Selective Role of the Catalytic PI3K Subunit p110β in Impaired Higher Order Cognition in Fragile X Syndrome

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

Darnell, J. C., Van Driesche, S. J., Zhang, C., Hung, K. Y. S., Mele, A., Fraser, C. E., Stone, E. F., Chen, C., Fak, J. J., Chi, S. W., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.013 · Cited by 2,072 · see citing works

Human and Rodent Homologies in Action Control: Corticostriatal Determinants of Goal-Directed and Habitual Action

Balleine, B. W., & O'Doherty, J. P. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.131 · Cited by 1,775 · see citing works

The mGluR theory of fragile X mental retardation

Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580 · see citing works

Goal-directed instrumental action: contingency and incentive learning and their cortical substrates

Balleine, B. W., & Dickinson, A. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00033-1 · Cited by 1,541 · see citing works

Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates

Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works

Assessing nest building in mice

Deacon, R. M. J. (2006) · Nature Protocols · doi:10.1038/nprot.2006.170 · Cited by 1,115 · see citing works

Correction of Fragile X Syndrome in Mice

Dölen, G., Osterweil, E., Rao, B. S. S., Smith, G. B., Auerbach, B. D., Chattarji, S., & Bear, M. F. (2007) · Neuron · doi:10.1016/j.neuron.2007.12.001 · Cited by 979 · see citing works

Dendritic Protein Synthesis, Synaptic Plasticity, and Memory

Sutton, M. A., & Schuman, E. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.014 · Cited by 894 · see citing works

Chronic Stress Causes Frontostriatal Reorganization and Affects Decision-Making

Dias-Ferreira, E., Sousa, J. C., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J. J., Costa, R. M., & Sousa, N. (2009) · Science · doi:10.1126/science.1171203 · Cited by 858 · see citing works

Coordination of Actions and Habits in the Medial Prefrontal Cortex of Rats

Killcross, S. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.4.400 · Cited by 748 · see citing works

FMRP targets distinct mRNA sequence elements to regulate protein expression

Ascano, M., Mukherjee, N., Bandaru, P., Miller, J. B., Nusbaum, J. D., Corcoran, D. L., Langlois, C., Munschauer, M., Dewell, S., Hafner, M., et al. (2012) · Nature · doi:10.1038/nature11737 · Cited by 701 · see citing works

Dysregulation of mTOR signaling in fragile X syndrome

Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E., & Zukin, R. S. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3696-09.2010 · Cited by 557 · see citing works

Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome

Gibson, J. R., Bartley, A. F., Hays, S. A., & Huber, K. M. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90752.2008 · Cited by 529 · see citing works

Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP

Yan, Q. J., Rammal, M., Tranfaglia, M., & Bauchwitz, R. P. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.06.004 · Cited by 521 · see citing works

RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice

Miyashiro, K. Y., Beckel-Mitchener, A., Purk, T. P., Becker, K. G., Barret, T., Liu, L., Carbonetto, S., Weiler, I. J., Greenough, W. T., & Eberwine, J. (2003) · Neuron · doi:10.1016/s0896-6273(03)00034-5 · Cited by 495 · see citing works

The role of prelimbic cortex in instrumental conditioning

Corbit, L. H., & Balleine, B. W. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.023 · Cited by 423 · see citing works

Hypersensitivity to mGluR5 and ERK1/2 Leads to Excessive Protein Synthesis in the Hippocampus of a Mouse Model of Fragile X Syndrome

Osterweil, E. K., Krueger, D. D., Reinhold, K., & Bear, M. F. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.3888-10.2010 · Cited by 384 · see citing works

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

Bhakar, A. L., Dölen, G., & Bear, M. F. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153138 · Cited by 370 · see citing works

Human orbitofrontal cortex mediates extinction learning while accessing conditioned representations of value

Gottfried, J. A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1314 · Cited by 353 · see citing works

The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ

Guillermet‐Guibert, J., Björklöf, K., Salpekar, A., Gonella, C., Ramadani, F., Bilancio, A., Meek, S. E., Smith, A. J. H., Okkenhaug, K., & Vanhaesebroeck, B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707761105 · Cited by 345 · see citing works

Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase

Bi, L., Okabe, I., Bernard, D. J., & Nussbaum, R. L. (2002) · Mammalian Genome · doi:10.1007/bf02684023 · Cited by 317 · see citing works

Genetic Removal of p70 S6 Kinase 1 Corrects Molecular, Synaptic, and Behavioral Phenotypes in Fragile X Syndrome Mice

Bhattacharya, A., Kaphzan, H., Alvarez-Dieppa, A. C., Murphy, J. P., Pierre, P., & Klann, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.022 · Cited by 316 · see citing works

THE EFFECT OF CONTINGENCY UPON THE APPETITIVE CONDITIONING OF FREE‐OPERANT BEHAVIOR

Hammond, L. J. (1980) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1980.34-297 · Cited by 291 · see citing works

Lesions of medial prefrontal cortex disrupt the acquisition but not the expression of goal-directed learning.

Ostlund, S. B., & Balleine, B. W. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1921-05.2005 · Cited by 291 · see citing works

PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

Rong, R., Ahn, J.-Y., Huang, H., Nagata, E., Kalman, D., Kapp, J. A., Tu, J., Worley, P. F., Snyder, S. H., & Ye, K. (2003) · Nature Neuroscience · doi:10.1038/nn1134 · Cited by 281 · see citing works

Circuit level defects in the developing neocortex of fragile X mice

Gonçalves, J. T., Anstey, J. E., Golshani, P., & Portera-Cailliau, C. (2013) · Nature Neuroscience · doi:10.1038/nn.3415 · Cited by 279 · see citing works

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

Ronesi, J. A., Collins, K. A., Hays, S. A., Tsai, N.-P., Guo, W., Birnbaum, S. G., Hu, J.-H., Worley, P. F., Gibson, J. R., & Huber, K. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3033 · Cited by 251 · see citing works

Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation

Ronesi, J. A., & Huber, K. M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5019-07.2008 · Cited by 244 · see citing works

Targeting the endocannabinoid system in the treatment of fragile X syndrome

Busquets-Garcia, A., Gomis-González, M., Guegan, T., Agustín-Pavón, C., Pastor, A., Mato, S., Pérez-Samartín, A., Matute, C., de la Torre, R., Dierssen, M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3127 · Cited by 241 · see citing works

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome

Gross, C., Nakamoto, M., Yao, X., Chan, C.-B., Yim, S. Y., Ye, K., Warren, S. T., & Bassell, G. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0402-10.2010 · Cited by 241 · see citing works

Fragile X mental retardation protein is necessary for neurotransmitter-activated protein translation at synapses

Weiler, I. J., Spangler, C. C., Klintsova, A. Y., Grossman, A. W., Kim, S. H., Bertaina-Anglade, V., Khaliq, H., de Vries, F. E., Lambers, F. A. E., Hatia, F., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407533101 · Cited by 210 · see citing works

Altered Neocortical Rhythmic Activity States inFmr1KO Mice Are Due to Enhanced mGluR5 Signaling and Involve Changes in Excitatory Circuitry

Hays, S. A., Huber, K. M., & Gibson, J. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3157-11.2011 · Cited by 167 · see citing works

Medial prefrontal cortex lesions in the female rat affect sexual and maternal behavior and their sequential organization.

Afonso, V. M., Sison, M., Lovic, V., & Fleming, A. S. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.515 · Cited by 152 · see citing works

Conditioning and extinction of a food-rewarded response after selective ablations of frontal cortex in rhesus monkeys

Butter, C. M., Mishkin, M., & Rosvold, H. E. (1963) · Experimental Neurology · doi:10.1016/0014-4886(63)90094-3 · Cited by 139 · see citing works

Functional Disconnection of the Orbitofrontal Cortex and Basolateral Amygdala Impairs Acquisition of a Rat Gambling Task and Disrupts Animals' Ability to Alter Decision-Making Behavior after Reinforcer Devaluation

Zeeb, F. D., & Winstanley, C. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3971-12.2013 · Cited by 120 · see citing works

Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding

Gourley, S. L., Swanson, A. M., Jacobs, A. M., Howell, J. L., Mo, M., Dileone, R., Koleske, A. J., & Taylor, J. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208342109 · Cited by 118 · see citing works

Increased Expression of the PI3K Enhancer PIKE Mediates Deficits in Synaptic Plasticity and Behavior in Fragile X Syndrome

Gross, C., Chang, C.-W., Kelly, S. M., Bhattacharya, A., McBride, S. M. J., Danielson, S. W., Jiang, M. Q., Chan, C. B., Ye, K., Gibson, J. R., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.03.060 · Cited by 117 · see citing works

Transient role of the rat prelimbic cortex in goal‐directed behaviour

Tran‐Tu‐Yen, D. A. S., Marchand, A. R., Pape, J., Scala, G. D., & Coutureau, É. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06834.x · Cited by 114 · see citing works

Opposing effects of amygdala and orbital prefrontal cortex lesions on the extinction of instrumental responding in macaque monkeys

Izquierdo, A., & Murray, E. A. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04434.x · Cited by 96 · see citing works

The orbitofrontal cortex regulates outcome‐based decision‐making via the lateral striatum

Gourley, S. L., Olevska, A., Zimmermann, K. S., Ressler, K. J., Dileone, R., & Taylor, J. R. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12239 · Cited by 94 · see citing works

Neural Estimates of Imagined Outcomes in the Orbitofrontal Cortex Drive Behavior and Learning

Takahashi, Y. K., Chang, C. Y., Lucantonio, F., Haney, R. Z., Berg, B. A., Yau, H., Bonci, A., & Schoenbaum, G. M. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.008 · Cited by 81 · see citing works

Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome

Thomas, A. M., Bui, N., Graham, D. F., Perkins, J. R., Yuva‐Paylor, L. A., & Paylor, R. E. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.049 · Cited by 74 · see citing works

Excess Protein Synthesis in FXS Patient Lymphoblastoid Cells Can Be Rescued with a p110β-Selective Inhibitor

Groß, C., & Bassell, G. J. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00363 · Cited by 69 · see citing works

Goal-directed responding is sensitive to lesions to the prelimbic cortex or basolateral nucleus of the amygdala but not to their disconnection.

Coutureau, É., Marchand, A. R., & Scala, G. D. (2009) · Behavioral Neuroscience · doi:10.1037/a0014818 · Cited by 66 · see citing works

Identification of Fragile X Syndrome Specific Molecular Markers in Human Fibroblasts: A Useful Model to Test the Efficacy of Therapeutic Drugs

Kumari, D., Bhattacharya, A., Nadel, J., Moulton, K., Zeak, N. M., Glicksman, A., Dobkin, C., Brick, D. J., Schwartz, P. H., Smith, C. B., et al. (2014) · Human Mutation · doi:10.1002/humu.22699 · Cited by 61 · see citing works

Medial prefrontal cortex infusions of bupivacaine or AP-5 block extinction of amphetamine conditioned place preference

Hsu, E. H., & Packard, M. G. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.006 · Cited by 49 · see citing works

Dissociable roles of medial orbitofrontal cortex in human operant extinction learning

Finger, E. C., Mitchell, D. G. V., Jones, M., & Blair, R. J. R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.08.021 · Cited by 45 · see citing works

Orbitofrontal cortex inactivation impairs between- but not within-session Pavlovian extinction: An associative analysis

Panayi, M. C., & Killcross, S. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.08.002 · Cited by 26 · see citing works

Prelimbic cortex bdnf knock-down reduces instrumental responding in extinctionPreprint

Gourley, S. L., Howell, J. L., Rios, M., Dileone, R., & Taylor, J. R. (2009) · Learning & Memory · doi:10.1101/lm.1547909 · Cited by 26 · see citing works

PREVENTION BY CYCLOHEXIMIDE OF THE AUDIOGENIC SEIZURES AND TRYPTOPHAN METABOLIC DISTURBANCES OF ETHANOL WITHDRAWAL IN RATS

Oretti, R. G., Bano, S., Morgan, C., Badawy, A. A. ‐., BONNER, A. B., Buckland, P. R., & McGuffin, P. (1996) · Alcohol and Alcoholism · doi:10.1093/oxfordjournals.alcalc.a008143 · Cited by 13 · see citing works

Advancing the understanding of autism disease mechanisms through genetics

de la Torre-Ubieta, L., Won, H., Stein, J. L., & Geschwind, D. H. (2016) · Nature Medicine · doi:10.1038/nm.4071 · Cited by 827 · see citing works

The ASD Living Biology: from cell proliferation to clinical phenotype

Courchesne, E., Pramparo, T., Gazestani, V. H., Lombardo, M. V., Pierce, K., & Lewis, N. E. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0056-y · Cited by 333 · see citing works

Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders

Sahin, M., & Sur, M. (2015) · Science · doi:10.1126/science.aab3897 · Cited by 295 · see citing works

Dysregulation and restoration of translational homeostasis in fragile X syndrome

Richter, J. D., Bassell, G. J., & Klann, E. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4001 · Cited by 275 · see citing works

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

Jiang, C.-C., Lin, L., Long, S., Ke, X., Fukunaga, K., Lu, Y., & Han, F. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01081-0 · Cited by 272 · see citing works

Pausing on Polyribosomes: Make Way for Elongation in Translational Control

Richter, J. D., & Coller, J. M. (2015) · Cell · doi:10.1016/j.cell.2015.09.041 · Cited by 204 · see citing works

Going and stopping: dichotomies in behavioral control by the prefrontal cortex

Gourley, S. L., & Taylor, J. R. (2016) · Nature Neuroscience · doi:10.1038/nn.4275 · Cited by 195 · see citing works

A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies

Kang, Y., Zhou, Y., Li, Y., Han, Y., Xu, J., Niu, W., Li, Z., Liu, S., Feng, H., Huang, W., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00913-6 · Cited by 166 · see citing works

Fragile X targeted pharmacotherapy: lessons learned and future directions

Erickson, C. A., Davenport, M. H., Schaefer, T. L., Wink, L. K., Pedapati, E. V., Sweeney, J. A., Fitzpatrick, S. E., Brown, W. T., Budimirovic, D. B., Hagerman, R. J., et al. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9186-9 · Cited by 153 · see citing works

Of Men and Mice: Modeling the Fragile X Syndrome

Dahlhaus, R. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00041 · Cited by 118 · see citing works

Dysregulation of mRNA Localization and Translation in Genetic Disease

Wang, E. T., Taliaferro, J. M., Lee, J.-A., Sudhakaran, I. P., Rossoll, W., Groß, C., Moss, K. R., & Bassell, G. J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2352-16.2016 · Cited by 115 · see citing works

FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory

Sawicka, K., Hale, C. R., Park, C. Y., Fak, J. J., Gresack, J. E., Driesche, S. J. V., Kang, J. J., Darnell, J. C., & Darnell, R. B. (2019) · eLife · doi:10.7554/elife.46919 · Cited by 113 · see citing works

Aberrant RNA translation in fragile X syndrome: From FMRP mechanisms to emerging therapeutic strategies

Banerjee, A., Ifrim, M. F., Valdez‐Sinon, A. N., Raj, N., & Bassell, G. J. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.008 · Cited by 103 · see citing works

Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back

Gross, C., Hoffmann, A., Bassell, G. J., & Berry-Kravis, E. M. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0355-9 · Cited by 105 · see citing works

Channelopathies in fragile X syndrome

Deng, P., & Klyachko, V. A. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00445-9 · Cited by 105 · see citing works

Characterizing autism spectrum disorders by key biochemical pathways

Subramanian, M. P., Timmerman, C., Schwartz, J. L., Pham, D. L., & Meffert, M. K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00313 · Cited by 71 · see citing works

Identification of FMR1-regulated molecular networks in human neurodevelopmentPreprint

Li, M., Shin, J., Risgaard, R. D., Parries, M., Wang, J., Chasman, D. A., Liu, S., Roy, S., Bhattacharyya, A., & Zhao, X. (2020) · Genome Research · doi:10.1101/gr.251405.119 · Cited by 71 · see citing works

Audiogenic Seizures in theFmr1Knock-Out Mouse Are Induced byFmr1Deletion in Subcortical, VGlut2-Expressing Excitatory Neurons and Require Deletion in the Inferior Colliculus

Gonzalez, D., Tomasek, M. P., Hays, S. A., Sridhar, V., Ammanuel, S. G., Chang, C.-W., Pawlowski, K. S., Huber, K. M., & Gibson, J. R. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0886-19.2019 · Cited by 64 · see citing works

MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome

Li, Y., Stockton, M. E., Bhuiyan, I., Eisinger, B. E., Gao, Y., Miller, J. L., Bhattacharyya, A., & Zhao, X. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad9370 · Cited by 66 · see citing works

What we can learn from a genetic rodent model about autism

Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works

Enhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model

Sethna, F., Feng, W., Ding, Q., Robison, A. J., Feng, Y., & Wang, H. (2017) · Nature Communications · doi:10.1038/ncomms14359 · Cited by 60 · see citing works

Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease

Tariq, K., & Luikart, B. W. (2021) · Exploration of Neuroprotective Therapy · doi:10.37349/ent.2021.00008 · Cited by 47 · see citing works

Cell-type-specific profiling of human cellular models of fragile X syndrome reveal PI3K-dependent defects in translation and neurogenesis.

Raj, N., McEachin, Z. T., Harousseau, W., Zhou, Y., Zhang, F., Merritt-Garza, M. E., Taliaferro, J. M., Kalinowska, M., Marro, S. G., Hales, C. M., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108991 · Cited by 54 · see citing works

Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice

Bhattacharya, A., Mamcarz, M., Mullins, C., Choudhury, A., Boyle, R. G., Smith, D. G., Walker, D. W., & Klann, E. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.369 · Cited by 51 · see citing works

PI3Kβ—A Versatile Transducer for GPCR, RTK, and Small GTPase Signaling

Bresnick, A. R., & Backer, J. (2019) · Endocrinology · doi:10.1210/en.2018-00843 · Cited by 50 · see citing works

Reward-Related Expectations Trigger Dendritic Spine Plasticity in the Mouse Ventrolateral Orbitofrontal Cortex

Whyte, A. J., Kietzman, H. W., Swanson, A. M., Butkovich, L. M., Barbee, B. R., Bassell, G. J., Groß, C., & Gourley, S. L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2031-18.2019 · Cited by 45 · see citing works

Modelling Learning and Memory in Drosophila to Understand Intellectual Disabilities

Mariano, V., Achsel, T., Bagni, C., & Kanellopoulos, A. K. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.07.034 · Cited by 46 · see citing works

Overexpression of Homer1a in the basal and lateral amygdala impairs fear conditioning and induces an autism-like social impairment

Banerjee, A., Luong, J. A., Ho, A., Saib, A., & Ploski, J. E. (2016) · Molecular Autism · doi:10.1186/s13229-016-0077-9 · Cited by 43 · see citing works

Involvement of the rodent prelimbic and medial orbitofrontal cortices in goal‐directed action: A brief review

Woon, E. P., Sequeira, M. K., Barbee, B. R., & Gourley, S. L. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24567 · Cited by 42 · see citing works

The Search for an Effective Therapy to Treat Fragile X Syndrome: Dream or Reality?

Castagnola, S., Bardoni, B., & Maurin, T. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00015 · Cited by 40 · see citing works

Prefrontal cortical BDNF: A regulatory key in cocaine- and food-reinforced behaviors

Pitts, E. G., Taylor, J. R., & Gourley, S. L. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.02.021 · Cited by 40 · see citing works

Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models

Brown, E., Lautz, J. D., Davis, T. R., Gniffke, E. P., VanSchoiack, A., Neier, S. C., Tashbook, N., Nicolini, C., Fahnestock, M. L., Schrum, A. G., et al. (2018) · Molecular Autism · doi:10.1186/s13229-018-0229-1 · Cited by 40 · see citing works

Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

Groß, C., Banerjee, A., Tiwari, D., Longo, F., White, A. R., Allen, A. G., Schroeder, L. M., Krzeski, J. C., Elsayed, N. A., Puckett, R. E., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0150-5 · Cited by 38 · see citing works

Neuroligin 3 Regulates Dendritic Outgrowth by Modulating Akt/mTOR Signaling

Xu, J., Du, Y.-L., Xu, J.-W., Hu, X., Gu, L.-F., Li, X., Hu, P.-H., Liao, T., Xia, Q.-Q., Sun, Q., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00518 · Cited by 35 · see citing works

Feedback modulation of neural network synchrony and seizure susceptibility by Mdm2-p53-Nedd4-2 signaling

Jewett, K. A., Christian, C. A., Bacos, J. T., Lee, K. Y., Zhu, J., & Tsai, N. (2016) · Molecular Brain · doi:10.1186/s13041-016-0214-6 · Cited by 36 · see citing works

Molecular Biomarkers in Fragile X Syndrome

Zafarullah, M., & Tassone, F. (2019) · Brain Sciences · doi:10.3390/brainsci9050096 · Cited by 36 · see citing works

Rare diseases of epigenetic origin: Challenges and opportunities

Fu, M. P., Merrill, S. M., Sharma, M., Gibson, W. T., Turvey, S. E., & Kobor, M. S. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1113086 · Cited by 33 · see citing works

Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo

Yang, F., You, H., Mizui, T., Ishikawa, Y., Takao, K., Miyakawa, T., Li, X., Bai, T., Xia, K., Zhang, L., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02595-5 · Cited by 34 · see citing works

Pharmacotherapy for Fragile X Syndrome: Progress to Date

Davenport, M. H., Schaefer, T. L., Friedmann, K., Fitzpatrick, S. E., & Erickson, C. A. (2016) · Drugs · doi:10.1007/s40265-016-0542-y · Cited by 31 · see citing works

Deletion of the KH1 Domain of <i>Fmr1</i> Leads to Transcriptional Alterations and Attentional Deficits in Rats

Golden, C. E. M., Breen, M. S., Koro, L., Sonar, S., Niblo, K., Browne, A., Burlant, N., Di Marino, D., De Rubeis, S., Baxter, M. G., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz029 · Cited by 29 · see citing works

Functional specialization of different PI3K isoforms for the control of neuronal architecture, synaptic plasticity, and cognition

Sánchez‐Castillo, C., Cuartero, M. I., Fernández‐Rodrigo, A., Briz, V., López-García, S., Jiménez-Sánchez, R., López, J. A., Graupera, M., & Esteban, J. A. (2022) · Science Advances · doi:10.1126/sciadv.abq8109 · Cited by 28 · see citing works

Defective phosphoinositide metabolism in autism

Groß, C. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23797 · Cited by 27 · see citing works

PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes

White, A. R., Tiwari, D., MacLeod, M. C., Danzer, S. C., & Groß, C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105026 · Cited by 26 · see citing works

The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice

Tiwari, D., Schaefer, T. L., Schroeder, L. M., Krzeski, J. C., Bunk, A. T., Parkins, E. V., Snider, A., Danzer, R., Williams, M. T., Vorhees, C. V., et al. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113437 · Cited by 24 · see citing works

Differential Adulthood Onset mGlu5Signaling Saves Prefrontal Function in the Fragile X Mouse

Martin, H. G. S., Lassalle, O., & Manzoni, O. J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw328 · Cited by 20 · see citing works

Mechanisms Driving the Emergence of Neuronal Hyperexcitability in Fragile X Syndrome

Bülow, P., Segal, M., & Bassell, G. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116315 · Cited by 19 · see citing works

Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family

Poopal, A. C., Schroeder, L. M., Horn, P. S., Bassell, G. J., & Groß, C. (2016) · Molecular Autism · doi:10.1186/s13229-015-0066-4 · Cited by 20 · see citing works

Dysregulation of translational control signaling in autism spectrum disorders

Hooshmandi, M., Wong, C., & Khoutorsky, A. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109746 · Cited by 17 · see citing works

Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model

Ding, Q., Sethna, F., Wu, X., Miao, Z., Chen, P., Zhang, Y., Xiao, H., Feng, W., Feng, Y., Li, X., et al. (2020) · Communications Biology · doi:10.1038/s42003-020-0833-4 · Cited by 18 · see citing works

A Highly Selective MNK Inhibitor Rescues Deficits Associated with Fragile X Syndrome in Mice

Shukla, T. N., de la Peña, J. B., Perish, J. M., Ploski, J. E., Stumpf, C. R., Webster, K. R., Thorn, C. A., & Campbell, Z. T. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00932-4 · Cited by 16 · see citing works

GABAA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome

Schaefer, T. L., Ashworth, A. A., Tiwari, D., Tomasek, M. P., Parkins, E. V., White, A. R., Snider, A., Davenport, M. H., Grainger, L. M., Becker, R. A., et al. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.678090 · Cited by 15 · see citing works

Rates of protein synthesis are reduced in peripheral blood mononuclear cells (PBMCs) from fragile X individuals

Dionne, O., Lortie, A., Gagnon, F., & Corbin, F. (2021) · PLoS ONE · doi:10.1371/journal.pone.0251367 · Cited by 13 · see citing works

Modelling Protein Synthesis as A Biomarker in Fragile X Syndrome Patient-Derived Cells

Pal, R., & Bhattacharya, A. (2019) · Brain Sciences · doi:10.3390/brainsci9030059 · Cited by 13 · see citing works

Carbamazepine Restores Neuronal Signaling, Protein Synthesis, and Cognitive Function in a Mouse Model of Fragile X Syndrome

Ding, Q., Zhang, F., Feng, Y., & Wang, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239327 · Cited by 11 · see citing works

Across Dimensions: Developing 2D and 3D Human iPSC-Based Models of Fragile X Syndrome

Lee, A., Xu, J., Wen, Z., & Jin, P. (2022) · Cells · doi:10.3390/cells11111725 · Cited by 10 · see citing works

Vorinostat Corrects Cognitive and Non-Cognitive Symptoms in a Mouse Model of Fragile X Syndrome

Ding, Q., Wu, X., Li, X., & Wang, H. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab081 · Cited by 10 · see citing works

The mGluR Theory of Fragile X: From Mice to Men

Stoppel, L. J., Osterweil, E. K., & Bear, M. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00009-3 · Cited by 9 · see citing works

The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome

Briševac, D., Scholz, R., Du, D., Elagabani, M. N., Köhr, G., & Kornau, H. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15230 · Cited by 7 · see citing works

Strain commonalities and differences in response-outcome decision making in mice

Zimmermann, K. S., Hsu, C.-C., & Gourley, S. L. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.03.016 · Cited by 6 · see citing works

PGC-1α integrates insulin signaling with mitochondrial physiology and behavior in a Drosophila model of Fragile X Syndrome

Weisz, E. D., Fenton, A. R., & Jongens, T. A. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00004-7 · Cited by 5 · see citing works

The PI3-Kinase p110β Isoform Controls Severity of Cocaine-Induced Sequelae and Alters the Striatal Transcriptome

Shapiro, L. P., Pitts, E. G., Li, D. C., Barbee, B. R., Hinton, E. A., Bassell, G. J., Groß, C., & Gourley, S. L. (2021) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.01.008 · Cited by 5 · see citing works

PI3King the right partner: unique interactions and signaling by p110ß

Dbouk, H. A. (2015) · Postdoc Journal · doi:10.14304/surya.jpr.v3n6.8 · Cited by 3 · see citing works

Drug Discovery for Targeted Pharmacotherapy of Fragile X Syndrome

Scharf, S., Gasparini, F., Spooren, W., & Lindemann, L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00018-4 · Cited by 1 · see citing works

Intracellular Signaling Networks in Fragile X Syndrome: Approaches to Drug Discovery and Therapeutics

Groß, C., & Bhattacharya, A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804461-2.00011-1 · Cited by 3 · see citing works

Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders

Şahin, M., & Sur, M. (2016) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 4 · see citing works

Genetic and Pharmacological Reversibility of Phenotypes in Mouse Models of Autism Spectrum Disorder

Schroeder, J. C., Deliu, E., Novarino, G., & Schmeißer, M. J. (2017) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-319-52498-6_10 · Cited by 2 · see citing works

Inhibiting proBDNF to mature BDNF conversion leads to autism-like phenotypes in vivoPreprint

You, H., Mizui, T., Kiyosue, K., Takao, K., Miyakawa, T., Kato, K., Otsuka, M., Bai, T., Xia, K., Lu, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.12.149104 · Cited by 2 · see citing works

FMRP and the Pathophysiology of Fragile X Syndrome

Barnes, S. A., Thomson, S. R., Kind, P. C., & Osterweil, E. K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800109-7.00008-x

Faculty Opinions recommendation of Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.

Konopka, G. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726083697.793545851

Dissecting the role of calcium signaling in Fragile X syndrome

Castagnola, S. (2019) · theses.fr (ABES) · doi:10.70675/3d35096bz79d0z46edz8a70zb783a8f60257

Socio-communicative and nucleus accumbens core dysfunctions in fragile X syndrome

Giua, G. (2023) · theses.fr (ABES) · doi:10.70675/e45d048ez2538z4905zba74z1de16201406a

Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome

Gross, C., Nakamoto, M., Yao, X., Chan, C.-B., Yim, S. Y., Ye, K., Warren, S. T., & Bassell, G. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.0402-10.2010 · Cited by 241 · see citing works

Neurobiology of Disease Excess Phosphoinositide 3-Kinase Subunit Synthesis and Activity as a Novel Therapeutic Target in Fragile X Syndrome

Bassell, G. J. (2016)

Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model

Groß, C., Banerjee, A., Tiwari, D., Longo, F., White, A. R., Allen, A. G., Schroeder, L. M., Krzeski, J. C., Elsayed, N. A., Puckett, R. E., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0150-5 · Cited by 38 · see citing works

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

Krueger‐Burg, D., Osterweil, E. K., Chen, S. P., Tye, L. D., & Bear, M. F. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013855108 · Cited by 150 · see citing works

Reversal of activity‐mediated spine dynamics and learning impairment in a mouse model of <scp>F</scp>ragile <scp>X</scp> syndrome

Boda, B., Mendez, P., Boury‐Jamot, B., Magara, F., & Muller, D. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12488 · Cited by 30 · see citing works