R., Sweeney, M. D., Halliday, M. R., Sagare, A. P., Zhao, Z., Toga, A. W., Jacobs, R. E., Liu, C. Y., Amezcua, L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.032 · Cited by 2,102 · see citing works

Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

Braak, H., de Vos, R. A. I., Bohl, J., & Del Tredici, K. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.012 · Cited by 1,354 · see citing works

Consumption of fermented milk product with probiotic modulates brain activity

Tillisch, K., Labus, J., Kilpatrick, L., Jiang, Z., Stains, J., Ebrat, B., Guyonnet, D., Legrain–Raspaud, S., Trotin, B., Naliboff, B., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.02.043 · Cited by 1,192 · see citing works

Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls

Unger, M. M., Spiegel, J., Dillmann, K.-U., Grundmann, D., Philippeit, H., Bürmann, J., Faßbender, K., Schwiertz, A., & Schäfer, K.-H. (2016) · Parkinsonism &amp; Related Disorders · doi:10.1016/j.parkreldis.2016.08.019 · Cited by 1,159 · see citing works

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

Soscia, S. J., Kirby, J. E., Washicosky, K. J., Tucker, S. M., Ingelsson, M., Hyman, B., Burton, M. A., Goldstein, L. E., Duong, S., Tanzi, R. E., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009505 · Cited by 1,060 · see citing works

In vitro characterization of conditions for amyloid-β peptide oligomerization and fibrillogenesis

Stine, W. B., Dahlgren, K. N., Krafft, G. A., & LaDu, M. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210207200 · Cited by 1,015 · see citing works

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease

Oddo, S. (2003) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.08.012 · Cited by 980 · see citing works

Reduced incidence of Prevotella and other fermenters in intestinal microflora of autistic children

Kang, D.-W., Park, J. G., Ilhan, Z. E., Wallstrom, G., LaBaer, J., Adams, J. B., & Krajmalnik-Brown, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068322 · Cited by 976 · see citing works

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

Kumar, D. K. V., Choi, S. H., Washicosky, K. J., Eimer, W. A., Tucker, S., Ghofrani, J., Lefkowitz, A., McColl, G., Goldstein, L. E., Tanzi, R. E., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf1059 · Cited by 971 · see citing works

The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat

Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., & Dinan, T. G. (2008) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2008.03.009 · Cited by 952 · see citing works

Gender Bias in Autoimmunity Is Influenced by Microbiota

Yurkovetskiy, L., Burrows, M. P., Khan, A. A., Graham, L., Volchkov, P., Becker, L., Antonopoulos, D. A., Umesaki, Y., & Chervonsky, A. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.013 · Cited by 912 · see citing works

High-fat diet alters gut microbiota physiology in mice

Daniel, H., Gholami, A. M., Berry, D., Desmarchelier, C., Hahne, H., Loh, G., Mondot, S., Lepage, P., Rothballer, M., Walker, A., et al. (2013) · The ISME Journal · doi:10.1038/ismej.2013.155 · Cited by 680 · see citing works

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

Moechars, D., Dewachter, I., Lorent, K., Reversé, D., Baekelandt, V., Naidu, A., Tesseur, I., Spittaels, K., Haute, C. V. D., Checler, F., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6483 · Cited by 668 · see citing works

Blood-Brain Barrier Leakage in Patients with Early Alzheimer Disease

van de Haar, H. J., Burgmans, S., Jansen, J. F. A., van Osch, M. J. P., van Buchem, M. A., Muller, M., Hofman, P. A. M., Verhey, F. R. J., & Backes, W. H. (2016) · Radiology · doi:10.1148/radiol.2016152244 · Cited by 601 · see citing works

A 32-Year Prospective Study of Change in Body Weight and Incident Dementia: The Honolulu-Asia Aging Study

Stewart, R., Masaki, K., Xue, Q.-L., Peila, R., Petrovitch, H., White, L. R., & Launer, L. J. (2005) · Archives of Neurology · doi:10.1001/archneur.62.1.55 · Cited by 478 · see citing works

Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

Storck, S. E., Meister, S., Nahrath, J., Meißner, J. N., Schubert, N., Di Spiezio, A., Baches, S., Vandenbroucke, R. E., Bouter, Y., Prikulis, I., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci81108 · Cited by 477 · see citing works

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

Joachim, C. L., Mori, H., & Selkoe, D. J. (1989) · Nature · doi:10.1038/341226a0 · Cited by 462 · see citing works

Bacterial Community Mapping of the Mouse Gastrointestinal Tract

Gu, S., Chen, D., Zhang, J., Lv, X., Wang, K., Duan, L.-P., Nie, Y., & Wu, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074957 · Cited by 439 · see citing works

Increased abundance of Sutterella spp. and Ruminococcus torques in feces of children with autism spectrum disorder

Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2013) · Molecular Autism · doi:10.1186/2040-2392-4-42 · Cited by 418 · see citing works

Accelerated Weight Loss May Precede Diagnosis in Alzheimer Disease

Johnson, D. K., Wilkins, C. H., & Morris, J. C. (2006) · Archives of Neurology · doi:10.1001/archneur.63.9.1312 · Cited by 339 · see citing works

The Association of Weight Change in Alzheimer's Disease with Severity of Disease and Mortality: A Longitudinal Analysis

White, H., Pieper, C., & Schmader, K. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb04537.x · Cited by 323 · see citing works

Age-Associated Remodeling of the Intestinal Epithelial Barrier

Tran, L., & Greenwood-Van Meerveld, B. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glt106 · Cited by 320 · see citing works

Effects of intestinal microbiota on anxiety-like behavior

Neufeld, K.-A. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Communicative &amp; Integrative Biology · doi:10.4161/cib.15702 · Cited by 311 · see citing works

May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry

Sherwin, E., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2016) · CNS Drugs · doi:10.1007/s40263-016-0370-3 · Cited by 297 · see citing works

Molecular analysis of the luminal- and mucosal-associated intestinal microbiota in diarrhea-predominant irritable bowel syndrome

Carroll, I. M., Ringel-Kulka, T., Keku, T. O., Chang, Y.-H., Packey, C. D., Sartor, R. B., & Ringel, Y. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00154.2011 · Cited by 292 · see citing works

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

Kuo, Y., Li, Z., Jiao, Y., Gaborit, N., Pani, A. K., Orrison, B. M., Bruneau, B. G., Giasson, B. I., Smeyne, R. J., Gershon, M. D., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq038 · Cited by 288 · see citing works

Frequency of Firmicutes and Bacteroidetes in gut microbiota in obese and normal weight Egyptian children and adults

Ismail, N. A., Ragab, S. H., ElBaky, A. A., Shoeib, A. R. S., Alhosary, Y., & Fekry, D. (2011) · Archives of Medical Science · doi:10.5114/aoms.2011.23418 · Cited by 268 · see citing works

A Molecular Analysis of Fecal and Mucosal Bacterial Communities in Irritable Bowel Syndrome

Codling, C., O’Mahony, L., Shanahan, F., Quigley, E. M. M., & Marchesi, J. R. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0934-x · Cited by 243 · see citing works

Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

Fleisher, A., Chen, K., Quiroz, Y. T., Jakimovich, L. J., Gomez, M. G., Langois, C. M., Langbaum, J. B. S., Ayutyanont, N., Roontiva, A., Thiyyagura, P., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70227-2 · Cited by 242 · see citing works

Incident dementia in women is preceded by weight loss by at least a decade

Knopman, D. S., Edland, S. D., Cha, R. H., Petersen, R. C., & Rocca, W. A. (2007) · Neurology · doi:10.1212/01.wnl.0000267661.65586.33 · Cited by 226 · see citing works

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

Sadleir, K. R., Eimer, W. A., Cole, S. L., & Vassar, R. (2015) · Molecular Neurodegeneration · doi:10.1186/1750-1326-10-1 · Cited by 213 · see citing works

The ageing gastrointestinal tract

Soenen, S., Rayner, C., Jones, K., & Horowitz, M. (2016) · Current opinion in clinical nutrition and metabolic care · doi:10.1097/mco.0000000000000238 · Cited by 211 · see citing works

The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: Further development of a rodent model of autism spectrum disorders

Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-153 · Cited by 200 · see citing works

Body mass index and incidence of dementia: The PAQUID study

Nourhashémi, F., Deschamps, V., Larrieu, S., Letenneur, L., Dartigues, J.-F., & Barberger-Gateau, P. (2003) · Neurology · doi:10.1212/01.wnl.0000038910.46217.aa · Cited by 193 · see citing works

Prevalence of small intestinal bacterial overgrowth in Parkinson’s disease

Gabrielli, M., Bonazzi, P., Scarpellini, E., Bendia, E., Lauritano, E. C., Fasano, A., Ceravolo, M. G., Capecci, M., Rita Bentivoglio, A., Provinciali, L., et al. (2011) · Movement Disorders · doi:10.1002/mds.23566 · Cited by 175 · see citing works

Pathogenic microbes, the microbiome, and Alzheimer’s disease (AD)

Hill, J. M., Clément, C., Pogue, A. I., Bhattacharjee, S., Zhao, Y., & Lukiw, W. J. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00127 · Cited by 169 · see citing works

Expression patterns of β‐amyloid precursor protein (β‐APP) in neural and nonneural human tissues from alzheimer's disease and control subjects

Arai, H., Lee, V. M. ‐., Messinger, M. L., Greenberg, B., Lowery, D. E., & Trojanowski, J. Q. (1991) · Annals of Neurology · doi:10.1002/ana.410300509 · Cited by 163 · see citing works

Simplex PCR Assay for Sex Determination in Mice

Clapcote, S. J., & Roder, J. (2005) · BioTechniques · doi:10.2144/05385bm05 · Cited by 154 · see citing works

Temperature Gradient Gel Electrophoresis of Fecal 16S rRNA Reveals Active Escherichia coli in the Microbiota of Patients with Ulcerative Colitis

Sokol, H., Lepage, P., Seksik, P., Dore, J. M., & Marteau, P. R. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.02600-05 · Cited by 140 · see citing works

Microbial Sources of Amyloid and Relevance to Amyloidogenesis and Alzheimer’s Disease (AD)

P, Z. Y. D. (2015) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000177 · Cited by 137 · see citing works

Decreased Parotid Saliva Gustin/Carbonic Anhydrase VI Secretion: An Enzyme Disorder Manifested by Gustatory and Olfactory Dysfunction

Henkin, R. I., Martin Brian, M., & Agarwal Raghunath, P. (1999) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)40663-9 · Cited by 130 · see citing works

Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity

Spitzer, P., Condic, M., Herrmann, M., Oberstein, T. J., Scharin-Mehlmann, M., Gilbert, D. F., Friedrich, O., Grömer, T., Kornhuber, J., Lang, R., et al. (2016) · Scientific Reports · doi:10.1038/srep32228 · Cited by 128 · see citing works

Gustin concentration changes relative to salivary zinc and taste in humans.

Shatzman, A. R., & Henkin, R. I. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.6.3867 · Cited by 119 · see citing works

Influence of Age and Age‐Related Diseases on Olfactory Functiona

Doty, R. L. (1989) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1989.tb20971.x · Cited by 115 · see citing works

Changes of the Enteric Nervous System in Amyloid-β Protein Precursor Transgenic Mice Correlate with Disease Progression

Semar, S., Klotz, M., Letièmbre, M., Ginneken, C. J. V., Braun, A., Jost, V., Bischof, M., Lammers, W. J. E. P., Liu, Y., Fassbender, K. C., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-120511 · Cited by 102 · see citing works

Overexpression of Mutant Amyloid-β Protein Precursor and Presenilin 1 Modulates Enteric Nervous System

Puig, K. L., Lutz, B. M., Urquhart, S. A., Rebel, A. A., Zhou, X., Manocha, G. D., Sens, M. A., Tuteja, A. K., Foster, N. L., & Combs, C. K. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142259 · Cited by 76 · see citing works

The role of carbonic anhydrase VI in bitter taste perception: evidence from the Car6−/− mouse model

Patrikainen, M. S., Pan, P., Kulesskaya, N., et al. (2014) · Journal of Biomedical Science · doi:10.1186/s12929-014-0082-2 · Cited by 64 · see citing works

CCK1 receptor is essential for normal meal patterning in mice fed high fat diet

Donovan, M. J., Paulino, G., & Raybould, H. E. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.07.003 · Cited by 63 · see citing works

Amyloid-β colocalizes with apolipoprotein B in absorptive cells of the small intestine

Galloway, S., Takechi, R., Pallebage‐Gamarallage, M. M., Dhaliwal, S. S., & Mamo, J. C. L. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-46 · Cited by 45 · see citing works

Impaired Satiation and Increased Feeding Behaviour in the Triple-Transgenic Alzheimer's Disease Mouse Model

Adebakin, A., Bradley, J., Gümüsgöz, S., Waters, E. J., & Lawrence, C. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045179 · Cited by 36 · see citing works

Establishment and properties of separate cultures of enteric neurons and enteric glia

Bannerman, P. G. C., Mirsky, R., & Jessen, K. R. (1988) · Brain Research · doi:10.1016/0006-8993(88)91162-6 · Cited by 35 · see citing works

A LONGITUDINAL ANALYSIS OF WEIGHT CHANGE IN ALZHEIMER'S DISEASE

White, H. K., Pieper, C. F., Schmader, K. E., & Fillenbaum, G. G. (1997) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1997.tb05187.x · Cited by 34 · see citing works

In Vivo Imaging of Enteric Neurogenesis in the Deep Tissue of Mouse Small Intestine

Goto, K., Kato, G., Kawahara, I., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054814 · Cited by 31 · see citing works

Supplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal model

Serquiz, A. C., Machado, R. J. D. A., Serquiz, R. P., et al. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.3109/14756366.2015.1103236 · Cited by 29 · see citing works

Microbial-Derived Metabolites Reflect an Altered Intestinal Microbiota during Catch-Up Growth in Undernourished Neonatal Mice

Preidis, G. A., Ajami, N. J., Wong, M. C., Bessard, B. C., Conner, M. E., & Petrosino, J. F. (2016) · Journal of Nutrition · doi:10.3945/jn.115.229179 · Cited by 24 · see citing works

Isolation, Characterization, and Differentiation of Thy1.1-Sorted Pancreatic Adult Progenitor Cell Populations

Stevenson, K. S., McGlynn, L. M., Hodge, M., McLinden, H., George, W. D., Davies, R. W., & Shiels, P. G. (2009) · Stem Cells and Development · doi:10.1089/scd.2008.0301 · Cited by 20 · see citing works

Identification of stool proteins in C57BL/6J mice by two-dimensional gel electrophoresis and MALDI-TOF mass spectrometry

Oleksiewicz, M. B., Kjeldal, H. Ø., & Klenø, T. G. (2005) · Biomarkers · doi:10.1080/13547500500038775 · Cited by 17 · see citing works

Fibrillar amyloid beta-protein inhibits the activity of high molecular weight brain protease and trypsin

Chauhan, V. P. S., Sheikh, A. M., Chauhan, A., Spivack, W. D., Fenko, M. D., & Malik, M. N. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7105 · Cited by 11 · see citing works

Binding of trypsin to fibrillar amyloid beta-protein

Chander, H., Chauhan, A., Węgiel, J., Malik, M. N., Sheikh, A. M., & Chauhan, V. P. S. (2006) · Brain Research · doi:10.1016/j.brainres.2006.01.079 · Cited by 11 · see citing works

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases

Quigley, E. M. M. (2017) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-017-0802-6 · Cited by 804 · see citing works

The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

Rutsch, A., Kantsjö, J. B., & Ronchi, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604179 · Cited by 821 · see citing works

Fecal microbiota transplantation alleviated Alzheimer’s disease-like pathogenesis in APP/PS1 transgenic mice

Sun, J., Xu, J., Ling, Y., Wang, F., Gong, T., Yang, C., Ye, S., Ye, K., Wei, D., Song, Z., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0525-3 · Cited by 532 · see citing works

Gut microbiota and dysbiosis in Alzheimer's disease: Implications for pathogenesis and treatment

Liu, S., Gao, J., Zhu, M., Liu, K., & Zhang, H.-L. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-02073-3 · Cited by 516 · see citing works

Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

Chen, C., Liao, J., Xia, Y., Liu, X., Jones, R., Haran, J., McCormick, B., Sampson, T. R., Alam, A., & Ye, K. (2022) · Gut · doi:10.1136/gutjnl-2021-326269 · Cited by 491 · see citing works

Altered Gut Microbiota in a Mouse Model of Alzheimer’s Disease

Zhang, L., Wang, Y., Xiayu, X., Shi, C., Chen, W., Song, N., Fu, X., Zhou, R., Xu, Y.-F., Huang, L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170020 · Cited by 449 · see citing works

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus

Zhao, Y., Jaber, V., & Lukiw, W. J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00318 · Cited by 379 · see citing works

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Colombo, A. V., Sadler, R. K., Llovera, G., Singh, V., Roth, S., Heindl, S., Sebastian Monasor, L., Verhoeven, A., Peters, F., Parhizkar, S., et al. (2021) · eLife · doi:10.7554/elife.59826 · Cited by 354 · see citing works

Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes

Dodiya, H. B., Kuntz, T., Shaik, S. M., Baufeld, C., Leibowitz, J., Zhang, X., Gottel, N., Zhang, X., Butovsky, O., Gilbert, J. A., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182386 · Cited by 288 · see citing works

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278 · see citing works

Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases?

Pellegrini, C., Antonioli, L., Colucci, R., Blandizzi, C., & Fornai, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1856-5 · Cited by 270 · see citing works

Altered gut microbiome composition in children with refractory epilepsy after ketogenic diet

Zhang, Y., Zhou, S., Zhou, Y., Yu, L., Zhang, L., & Wang, Y. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.06.015 · Cited by 269 · see citing works

Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer’s disease during lifespan

Bäuerl, C., Collado, M. C., Diaz Cuevas, A., Viña, J., & Pérez Martínez, G. (2018) · Letters in Applied Microbiology · doi:10.1111/lam.12882 · Cited by 238 · see citing works

The Microbiome as a Modifier of Neurodegenerative Disease Risk

Fang, P., Kazmi, S. A., Jameson, K. G., & Hsiao, E. Y. (2020) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2020.06.008 · Cited by 226 · see citing works

The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment

Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225 · see citing works

Gut microbiota, cognitive frailty and dementia in older individuals: A systematic review

Ticinesi, A., Tana, C., Nouvenne, A., Prati, B., Lauretani, F., & Meschi, T. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s139163 · Cited by 215 · see citing works

Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle

Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204 · see citing works

Steroids, stress and the gut microbiome-brain axis

Tetel, M. J., de Vries, G. J., Melcangi, R. C., Panzica, G., & O'Mahony, S. M. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12548 · Cited by 187 · see citing works

Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice

Lee, H.-J., Lee, K.-E., Kim, J.-K., & Kim, D.-H. (2019) · Scientific Reports · doi:10.1038/s41598-019-48342-7 · Cited by 164 · see citing works

Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer’s disease

Mezö, C., Dokalis, N., Mossad, O., Staszewski, O., Neuber, J., Yilmaz, B., Schnepf, D., de Agüero, M. G., Ganal-Vonarburg, S. C., Macpherson, A. J., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00988-5 · Cited by 120 · see citing works

Of microbes and minds: A narrative review on the second brain aging

Calvani, R., Picca, A., Lo Monaco, M. R., Landi, F., Bernabei, R., & Marzetti, E. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00053 · Cited by 92 · see citing works

Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer’s disease progression based on the “brain-gut” axis through multiple integrated omics

Gu, X., Zhou, J., Zhou, Y., Wang, H., Si, N., Ren, W., Zhao, W., Fan, X., Gao, W., Wei, X., et al. (2021) · Alzheimer's Research &amp; Therapy · doi:10.1186/s13195-021-00779-7 · Cited by 81 · see citing works

The intestinal microbiome and its relevance for functionality in older persons

Ticinesi, A., Tana, C., & Nouvenne, A. (2019) · Current Opinion in Clinical Nutrition &amp; Metabolic Care · doi:10.1097/mco.0000000000000521 · Cited by 80 · see citing works

The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms

Chandra, S., Di Meco, A., Dodiya, H. B., Popovic, J., Cuddy, L. K., Weigle, I. Q., Zhang, X., Sadleir, K., Sisodia, S. S., & Vassar, R. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00635-2 · Cited by 58 · see citing works

The Role of the Microbiota-Gut-Brain Axis in the Development of Alzheimer’s Disease

Wiatrak, B., Balon, K., Jawień, P., Bednarz, D., Jęśkowiak, I., & Szeląg, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094862 · Cited by 58 · see citing works

The microbiome: A target for Alzheimer disease?

Seo, D.-O., Boros, B. D., & Holtzman, D. M. (2019) · Cell Research · doi:10.1038/s41422-019-0227-7 · Cited by 56 · see citing works

Influence of commensal microbiota on the enteric nervous system and its role in neurodegenerative diseases

Endres, K., & Schäfer, K.-H. (2018) · Journal of Innate Immunity · doi:10.1159/000488629 · Cited by 52 · see citing works

Gut microbiome and Alzheimer’s disease: What we know and what remains to be explored

Kapoor, B., Biswas, P., Gulati, M., Rani, P., & Gupta, R. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102570 · Cited by 46 · see citing works

Mesoporous silica nanoparticle-encapsulated Bifidobacterium attenuates brain Aβ burden and improves olfactory dysfunction of APP/PS1 mice by nasal delivery

Liu, N., Yang, C., Liang, X., Cao, K., Xie, J., Luo, Q., & Luo, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01642-z · Cited by 45 · see citing works

Primary Cilia Structure Is Prolonged in Enteric Neurons of 5xFAD Alzheimer’s Disease Model Mice

Nguyen, V. T. T., Brücker, L., Volz, A.-K., Baumgärtner, J. C., dos Santos Guilherme, M., Valeri, F., May-Simera, H., & Endres, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413564 · Cited by 16 · see citing works

Vitamins for the Gut Microbiome

Steinert, R. E., Lee, Y. K., & Sybesma, W. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.11.005 · Cited by 115 · see citing works

Microbiome-based stratification to guide dietary interventions to improve human health

Liu, Z., de Vries, B., Gerritsen, J., Smidt, H., & Zoetendal, E. G. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.07.004 · Cited by 42 · see citing works

A Microbiome Restoration Strategy Modulates the Gut Microbiome and Metabolic Markers in Healthy Adults

Li, F. (2021) · doi:10.52843/cassyni.wk4b29

Vegetarian Diets and the Microbiome

Orlich, M. J., Segovia‐Siapco, G., & Jung, S. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803968-7.00024-1 · Cited by 8 · see citing works

Precision Nutrition from the View of the Gut Microbiome

Dikarlo, P., Dorst, I., Moskalenko, O., & Yateem, M. (2022) · Springer eBooks · doi:10.1007/978-3-031-10153-3_4 · Cited by 3 · see citing works