Sonenberg, Nahum

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

Pelletier, J., Graff, J., Ruggero, D., & Sonenberg, N. (2015) · Cancer Research

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 367

mRNA helicases: the tacticians of translational control

Parsyan, A., Svitkin, Y., Shahbazian, D., Gkogkas, C., Lasko, P., Merrick, W. C., & Sonenberg, N. (2011) · Nature Reviews Molecular Cell Biology

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 323

A Mechanism for Translationally Coupled mRNA Turnover

Grosset, C., Chen, C.-Y. A., Xu, N., Sonenberg, N., Jacquemin-Sablon, H., & Shyu, A.-B. (2000) · Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 295

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E

Rosenwald, I. B., Lazaris-Karatzas, A., Sonenberg, N., & Schmidt, E. V. (1993) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysPI3K/AKT/mTOR signaling in cancer

Cited by 287

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

Svitkin, Y. V., Cheng, Y. M., Chakraborty, T., Presnyak, V., John, M., & Sonenberg, N. (2017) · Nucleic Acids Research

RNA and protein synthesis mechanismsRNA modifications and cancer

Cited by 278

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes

Gkogkas, C. G., Khoutorsky, A., Cao, R., Jafarnejad, S. M., Prager-Khoutorsky, M., Giannakas, N., Kaminari, A., Fragkouli, A., Nader, K., Price, T. J., et al. (2014) · Cell Reports

Genetics and Neurodevelopmental DisordersRNA and protein synthesis mechanisms

Cited by 201

A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 Is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A

Yang, H.-S., Cho, M.-H., Zakowicz, H., Hegamyer, G., Sonenberg, N., & Colburn, N. H. (2004) · Molecular and Cellular Biology

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 199

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA

Kundu, P., Fabian, M. R., Sonenberg, N., Bhattacharyya, S. N., & Filipowicz, W. (2012) · Nucleic Acids Research

RNA Research and SplicingMicroRNA in disease regulation

Cited by 180

Leishmania Repression of Host Translation through mTOR Cleavage Is Required for Parasite Survival and Infection

Jaramillo, M., Gomez, M. A., Larsson, O., Shio, M. T., Topisirovic, I., Contreras, I., Luxenburg, R., Rosenfeld, A., Colina, R., McMaster, R. W., et al. (2011) · Cell Host & Microbe

Research on Leishmaniasis StudiesPI3K/AKT/mTOR signaling in cancer

Cited by 171

Antidepressant actions of ketamine engage cell-specific translation via eIF4E

Aguilar-Valles, A., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Khlaifia, A., Skaleka, A., Lopez-Canul, M., Torres-Berrio, A., Bermudez, S., Rurak, G. M., et al. (2021) · Nature

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 144

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

De Gregorio, D., Popic, J., Enns, J. P., Inserra, A., Skalecka, A., Markopoulos, A., Posa, L., Lopez-Canul, M., He, Q., Lafferty, C. K., et al. (2021) · Proceedings of the National Academy of Sciences

Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on Behavior

Cited by 139

Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice

Zu, T., Guo, S., Bardhi, O., Ryskamp, D. A., Li, J., Khoramian Tusi, S., Engelbrecht, A., Klippel, K., Chakrabarty, P., Nguyen, L., et al. (2020) · Proceedings of the National Academy of Sciences

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 133

Interaction of eIF4G with poly(A)-binding protein stimulates translation and is critical for Xenopus oocyte maturation

Wakiyama, M., Imataka, H., & Sonenberg, N. (2000) · Current Biology

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 126

The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs

Signer, R. A. J., Qi, L., Zhao, Z., Thompson, D., Sigova, A. A., Fan, Z. P., DeMartino, G. N., Young, R. A., Sonenberg, N., & Morrison, S. J. (2016) · Genes & Development

Hematopoietic Stem Cell TransplantationRNA and protein synthesis mechanisms

Cited by 115

The ELAV Protein HuD Stimulates Cap-Dependent Translation in a Poly(A)- and eIF4A-Dependent Manner

Fukao, A., Sasano, Y., Imataka, H., Inoue, K., Sakamoto, H., Sonenberg, N., Thoma, C., & Fujiwara, T. (2009) · Molecular Cell

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 100

MNK Inhibition Sensitizes KRAS -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression

Knight, J. R. P., Alexandrou, C., Skalka, G. L., Vlahov, N., Pennel, K., Officer, L., Teodosio, A., Kanellos, G., Gay, D. M., May-Wilson, S., et al. (2021) · Cancer Discovery

PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase Signaling

Cited by 96

Metformin for treatment of fragile X syndrome and other neurological disorders

Gantois, I., Popic, J., Khoutorsky, A., & Sonenberg, N. (2019) · Annual Review of Medicine

Genetics and Neurodevelopmental DisordersNeuroscience and Neuropharmacology Research

Cited by 87

Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E

Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., Sharma, V., Cao, R., Rummel, C., Tanti, A., et al. (2018) · Nature Communications

Tryptophan and brain disordersTreatment of Major Depression

Cited by 82

Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse

Sénéchal, P., Robert, F., Cencic, R., Yanagiya, A., Chu, J., Sonenberg, N., Paquet, M., & Pelletier, J. (2021) · Cellular and Molecular Life Sciences

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 20

Impaired hippocampal plasticity associated with loss of recycling endosomal SLC9A6/NHE6 is ameliorated by the TrkB agonist 7,8-dihydroxyflavone

Gao, A. Y. L., Inglebert, Y., Shi, R., Ilie, A., Popic, J., Mustian, J., Sonenberg, N., Orlowski, J., & McKinney, R. A. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 5

Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain

Lister, K. C., Wong, C., Uttam, S., Parisien, M., Stecum, P., Brown, N., Cai, W., Ho-Tieng, D., Hooshmandi, M., Gu, N., et al. (2026) · eLife

Pain Mechanisms and TreatmentsNeuroscience and Neuropharmacology Research

Cited by 2