Kessler, Benedikt M.

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

Cohen, H. Y., Miller, C., Bitterman, K. J., Wall, N. R., Hekking, B., Kessler, B., Howitz, K. T., Gorospe, M., de Cabo, R., & Sinclair, D. A. (2004) · Science

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 1,924

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., et al. (2018) · Nature

Genomics, phytochemicals, and oxidative stressImmune cells in cancer

Cited by 1,885

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Peng, Y., Mentzer, A. J., Liu, G., Yao, X., Yin, Z., Dong, D., Dejnirattisai, W., Rostron, T., Supasa, P., Liu, C., et al. (2020) · Nature Immunology

SARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approaches

Cited by 1,179

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.

Chauhan, D., Tian, Z., Nicholson, B., Kumar, K. G. S., Zhou, B., Carrasco, R., McDermott, J. L., Leach, C. A., Fulcinniti, M., Kodrasov, M. P., et al. (2012) · Cancer Cell

Ubiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments

Cited by 589

Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

Borodovsky, A., Ovaa, H., Kolli, N., Gan-Erdene, T., Wilkinson, K. D., Ploegh, H. L., & Kessler, B. M. (2002) · Chemistry & Biology

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 588

Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling

Adam, J., Hatipoglu, E., O'Flaherty, L., Ternette, N., Sahgal, N., Lockstone, H., Baban, D., Nye, E., Stamp, G. W., Wolhuter, K., et al. (2011) · Cancer Cell

Genomics, phytochemicals, and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 585

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull, A. P., Ioannidis, S., Krajewski, W. W., Pinto-Fernandez, A., Heride, C., Martin, A. C. L., Tonkin, L. M., Townsend, E. C., Buker, S. M., Lancia, D. R., et al. (2017) · Nature

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 463

Neuronal loss and brain atrophy in mice lacking cathepsins B and L

Felbor, U., Kessler, B., Mothes, W., Goebel, H. H., Ploegh, H. L., Bronson, R. T., & Olsen, B. R. (2002) · Proceedings of the National Academy of Sciences

Protease and Inhibitor MechanismsCalpain Protease Function and Regulation

Cited by 334

Aberrant succination of proteins in fumarate hydratase‐deficient mice and HLRCC patients is a robust biomarker of mutation status

Bardella, C., El‐Bahrawy, M., Frizzell, N., Adam, J., Ternette, N., Hatipoglu, E., Howarth, K., O'Flaherty, L., Roberts, I., Turner, G., et al. (2011) · The Journal of Pathology

Cancer, Hypoxia, and MetabolismRenal cell carcinoma treatment

Cited by 281

Protein sequences bound to mineral surfaces persist into deep time

Demarchi, B., Hall, S., Roncal-Herrero, T., Freeman, C. L., Woolley, J., Crisp, M. K., Wilson, J., Fotakis, A., Fischer, R., Kessler, B. M., et al. (2016) · eLife

Pleistocene-Era Hominins and ArchaeologyPaleontology and Evolutionary Biology

Cited by 279

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

Papadakis, M., Hadley, G., Xilouri, M., Hoyte, L. C., Nagel, S., McMenamin, M. M., Tsaknakis, G., Watt, S. M., Drakesmith, C. W., Chen, R., et al. (2013) · Nature Medicine

Autophagy in Disease and TherapyNeurological Disease Mechanisms and Treatments

Cited by 232

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway

Altun, M., Besche, H. C., Overkleeft, H. S., Piccirillo, R., Edelmann, M. J., Kessler, B. M., Goldberg, A. L., & Ulfhake, B. (2010) · Journal of Biological Chemistry

Muscle Physiology and DisordersUbiquitin and proteasome pathways

Cited by 226

Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor

Coleman, M. L., McDonough, M. A., Hewitson, K. S., Coles, C., Mecinovicí, J., Edelmann, M., Cook, K. M., Cockman, M. E., Lancaster, D. E., Kessler, B. M., et al. (2007) · Journal of Biological Chemistry

Cancer, Hypoxia, and MetabolismMetal-Catalyzed Oxygenation Mechanisms

Cited by 222

Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells

Ovaa, H., Kessler, B. M., Rolén, U., Galardy, P. J., Ploegh, H. L., & Masucci, M. G. (2004) · Proceedings of the National Academy of Sciences

Ubiquitin and proteasome pathwaysProtein Degradation and Inhibitors

Cited by 190

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic β-subunits

Kessler, B. M., Tortorella, D., Altun, M., Kisselev, A. F., Fiebiger, E., Hekking, B. G., Ploegh, H. L., & Overkleeft, H. S. (2001) · Chemistry & Biology

Ubiquitin and proteasome pathwaysProtease and Inhibitor Mechanisms

Cited by 163

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

Ternette, N., Yang, M., Laroyia, M., Kitagawa, M., O’Flaherty, L., Wolhulter, K., Igarashi, K., Saito, K., Kato, K., Fischer, R., et al. (2013) · Cell Reports

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 158

Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans

Ge, W., Wolf, A., Feng, T., Ho, C.-H., Sekirnik, R., Zayer, A., Granatino, N., Cockman, M. E., Loenarz, C., Loik, N. D., et al. (2012) · Nature Chemical Biology

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 154

Identification of Proteins Associated with Murine Cytomegalovirus Virions

Kattenhorn, L. M., Mills, R., Wagner, M., Lomsadze, A., Makeev, V., Borodovsky, M., Ploegh, H. L., & Kessler, B. M. (2004) · Journal of Virology

Cytomegalovirus and herpesvirus researchAdvanced Proteomics Techniques and Applications

Cited by 147

Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis

Thompson, A. G., Gray, E., Thézénas, M., Charles, P. D., Evetts, S., Hu, M. T., Talbot, K., Fischer, R., Kessler, B. M., & Turner, M. R. (2018) · Annals of Neurology

Amyotrophic Lateral Sclerosis ResearchMultiple Sclerosis Research Studies

Cited by 130

Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways

Valli, A., Rodriguez, M., Moutsianas, L., Fischer, R., Fedele, V., Huang, H.-L., Van Stiphout, R., Jones, D., Mccarthy, M., Vinaxia, M., et al. (2015) · Oncotarget

Cancer, Hypoxia, and MetabolismCancer, Lipids, and Metabolism

Cited by 79

Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis

Singleton, D. C., Rouhi, P., Zois, C. E., Haider, S., Li, J.-L., Kessler, B. M., Cao, Y., & Harris, A. L. (2015) · Oncogene

Cancer, Hypoxia, and MetabolismMechanisms of cancer metastasis

Cited by 52

Urinary peptide profiling identifies a panel of putative biomarkers for diagnosing and staging endometriosis

El-Kasti, M. M., Wright, C., Fye, H. K. S., Roseman, F., Kessler, B. M., & Becker, C. M. (2011) · Fertility and Sterility

Endometriosis Research and TreatmentAdvanced Proteomics Techniques and Applications

Cited by 44

Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation

Chen, Z., Ioris, R. M., Richardson, S., Van Ess, A. N., Vendrell, I., Kessler, B. M., Buffa, F. M., Busino, L., Clifford, S. C., Bullock, A. N., et al. (2022) · Cell Death & Differentiation

Glioma Diagnosis and TreatmentChromatin Remodeling and Cancer

Cited by 41

Development of a T-cell Receptor Mimic Antibody against Wild-Type p53 for Cancer Immunotherapy

Li, D., Bentley, C., Anderson, A., Wiblin, S., Cleary, K. L. S., Koustoulidou, S., Hassanali, T., Yates, J., Greig, J., Nordkamp, M. O., et al. (2017) · Cancer Research

Immunotherapy and Immune ResponsesMonoclonal and Polyclonal Antibodies Research

Cited by 38