Youle, Richard J.

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

Karbowski, M., Arnoult, D., Chen, H., Chan, D. C., Smith, C. L., & Youle, R. J. (2004) · The Journal of Cell Biology

Mitochondrial Function and PathologyCell death mechanisms and regulation

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The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria

Jin, S. M., & Youle, R. J. (2013) · Autophagy

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

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Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control

Narendra, D. P., & Youle, R. J. (2011) · Antioxidants & Redox Signaling

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

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Control of mitochondrial permeability by Bcl-2 family members

Sharpe, J. C., Arnoult, D., & Youle, R. J. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Cell death mechanisms and regulationMitochondrial Function and Pathology

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High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Hasson, S. A., Kane, L. A., Yamano, K., Huang, C.-H., Sliter, D. A., Buehler, E., Wang, C., Heman-Ackah, S. M., Hessa, T., Guha, R., et al. (2013) · Nature

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

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Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Pickrell, A. M., Huang, C.-H., Kennedy, S. R., Ordureau, A., Sideris, D. P., Hoekstra, J. G., Harper, J. W., & Youle, R. J. (2015) · Neuron

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

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MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5

Nezich, C. L., Wang, C., Fogel, A. I., & Youle, R. J. (2015) · Journal of Cell Biology

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

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Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy

Yamano, K., Fogel, A. I., Wang, C., van der Bliek, A. M., & Youle, R. J. (2014) · eLife

Autophagy in Disease and TherapyCellular transport and secretion

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Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

Lee, S., Jeong, S.-Y., Lim, W.-C., Kim, S., Park, Y.-Y., Sun, X., Youle, R. J., & Cho, H. (2007) · Journal of Biological Chemistry

Mitochondrial Function and PathologyTelomeres, Telomerase, and Senescence

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Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1

Park, Y.-Y., Lee, S., Karbowski, M., Neutzner, A., Youle, R. J., & Cho, H. (2010) · Journal of Cell Science

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

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Mutations in Fis1 disrupt orderly disposal of defective mitochondria

Shen, Q., Yamano, K., Head, B. P., Kawajiri, S., Cheung, J. T. M., Wang, C., Cho, J.-H., Hattori, N., Youle, R. J., & van der Bliek, A. M. (2014) · Molecular Biology of the Cell

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

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Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance

Anding, A. L., Wang, C., Chang, T.-K., Sliter, D. A., Powers, C. M., Hofmann, K., Youle, R. J., & Baehrecke, E. H. (2018) · Current Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

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Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain

Sarraf, S. A., Shah, H. V., Kanfer, G., Pickrell, A. M., Holtzclaw, L. A., Ward, M. E., & Youle, R. J. (2020) · Molecular Cell

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

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A Systematic Search for Endoplasmic Reticulum (ER) Membrane-associated RING Finger Proteins Identifies Nixin/ZNRF4 as a Regulator of Calnexin Stability and ER Homeostasis

Neutzner, A., Neutzner, M., Benischke, A.-S., Ryu, S.-W., Frank, S., Youle, R. J., & Karbowski, M. (2011) · Journal of Biological Chemistry

Endoplasmic Reticulum Stress and DiseaseUbiquitin and proteasome pathways

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