Geschwind, Daniel H.

Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders

Bakkaloglu, B., O'Roak, B. J., Louvi, A., Gupta, A. R., Abelson, J. F., Morgan, T. M., Chawarska, K., Klin, A., Ercan-Sencicek, A. G., Stillman, A. A., et al. (2008) · The American Journal of Human Genetics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 537

Cortical Evolution: Judge the Brain by Its Cover

Geschwind, D. H., & Rakic, P. (2013) · Neuron

Neurogenesis and neuroplasticity mechanismsGenetics and Neurodevelopmental Disorders

Cited by 519

A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation

Polioudakis, D., de la Torre-Ubieta, L., Langerman, J., Elkins, A. G., Shi, X., Stein, J. L., Vuong, C. K., Nichterwitz, S., Gevorgian, M., Opland, C. K., et al. (2019) · Neuron

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 513

Advances in Autism

Geschwind, D. H. (2009) · Annual Review of Medicine

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 512

Reliability of human cortical organoid generation

Yoon, S.-J., Elahi, L. S., Pașca, A. M., Marton, R. M., Gordon, A., Revah, O., Miura, Y., Walczak, E. M., Holdgate, G. M., Fan, H. C., et al. (2019) · Nature Methods

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 507

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease

Depp, C., Sun, T., Sasmita, A. O., Spieth, L., Berghoff, S. A., Nazarenko, T., Overhoff, K., Steixner-Kumar, A. A., Subramanian, S., Arinrad, S., et al. (2023) · Nature

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 493

Elevated gene expression levels distinguish human from non-human primate brains

Cáceres, M., Lachuer, J., Zapala, M. A., Redmond, J. C., Kudo, L., Geschwind, D. H., Lockhart, D. J., Preuss, T. M., & Barlow, C. (2003) · Proceedings of the National Academy of Sciences

Primate Behavior and EcologyGenetics and Neurodevelopmental Disorders

Cited by 491

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights

Gusev, A., Mancuso, N., Won, H., Kousi, M., Finucane, H. K., Reshef, Y., Song, L., Safi, A., Schizophrenia Working Group of the Psychiatric Genomics Consortium, McCarroll, S., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologySchizophrenia research and treatment

Cited by 491

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

Bayraktar, O. A., Bartels, T., Holmqvist, S., Kleshchevnikov, V., Martirosyan, A., Polioudakis, D., Ben Haim, L., Young, A. M. H., Batiuk, M. Y., Prakash, K., et al. (2020) · Nature Neuroscience

Single-cell and spatial transcriptomicsNeurogenesis and neuroplasticity mechanisms

Cited by 489

A gut-derived metabolite alters brain activity and anxiety behaviour in mice

Needham, B. D., Funabashi, M., Adame, M. D., Wang, Z., Boktor, J. C., Haney, J., Wu, W.-L., Rabut, C., Ladinsky, M. S., Hwang, S.-J., et al. (2022) · Nature

Gut microbiota and healthTryptophan and brain disorders

Cited by 489

Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila

Jackson, G. R., Wiedau-Pazos, M., Sang, T.-K., Wagle, N., Brown, C. A., Massachi, S., & Geschwind, D. H. (2002) · Neuron

Alzheimer's disease research and treatmentsNeurobiology and Insect Physiology Research

Cited by 488

Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways

Miller, J. A., Horvath, S., & Geschwind, D. H. (2010) · Proceedings of the National Academy of Sciences

Bioinformatics and Genomic NetworksAlzheimer's disease research and treatments

Cited by 480

A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer’s Disease

Seyfried, N. T., Dammer, E. B., Swarup, V., Nandakumar, D., Duong, D. M., Yin, L., Deng, Q., Nguyen, T., Hales, C. M., Wingo, T., et al. (2017) · Cell Systems

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 477

Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

Reiman, E. M., Arboleda-Velasquez, J. F., Quiroz, Y. T., Huentelman, M. J., Beach, T. G., Caselli, R. J., Chen, Y., Su, Y., Myers, A. J., Hardy, J., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 473

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

Marchetto, M. C., Belinson, H., Tian, Y., Freitas, B. C., Fu, C., Vadodaria, K. C., Beltrao-Braga, P. C., Trujillo, C. A., Mendes, A. P. D., Padmanabhan, K., et al. (2017) · Molecular Psychiatry

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 466

Inherited and de novo genetic risk for autism impacts shared networks

Ruzzo, E. K., Pérez-Cano, L., Jung, J.-Y., Wang, L.-K., Kashef-Haghighi, D., Hartl, C., Singh, C., Xu, J., Hoekstra, J. N., Leventhal, O., et al. (2019) · Cell

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 457

Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes

Zhou, X., Feliciano, P., Shu, C., Wang, T., Astrovskaya, I., Hall, J. B., Obiajulu, J. U., Wright, J. R., Murali, S. C., Xu, S. X., et al. (2022) · Nature Genetics

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 453

Defining the genetic, genomic, cellular, and diagnostic architectures of psychiatric disorders

Sullivan, P. F., & Geschwind, D. H. (2019) · Cell

Genetic Associations and EpidemiologySchizophrenia research and treatment

Cited by 452

Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders

Study, S. S., Singh, T., Study, I., Study, D., UK10 K Consortium, Kurki, M. I., Curtis, D., Purcell, S. M., Crooks, L., McRae, J., et al. (2016) · Nature Neuroscience

Schizophrenia research and treatmentGenomics and Rare Diseases

Cited by 452

The PsychENCODE project

Akbarian, S., Liu, C., Knowles, J. A., Vaccarino, F. M., Farnham, P. J., Crawford, G. E., Jaffe, A. E., Pinto, D., Dracheva, S., Geschwind, D. H., et al. (2015) · Nature Neuroscience

Genomics and Chromatin DynamicsGenetic Associations and Epidemiology

Cited by 451

Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders

Parikshak, N. N., Gandal, M. J., & Geschwind, D. H. (2015) · Nature Reviews Genetics

Bioinformatics and Genomic NetworksGenetics and Neurodevelopmental Disorders

Cited by 430

Genetics and genomics of psychiatric disease

Geschwind, D. H., & Flint, J. (2015) · Science

Genetic Associations and EpidemiologySchizophrenia research and treatment

Cited by 424

Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes

Bucan, M., Abrahams, B. S., Wang, K., Glessner, J. T., Herman, E. I., Sonnenblick, L. I., Alvarez Retuerto, A. I., Imielinski, M., Hadley, D., Bradfield, J. P., et al. (2009) · PLoS Genetics

Autism Spectrum Disorder ResearchGenomic variations and chromosomal abnormalities

Cited by 424

Common genetic variants, acting additively, are a major source of risk for autism

Klei, L., Sanders, S. J., Murtha, M. T., Hus, V., Lowe, J. K., Willsey, A. J., Moreno-De-Luca, D., Yu, T. W., Fombonne, E., Geschwind, D., et al. (2012) · Molecular Autism

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 418