Lyons, Jonathan J.

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

Lyons, J. J., Yu, X., Hughes, J. D., Le, Q. T., Jamil, A., Bai, Y., Ho, N., Zhao, M., Liu, Y., O'Connell, M. P., et al. (2016) · Nature Genetics

Mast cells and histamineGastrointestinal motility and disorders

Cited by 394

Updated Diagnostic Criteria and Classification of Mast Cell Disorders: A Consensus Proposal

Valent, P., Akin, C., Hartmann, K., Alvarez-Twose, I., Brockow, K., Hermine, O., Niedoszytko, M., Schwaab, J., Lyons, J. J., Carter, M. C., et al. (2021) · HemaSphere

Mast cells and histamineGastrointestinal Tumor Research and Treatment

Cited by 317

Heritable risk for severe anaphylaxis associated with increased α-tryptase–encoding germline copy number at TPSAB1

Lyons, J. J., Chovanec, J., O’Connell, M. P., Liu, Y., Šelb, J., Zanotti, R., Bai, Y., Kim, J., Le, Q. T., DiMaggio, T., et al. (2021) · Journal of Allergy and Clinical Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 230

Hereditary Alpha Tryptasemia

Lyons, J. J. (2018) · Immunology and Allergy Clinics of North America

Mast cells and histamineCoagulation, Bradykinin, Polyphosphates, and Angioedema

Cited by 179

Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome

Valent, P., Bonadonna, P., Hartmann, K., Broesby-Olsen, S., Brockow, K., Butterfield, J. H., Triggiani, M., Lyons, J. J., Oude Elberink, J. N. G., Arock, M., et al. (2019) · International Archives of Allergy and Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 146

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities

Lyons, J. J., Sun, G., Stone, K. D., Nelson, C., Wisch, L., O'Brien, M., Jones, N., Lindsley, A., Komarow, H. D., Bai, Y., et al. (2014) · Journal of Allergy and Clinical Immunology

Mast cells and histamineAsthma and respiratory diseases

Cited by 136

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

Le, Q. T., Lyons, J. J., Naranjo, A. N., Olivera, A., Lazarus, R. A., Metcalfe, D. D., Milner, J. D., & Schwartz, L. B. (2019) · Journal of Experimental Medicine

Mast cells and histamineProtease and Inhibitor Mechanisms

Cited by 126

Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

Sharma, M., Leung, D., Momenilandi, M., Jones, L. C. W., Pacillo, L., James, A. E., Murrell, J. R., Delafontaine, S., Maimaris, J., Vaseghi-Shanjani, M., et al. (2023) · Journal of Experimental Medicine

Immunodeficiency and Autoimmune DisordersAsthma and respiratory diseases

Cited by 125

Defining baseline variability of serum tryptase levels improves accuracy in identifying anaphylaxis

Mateja, A., Wang, Q., Chovanec, J., Kim, J., Wilson, K. J., Schwartz, L. B., Glover, S. C., Carter, M. C., Metcalfe, D. D., Brittain, E., et al. (2022) · Journal of Allergy and Clinical Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 91

Global classification of mast cell activation disorders: an ICD-10-CM–adjusted proposal of the ECNM-AIM Consortium

Valent, P., Hartmann, K., Bonadonna, P., Gülen, T., Brockow, K., Alvarez-Twose, I., Hermine, O., Niedoszytko, M., Carter, M. C., Hoermann, G., et al. (2022) · The Journal of Allergy and Clinical Immunology: In Practice

Mast cells and histamineAsthma and respiratory diseases

Cited by 90

Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review

Gülen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, H. N. G., Butterfield, J. H., et al. (2021) · The Journal of Allergy and Clinical Immunology: In Practice

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 83

First Identification of an Inherited TPSAB1 Quintuplication in a Patient with Clonal Mast Cell Disease

Sabato, V., Chovanec, J., Faber, M., Milner, J. D., Ebo, D., & Lyons, J. J. (2018) · Journal of Clinical Immunology

Mast cells and histamineImmunodeficiency and Autoimmune Disorders

Cited by 73

Routine KIT p.D816V screening identifies clonal mast cell disease in patients with Hymenoptera allergy regularly missed using baseline tryptase levels alone

Šelb, J., Rijavec, M., Eržen, R., Zidarn, M., Kopač, P., Škerget, M., Bajrović, N., Luzar, A. D., Park, Y. H., Liu, Y., et al. (2021) · Journal of Allergy and Clinical Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 65

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis

Hox, V., O'Connell, M. P., Lyons, J. J., Sackstein, P., Dimaggio, T., Jones, N., Nelson, C., Boehm, M., Holland, S. M., Freeman, A. F., et al. (2016) · Journal of Allergy and Clinical Immunology

Mast cells and histamineImmunodeficiency and Autoimmune Disorders

Cited by 64

Clinical relevance of inherited genetic differences in human tryptases

Glover, S. C., Carter, M. C., Korošec, P., Bonadonna, P., Schwartz, L. B., Milner, J. D., Caughey, G. H., Metcalfe, D. D., & Lyons, J. J. (2021) · Annals of Allergy, Asthma & Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 64

Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms

Chovanec, J., Tunc, I., Hughes, J., Halstead, J., Mateja, A., Liu, Y., O’Connell, M. P., Kim, J., Park, Y. H., Wang, Q., et al. (2023) · Blood Advances

Mast cells and histamineGenomics and Rare Diseases

Cited by 62

Hymenoptera venom-induced anaphylaxis and hereditary alpha-tryptasemia

O’Connell, M. P., & Lyons, J. J. (2020) · Current Opinion in Allergy & Clinical Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 53

Inherited and acquired determinants of serum tryptase levels in humans

Lyons, J. J. (2021) · Annals of Allergy, Asthma & Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 52

Elevated Basal Serum Tryptase: Disease Distribution and Variability in a Regional Health System

Waters, A. M., Park, H. J., Weskamp, A. L., Mateja, A., Kachur, M. E., Lyons, J. J., Rosen, B. J., & Boggs, N. A. (2022) · The Journal of Allergy and Clinical Immunology In Practice

Mast cells and histamineEosinophilic Disorders and Syndromes

Cited by 46

Mast cell activation syndrome: Current understanding and research needs

Castells, M., Giannetti, M. P., Hamilton, M. J., Novak, P., Pozdnyakova, O., Nicoloro-SantaBarbara, J., Jennings, S. V., Francomano, C., Kim, B., Glover, S. C., et al. (2024) · Journal of Allergy and Clinical Immunology

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 45

Distinct small intestine mast cell histologic changes in patients with hereditary alpha-tryptasemia and mast cell activation syndrome

Hamilton, M. J., Zhao, M., Giannetti, M. P., Weller, E., Hufdhi, R., Novak, P., Mendoza-Alvarez, L. B., Hornick, J., Lyons, J. J., Glover, S. C., et al. (2021) · American Journal of Surgical Pathology

Mast cells and histamineGastrointestinal motility and disorders

Cited by 44

Patients with mast cell activation symptoms and elevated baseline serum tryptase level have unique bone marrow morphology

Giannetti, M. P., Akin, C., Hufdhi, R., Hamilton, M. J., Weller, E., van Anrooij, B., Lyons, J. J., Hornick, J. L., Pinkus, G., Castells, M., et al. (2021) · Journal of Allergy and Clinical Immunology

Mast cells and histamineEosinophilic Disorders and Syndromes

Cited by 43

Hereditary alpha-tryptasemia: a commonly inherited modifier of anaphylaxis

Wu, R., & Lyons, J. J. (2021) · Current Allergy and Asthma Reports

Mast cells and histamineFood Allergy and Anaphylaxis Research

Cited by 43

Severe food allergy reactions are associated with α-tryptase

Lang, A., Kubala, S., Grieco, M. C., Mateja, A., Pongracic, J., Liu, Y., Frischmeyer-Guerrerio, P. A., Kumar, R., & Lyons, J. J. (2023) · Journal of Allergy and Clinical Immunology

Food Allergy and Anaphylaxis ResearchMast cells and histamine

Cited by 36