Walensky, Loren D.

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Letai, A., Bassik, M. C., Walensky, L. D., Sorcinelli, M. D., Weiler, S., & Korsmeyer, S. J. (2002) · Cancer Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 1,677

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix

Walensky, L. D., Kung, A. L., Escher, I., Malia, T. J., Barbuto, S., Wright, R. D., Wagner, G., Verdine, G. L., & Korsmeyer, S. J. (2004) · Science

Cell death mechanisms and regulationChemical Synthesis and Analysis

Cited by 1,349

BAX activation is initiated at a novel interaction site

Gavathiotis, E., Suzuki, M., Davis, M. L., Pitter, K., Bird, G. H., Katz, S. G., Tu, H.-C., Kim, H., Cheng, E. H.-Y., Tjandra, N., et al. (2008) · Nature

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 700

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

Perry, J. A., Kiezun, A., Tonzi, P., Van Allen, E. M., Carter, S. L., Baca, S. C., Cowley, G. S., Bhatt, A. S., Rheinbay, E., Pedamallu, C. S., et al. (2014) · Proceedings of the National Academy of Sciences

Sarcoma Diagnosis and TreatmentPI3K/AKT/mTOR signaling in cancer

Cited by 481

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

Stewart, M. L., Fire, E., Keating, A. E., & Walensky, L. D. (2010) · Nature Chemical Biology

Cell death mechanisms and regulationChemical Synthesis and Analysis

Cited by 418

A Stapled BID BH3 Helix Directly Binds and Activates BAX

Walensky, L. D., Pitter, K., Morash, J., Oh, K. J., Barbuto, S., Fisher, J., Smith, E., Verdine, G. L., & Korsmeyer, S. J. (2006) · Molecular Cell

Cell death mechanisms and regulationChemical Synthesis and Analysis

Cited by 383

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

Gavathiotis, E., Reyna, D. E., Davis, M. L., Bird, G. H., & Walensky, L. D. (2010) · Molecular Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 310

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

Danial, N. N., Walensky, L. D., Zhang, C.-Y., Choi, C. S., Fisher, J. K., Molina, A. J. A., Datta, S. R., Pitter, K. L., Bird, G. H., Wikstrom, J. D., et al. (2008) · Nature Medicine

Pancreatic function and diabetesCell death mechanisms and regulation

Cited by 307

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore

Walensky, L. D., & Gavathiotis, E. (2011) · Trends in Biochemical Sciences

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 173

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

Carpio, M. A., Michaud, M., Zhou, W., Fisher, J. K., Walensky, L. D., & Katz, S. G. (2015) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationEndoplasmic Reticulum Stress and Disease

Cited by 127

Allosteric inhibition of antiapoptotic MCL-1

Lee, S., Wales, T. E., Escudero, S., Cohen, D. T., Luccarelli, J., Gallagher, C. G., Cohen, N. A., Huhn, A. J., Bird, G. H., Engen, J. R., et al. (2016) · Nature Structural & Molecular Biology

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 59

A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

Bird, G. H., Patten, J. J., Zavadoski, W., Barucci, N., Godes, M., Moyer, B. M., Owen, C. D., DaSilva-Jardine, P., Neuberg, D. S., Bowen, R. A., et al. (2024) · Nature Communications

SARS-CoV-2 and COVID-19 ResearchChemical Synthesis and Analysis

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