Barone, Eugenio

Elevated risk of type 2 diabetes for development of Alzheimer disease: A key role for oxidative stress in brain

Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 402

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain

Perluigi, M., Pupo, G., Tramutola, A., Cini, C., Coccia, R., Barone, E., Head, E., Butterfield, D. A., & Di Domenico, F. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 155

The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation

Barone, E., Di Domenico, F., Mancuso, C., & Butterfield, D. A. (2014) · Neurobiology of Disease

Heme Oxygenase-1 and Carbon MonoxideAlzheimer's disease research and treatments

Cited by 127

The Triangle of Death in Alzheimer's Disease Brain: The Aberrant Cross-Talk Among Energy Metabolism, Mammalian Target of Rapamycin Signaling, and Protein Homeostasis Revealed by Redox Proteomics

Di Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. A. (2017) · Antioxidants & Redox Signaling

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 114

Impairment of biliverdin reductase-A promotes brain insulin resistance in Alzheimer disease: A new paradigm

Barone, E., Di Domenico, F., Cassano, T., Arena, A., Tramutola, A., Lavecchia, M. A., Coccia, R., Butterfield, D. A., & Perluigi, M. (2016) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 100

Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease

Barone, E., Tramutola, A., Triani, F., Calcagnini, S., Di Domenico, F., Ripoli, C., Gaetani, S., Grassi, C., Butterfield, D. A., Cassano, T., et al. (2019) · Molecular Neurobiology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 86

Cholesterol-independent neuroprotective and neurotoxic activities of statins: Perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders

Butterfield, D. A., Barone, E., & Mancuso, C. (2011) · Pharmacological Research

Alzheimer's disease research and treatmentsLipoproteins and Cardiovascular Health

Cited by 80

Biliverdin reductase‐A: a novel drug target for atorvastatin in a dog pre‐clinical model of Alzheimer disease

Barone, E., Mancuso, C., Di Domenico, F., Sultana, R., Murphy, M. P., Head, E., & Butterfield, D. A. (2012) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsHeme Oxygenase-1 and Carbon Monoxide

Cited by 75

Bach1 Overexpression in Down Syndrome Correlates with the Alteration of the HO-1/BVR-A System: Insights for Transition to Alzheimer's Disease

Di Domenico, F., Pupo, G., Mancuso, C., Barone, E., Paolini, F., Arena, A., Blarzino, C., Schmitt, F. A., Head, E., Butterfield, D. A., et al. (2015) · Journal of Alzheimer’s Disease

Heme Oxygenase-1 and Carbon MonoxideDown syndrome and intellectual disability research

Cited by 75

Brain insulin resistance triggers early onset Alzheimer disease in Down syndrome

Tramutola, A., Lanzillotta, C., Di Domenico, F., Head, E., Butterfield, D. A., Perluigi, M., & Barone, E. (2020) · Neurobiology of Disease

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 73

HNE-modified proteins in Down syndrome: Involvement in development of Alzheimer disease neuropathology

Barone, E., Head, E., Butterfield, D. A., & Perluigi, M. (2017) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsDown syndrome and intellectual disability research

Cited by 53

Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology

Tramutola, A., Di Domenico, F., Barone, E., Arena, A., Giorgi, A., di Francesco, L., Schininà, M. E., Coccia, R., Head, E., Butterfield, D. A., et al. (2017) · Antioxidants & Redox Signaling

Alzheimer's disease research and treatmentsUbiquitin and proteasome pathways

Cited by 49

Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: a harmful synergistic path in down syndrome

Lanzillotta, C., Tramutola, A., Di Giacomo, G., Marini, F., Butterfield, D. A., Di Domenico, F., Perluigi, M., & Barone, E. (2021) · Free Radical Biology and Medicine

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 47

Activation of p53 in Down Syndrome and in the Ts65Dn mouse brain is associated with a pro-apoptotic phenotype

Tramutola, A., Pupo, G., Di Domenico, F., Barone, E., Arena, A., Lanzillotta, C., Broekaart, D., Blarzino, C., Head, E., Butterfield, D. A., et al. (2016) · Journal of Alzheimer s Disease

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 40

Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal‐derived extracellular vesicles

Perluigi, M., Picca, A., Montanari, E., Calvani, R., Marini, F., Matassa, R., Tramutola, A., Villani, A., Familiari, G., Domenico, F. D., et al. (2022) · Alzheimer's & Dementia

Down syndrome and intellectual disability researchExtracellular vesicles in disease

Cited by 35

Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection

Tramutola, A., Abate, G., Lanzillotta, C., Triani, F., Barone, E., Iavarone, F., Vincenzoni, F., Castagnola, M., Marziano, M., Memo, M., et al. (2018) · Free Radical Biology and Medicine

Alzheimer's disease research and treatmentsRedox biology and oxidative stress

Cited by 26

Lack of p53 Affects the Expression of Several Brain Mitochondrial Proteins: Insights from Proteomics into Important Pathways Regulated by p53

Fiorini, A., Sultana, R., Barone, E., Cenini, G., Perluigi, M., Mancuso, C., Cai, J., Klein, J. B., St. Clair, D., & Butterfield, D. A. (2012) · PLoS ONE

Mitochondrial Function and PathologyCancer-related Molecular Pathways

Cited by 16

Brain insulin resistance: an early risk factor for Alzheimer's disease development in Down syndrome

Barone, E. (2022) · Neural Regeneration Research

Down syndrome and intellectual disability researchAlzheimer's disease research and treatments

Cited by 6