Nimer, Stephen D.

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

Moran-Crusio, K., Reavie, L., Shih, A., Abdel-Wahab, O., Ndiaye-Lobry, D., Lobry, C., Figueroa, M. E., Vasanthakumar, A., Patel, J., Zhao, X., et al. (2011) · Cancer Cell

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

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p53 Regulates Hematopoietic Stem Cell Quiescence

Liu, Y., Elf, S. E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J. M., Deblasio, A., Menendez, S., et al. (2009) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer-related Molecular Pathways

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Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-Like Tyrosine Kinase 3 Receptor (FLT3) and Multi-Targeted Kinase Inhibitor, in Patients With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome With Either Wild-Type or Mutated FLT3

Fischer, T., Stone, R. M., DeAngelo, D. J., Galinsky, I., Estey, E., Lanza, C., Fox, E., Ehninger, G., Feldman, E. J., Schiller, G. J., et al. (2010) · Journal of Clinical Oncology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

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PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Huang, G., Zhang, P., Hirai, H., Elf, S., Yan, X., Chen, Z., Koschmieder, S., Okuno, Y., Dayaram, T., Growney, J. D., et al. (2008) · Nature Genetics

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 259

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

Guryanova, O. A., Shank, K., Spitzer, B., Luciani, L., Koche, R. P., Garrett-Bakelman, F. E., Ganzel, C., Durham, B. H., Mohanty, A., Hoermann, G., et al. (2016) · Nature Medicine

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

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The Leukemogenicity of AML1-ETO Is Dependent on Site-Specific Lysine Acetylation

Wang, L., Gural, A., Sun, X.-J., Zhao, X., Perna, F., Huang, G., Hatlen, M. A., Vu, L., Liu, F., Xu, H., et al. (2011) · Science

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 242

Mutational Cooperativity Linked to Combinatorial Epigenetic Gain of Function in Acute Myeloid Leukemia

Shih, A. H., Jiang, Y., Meydan, C., Shank, K., Pandey, S., Barreyro, L., Antony-Debre, I., Viale, A., Socci, N., Sun, Y., et al. (2015) · Cancer Cell

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

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The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

Mulloy, J. C., Cammenga, J., MacKenzie, K. L., Berguido, F. J., Moore, M. A. S., & Nimer, S. D. (2002) · Blood

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 208

The AML1/ETO fusion protein activates transcription of BCL-2

Klampfer, L., Zhang, J., Zelenetz, A. O., Uchida, H., & Nimer, S. D. (1996) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 182

Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

Kotini, A. G., Chang, C.-J., Boussaad, I., Delrow, J. J., Dolezal, E. K., Nagulapally, A. B., Perna, F., Fishbein, G. A., Klimek, V. M., Hawkins, R. D., et al. (2015) · Nature Biotechnology

Pluripotent Stem Cells ResearchAcute Myeloid Leukemia Research

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Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia

Shih, A. H., Chung, S. S., Dolezal, E. K., Zhang, S.-J., Abdel-Wahab, O. I., Park, C. Y., Nimer, S. D., Levine, R. L., & Klimek, V. M. (2013) · Haematologica

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 135

AML1A and AML1B can transactivate the human IL-3 promoter

Uchida, H., Zhang, J., & Nimer, S. D. (1997) · The Journal of Immunology

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

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Covalent Modifications of RUNX Proteins: Structure Affects Function

Blumenthal, E., Greenblatt, S., Huang, G., Ando, K., Xu, Y., & Nimer, S. D. (2017) · Advances in Experimental Medicine and Biology

Genomics and Chromatin DynamicsCancer-related gene regulation

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