Tager, Andrew M.

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis

Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinković, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology

Hippo pathway signaling and YAP/TAZInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 874

The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

Tager, A. M., LaCamera, P., Shea, B. S., Campanella, G. S., Selman, M., Zhao, Z., Polosukhin, V., Wain, J., Karimi-Shah, B. A., Kim, N. D., et al. (2008) · Nature Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSphingolipid Metabolism and Signaling

Cited by 823

Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9

Mandal, P. K., Ferreira, L. M. R., Collins, R., Meissner, T. B., Boutwell, C. L., Friesen, M., Vrbanac, V., Garrison, B. S., Stortchevoi, A., Bryder, D., et al. (2014) · Cell stem cell

CRISPR and Genetic EngineeringCAR-T cell therapy research

Cited by 475

A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells

Stary, G., Olive, A., Radovic-Moreno, A. F., Gondek, D., Alvarez, D., Basto, P. A., Perro, M., Vrbanac, V. D., Tager, A. M., Shi, J., et al. (2015) · Science

Reproductive tract infections researchImmunotherapy and Immune Responses

Cited by 379

HIV-infected T cells are migratory vehicles for viral dissemination

Murooka, T. T., Deruaz, M., Marangoni, F., Vrbanac, V. D., Seung, E., von Andrian, U. H., Tager, A. M., Luster, A. D., & Mempel, T. R. (2012) · Nature

HIV Research and TreatmentHIV/AIDS Research and Interventions

Cited by 322

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

Lagares, D., Santos, A., Grasberger, P. E., Liu, F., Probst, C. K., Rahimi, R. A., Sakai, N., Kuehl, T., Ryan, J., Bhola, P., et al. (2017) · Science Translational Medicine

Systemic Sclerosis and Related DiseasesCell death mechanisms and regulation

Cited by 246

The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis

Knipe, R. S., Tager, A. M., & Liao, J. K. (2015) · Pharmacological Reviews

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisPulmonary Hypertension Research and Treatments

Cited by 233

The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury

Funke, M., Zhao, Z., Xu, Y., Chun, J., & Tager, A. M. (2012) · American Journal of Respiratory Cell and Molecular Biology

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSphingolipid Metabolism and Signaling

Cited by 141

Contribution of CCR4 and CCR8 to antigen-specific TH2 cell trafficking in allergic pulmonary inflammation

Mikhak, Z., Fukui, M., Farsidjani, A., Medoff, B. D., Tager, A. M., & Luster, A. D. (2009) · Journal of Allergy and Clinical Immunology

Asthma and respiratory diseasesChemokine receptors and signaling

Cited by 127

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., et al. (2020) · Science Translational Medicine

Liver physiology and pathologySphingolipid Metabolism and Signaling

Cited by 122

Screening for YAP inhibitors identifies statins as modulators of fibrosis

Santos, D. M., Pantano, L., Pronzati, G., Grasberger, P., Probst, C. K., Black, K. E., Spinney, J. J., Hariri, L. P., Nichols, R., Lin, Y., et al. (2020) · American Journal of Respiratory Cell and Molecular Biology

Hippo pathway signaling and YAP/TAZInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Cited by 72

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis

Montesi, S. B., Mathai, S. K., Brenner, L. N., Gorshkova, I. A., Berdyshev, E. V., Tager, A. M., & Shea, B. S. (2014) · BMC Pulmonary Medicine

Interstitial Lung Diseases and Idiopathic Pulmonary FibrosisSphingolipid Metabolism and Signaling

Cited by 66

Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis

Haak, A., Kostallari, E., Sicard, D., Ligresti, G., Choi, K. M., Caporarello, N., Jones, D., Tan, Q., Meridew, J., Diaz Espinosa, A., et al. (2019) · Mechanisms of lung injury and repair

Hippo pathway signaling and YAP/TAZInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

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