Bassell, Gary J.

Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function

Bassell, G. J., & Warren, S. T. (2008) · Neuron

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 1,051

A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome

Dictenberg, J. B., Swanger, S. A., Antar, L. N., Singer, R. H., & Bassell, G. J. (2008) · Developmental Cell

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 511

Dysregulated Metabotropic Glutamate Receptor-Dependent Translation of AMPA Receptor and Postsynaptic Density-95 mRNAs at Synapses in a Mouse Model of Fragile X Syndrome

Muddashetty, R. S., Kelić, S., Gross, C., Xu, M., & Bassell, G. J. (2007) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 421

Metabotropic Glutamate Receptor Activation Regulates Fragile X Mental Retardation Protein and Fmr1 mRNA Localization Differentially in Dendrites and at Synapses

Antar, L. N., Afroz, R., Dictenberg, J. B., Carroll, R. C., & Bassell, G. J. (2004) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 411

Reversible Inhibition of PSD-95 mRNA Translation by miR-125a, FMRP Phosphorylation, and mGluR Signaling

Muddashetty, R. S., Nalavadi, V. C., Gross, C., Yao, X., Xing, L., Laur, O., Warren, S. T., & Bassell, G. J. (2011) · Molecular Cell

Genetics and Neurodevelopmental DisordersMicroRNA in disease regulation

Cited by 364

Dysregulation and restoration of translational homeostasis in fragile X syndrome

Richter, J. D., Bassell, G. J., & Klann, E. (2015) · Nature Reviews Neuroscience

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 275

The ALS disease protein TDP-43 is actively transported in motor neuron axons and regulates axon outgrowth

Fallini, C., Bassell, G. J., & Rossoll, W. (2012) · Human Molecular Genetics

Amyotrophic Lateral Sclerosis ResearchRNA Research and Splicing

Cited by 247

Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors

Nakamoto, M., Nalavadi, V., Epstein, M. P., Narayanan, U., Bassell, G. J., & Warren, S. T. (2007) · Proceedings of the National Academy of Sciences

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 245

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome

Gross, C., Nakamoto, M., Yao, X., Chan, C.-B., Yim, S. Y., Ye, K., Warren, S. T., & Bassell, G. J. (2010) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 241

FMRP Phosphorylation Reveals an Immediate-Early Signaling Pathway Triggered by Group I mGluR and Mediated by PP2A

Narayanan, U., Nalavadi, V., Nakamoto, M., Pallas, D. C., Ceman, S., Bassell, G. J., & Warren, S. T. (2007) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 228

The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons

Fallini, C., Zhang, H., Su, Y., Silani, V., Singer, R. H., Rossoll, W., & Bassell, G. J. (2011) · The Journal of Neuroscience

Neurogenetic and Muscular Disorders ResearchRNA Research and Splicing

Cited by 221

S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade

Narayanan, U., Nalavadi, V., Nakamoto, M., Thomas, G., Ceman, S., Bassell, G. J., & Warren, S. T. (2008) · Journal of Biological Chemistry

Genetics and Neurodevelopmental DisordersPI3K/AKT/mTOR signaling in cancer

Cited by 216

Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2

Gross, C., Yao, X., Pong, D. L., Jeromin, A., & Bassell, G. J. (2011) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 161

Dephosphorylation-Induced Ubiquitination and Degradation of FMRP in Dendrites: A Role in Immediate Early mGluR-Stimulated Translation

Nalavadi, V. C., Muddashetty, R. S., Gross, C., & Bassell, G. J. (2012) · The Journal of Neuroscience

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 128

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

Gross, C., Chang, C.-W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., et al. (2015) · Cell Reports

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 117

Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back

Gross, C., Hoffmann, A., Bassell, G. J., & Berry-Kravis, E. M. (2015) · Neurotherapeutics

Genetics and Neurodevelopmental DisordersAutism Spectrum Disorder Research

Cited by 105

Analysis of FMRP mRNA target datasets reveals highly associated mRNAs mediated by G-quadruplex structures formed via clustered WGGA sequences

Suhl, J. A., Chopra, P., Anderson, B. R., Bassell, G. J., & Warren, S. T. (2014) · Human Molecular Genetics

Genetics and Neurodevelopmental DisordersRNA Research and Splicing

Cited by 81

GAP‐43 mRNA in growth cones is associated with HuD and ribosomes

Smith, C. L., Afroz, R., Bassell, G. J., Furneaux, H. M., Perrone‐Bizzozero, N. I., & Burry, R. W. (2004) · Journal of Neurobiology

Axon Guidance and Neuronal SignalingRNA Research and Splicing

Cited by 81

Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

Gross, C., Raj, N., Molinaro, G., Allen, A. G., Whyte, A. J., Gibson, J. R., Huber, K. M., Gourley, S. L., & Bassell, G. J. (2015) · Cell Reports

Genetics and Neurodevelopmental DisordersPI3K/AKT/mTOR signaling in cancer

Cited by 71

Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders

Gross, C., & Bassell, G. J. (2014) · Frontiers in Molecular Neuroscience

PI3K/AKT/mTOR signaling in cancerGenetics and Neurodevelopmental Disorders

Cited by 63

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.

Raj, N., McEachin, Z. T., Harousseau, W., Zhou, Y., Zhang, F., Merritt-Garza, M. E., Taliaferro, J. M., Kalinowska, M., Marro, S. G., Hales, C. M., et al. (2021) · Cell Reports

Genetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 54

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns.

Das Sharma, S., Pal, R., Reddy, B. K., Selvaraj, B. T., Raj, N., Samaga, K. K., Srinivasan, D. J., Ornelas, L., Sareen, D., Livesey, M. R., et al. (2020) · Molecular Autism

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 28

Muscleblind-like proteins use modular domains to localize RNAs by riding kinesins and docking to membranes

Hildebrandt, R. P., Moss, K. R., Janusz-Kaminska, A., Knudson, L. A., Denes, L. T., Saxena, T., Boggupalli, D. P., Li, Z., Lin, K., Bassell, G. J., et al. (2022) · Nature Communications

RNA Research and SplicingAmyotrophic Lateral Sclerosis Research

Cited by 22