Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction
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Ghrelin exerts a wide range of physiological actions throughout the body and appears to be a promising target for disease therapy. Endogenous ghrelin receptors (GHSRs) are present in extrahypothalamic sites including the substantia nigra pars compacta (SNc), which is related to phenotypic dysregulation or frank degeneration in Parkinson's disease (PD). Here we found a dramatic decrease in the expression of GHSR in PD-specific induced pluripotent stem cell (iPSC)-derived dopaminergic (DAnergic) neurons generated from patients carrying parkin gene (PARK2) mutations compared to those from healthy controls. Consistently, a significant decrease in the expression of GHSR was found in DAnergic neurons of isogenic PARK2-iPSC lines that mimicked loss of function of the PARK2 gene through CRISPR Cas9 technology. Furthermore, either intracerebroventricular injection or microinjection into the SNc of the selective GHSR1a antagonist [D-Lys3]-GHRP6 in normal mice produced cataleptic behaviors related to dysfunction of motor coordination. These findings suggest that the down-regulation of GHSRs in SNc-DA neurons induced the initial dysfunction of DA neurons, leading to extrapyramidal disorder under PD.
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Inhibition of central GHSR1α activation via intra-SN administration of a selective GHSR1α inhibitor resulted in impaired motor coordination.
“the inhibition of central GHSR1α activation via intra-SN administration of a selective GHSR1α inhibitor resulted in impaired motor coordination.”
From Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases (2024) · cites this paper as [562]
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221 · see citing works
Self-citationGhrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works
Self-citationA role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443 · see citing works
Watterson, K. R., Bestow, D., Gallagher, J. R., Hamilton, D. L., Ashford, F. B., Meakin, P. J., & Ashford, M. L. J. (2012) · Neurosignals · doi:10.1159/000334144 · Cited by 3,395 · see citing works
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Howard, A., Feighner, S., Cully, D., Arena, J. P., Liberator, P., Rosenblum, C., Hamelin, M., Hreniuk, D. L., Palyha, O., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,106 · see citing works
Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works
PHARMACOLOGICAL EFFECTS PRODUCED BY INTRACEREBRAL INJECTION OF DRUGS IN THE CONSCIOUS MOUSE
Haley, T. J., & McCormick, W. (1957) · British Journal of Pharmacology and Chemotherapy · doi:10.1111/j.1476-5381.1957.tb01354.x · Cited by 1,535 · see citing works
Expression of ghrelin receptor mRNA in the rat and the mouse brain
Zigman, J. M., Jones, J. E., Lee, C. E., Saper, C. B., & Elmquist, J. K. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20823 · Cited by 1,074 · see citing works
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984 · see citing works
PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
Shin, J.-H., Ko, H. S., Kang, H., Lee, Y., Lee, Y.-I., Pletinkova, O., Troconso, J. C., Dawson, V. L., & Dawson, T. M. (2011) · Cell · doi:10.1016/j.cell.2011.02.010 · Cited by 953 · see citing works
Ghrelin controls hippocampal spine synapse density and memory performance
Diano, S., Farr, S. A., Benoit, S. C., McNay, E. C., da Silva, I., Horvath, B., Gaskin, F. S., Nonaka, N., Jaeger, L. B., Banks, W. A., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1656 · Cited by 828 · see citing works
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
Sulzer, D. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.009 · Cited by 583 · see citing works
Abbas, N., Lücking, C. B., Ricard, S., Dürr, A., Bonifati, V., Michele, G. D., Bouley, S., Vaughan, J. R., Gasser, T., Marconi, R., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.4.567 · Cited by 529 · see citing works
Imaizumi, Y., Okada, Y., Akamatsu, W., Koike, M., Kuzumaki, N., Hayakawa, H., Nihira, T., Kobayashi, T., Ohyama, M., Sato, S., et al. (2012) · Molecular Brain · doi:10.1186/1756-6606-5-35 · Cited by 378 · see citing works
Self-citationAndrews, Z. B., Erion, D., Beiler, R., Liu, Z.-W., Abizaid, A., Zigman, J., Elsworth, J. D., Savitt, J. M., DiMarchi, R., Tschöp, M., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3890-09.2009 · Cited by 289 · see citing works
iPS cell technologies: significance and applications to CNS regeneration and disease
Okano, H., & Yamanaka, S. (2014) · Molecular Brain · doi:10.1186/1756-6606-7-22 · Cited by 232 · see citing works
Self-citationMoon, M., Kim, H. G., Hwang, L., Seo, J.-H., Kim, S., Hwang, S., Kim, S., Lee, D., Chung, H., Oh, M. S., et al. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9037-x · Cited by 203 · see citing works
Ghrelin antagonizes MPTP-induced neurotoxicity to the dopaminergic neurons in mouse substantia nigra
Jiang, H., Li, L.-J., Wang, J., & Xie, J.-X. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.006 · Cited by 144 · see citing works
Ubiquitin, proteasome and parkin
Tanaka, K., Suzuki, T., Hattori, N., & Mizuno, Y. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.026 · Cited by 119 · see citing works
Self-citationPeptide hormone ghrelin enhances neuronal excitability by inhibition of Kv7/KCNQ channels
Shi, L., Bian, X., Qu, Z., Ma, Z., Zhou, Y., Wang, K., Jiang, H., & Xie, J. (2013) · Nature Communications · doi:10.1038/ncomms2439 · Cited by 103 · see citing works
Imaizumi, K., Sone, T., Ibata, K., Fujimori, K., Yuzaki, M., Akamatsu, W., & Okano, H. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.10.005 · Cited by 99 · see citing works
Self-citationAdult Conditional Knockout of PGC-1α Leads to Loss of Dopamine Neurons
Jiang, H.-S., Kang, S.-U., Zhang, S.-R., Karuppagounder, S. S., Xu, J.-C., Lee, Y.-K., Kang, B.-G., Lee, Y., Zhang, J., Pletnikova, O., et al. (2016) · eNeuro · doi:10.1523/eneuro.0183-16.2016 · Cited by 90 · see citing works
Ghrelin Stimulation of Growth Hormone-Releasing Hormone Neurons Is Direct in the Arcuate Nucleus
Osterstock, G., Escobar, P., Mitutsova, V., Gouty‐Colomer, L., Fontanaud, P., Molino, F., Fehrentz, J., Carmignac, D. F., Martínez, J., Guérineau, N. C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009159 · Cited by 76 · see citing works
Parkin and defective ubiquitination in Parkinson’s disease
Dawson, T. M. (2006) · Springer eBooks · doi:10.1007/978-3-211-45295-0_32 · Cited by 74 · see citing works
Fujimori, K., Matsumoto, T., Kisa, F., Hattori, N., Okano, H., & Akamatsu, W. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.09.024 · Cited by 71 · see citing works
Self-citationSuzuki, S., Akamatsu, W., Kisa, F., Sone, T., Ishikawa, K., Kuzumaki, N., Katayama, H., Miyawaki, A., Hattori, N., & Okano, H. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.188 · Cited by 70 · see citing works
Self-citationMatsumoto, T., Fujimori, K., Andoh-Noda, T., Ando, T., Kuzumaki, N., Toyoshima, M., Tada, H., Imaizumi, K., Ishikawa, M., Yamaguchi, R., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.01.010 · Cited by 67 · see citing works
Self-citationAlbarran-Zeckler, R. G., Brantley, A. F., & Smith, R. G. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.012 · Cited by 64 · see citing works
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Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works
Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing
Cunnane, S. C., Trushina, E., Morland, C., Prigione, A., Casadesus, G., Andrews, Z. B., Beal, M. F., Bergersen, L. H., Brinton, R. D., de la Monte, S., et al. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-0072-x · Cited by 1,003 · see citing works
Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies
Zhang, X., Tang, B., & Guo, J. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00392-8 · Cited by 205 · see citing works
Tabata, Y., Imaizumi, Y., Sugawara, M., Andoh-Noda, T., Banno, S., Chai, M., Sone, T., Yamazaki, K., Ito, M., Tsukahara, K., et al. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.09.006 · Cited by 90 · see citing works
Self-citationCRISPR-Cas9-Based Technology and Its Relevance to Gene Editing in Parkinson’s Disease
Rahman, M. U., Bilal, M., Shah, J. A., Kaushik, A. K., Teissèdre, P., & Kujawska, M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061252 · Cited by 65 · see citing works
CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson’s Disease
Safari, F., Hatam, G., Behzad‐Behbahani, A., Tabar, V. R., Barekati‐Mowahed, M., Petramfar, P., & Khademi, F. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-019-00761-w · Cited by 64 · see citing works
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Zheng, Y., Zhang, L., Xie, J., & Shi, L. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.646726 · Cited by 54 · see citing works
CRISPR/Cas system: An emerging technology in stem cell research
Valenti, M. T., Serena, M., Carbonare, L. D., & Zipeto, D. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i11.937 · Cited by 52 · see citing works
CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease
Pinjala, P., Tryphena, K. P., Prasad, R., Khatri, D. K., Sun, W., Singh, S. B., Gugulothu, D. B., Srivastava, S., & Vora, L. K. (2023) · Biomaterials Research · doi:10.1186/s40824-023-00381-y · Cited by 50 · see citing works
Pandey, S., Jirásko, M., Lochman, J., Chvátal, A., Dvorakova, M. C., & Kučera, R. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091485 · Cited by 37 · see citing works
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Xiao, X., Bi, M., Jiao, Q., Chen, X., Du, X., & Jiang, H. F. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101187 · Cited by 38 · see citing works
Jayaramayya, K., Iyer, M., Venkatesan, D., Balasubramanian, V., Narayanasamy, A., Subramaniam, M. D., Cho, S., & Vellingiri, B. (2020) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2020.02.001 · Cited by 34 · see citing works
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Dong, D., Xie, J.-X., & Wang, J. (2019) · Neuroscience Bulletin · doi:10.1007/s12264-019-00407-3 · Cited by 34 · see citing works
Mohamed, Y. T., Salama, A., Rabie, M. A., & Fattah, M. A. A. E. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109571 · Cited by 34 · see citing works
Jhuo, C., Hsieh, S., Chen, C., Chen, W., & Tzen, J. T. C. (2020) · Nutrients · doi:10.3390/nu12123665 · Cited by 26 · see citing works
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Airapetov, M. I., Eresko, S. O., Aa, L., Бычков, Э. Р., & Shabanov, P. D. (2021) · Physiological Reports · doi:10.14814/phy2.15113 · Cited by 25 · see citing works
Iwasawa, C., Kuzumaki, N., Suda, Y., Kagawa, R., Oka, Y., Hattori, N., Okano, H., & Narita, M. (2019) · Molecular Brain · doi:10.1186/s13041-019-0426-7 · Cited by 25 · see citing works
Self-citationAcylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux
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Lebedeva, O. S., & Lagarkova, M. A. (2018) · Biochemistry (Moscow) · doi:10.1134/s0006297918090067 · Cited by 19 · see citing works
Minalyan, A., Gabrielyan, L., Pietra, C., Taché, Y., & Wang, L. (2019) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2019.00013 · Cited by 19 · see citing works
Gaggi, G., Credico, A. D., Izzicupo, P., Iannetti, G., Baldassarre, A. D., & Ghinassi, B. (2021) · Biomedicines · doi:10.3390/biomedicines9070754 · Cited by 19 · see citing works
Gross, J., Kim, D. W., Zhou, Y., Jansen, D. J., Slosky, L. M., Clark, N. B., Ray, C., Hu, X., Southall, N. T., Wang, A., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112397119 · Cited by 18 · see citing works
Behl, T., Madaan, P., Sehgal, A., Singh, S., Makeen, H. A., Albratty, M., Alhazmi, H. A., Meraya, A. M., & BUNGAU, S. G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094565 · Cited by 19 · see citing works
Hajare, S., & Kulkarni, Y. A. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149975 · Cited by 16 · see citing works
Gondoh, E., Hamada, Y., Mori, T., Iwazawa, Y., Shinohara, A., Narita, M., Sato, D., Tezuka, H., Yamauchi, T., Tsujimura, M., et al. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01928-x · Cited by 15 · see citing works
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Esteves, F., Brito, D. V. C., Rajado, A. T., Silva, N., Apolónio, J. D., Roberto, V. P., Araújo, I. M., Nóbrega, C., Castelo‐Branco, P., Bragança, J., et al. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111854 · Cited by 15 · see citing works
Mehmood, A., Ali, W., Din, Z. U., Song, S., Sohail, M., Shah, W., Guo, J., Guo, R., Ilahi, I., Shah, S., et al. (2021) · Brain and Behavior · doi:10.1002/brb3.2280 · Cited by 14 · see citing works
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Bae, H. J., Bae, H. J., Kim, J. Y., Park, K., Yang, X., Jung, S. Y., Park, S. J., Kim, D. H., Shin, C. Y., & Ryu, J. H. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110646 · Cited by 13 · see citing works
Mehdar, K. M. (2020) · Folia Morphologica · doi:10.5603/fm.a2020.0077 · Cited by 12 · see citing works
Chen, L., Liu, C., Xue, Y., & Chen, X. (2023) · Neuropeptides · doi:10.1016/j.npep.2023.102337 · Cited by 12 · see citing works
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Tang, T., Bi, M., Diao, M.-N., Zhang, X., Chen, L., Xiao, X., Jiao, Q., Chen, X., Yan, C., Du, X., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01063-0 · Cited by 11 · see citing works
Ghrelin alleviates 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells
Xue, Y., He, X., Yuan, W., Yang, C., Zhu, L., Liu, F., & Feng, J. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.314314 · Cited by 10 · see citing works
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Elabi, O., Duskova, K., Davies, J. S., & Lane, E. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.10.045 · Cited by 7 · see citing works
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Self-citationZhang, X., Cheng, Z., Dong, S., Rayner, C. K., Wu, T., Zhong, M., Zhang, G., Wang, K., & Hu, S. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155198 · Cited by 8 · see citing works
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Li, Y., Qing‐Xiu, L., Wang, J., Xiang, H., Zhang, R., & Huang, C.-Q. (2021) · International Journal of Neuroscience · doi:10.1080/00207454.2021.1928114 · Cited by 8 · see citing works
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Gouveia, H. J. C. B., dos Santos, O. H., & Frasnelli, J. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01066-0 · Cited by 5 · see citing works
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Suzuki, C., Yamaguchi, J., Mitsui, S., Sanada, T., Trejo, J. A. O., Kakuta, S., Tanaka, K., Suda, Y., Hatano, T., Hattori, N., et al. (2024) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2024.167494 · Cited by 4 · see citing works
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Bowler, B., Nasir, A. R., Szewczyk, A., Ocañas, S. R., Unnikrishnan, A., & Nouh, C. D. (2026) · Pathophysiology · doi:10.3390/pathophysiology33040074
- Authors
- Suda, Y., Kuzumaki, N., Sone, T., Narita, M., Tanaka, K., Hamada, Y., Iwasawa, C., Shibasaki, M., Maekawa, A., Matsuo, M., Akamatsu, W., Hattori, N., Okano, H., & Narita, M.
- Affiliations
- Hoshi University (JP)
- Keio University (JP)
- Institute of Medical Science, The University of Tokyo (JP)
- Juntendo University (JP)
- Corresponding author
- Kuzumaki, Naoko
- Narita, Michiko
- Okano, Hideyuki
- Narita, Minoru
- Venue
- Molecular Brain
- Published
- 2018-02-20
- Volume
- 11
- Issue
- 1
- Pages
- 6-6
- ISSN
- 1756-6606 (ISSN-L)
- PMC
- PMC5819262
- OpenAlex
- W2795703705
- Cited by
- 60
- References
- 29
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 6 · 2019: 7 · 2018: 3
- FWCI
- 4.58
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Molecular Brain (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (JP16K08280, JP25830055)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- growth hormone secretagogue receptor, Parkinson's disease, substantia nigra pars compacta, dopaminergic neurons, Parkin, PARK2 mutations, iPSC-derived neurons, catalepsy, motor impairment, extrapyramidal disorders
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Humans, Injections, Intraventricular, Male, Mice, Inbred C57BL, Motor Activity, Oligopeptides, Parkinson Disease, Substantia Nigra, Down-Regulation, Ubiquitin-Protein Ligases, Receptors, Ghrelin, Gene Knockout Techniques, Gene Knock-In Techniques, Induced Pluripotent Stem Cells, Dopaminergic Neurons
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