Berkhout, Ben

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy

Autophagy in Disease and TherapyCalcium signaling and nucleotide metabolism

Cited by 5,894

Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry

Hofmann, H., Pyrc, K., van der Hoek, L., Geier, M., Berkhout, B., & Pöhlmann, S. (2005) · Proceedings of the National Academy of Sciences

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 824

Tat trans-activates the human immunodeficiency virus through a nascent RNA target

Berkhout, B., Silverman, R. H., & Jeang, K.-T. (1989) · Cell

HIV Research and TreatmentRNA and protein synthesis mechanisms

Cited by 647

Tet-On Systems For Doxycycline-inducible Gene Expression

T. Das, A., Tenenbaum, L., & Berkhout, B. (2016) · Current Gene Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 434

Optimization of the Tet-On system for regulated gene expression through viral evolution

Zhou, X., Vink, M., Klaver, B., Berkhout, B., & Das, A. T. (2006) · Gene Therapy

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 224

Role of the DIS hairpin in replication of human immunodeficiency virus type 1

Berkhout, B., & van Wamel, J. L. (1996) · Journal of Virology

HIV Research and TreatmentRNA and protein synthesis mechanisms

Cited by 219

Two alternating structures of the HIV-1 leader RNA

HUTHOFF, H., & BERKHOUT, B. (2001) · RNA

RNA and protein synthesis mechanismsHIV Research and Treatment

Cited by 209

A novel long distance base-pairing interaction in human immunodeficiency virus type 1 RNA occludes the Gag start codon

Abbink, T. E. M., & Berkhout, B. (2003) · Journal of Biological Chemistry

RNA and protein synthesis mechanismsHIV Research and Treatment

Cited by 203

Reduced replication of human immunodeficiency virus type 1 mutants that use reverse transcription primers other than the natural tRNA(3Lys)

Das, A. T., Klaver, B., & Berkhout, B. (1995) · Journal of Virology

HIV Research and TreatmentRNA and protein synthesis mechanisms

Cited by 149

Viral Evolution as a Tool to Improve the Tetracycline-regulated Gene Expression System

Das, A. T., Zhou, X., Vink, M., Klaver, B., Verhoef, K., Marzio, G., & Berkhout, B. (2004) · Journal of Biological Chemistry

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 129

The HIV-1 leader RNA conformational switch regulates RNA dimerization but does not regulate mRNA translation

Abbink, T. E. M., Ooms, M., Haasnoot, P. C. J., & Berkhout, B. (2005) · Biochemistry

RNA and protein synthesis mechanismsHIV Research and Treatment

Cited by 122

The biased nucleotide composition of the HIV genome: a constant factor in a highly variable virus

van der Kuyl, A. C., & Berkhout, B. (2012) · Retrovirology

HIV Research and TreatmentRNA and protein synthesis mechanisms

Cited by 94

The tRNA primer activation signal in the human immunodeficiency virus type 1 genome is important for initiation and processive elongation of reverse transcription

Beerens, N., & Berkhout, B. (2002) · Journal of Virology

HIV Research and TreatmentRNA and protein synthesis mechanisms

Cited by 91

Strict Control of Human Immunodeficiency Virus Type 1 Replication by a Genetic Switch: Tet for Tat

Verhoef, K., Marzio, G., Hillen, W., Bujard, H., & Berkhout, B. (2001) · Journal of Virology

HIV Research and TreatmentVirus-based gene therapy research

Cited by 88

In vitro evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies

Marzio, G., Verhoef, K., Vink, M., & Berkhout, B. (2001) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentEvolution and Genetic Dynamics

Cited by 81

The ability of the HIV-1 AAUAAA signal to bind polyadenylation factors is controlled by local RNA structure

Klasens, B. I. F., Thiesen, M., Virtanen, A., & Berkhout, B. (1999) · Nucleic Acids Research

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 80

RNAi-mediated antiviral immunity in mammals

Berkhout, B. (2018) · Current Opinion in Virology

interferon and immune responsesRNA Interference and Gene Delivery

Cited by 78

The tendency of lentiviral open reading frames to become A-rich: constraints imposed by viral genome organization and cellular tRNA availability

van Hemert, F. J., & Berkhout, B. (1995) · Journal of Molecular Evolution

RNA and protein synthesis mechanismsHIV Research and Treatment

Cited by 74

The first strand transfer during HIV-1 reverse transcription can occur either intramolecularly or intermolecularly

van Wamel, J. L. B., & Berkhout, B. (1998) · Virology

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 63

A conserved hairpin structure predicted for the poly(A) signal of human and simian immunodeficiency viruses

Berkhout, B., Klaver, B., & Das, A. T. (1995) · Virology

RNA Research and SplicingHIV Research and Treatment

Cited by 57

Role of HIV-1 RNA and protein determinants for the selective packaging of spliced and unspliced viral RNA and host U6 and 7SL RNA in virus particles

Didierlaurent, L., Racine, P. J., Houzet, L., Chamontin, C., Berkhout, B., & Mougel, M. (2011) · Nucleic Acids Research

HIV Research and TreatmentRNA Research and Splicing

Cited by 57

Mutation of nucleotides around the +1 position of type 3 polymerase III promoters: The effect on transcriptional activity and start site usage

Gao, Z., Harwig, A., Berkhout, B., & Herrera-Carrillo, E. (2017) · Transcription

Genomics and Chromatin DynamicsRNA Interference and Gene Delivery

Cited by 47

A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses

Chtarto, A., Humbert-Claude, M., Bockstael, O., Das, A. T., Boutry, S., Breger, L. S., Klaver, B., Melas, C., Barroso-Chinea, P., Gonzalez-Hernandez, T., et al. (2016) · Molecular Therapy - Methods & Clinical Development

Virus-based gene therapy researchRNA Interference and Gene Delivery

Cited by 43

Switching the in vitro tRNA usage of HIV-1 by simultaneous adaptation of the PBS and PAS

BEERENS, N., & BERKHOUT, B. (2002) · RNA

RNA and protein synthesis mechanismsHIV Research and Treatment

Cited by 41