Testa, Joseph R.

Germline BAP1 Mutations Predispose to Malignant Mesothelioma

Testa, J. R., Cheung, M., Pei, J., Below, J. E., Tan, Y., Sementino, E., Cox, N. J., Dogan, A. U., Pass, H. I., Trusa, S., et al. (2011) · Nature Genetics

Occupational and environmental lung diseasesBRCA gene mutations in cancer

Cited by 1,076

AKT plays a central role in tumorigenesis

Testa, J. R., & Bellacosa, A. (2001) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 944

TNF-α Inhibits Asbestos-Induced Cytotoxicity via a NF-ΚB-Dependent Pathway, a Possible Mechanism for Asbestos-Induced Oncogenesis

Yang, H., Bocchetta, M., Kroczynska, B., Elmishad, A. G., Chen, Y., Liu, Z., Bubici, C., Mossman, B. T., Pass, H. I., Testa, J. R., et al. (2006) · Proceedings of the National Academy of Sciences

Occupational and environmental lung diseasesNF-κB Signaling Pathways

Cited by 322

Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma

Xu, J., Kadariya, Y., Cheung, M., Pei, J., Talarchek, J., Sementino, E., Tan, Y., Menges, C. W., Cai, K. Q., Litwin, S., et al. (2014) · Cancer Research

Occupational and environmental lung diseasesTGF-β signaling in diseases

Cited by 144

The drug efflux pump MDR1 promotes intrinsic and acquired resistance to PROTACs in cancer cells

Kurimchak, A. M., Herrera-Montávez, C., Montserrat-Sangrà, S., Araiza-Olivera, D., Hu, J., Neumann-Domer, R., Kuruvilla, M., Bellacosa, A., Testa, J. R., Jin, J., et al. (2022) · Science Signaling

Protein Degradation and InhibitorsDrug Transport and Resistance Mechanisms

Cited by 136

In vitro hypoxia-conditioned colon cancer cell lines derived from HCT116 and HT29 exhibit altered apoptosis susceptibility and a more angiogenic profile in vivo

Yao, K., Gietema, J. A., Shida, S., Selvakumaran, M., Fonrose, X., Haas, N. B., Testa, J., & O'Dwyer, P. J. (2005) · British Journal of Cancer

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 82

Cellular and molecular parameters of mesothelioma

Ramos‐Nino, M. E., Testa, J. R., Altomare, D. A., Pass, H. I., Carbone, M., Bocchetta, M., & Mossman, B. T. (2006) · Journal of Cellular Biochemistry

Occupational and environmental lung diseasesIntraperitoneal and Appendiceal Malignancies

Cited by 71

Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis

Altomare, D. A., Menges, C. W., Xu, J., Pei, J., Zhang, L., Tadevosyan, A., Neumann-Domer, E., Liu, Z., Carbone, M., Chudoba, I., et al. (2011) · PLoS ONE

Cancer-related Molecular PathwaysOccupational and environmental lung diseases

Cited by 65