Cellular and molecular parameters of mesothelioma
Open accessAbstract
Malignant mesotheliomas (MM) are neoplasms arising from mesothelial cells that line the body cavities, most commonly the pleural and peritoneal cavities. Although traditionally recognized as associated with occupational asbestos exposures, MMs can appear in individuals with no documented exposures to asbestos fibers, and emerging data suggest that genetic susceptibility and simian virus 40 (SV40) infections also facilitate the development of MMs. Both asbestos exposure and transfection of human mesothelial cells with SV40 large and small antigens (Tag, tag) cause genetic modifications and cell signaling events, most notably the induction of cell survival pathways and activation of receptors, and other proteins that favor the growth and establishment of MMs as well as their resistance to chemotherapy. Recent advances in high‐throughput technologies documenting gene and protein expression in patients and animal models of MMs can now be validated in human MM tissue arrays. These have revealed expression profiles that allow more accurate diagnosis and prognosis of MMs. More importantly, serum proteomics has revealed two new candidates (osteopontin and serum mesothelin‐related protein or SMRP) potentially useful in screening individuals for MMs. These mechanistic approaches offer new hope for early detection and treatment of these devastating tumors. J. Cell. Biochem. 98: 723–734, 2006. © 2006 Wiley‐Liss, Inc.
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Environmental exposure to asbestos fibres has been linked to malignant mesothelioma.
“Asbestos fibres have been associated with development of malignant mesotheliomas after environmental exposures (2).”
From Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) · cites this paper as [2]
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Self-citation
Flagged first, then by citations
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Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
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Inflammatory Cytokines Contribute to Asbestos-Induced Injury of Mesothelial Cells
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- Authors
- Ramos‐Nino, M. E., Testa, J. R., Altomare, D. A., Pass, H. I., Carbone, M., Bocchetta, M., & Mossman, B. T.
- Affiliations
- Fox Chase Cancer Center (US)
- NYU Langone Health (US)
- Loyola University Chicago (US)
- University of Vermont (US)
- ORCID
- Venue
- Journal of Cellular Biochemistry
- Publisher
- Wiley
- Published
- 2006-02-10
- Volume
- 98
- Issue
- 4
- Pages
- 723-734
- ISSN
- 0730-2312 (ISSN-L)
- 1097-4644
- PMC
- PMC2766267
- OpenAlex
- W2057869668
- Cited by
- 71
- References
- 135
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2019: 3 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 6
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cellular Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p01ca114047-05)
- National Cancer Institute (K01CA104159, R01CA045745, R01CA106567, CA-45745, P01CA-114047, R01CA10656, R01CA082657-01)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Surgery › Intraperitoneal and Appendiceal Malignancies
- Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
- Keywords
- malignant mesothelioma, asbestos exposure, simian virus 40, mesothelial cells, genetic susceptibility, cell survival signaling, chemoresistance, gene expression profiling, serum proteomics, osteopontin, early detection, pleural mesothelioma, peritoneal mesothelioma
- MeSH terms
- Animals, Asbestos, Cell Transformation, Neoplastic, Cell Transformation, Viral, Humans, Mesothelioma, Peritoneal Neoplasms, Pleural Neoplasms, Simian virus 40, Tumor Virus Infections, Polyomavirus Infections
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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