Cited by 122Liver physiology and pathologySphingolipid Metabolism and SignalingHippo pathway signaling and YAP/TAZ

Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Open access
Alsamman, Sarah, Christenson, Stephanie A., Yu, Amy, Ayad, Nadia M. E., Mooring, Meghan S., Segal, Joe M., Hu, Jimmy Kuang-Hsien, Schaub, Johanna R. +25 more·2020·Science Translational Medicine

Abstract

Acid ceramidase inhibition promotes YAP/TAZ degradation to inactivate fibroblasts, decrease matrix stiffness, and reduce fibrosis in mice.

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Crossref · 10.1126/scitranslmed.aay8798

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Authors
Alsamman, S., Christenson, S. A., Yu, A., Ayad, N. M. E., Mooring, M. S., Segal, J. M., Hu, J. K.-H., Schaub, J. R., Ho, S. S., Rao, V., Marlow, M. M., Turner, S. M., Sedki, M., Pantano, L., Ghoshal, S., Ferreira, D. D. S., Ma, H.-Y., Duwaerts, C. C., Espanol-Suner, R., Wei, L., Newcomb, B., Mileva, I., Canals, D., Hannun, Y. A., Chung, R. T., Mattis, A. N., Fuchs, B. C., Tager, A. M., Yimlamai, D., Weaver, V. M., Mullen, A. C., Sheppard, D., & Chen, J. Y.
Affiliations
  • University of California, San Francisco (US)
  • Yale University (US)
  • University of California, Los Angeles (US)
  • Pliant (United States) (US)
  • Kaiser Permanente (US)
  • Harvard University (US)
  • Athinoula A. Martinos Center for Biomedical Imaging, Institute for Innovation in Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
  • Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA.
  • Stony Brook University (US)
  • Massachusetts General Hospital (US)
Corresponding author
  • Tager, Andrew M.
  • Sheppard, Dean
  • Chen, Jennifer Y.
Venue
Science Translational Medicine
Published
2020-08-19
Volume
12
Issue
557
ISSN
  • 1946-6234 (ISSN-L)
  • 1946-6242
OpenAlex
W3073968329
Cited by
122
References
89
Citations by year
2026: 13 · 2025: 23 · 2024: 19 · 2023: 21 · 2022: 24 · 2021: 20 · 2020: 2
FWCI
9.85
Type
journal article
Language
en
Open access
Locations
  • Science Translational Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (K08DK114548, P30DK026743)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
Keywords
acid ceramidase, liver fibrosis, hepatic stellate cells, YAP/TAZ signaling, ceramide, tricyclic antidepressants, β-TrCP, proteasomal degradation, antifibrotic therapy, therapeutic target
MeSH terms
Animals, Fibrosis, Humans, Signal Transduction, Adaptor Proteins, Signal Transducing, Mice, Hepatic Stellate Cells, Acid Ceramidase

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