Urinary peptide profiling identifies a panel of putative biomarkers for diagnosing and staging endometriosis
Open accessAbstract
Objective To identify a potential diagnostic endometriosis marker using matrix-enhanced laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS)-based urinary proteomics.Design Prospective randomized pilot study.Setting University hospital, tertiary referral center for endometriosis.Patient(s) 53 women undergoing laparoscopic surgery for pain and/or infertility comprising 30 women without endometriosis and 23 with endometriosis.Intervention(s) Laparoscopy and urine specimens.Main outcome measure(s) Urinary peptide profiles.Result(s) We observed distinct patterns of peptide profiles in the urine samples of women presenting with typical clinical symptoms of endometriosis. Six statistically significant putative peptide markers were identified (four during the periovulatory phase and two during the luteal phase) by comparing controls with moderate/severe endometriosis patients. The periovulatory peptide mass of 1,767.1 Da and the luteal peptide mass of 1,824.3 Da both showed a sensitivity of 75% and a specificity of 85% and 71%, respectively. Also detected were seven peptide markers (two during the periovulatory phase and five during the luteal phase) by comparing the urinary peptide profiles of patients with minimal/mild to moderate/severe endometriosis. The periovulatory peptide mass of 3,280.9 Da and the luteal peptide mass of 1,933.8 Da showed a sensitivity of 82% and 75% and a specificity of 88% and 75%, respectively.Conclusion(s) Urinary proteomic analysis may provide a novel method of diagnosing and staging endometriosis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several groups have reported differential peptide profiles in the urine of women with endometriosis relative to women without endometriosis at surgery using MALDI-TOF MS.
“Using matrix assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF MS), several groups have reported differential peptide profiles in the urine of women with endometriosis relative to that of women without endometriosis at surgery [102, 106].”
From Update on biomarkers for the detection of endometriosis (2015) · cites this paper as [106]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Anderson, N. L., & Anderson, N. G. (2002) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r200007-mcp200 · Cited by 4,414 · see citing works
Giudice, L. C., & Kao, L. C. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17403-5 · Cited by 3,166 · see citing works
Revised American Society for Reproductive Medicine classification of endometriosis: 1996
American Society for Reproductive Medicine (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81391-x · Cited by 3,018 · see citing works
Bulun, S. E. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804690 · Cited by 1,772 · see citing works
ESHRE guideline for the diagnosis and treatment of endometriosis
Kennedy, S., Bergqvist, A., Chapron, C., D’Hooghe, T., Dunselman, G., Greb, R., Hummelshoj, L., Prentice, A., & Saridogan, E. (2005) · Human Reproduction · doi:10.1093/humrep/dei135 · Cited by 1,584 · see citing works
Vercellini, P., Fedele, L., Aimi, G., Pietropaolo, G., Consonni, D., & Crosignani, P. G. (2007) · Human Reproduction · doi:10.1093/humrep/del339 · Cited by 547 · see citing works
Clinical proteomics: translating benchside promise into bedside reality
Petricoin, E. F., Zoon, K. C., Kohn, E. C., Barrett, J. C., & Liotta, L. A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd891 · Cited by 545 · see citing works
Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK
Hadfield, R., Mardon, H., Barlow, D., & Kennedy, S. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019270 · Cited by 517 · see citing works
Berkley, K. J., Rapkin, A. J., & Papka, R. E. (2005) · Science · doi:10.1126/science.1111445 · Cited by 455 · see citing works
Decramer, S., de Peredo, A. G., Breuil, B., Mischak, H., Monsarrat, B., Bascands, J., & Schanstra, J. P. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r800001-mcp200 · Cited by 446 · see citing works
Peripheral biomarkers of endometriosis: a systematic review
May, K. E., Conduit-Hulbert, S. A., Villar, J., Kirtley, S., Kennedy, S. H., & Becker, C. M. (2010) · Human Reproduction Update · doi:10.1093/humupd/dmq009 · Cited by 418 · see citing works
Self-citationProtein and antibody arrays and their medical applications
Cahill, D. J. (2001) · Journal of Immunological Methods · doi:10.1016/s0022-1759(01)00325-8 · Cited by 288 · see citing works
Fiedler, M., Baumann, S., Leichtle, A. B., Oltmann, A., Kase, J., Thiery, J., & Ceglarek, U. (2007) · Clinical Chemistry · doi:10.1373/clinchem.2006.077834 · Cited by 170 · see citing works
Non-invasive diagnosis of endometriosis based on a combined analysis of six plasma biomarkers
Mihalyi, A., Gevaert, O., Kyama, C. M., Simsa, P., Pochet, N., De Smet, F., De Moor, B., Meuleman, C., Billen, J., Blanckaert, N., et al. (2010) · Human Reproduction · doi:10.1093/humrep/dep425 · Cited by 161 · see citing works
Farquhar, C. M. (2007) · BMJ · doi:10.1136/bmj.39073.736829.be · Cited by 146 · see citing works
DNA microarray analysis of gene expression markers of endometriosis
Eyster, K. M., Boles, A. L., Brannian, J. D., & Hansen, K. A. (2002) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02955-7 · Cited by 130 · see citing works
Panel of markers can accurately predict endometriosis in a subset of patients
Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J. L., & Barnhart, K. T. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.05.014 · Cited by 116 · see citing works
Comprehensive Proteomic Analysis of Human Endometrial Fluid Aspirate
Casado‐Vela, J., Rodríguez‐Suárez, E., Iloro, I., Ametzazurra, A., Alkorta, N., García-Velasco, J. A., Matorras, R., Prieto, B., González, S., Nagore, D., et al. (2009) · Journal of Proteome Research · doi:10.1021/pr9004426 · Cited by 116 · see citing works
Fowler, P., Tattum, J., Bhattacharya, S., Klonisch, T. C., Hombach‐Klonisch, S., Gazvani, R., Lea, R. G., Miller, I. D., Simpson, W. G., & Cash, P. (2006) · PROTEOMICS · doi:10.1002/pmic.200600469 · Cited by 102 · see citing works
Zhang, H., Niu, Y., Feng, J., Guo, H., Ye, X., & Cui, H. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.01.028 · Cited by 101 · see citing works
Ametzazurra, A., Matorras, R., García-Velasco, J. A., Prieto, B., Simón, L., Martinez, A., & Nagore, D. (2008) · Human Reproduction · doi:10.1093/humrep/den450 · Cited by 85 · see citing works
Post-Translational Modifications and Protein-Specific Isoforms in Endometriosis Revealed by 2D DIGE
Stephens, A. N., Hannan, N. J., Rainczuk, A., Meehan, K. L., Chen, J., Nicholls, P. K., Rombauts, L. J. F., Stanton, P. G., Robertson, D. M., & Salamonsen, L. A. (2010) · Journal of Proteome Research · doi:10.1021/pr901131p · Cited by 76 · see citing works
Why We Need a Noninvasive Diagnostic Test for Minimal to Mild Endometriosis with a High Sensitivity
D’Hooghe, T. M., Mihalyi, A., Simsa, P., Kyama, C. M., Peeraer, K., Loecker, P. D., Meeuwis, L., Segal, L., & Meuleman, C. (2006) · Gynecologic and Obstetric Investigation · doi:10.1159/000093120 · Cited by 61 · see citing works
Discovery of a novel biomarker in the urine in women with endometriosis
Tokushige, N., Markham, R., Crossett, B., Ahn, S. B., Nelaturi, V. L., Khan, A., & Fraser, I. S. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.05.016 · Cited by 61 · see citing works
Diagnostic Potential for Urinary Proteomics
Hortin, G. L., & Sviridov, D. O. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.3.237 · Cited by 60 · see citing works
Seeber, B., Sammel, M. D., Fan, X., Gerton, G. L., Shaunik, A., Chittams, J. L., & Barnhart, K. T. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.12.121 · Cited by 59 · see citing works
Proteomic Analysis of Peritoneal Fluid in Women with Endometriosis
Ferrero, S., Gillott, D. J., Remorgida, V., Anserini, P., Leung, K., Ragni, N., & Grudzinskas, J. G. (2007) · Journal of Proteome Research · doi:10.1021/pr060680q · Cited by 55 · see citing works
Review of proteomics with applications to genetic epidemiology
Sellers, T. A., & Yates, J. R. (2003) · Genetic Epidemiology · doi:10.1002/gepi.10226 · Cited by 52 · see citing works
Wang, L., Zheng, W., Mu, L., & Zhang, S. (2008) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2008.01.018 · Cited by 47 · see citing works
Kyama, C. M., T’Jampens, D., Mihalyi, A., Simsa, P., Debrock, S., Waelkens, E., Landuyt, B., Meuleman, C., Fulop, V., Mwenda, J. M., et al. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.12.024 · Cited by 46 · see citing works
Liu, H., Lang, J., Zhou, Q., Shan, D., & Li, Q. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2006.08.095 · Cited by 43 · see citing works
Bernert, G., Fountoulakis, M., & Lübec, G. (2002) · PROTEOMICS · doi:10.1002/1615-9861(200212)2:12 · Cited by 42 · see citing works
Proteomic approaches in endometriosis research
Poliness, A. E., Healey, M., Brennecke, S. P., & Moses, E. K. (2004) · PROTEOMICS · doi:10.1002/pmic.200300791 · Cited by 40 · see citing works
Matrix metalloproteinases are elevated in the urine of patients with endometriosis
Becker, C. M., Louis, G., Exarhopoulos, A., Mechsner, S., Ebert, A. D., Zurakowski, D., & Moses, M. A. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.02.040 · Cited by 40 · see citing works
Self-citationWölfler, M. M., Schwamborn, K., Otten, D., Hornung, D., Liu, H., & Rath, W. H. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.064 · Cited by 35 · see citing works
Proteomic analysis of peritoneal fluid in fertile and infertile women with endometriosis.
Ferrero, S., Gillott, D. J., Remorgida, V., Anserini, P., Ragni, N., & Grudzinskas, J. G. (2009) · PubMed · Cited by 35 · see citing works
Jing, J., Qiao, Y., Suginami, H., Taniguchi, F., Shi, H., & Wang, X. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.08.078 · Cited by 34 · see citing works
Demir, A. Y., Demol, H., Puype, M., de Goeij, A. F. P. M., Dunselman, G. A. J., Herrler, A., Evers, J. L. H., Vandekerckhove, J. S., & Groothuis, P. G. (2004) · PROTEOMICS · doi:10.1002/pmic.200300827 · Cited by 30 · see citing works
Peritoneal fluid proteome in women with different ASRM stages of endometriosis
Ferrero, S., Gillott, D. J., Remorgida, V., Anserini, P., Ragni, N., & Grudzinskas, J. G. (2008) · Gynecological Endocrinology · doi:10.1080/09513590802173824 · Cited by 27 · see citing works
Zhang, H., Feng, J., Chang, X., Li, Z., Wu, X., & Cui, H. (2009) · Chinese Medical Journal · doi:10.3760/cma.j.issn.0366-6999.2009.04.003 · Cited by 26 · see citing works
Wang, L., Zheng, W., Yu, J., Jiang, W., Mu, L., & Zhang, S. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.055 · Cited by 22 · see citing works
Role of interleukin-1 receptor type II in the pathogenesis of endometriosis
Hou, Z., Zhou, J., Ma, X., Fan, L., Liao, L., & Liu, J. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.01.044 · Cited by 20 · see citing works
High-Throughput Biomarker Discovery and Identification by Mass Spectrometry
Menzel, C., Guillou, V., Kellmann, M., Khamenya, V., Juergens, M., & Schulz‐Knappe, P. (2005) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/138620705774962373 · Cited by 13 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Berkley KJ, Rapkin AJ, Papka RE. The pains of endo- metriosis. Science 2005;308:1587-9.
- Seliger B, Kellner R. Design of proteome-based stud- ies in combination with serology for the identification of biomarkers and novel targets. Proteomics 2002;2:1641-51.
- Menzel C, Guillou V, Kellmann M, Khamenya V, Juergens M, Schulz-Knappe P. High-throughput bio- marker discovery and identification by mass spec- trometry. Comb Chem High Throughput Screen 2005;8:743-55.
- Anderson NL, Anderson NG. The human plasma pro- teome: history, character, and diagnostic prospects [published correction appears in Mol Cell Proteomics 2003;2:50]. Mol Cell Proteomics 2002;1:845-67.
Cited by
Sorted by citations
Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives
Anastasiu, C. V., Moga, M., Neculau, A. E., Bălan, A., Scârneciu, I., Dragomir, R. M., Dull, A.-M., & Chicea, L.-M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051750 · Cited by 202 · see citing works
Update on biomarkers for the detection of endometriosis
Fassbender, A., Burney, R. O., F. O, D., D’Hooghe, T., & Giudice, L. (2015) · BioMed Research International · doi:10.1155/2015/130854 · Cited by 195 · see citing works
“Using matrix assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDITOF MS), several groups have reported differential peptide profiles in the urine of women with endometriosis relative to that of women without endometriosis at surgery [102, 106].”
Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis
Jia, S.-Z., Yang, Y., Lang, J., Sun, P., & Leng, J. (2013) · Human Reproduction · doi:10.1093/humrep/des413 · Cited by 172 · see citing works
Molecular classification of endometriosis and disease stage using high-dimensional genomic data
Tamaresis, J. S., Irwin, J. C., Goldfien, G. A., Rabban, J. T., Burney, R. O., Nezhat, C., DePaolo, L. V., & Giudice, L. C. (2014) · Endocrinology · doi:10.1210/en.2014-1490 · Cited by 168 · see citing works
Endometriosis classification: an update
Adamson, G. D. (2011) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328348a3ba · Cited by 119 · see citing works
Urinary biomarkers for the non-invasive diagnosis of endometriosis
Liu, E., Nisenblat, V., Farquhar, C. M., Fraser, I. S., Bossuyt, P. M., JOHNSON, N. P., & Hull, M. L. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012019 · Cited by 89 · see citing works
Noninvasive biomarkers of endometriosis: myth or reality?
Lanišnik Rižner, T. (2014) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2014.899905 · Cited by 52 · see citing works
Endometriosis research in the -omics era
Goulielmos, G. N., Matalliotakis, M., Matalliotaki, C., Eliopoulos, E., Matalliotakis, I., & Zervou, M. I. (2020) · Gene · doi:10.1016/j.gene.2020.144545 · Cited by 49 · see citing works
Kimber-Trojnar, Ż., Pilszyk, A., Niebrzydowska-Tatus, M., Pilszyk, Z., Ruszała, M., & Leszczyńska‐Gorzelak, B. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132762 · Cited by 54 · see citing works
Vitamin D in endometriosis: A causative or confounding factor?
Sayegh, L., Fuleihan, G. E., & Nassar, A. H. (2013) · Metabolism · doi:10.1016/j.metabol.2013.09.012 · Cited by 50 · see citing works
Current biomarkers for the detection of endometriosis
Tian, Z., Chang, X., Zhao, Y. P., & Zhu, H. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001063 · Cited by 45 · see citing works
The genetics and biochemistry of endometriosis
Burney, R. O. (2013) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e3283630d56 · Cited by 34 · see citing works
The Diagnostic Accuracy of Combined Enolase/Cr, CA125, and CA19‐9 in the Detection of Endometriosis
Rokhgireh, S., Mehdizadehkashi, A., Chaichian, S., Delbandi, A., Allahqoli, L., Ahmadi-Pishkuhi, M., Khodaverdi, S., & Alkatout, İ. (2020) · BioMed Research International · doi:10.1155/2020/5208279 · Cited by 36 · see citing works
Urine peptide patterns for non-invasive diagnosis of endometriosis: a preliminary prospective study
Wang, L., Liu, H. Y., Shi, H., Lang, J., & Sun, W. (2014) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2014.03.011 · Cited by 34 · see citing works
Williams, K. E., Miroshnychenko, O., Johansen, E. B., Niles, R. K., Sundaram, R., Kannan, K., Albertolle, M. E., Zhou, Y., Prasad, N., Drake, P. M., et al. (2014) · Journal of Proteomics · doi:10.1016/j.jprot.2014.09.015 · Cited by 30 · see citing works
Chen, X., Liu, H., Sun, W., Guo, Z., & Lang, J. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103398 · Cited by 30 · see citing works
Méar, L., Com, E., Fathallah, K., Laetitia Guillot, D., Lavigne, R., Guével, B., Fauconnier, A., Vialard, F., & Pineau, C. (2022) · Diagnostics · doi:10.3390/diagnostics12020419 · Cited by 29 · see citing works
Siciliano, R. A., Mazzeo, M. F., Spada, V., Facchiano, A. M., d’Acierno, A., Stocchero, M., FRANCISCIS, P. D., Colacurci, N., Sannolo, N., & Miraglia, N. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.943718 · Cited by 28 · see citing works
Siva, A. B., Srivastava, P., & Shivaji, S. (2013) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201200082 · Cited by 25 · see citing works
Gedefaw, G. A., Wu, L., Alemu, B. K., Lee, W. F., Fung, L. W. Y., Cheung, E. C. W., Zhang, T., & Wang, C. C. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05474-3 · Cited by 24 · see citing works
Zafari, N., Bahramy, A., Zolbin, M. M., Allahyari, S. E., Farazi, E., Hassannejad, Z., & Yekaninejad, M. S. (2021) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2021.1960508 · Cited by 20 · see citing works
Dolińska, W., Draper, H., Othman, L., Thompson, C., Girvan, S., Cunningham, K., Allen, J., Rigby, A. S., Phillips, K., & Guinn, B. (2022) · F&S Reviews · doi:10.1016/j.xfnr.2022.12.001 · Cited by 21 · see citing works
Evaluation of elevated urinary enolase I levels in patients with endometriosis
Yun, B. H., Lee, Y. S., Chon, S. J., Jung, Y. S., Yim, S. Y., Kim, H. Y., Park, J. H., Seo, S. K., Cho, S., Choi, Y. S., et al. (2014) · Biomarkers · doi:10.3109/1354750x.2013.863973 · Cited by 17 · see citing works
Biomarker development in endometriosis
Burney, R. O. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.936692 · Cited by 16 · see citing works
Integrated analysis of mRNA and protein expression profiling in tubal endometriosis
Qi, H., Zhang, H., Zhao, X., Qin, Y., Liang, G., He, X., & Zhang, J. (2020) · Reproduction · doi:10.1530/rep-19-0587 · Cited by 14 · see citing works
Modulation of urinary peptidome in humans exposed to high altitude hypoxia
Mainini, V., Gianazza, E., Chinello, C., Bilo, G., Revera, M., Giuliano, A., Caldara, G., Lombardi, C., Piperno, A., Magni, F., et al. (2011) · Molecular BioSystems · doi:10.1039/c1mb05377a · Cited by 14 · see citing works
Proteomics in the Diagnosis of Endometriosis: Opportunities and Challenges
Ferrero, S. (2018) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201800183 · Cited by 13 · see citing works
Diagnostic Value of Circulating MicroRNAs for Endometriosis: a Meta-analysis
Zhou, L., Chen, Y., Gao, J., Shankar, S., & Zhang, G. (2020) · Reproductive Sciences · doi:10.1007/s43032-019-00024-5 · Cited by 10 · see citing works
CYFRA 21-1 in urine: a diagnostic marker for endometriosis?
Gjavotchanoff, R. (2015) · International Journal of Women s Health · doi:10.2147/ijwh.s75288 · Cited by 10 · see citing works
Iloro, I., González, E., Juan, V. G., Mato, J. M., Falcón‐Pérez, J. M., & Elortza, F. (2013) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6644-9 · Cited by 8 · see citing works
OMICs Studies and Endometriosis Biomarker Identification
Saare, M., Peters, M., Aints, A., Laisk, T., Salumets, A., & Altmäe, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-59856-7_12 · Cited by 8 · see citing works
Kartsova, L. A., Бессонова, Е. А., Deev, V., & Алексеевна, К. Е. (2023) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2022.2156770 · Cited by 7 · see citing works
Biomarkers for Endometriosis in Saliva, Urine, and Peritoneal Fluid
Gueye, N.-A., Stanhiser, J., Valentine, L. N., Kotlyar, A. M., Goodman, L. R., & Falcone, T. (2017) · Springer eBooks · doi:10.1007/978-3-319-59856-7_8 · Cited by 6 · see citing works
Marianowski, P., Szymusik, I., Barcz, E., Wielgoś, M., & Hibner, M. (2013) · Ginekologia Polska · doi:10.17772/gp/1655 · Cited by 4 · see citing works
The diagnosis of endometriosis with the help of mass spectrometry (a review)
Borisova, A. V., Kozachenko, K. A. V., Starodubtseva, N. L., Бугрова, А. Е., Евгеньевич, Ф. В., & Adamjan, L. V. (2015) · Russian Journal of Human Reproduction · doi:10.17116/repro201521659-68 · Cited by 3 · see citing works
The inhibition of bone morphogenetic protein 1 attenuates endometriosis lesions in vivo and in vitro
Han, X., Hu, F., Chen, F., & Wang, W. (2020) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05612-4 · Cited by 2 · see citing works
Proteomic Biomarkers for Endometriosis
Fassbender, A., Hubert, A., Waelkens, E., Dorien, O., & D’Hooghe, T. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-59856-7_10 · Cited by 2 · see citing works
Endometriosis Biomarkers in Body Fluids
Dakubo, G. D. (2016) · Springer eBooks · doi:10.1007/978-3-319-48360-3_14 · Cited by 1 · see citing works
Biomarkers in endometriosis-associated pain
Margatho, D., & Bahamondes, L. G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818988-7.00036-4
Endometriosis Research: From Bench to Bedside
Laganà, A. S., & La Rosa, V. L. (2022) · MDPI eBooks · doi:10.3390/books978-3-0365-2798-7
Azeze, G. G., Wu, L., Alemu, B. K., Lee, W. F., Fung, L. W. Y., Cheung, E. C. W., Zhang, T., & Wang, C. C. (2024) · Figshare · doi:10.6084/m9.figshare.26384695
Azeze, G. G., Wu, L., Alemu, B. K., Lee, W. F., Fung, L. W. Y., Cheung, E. C. W., Zhang, T., & Wang, C. C. (2024) · Figshare · doi:10.6084/m9.figshare.26384573
Molecular Insights Into Endometriosis for Early Detection and Therapeutic Targets
Kuai, M., Li, B., Shi, Z., 黄庆通, Pan, Y., Tang, M., Gao, X., Fang, J., & Lü, P. (2026) · Reproductive Sciences · doi:10.1007/s43032-026-02124-5
- Authors
- El-Kasti, M. M., Wright, C., Fye, H. K. S., Roseman, F., Kessler, B. M., & Becker, C. M.
- Affiliations
- Centre for Human Genetics (GB)
- John Radcliffe Hospital (GB)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 95
- Issue
- 4
- Pages
- 1261-1266.e6
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2066876575
- Cited by
- 44
- References
- 43
- Citations by year
- 2026: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 6 · 2013: 6 · 2012: 1
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Action Medical Research
- National Institute for Health and Care Research
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, urinary biomarkers, endometriosis diagnosis, endometriosis staging, urine proteomics, MALDI-TOF mass spectrometry, periovulatory period, luteal phase, sensitivity and specificity
- MeSH terms
- Adult, Endometriosis, Female, Humans, Middle Aged, Peptides, Pilot Projects, Prospective Studies, Biomarkers, Disease Progression, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Protein Array Analysis, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
