Thoreen, Carson C.
Yale University
7 papers on CoChatORCID 0000-0003-1164-7224
Most cited papers
- Verified
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science
PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer
Cited by 2,773
- Verified
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Thoreen, C. C., Kang, S. A., Chang, J. W., Liu, Q., Zhang, J., Gao, Y., Reichling, L. J., Sim, T., Sabatini, D. M., & Gray, N. S. (2009) · Journal of Biological Chemistry
PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy
Cited by 1,803
- Verified
A unifying model for mTORC1-mediated regulation of mRNA translation
Thoreen, C. C., Chantranupong, L., Keys, H. R., Wang, T., Gray, N. S., & Sabatini, D. M. (2012) · Nature
PI3K/AKT/mTOR signaling in cancerRNA and protein synthesis mechanisms
Cited by 1,477
- Verified
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Sancak, Y., Thoreen, C. C., Peterson, T. R., Lindquist, R. A., Kang, S. A., Spooner, E., Carr, S. A., & Sabatini, D. M. (2007) · Molecular Cell
PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer
Cited by 1,236
- Verified
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., & Sabatini, D. M. (2009) · Cell
PI3K/AKT/mTOR signaling in cancerMultiple Myeloma Research and Treatments
Cited by 1,202
- Verified
Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1 H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer
Liu, Q., Chang, J. W., Wang, J., Kang, S. A., Thoreen, C. C., Markhard, A., Hur, W., Zhang, J., Sim, T., Sabatini, D. M., et al. (2010) · Journal of Medicinal Chemistry
PI3K/AKT/mTOR signaling in cancerHeterocyclic Compound Synthesis and Bioactivity
Cited by 257
- Verified
Quantitative profiling of human translation initiation reveals elements that potently regulate endogenous and therapeutically modified mRNAs
Lewis, C. J. T., Xie, L. H., Bhandarkar, S. M., Jin, D., Abdallah, K., Draycott, A. S., Chen, Y., Thoreen, C. C., & Gilbert, W. V. (2025) · Molecular Cell
RNA and protein synthesis mechanismsRNA Research and Splicing
Cited by 28
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