Youle, Richard J.

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 4,026

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., et al. (2012) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 3,996

Mitochondrial Fission, Fusion, and Stress

Youle, R. J., & van der Bliek, A. M. (2012) · Science

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 3,674

Mechanisms of mitophagy

Youle, R. J., & Narendra, D. P. (2011) · Nature Reviews Molecular Cell Biology

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 3,273

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 2,944

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Lazarou, M., Sliter, D. A., Kane, L. A., Sarraf, S. A., Wang, C., Burman, J. L., Sideris, D. P., Fogel, A. I., & Youle, R. J. (2015) · Nature

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 2,774

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

Pickrell, A. M., & Youle, R. J. (2015) · Neuron

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 2,310

Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance

Pickles, S., Vigié, P., & Youle, R. J. (2018) · Current Biology

Autophagy in Disease and TherapyMitochondrial Function and Pathology

Cited by 2,081

The Role of Mitochondria in Apoptosis

Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 1,987

The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

Frank, S., Gaume, B., Bergmann-Leitner, E. S., Leitner, W. W., Robert, E. G., Catez, F., Smith, C. L., & Youle, R. J. (2001) · Developmental Cell

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,755

The mitochondrial basis of aging

Sun, N., Youle, R. J., & Finkel, T. (2016) · Molecular Cell

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 1,441

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

Jin, S. M., Lazarou, M., Wang, C., Kane, L. A., Narendra, D. P., & Youle, R. J. (2010) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsMitochondrial Function and Pathology

Cited by 1,375

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

Tanaka, A., Cleland, M. M., Xu, S., Narendra, D. P., Suen, D.-F., Karbowski, M., & Youle, R. J. (2010) · Journal of Cell Biology

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 1,369

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

Kane, L. A., Lazarou, M., Fogel, A. I., Li, Y., Yamano, K., Sarraf, S. A., Banerjee, S., & Youle, R. J. (2014) · Journal of Cell Biology

Parkinson's Disease Mechanisms and TreatmentsUbiquitin and proteasome pathways

Cited by 1,298

RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation

Sliter, D. A., Martinez, J., Hao, L., Chen, X., Sun, N., Fischer, T. D., Burman, J. L., Li, Y., Zhang, Z., Narendra, D. P., et al. (2018) · Nature

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,287

Mitochondrial dynamics and apoptosis

Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,270

Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells

Otera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J., & Mihara, K. (2010) · Journal of Cell Biology

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 1,110

Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

Lee, Y.-J., Jeong, S.-Y., Karbowski, M., Smith, C. L., & Youle, R. J. (2004) · Molecular Biology of the Cell

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 1,042

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

Karbowski, M., Lee, Y.-J., Gaume, B., Jeong, S.-Y., Frank, S., Nechushtan, A., Santel, A., Fuller, M., Smith, C. L., & Youle, R. J. (2002) · The Journal of Cell Biology

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 846

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Richter, B., Sliter, D. A., Herhaus, L., Stolz, A., Wang, C., Beli, P., Zaffagnini, G., Wild, P., Martens, S., Wagner, S. A., et al. (2016) · Proceedings of the National Academy of Sciences

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 755

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

Lazarou, M., Jin, S. M., Kane, L. A., & Youle, R. J. (2012) · Developmental Cell

Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and Therapy

Cited by 670

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

Edlich, F., Banerjee, S., Suzuki, M., Cleland, M. M., Arnoult, D., Wang, C., Neutzner, A., Tjandra, N., & Youle, R. J. (2011) · Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 630

Role of Bax and Bak in mitochondrial morphogenesis

Karbowski, M., Norris, K. L., Cleland, M. M., Jeong, S.-Y., & Youle, R. J. (2006) · Nature

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 625

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

Burman, J. L., Pickles, S., Wang, C., Sekine, S., Vargas, J. N. S., Zhang, Z., Youle, A. M., Nezich, C. L., Wu, X., Hammer, J. A., et al. (2017) · Journal of Cell Biology

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 479