Hattori, Nobutaka

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 5,227

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) · Nature Genetics

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 2,024

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C. A., Sou, Y.-S., Saiki, S., Kawajiri, S., Sato, F., et al. (2010) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 1,969

Ubiquitination of a new form of α-synuclein by parkin from human brain: implications for Parkinson's disease

Shimura, H., Schlossmacher, M. G., Hattori, N., Frosch, M. P., Trockenbacher, A., Schneider, R., Mizuno, Y., Kosik, K. S., & Selkoe, D. J. (2001) · Science

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 1,053

An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin

Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y., & Takahashi, R. (2001) · Cell

Parkinson's Disease Mechanisms and TreatmentsEndoplasmic Reticulum Stress and Disease

Cited by 1,050

Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease.

Yoritaka, A., Hattori, N., Uchida, K., Tanaka, M., Stadtman, E. R., & Mizuno, Y. (1996) · Proceedings of the National Academy of Sciences

Parkinson's Disease Mechanisms and TreatmentsRedox biology and oxidative stress

Cited by 981

A rotarod test for evaluation of motor skill learning

Shiotsuki, H., Yoshimi, K., Shimo, Y., Funayama, M., Takamatsu, Y., Ikeda, K., Takahashi, R., Kitazawa, S., & Hattori, N. (2010) · Journal of Neuroscience Methods

Motor Control and AdaptationParkinson's Disease Mechanisms and Treatments

Cited by 627

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

Shiba-Fukushima, K., Imai, Y., Yoshida, S., Ishihama, Y., Kanao, T., Sato, S., & Hattori, N. (2012) · Scientific Reports

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 577

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

Okatsu, K., Saisho, K., Shimanuki, M., Nakada, K., Shitara, H., Sou, Y., Kimura, M., Sato, S., Hattori, N., Komatsu, M., et al. (2010) · Genes to Cells

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 397

Parkinson's Disease–Associated Kinase PINK1 Regulates Miro Protein Level and Axonal Transport of Mitochondria

Liu, S., Sawada, T., Lee, S., Yu, W., Silverio, G., Alapatt, P., Millan, I., Shen, A., Saxton, W., Kanao, T., et al. (2012) · PLoS Genetics

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 371

TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation

Matsumoto, G., Shimogori, T., Hattori, N., & Nukina, N. (2015) · Human Molecular Genetics

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 317

Mutations in Fis1 disrupt orderly disposal of defective mitochondria

Shen, Q., Yamano, K., Head, B. P., Kawajiri, S., Cheung, J. T. M., Wang, C., Cho, J.-H., Hattori, N., Youle, R. J., & van der Bliek, A. M. (2014) · Molecular Biology of the Cell

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 209

Point Mutations (Thr240Arg and Ala311Stop) in theParkinGene

Hattori, N., Matsumine, H., Asakawa, S., Kitada, T., Yoshino, H., Elibol, B., Brookes, A. J., Yamamura, Y., Kobayashi, T., Wang, M., et al. (1998) · Biochemical and Biophysical Research Communications

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 181

Effect of Wild-type or Mutant Parkin on Oxidative Damage, Nitric Oxide, Antioxidant Defenses, and the Proteasome

Hyun, D.-H., Lee, M., Hattori, N., Kubo, S.-I., Mizuno, Y., Halliwell, B., & Jenner, P. (2002) · Journal of Biological Chemistry

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 172

Neurite orientation dispersion and density imaging in the substantia nigra in idiopathic Parkinson disease

Kamagata, K., Hatano, T., Okuzumi, A., Motoi, Y., Abe, O., Shimoji, K., Kamiya, K., Suzuki, M., Hori, M., Kumamaru, K. K., et al. (2016) · European Radiology

Advanced Neuroimaging Techniques and ApplicationsParkinson's Disease Mechanisms and Treatments

Cited by 135

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice

Sato, S., Uchihara, T., Fukuda, T., Noda, S., Kondo, H., Saiki, S., Komatsu, M., Uchiyama, Y., Tanaka, K., & Hattori, N. (2018) · Scientific Reports

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 125

Variants in saposin D domain of prosaposin gene linked to Parkinson’s disease

Oji, Y., Hatano, T., Ueno, S.-I., Funayama, M., Ishikawa, K.-I., Okuzumi, A., Noda, S., Sato, S., Satake, W., Toda, T., et al. (2020) · Brain

Parkinson's Disease Mechanisms and TreatmentsLysosomal Storage Disorders Research

Cited by 116

Gray Matter Abnormalities in Idiopathic Parkinson's Disease: Evaluation by Diffusional Kurtosis Imaging and Neurite Orientation Dispersion and Density Imaging

Kamagata, K., Zalesky, A., Hatano, T., Ueda, R., Di Biase, M. A., Okuzumi, A., Shimoji, K., Hori, M., Caeyenberghs, K., Pantelis, C., et al. (2017) · Human Brain Mapping

Advanced Neuroimaging Techniques and ApplicationsParkinson's Disease Mechanisms and Treatments

Cited by 106

Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain

Miyamoto, N., Tanaka, R., Shimura, H., Watanabe, T., Mori, H., Onodera, M., Mochizuki, H., Hattori, N., & Urabe, T. (2010) · Journal of Cerebral Blood Flow & Metabolism

Neurological Disease Mechanisms and TreatmentsNeurogenesis and neuroplasticity mechanisms

Cited by 86

The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties

Matsumoto, S.-E., Motoi, Y., Ishiguro, K., Tabira, T., Kametani, F., Hasegawa, M., & Hattori, N. (2015) · Human Molecular Genetics

Alzheimer's disease research and treatmentsPrion Diseases and Protein Misfolding

Cited by 66

Depletion of p62 reduces nuclear inclusions and paradoxically ameliorates disease phenotypes in Huntington's model mice

Kurosawa, M., Matsumoto, G., Kino, Y., Okuno, M., Kurosawa-Yamada, M., Washizu, C., Taniguchi, H., Nakaso, K., Yanagawa, T., Warabi, E., et al. (2015) · Human Molecular Genetics

Genetic Neurodegenerative DiseasesAmyotrophic Lateral Sclerosis Research

Cited by 63

Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction

Suda, Y., Kuzumaki, N., Sone, T., Narita, M., Tanaka, K., Hamada, Y., Iwasawa, C., Shibasaki, M., Maekawa, A., Matsuo, M., et al. (2018) · Molecular Brain

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 60

Neurite orientation dispersion and density imaging of the nigrostriatal pathway in Parkinson’s disease: retrograde degeneration observed by tract-profile analysis

Andica, C., Kamagata, K., Hatano, T., Okuzumi, A., Saito, A., Nakazawa, M., Ueda, R., Motoi, Y., Kamiya, K., Suzuki, M., et al. (2018) · Parkinsonism & Related Disorders

Advanced Neuroimaging Techniques and ApplicationsParkinson's Disease Mechanisms and Treatments

Cited by 60

Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice

Kuroki, T., Tanaka, R., Shimada, Y., Yamashiro, K., Ueno, Y., Shimura, H., Urabe, T., & Hattori, N. (2016) · Stroke

Acute Ischemic Stroke ManagementNeuroprotection in Cerebral Ischemia

Cited by 60