Flores, Juana M.

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 1,482

The Signaling Adaptor p62 Is an Important NF-κB Mediator in Tumorigenesis

Duran, A., Linares, J. F., Galvez, A. S., Wikenheiser, K., Flores, J. M., Diaz-Meco, M. T., & Moscat, J. (2008) · Cancer Cell

NF-κB Signaling PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 541

'Super p53' mice exhibit enhanced DNA damage response, are tumor resistant and age normally

García‐Cao, I., García‐Cao, M., Martín‐Caballero, J., Criado, L. M., Klatt, P., Flores, J. M., Weill, J., Blasco, M. A., & Serrano, M. (2002) · The EMBO Journal

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 529

Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice

Tomás-Loba, A., Flores, I., Fernández-Marcos, P. J., Cayuela, M. L., Maraver, A., Tejera, A., Borrás, C., Matheu, A., Klatt, P., Flores, J. M., et al. (2008) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 484

Delayed ageing through damage protection by the Arf/p53 pathway

Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature

Genetics, Aging, and Longevity in Model OrganismsCancer-related Molecular Pathways

Cited by 466

Increased epidermal tumors and increased skin wound healing in transgenic mice overexpressing the catalytic subunit of telomerase, mTERT, in basal keratinocytes

González‐Suárez, E., Samper, E., Ramírez, A., Flores, J. M., Martín‐Caballero, J., Jorcano, J. L., & Blasco, M. A. (2001) · The EMBO Journal

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 372

Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis

González-Suárez, E., Samper, E., Flores, J. M., & Blasco, M. A. (2000) · Nature Genetics

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 347

The Atypical PKC-Interacting Protein p62 Is an Important Mediator of RANK-Activated Osteoclastogenesis

Durán, A., Serrano, M., Leitges, M., Flores, J. M., Picard, S., Brown, J. P., Moscat, J., & Diaz-Meco, M. T. (2004) · Developmental Cell

Bone Metabolism and DiseasesNF-κB Signaling Pathways

Cited by 316

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62

Rodriguez, A., Durán, A., Selloum, M., Champy, M.-F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., & Moscat, J. (2006) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesPeroxisome Proliferator-Activated Receptors

Cited by 290

Restoration of telomerase activity rescues chromosomal instability and premature aging in Terc−/− mice with short telomeres

Samper, E., Flores, J. M., & Blasco, M. A. (2001) · The EMBO Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 263

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction

Povedano, J. M., Martinez, P., Flores, J. M., Mulero, F., & Blasco, M. A. (2015) · Cell Reports

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisTelomeres, Telomerase, and Senescence

Cited by 225

Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

Blanco, R., Muñoz, P., Flores, J. M., Klatt, P., & Blasco, M. A. (2007) · Genes & Development

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 135

Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity

Vera, E., Bernardes de Jesus, B., Foronda, M., Flores, J. M., & Blasco, M. A. (2013) · PLoS ONE

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 111

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice

González-Suárez, E., Geserick, C., Flores, J. M., & Blasco, M. A. (2005) · Oncogene

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 109

Increased p53 activity does not accelerate telomere‐driven ageing

García‐Cao, I., García‐Cao, M., Tomás‐Loba, A., Martin‐Caballero, J., Flores, J. M., Klatt, P., Blasco, M. A., & Serrano, M. (2006) · The EMBO Reports

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 102

Constitutive Expression of Tert in Thymocytes Leads to Increased Incidence and Dissemination of T-Cell Lymphoma in Lck-Tert Mice

Canela, A., Martín-Caballero, J., Flores, J. M., & Blasco, M. A. (2004) · Molecular and Cellular Biology

Telomeres, Telomerase, and SenescenceLymphoma Diagnosis and Treatment

Cited by 90

Essential role for the TRF 2 telomere protein in adult skin homeostasis

Martínez, P., Ferrara‐Romeo, I., Flores, J. M., & Blasco, M. A. (2014) · Aging Cell

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 26

Distinct p21 requirements for regulating normal and self-reactive T cells through IFN-γ production

Daszkiewicz, L., Vázquez-Mateo, C., Rackov, G., Ballesteros-Tato, A., Weber, K., Madrigal-Avilés, A., Di Pilato, M., Fotedar, A., Fotedar, R., Flores, J. M., et al. (2015) · Scientific Reports

T-cell and B-cell ImmunologySystemic Lupus Erythematosus Research

Cited by 26