Telomerase Reverse Transcriptase Synergizes with Calorie Restriction to Increase Health Span and Extend Mouse Longevity
Open accessAbstract
Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, can delay the onset of cancer and age-related diseases in several species, including mice. In addition, depending of the genetic background, CR can also increase or decrease mouse longevity. This has highlighted the importance of identifying the molecular pathways that interplay with CR in modulating longevity. Significant lifespan extension in mice has been recently achieved through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a cancer protective background. Given the CR cancer-protective effects in rodents, we set to address here whether CR impacts on telomere length and synergizes with mTERT to extend mouse longevity. CR significantly decreased tumor incidence in TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type (WT) controls under the same diet, indicating a synergy between TgTERT and CR in increasing mouse longevity. In addition, longitudinal telomere length measurements in peripheral blood leukocytes from individual mice showed that CR resulted in maintenance and/or elongation telomeres in a percentage of WT mice, a situation that mimics telomere dynamics in TgTERT cohorts. These results demonstrate that CR attenuates telomere erosion associated to aging and that synergizes with TERT over-expression in increasing "health span" and extending mouse longevity.
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Short-term caloric restriction in mice increases overexpression of telomerase reverse transcriptase (TERT), which reduces telomere erosion from various tissues such as muscles, kidney, and lungs.
“Short-term caloric restriction in mice increases expression of all seven sirtuin (SIRT1-SIRT7) proteins (Maldonado et al. 2021) and overexpression of telomerase reverse transcriptase (TERT) which reduces telomere erosion from various tissues such as muscles, kidney, and lungs (Vera et al. 2013).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Vera et al. 2013
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Yeast Genetic Modeling of Pbp1/ATXN2-linked Neurodegenerative Diseases
Szafranski, K. M. J. (2016) · TSpace (University of Toronto)
- Authors
- Vera, E., Bernardes de Jesus, B., Foronda, M., Flores, J. M., & Blasco, M. A.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- Universidad Complutense de Madrid (ES)
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-01-22
- Volume
- 8
- Issue
- 1
- Pages
- e53760
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3551964
- OpenAlex
- W2051658606
- Cited by
- 111
- References
- 62
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 9 · 2023: 8 · 2022: 9 · 2021: 16 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 6 · 2016: 9 · 2015: 14 · 2014: 11 · 2013: 2
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Eli Lilly and Company
- European Commission
- Ministerio de Ciencia e Innovación
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- caloric restriction, telomerase reverse transcriptase, healthspan, telomere length, telomere maintenance, telomere shortening, aging, cancer protection, tumor incidence, leukocyte telomeres
- MeSH terms
- Aging, Animals, Body Weight, Chromosome Aberrations, Health, Humans, Longevity, Longitudinal Studies, Male, Mice, Inbred C57BL, Mice, Transgenic, Biomarkers, Telomere, Telomerase, Caloric Restriction, Mice, Telomere Shortening
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