Christianson, David W.

Carboxypeptidase A

Christianson, D. W., & Lipscomb, W. N. (1989) · Accounts of Chemical Research

Peptidase Inhibition and AnalysisProtease and Inhibitor Mechanisms

Cited by 606

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

Deardorff, M. A., Bando, M., Nakato, R., Watrin, E., Itoh, T., Minamino, M., Saitoh, K., Komata, M., Katou, Y., Clark, D., et al. (2012) · Nature

Genomics and Chromatin DynamicsDNA Repair Mechanisms

Cited by 577

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

Hai, Y., & Christianson, D. W. (2016) · Nature Chemical Biology

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 521

Endothelial Arginase II: A Novel Target for the Treatment of Atherosclerosis

Ryoo, S., Gupta, G., Benjo, A., Lim, H. K., Camara, A., Sikka, G., Lim, H. K., Sohi, J., Santhanam, L., Soucy, K., et al. (2008) · Circulation Research

Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease Prevention

Cited by 236

Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors,

Dowling, D. P., Gantt, S. L., Gattis, S. G., Fierke, C. A., & Christianson, D. W. (2008) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 200

Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

Hai, Y., Shinsky, S. A., Porter, N. J., & Christianson, D. W. (2017) · Nature Communications

Polyamine Metabolism and ApplicationsHistone Deacetylase Inhibitors Research

Cited by 200

Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors

Porter, N. J., Mahendran, A., Breslow, R., & Christianson, D. W. (2017) · Proceedings of the National Academy of Sciences

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 190

Structural Basis of the Antiproliferative Activity of Largazole, a Depsipeptide Inhibitor of the Histone Deacetylases

Cole, K. E., Dowling, D. P., Boone, M. A., Phillips, A. J., & Christianson, D. W. (2011) · Journal of the American Chemical Society

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 153

Structure, mechanism, and inhibition of the zinc-dependent histone deacetylases

Porter, N. J., & Christianson, D. W. (2019) · Current Opinion in Structural Biology

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 146

Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity

Porter, N. J., Osko, J. D., Diedrich, D., Kurz, T., Hooker, J. M., Hansen, F. K., & Christianson, D. W. (2018) · Journal of Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 111

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

Vögerl, K., Ong, N., Senger, J., Herp, D., Schmidtkunz, K., Marek, M., Müller, M., Bartel, K., Shaik, T. B., Porter, N. J., et al. (2019) · Journal of Medicinal Chemistry

Histone Deacetylase Inhibitors ResearchPhenothiazines and Benzothiazines Synthesis and Activities

Cited by 104

Crystal Structure of Human Liver Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

Di Costanzo, L., Drury, J. E., Penning, T. M., & Christianson, D. W. (2008) · Journal of Biological Chemistry

Enzyme Structure and FunctionSteroid Chemistry and Biochemistry

Cited by 79

General Base–General Acid Catalysis in Human Histone Deacetylase 8

Gantt, S. M. L., Decroos, C., Lee, M. S., Gullett, L. E., Bowman, C. M., Christianson, D. W., & Fierke, C. A. (2016) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 67

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6

Porter, N. J., Wagner, F. F., & Christianson, D. W. (2018) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme function and inhibition

Cited by 64

Variable Active Site Loop Conformations Accommodate the Binding of Macrocyclic Largazole Analogues to HDAC8

Decroos, C., Clausen, D. J., Haines, B. E., Wiest, O., Williams, R. M., & Christianson, D. W. (2015) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 58

Structural and Functional Influence of the Glycine-Rich Loop G 302 GGGY on the Catalytic Tyrosine of Histone Deacetylase 8

Porter, N. J., Christianson, N. H., Decroos, C., & Christianson, D. W. (2016) · Biochemistry

Histone Deacetylase Inhibitors ResearchEnzyme Structure and Function

Cited by 33

Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase

Decroos, C., Bowman, C. M., & Christianson, D. W. (2013) · Bioorganic & Medicinal Chemistry

Polyamine Metabolism and ApplicationsEnzyme function and inhibition

Cited by 17

Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase

Decroos, C., & Christianson, D. W. (2015) · Biochemistry

Polyamine Metabolism and ApplicationsEnzyme Structure and Function

Cited by 12