Protein nitration profile of CD3+ lymphocytes from Alzheimer disease patients: Novel hints on immunosenescence and biomarker detection
Open accessAbstract
Alzheimer's disease (AD) is a progressive form of dementia characterized by increased production of amyloid-β plaques and hyperphosphorylated tau protein, mitochondrial dysfunction, elevated oxidative stress, reduced protein clearance, among other. Several studies showed systemic modifications of immune and inflammatory systems due, in part, to decreased levels of CD3+ lymphocytes in peripheral blood in AD. Considering that oxidative stress, both in the brain and in the periphery, can influence the activation and differentiation of T-cells, we investigated the 3-nitrotyrosine (3-NT) proteome of blood T-cells derived from AD patients compared to non-demented (ND) subjects by using a proteomic approach. 3-NT is a formal protein oxidation and index of nitrosative stress. We identified ten proteins showing increasing levels of 3-NT in CD3+ T-cells from AD patients compared with ND subjects. These proteins are involved in energy metabolism, cytoskeletal structure, intracellular signaling, protein folding and turnover, and antioxidant response and provide new insights into the molecular mechanism that impact reduced T-cell differentiation in AD. Our results highlight the role of peripheral oxidative stress in T-cells related to immune-senescence during AD pathology focusing on the specific targets of protein nitration that conceivably can be suitable to further therapies. Further, our data demonstrate common targets of protein nitration between the brain and the periphery, supporting their significance as disease biomarkers.
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Elevated 3-NT levels in age-related diseases such as AD and PD indicate the impact of 3-NT accumulation in human aging.
“elevated 3-NT levels in age-related diseases, such as AD and PD, indicate the impact of 3-NT accumulation in human aging”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [191]
The Discussion (page unavailable) reports elevated 3-nitrotyrosine in AD lymphocytes and suggests that nitrosative stress might link ageing and AD. The paper does not establish elevated 3-NT in Parkinson’s disease or show that 3-NT accumulation affects human aging generally; its aging link is tentative. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIn AD patients, total 3-NT levels are increased in PBMC compared to non-demented subjects (slot blot).
“Increased total 3-NT levels in PBMC of AD patients”
From Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases (2021) · cites this paper as [191]
The Redox proteomics data section reports about 25% higher total protein nitration in AD T-cells than in non-demented T-cells, and the Figure Legends identify slot blot as the method. The Subjects section says PBMCs were collected and then fractionated; the reported increase is for T-cells, not PBMCs as a whole. Page numbers are unavailable in our copy. (LLM, conf=0.90)
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- Authors
- Tramutola, A., Abate, G., Lanzillotta, C., Triani, F., Barone, E., Iavarone, F., Vincenzoni, F., Castagnola, M., Marziano, M., Memo, M., Garrafa, E., Butterfield, D. A., Perluigi, M., Di Domenico, F., & Uberti, D.
- Affiliations
- Sapienza University of Rome (IT)
- University of Brescia (IT)
- Agostino Gemelli University Polyclinic (IT)
- University of Kentucky (US)
- Corresponding author
- Uberti, Daniela
- ORCID
- Venue
- Free Radical Biology and Medicine
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 129
- Pages
- 430-439
- ISSN
- 0891-5849 (ISSN-L)
- OpenAlex
- W2896656976
- Cited by
- 26
- References
- 89
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 8 · 2019: 7
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Free Radical Biology and Medicine (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Instruction, Universities and Research (RBSI144MT)
- Sapienza University of Rome
- European Union's Seventh Framework Programme (FP7/2007-2013, 624341)
- Banca d'Italia (12868/17)
- Fondazione Cariplo (RG116154C9214D1A, C26H15JT9X, 2014-0769)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, protein nitration, nitrotyrosine, CD3+ T cells, immunosenescence, oxidative stress, nitrosative stress, T cell differentiation, disease biomarkers, peripheral blood, energy metabolism, antioxidant response
- MeSH terms
- Nitrosative Stress, Aged, Aged, 80 and over, Alzheimer Disease, Antioxidants, Cell Separation, Cytoskeletal Proteins, Energy Metabolism, Female, Humans, Lymphocytes, Male, Middle Aged, Nitro Compounds, Tyrosine, Signal Transduction, Biomarkers, Gene Expression, Case-Control Studies, CD3 Complex, Oxidative Stress, Proteome, Primary Cell Culture
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