Advances in adoptive cellular therapy for colorectal cancer: A narrative review
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Background and Objective: In recent years, adoptive cell therapy (ACT) has shown great potential in antitumor treatment. To significantly improve the clinical efficacy of ACT against solid tumors, we may need to carefully study the latest developments in ACT. As one of the most common malignancies, colorectal cancer (CRC) is a major risk to human health and has become a significant burden on global healthcare systems. This article reviews the recent advances in the treatment of CRC with ACT. Methods: We searched PubMed for articles related to ACT for CRC published as of August 31, 2022, and retrieved relevant clinical trial information on the National Institutes of Health ClinicalTrials.gov website. Based on search results, comprehensive and systematic review is made. Key Content and Findings: This article provides an overview of the research progress of ACT for CRC, including chimeric antigen receptor (CAR) T-cell therapy, T-cell receptor (TCR)-engineered T-cell therapy, and tumor-infiltrating lymphocyte (TIL) therapy. Common tumor-associated antigens (TAAs) in clinical trials of CAR-T cell therapy for CRC are described. Conclusions: Despite many obstacles, ACT shows great promise in treating CRC. Therefore, more basic experimental studies and clinical trials are warranted to further clarify the effectiveness and safety of ACT.
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ACT provides its anticarcinogenic effect through isolating the expansion of a large volume of T cells that may overcome certain suppressive immunomodulatory parameters.
“In contrast to ICIs that greatly exert their action through antagonism of suppressor T-cell receptors, ACT providesits anticarcinogenic effect through isolating the expansion of a great volume of T cells that may overcome certain suppressive immunomodulatory parameters [19].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [19]
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WITHDRAWNPreprint
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“They had good potential for colorectal cancer and leukemia treatment [111,112].”
BackgroundCurrent and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
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- Authors
- Yi, X., & Hu, W.
- Affiliations
- Soochow University (CN)
- Corresponding author
- Hu, Wenwei
- ORCID
- Venue
- Annals of Translational Medicine
- Publisher
- AME Publishing Company
- Published
- 2022-12
- Volume
- 10
- Issue
- 24
- Pages
- 1404-1404
- ISSN
- 2305-5839 (ISSN-L)
- 2305-5847
- PMC
- PMC9843349
- OpenAlex
- W4313364133
- Cited by
- 14
- References
- 159
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 1
- FWCI
- 0.34
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Annals of Translational Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- adoptive immunotherapy, colorectal cancer, CAR T-cell therapy, T cell receptor-engineered T cells, tumor-associated antigens, cancer immunotherapy
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