Hu, Wenwei

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

Bond, G. L., Hu, W., Bond, E. E., Robins, H., Lutzker, S. G., Arva, N. C., Bargonetti, J., Bartel, F., Taubert, H., Wuerl, P., et al. (2004) · Cell

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 1,265

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Hu, W., Zhang, C., Wu, R., Sun, Y., Levine, A., & Feng, Z. (2010) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 862

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research

PI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

Cited by 633

Tumour-associated mutant p53 drives the Warburg effect

Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., Lin, M., Yu, H., Liu, L., Levine, A. J., et al. (2013) · Nature Communications

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 434

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

Zhang, C., Lin, M., Wu, R., Wang, X., Yang, B., Levine, A. J., Hu, W., & Feng, Z. (2011) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCancer, Hypoxia, and Metabolism

Cited by 431

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

Yue, X., Zhao, Y., Xu, Y., Zheng, M., Feng, Z., & Hu, W. (2017) · Journal of Molecular Biology

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 308

The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma

Hu, W. (2002) · Carcinogenesis

Carcinogens and Genotoxicity AssessmentDNA Repair Mechanisms

Cited by 287

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysGenetics, Aging, and Longevity in Model Organisms

Cited by 264

Chronic restraint stress attenuates p53 function and promotes tumorigenesis

Feng, Z., Liu, L., Zhang, C., Zheng, T., Wang, J., Lin, M., Zhao, Y., Wang, X., Levine, A. J., & Hu, W. (2012) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCancer, Stress, Anesthesia, and Immune Response

Cited by 209

Single-nucleotide polymorphisms in the p53 pathway regulate fertility in humans

Kang, H.-J., Feng, Z., Sun, Y., Atwal, G., Murphy, M. E., Rebbeck, T. R., Rosenwaks, Z., Levine, A. J., & Hu, W. (2009) · Proceedings of the National Academy of Sciences

Reproductive Biology and FertilityReproductive System and Pregnancy

Cited by 193

Autophagy promotes mammalian survival by suppressing oxidative stress and p53

Yang, Y., Karsli-Uzunbas, G., Poillet-Perez, L., Sawant, A., Hu, Z. S., Zhao, Y., Moore, D., Hu, W., & White, E. (2020) · Genes & Development

Autophagy in Disease and TherapyGenetics, Aging, and Longevity in Model Organisms

Cited by 100

Advances in adoptive cellular therapy for colorectal cancer: A narrative review

Yi, X., & Hu, W. (2022) · Annals of Translational Medicine

CAR-T cell therapy researchImmunotherapy and Immune Responses

Cited by 14