The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: It's time for reconciliation
Open accessAbstract
Alzheimer disease (AD) is the most common form of dementia among the elderly and is characterized by progressive loss of memory and cognition. These clinical features are due in part to the increase of reactive oxygen and nitrogen species that mediate neurotoxic effects. The up-regulation of the heme oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system is one of the earlier events in the adaptive response to stress. HO-1/BVR-A reduces the intracellular levels of pro-oxidant heme and generates equimolar amounts of the free radical scavengers biliverdin-IX alpha (BV)/bilirubin-IX alpha (BR) as well as the pleiotropic gaseous neuromodulator carbon monoxide (CO) and ferrous iron. Two main and opposite hypotheses for a role of the HO-1/BVR-A system in AD propose that this system mediates neurotoxic and neuroprotective effects, respectively. This apparent controversy was mainly due to the fact that for over about 20years HO-1 was the only player on which all the analyses were focused, excluding the other important and essential component of the entire system, BVR. Following studies from the Butterfield laboratory that reported alterations in BVR activity along with decreased phosphorylation and increased oxidative/nitrosative post-translational modifications in the brain of subjects with AD and amnestic mild cognitive impairment (MCI) subjects, a debate was opened on the real pathophysiological and clinical significance of BVR-A. In this paper we provide a review of the main discoveries about the HO/BVR system in AD and MCI, and propose a mechanism that reconciles these two hypotheses noted above of neurotoxic and the neuroprotective aspects of this important stress responsive system.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Even though atorvastatin is not a direct antioxidant and cannot cross the BBB, it produces antioxidant-like effects in the brain.
“It also suggests that atorvastatin, although not a direct antioxidant and not able to cross the BBB, leads to antioxidant-like effects in brain100.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [100]
In “Reconciliation of the two hypotheses” (page unavailable), the paper reports reduced brain oxidative-stress markers after atorvastatin treatment in aged beagles, supporting antioxidant-like effects in that preclinical model. It says atorvastatin can cross the BBB “only to a minute extent,” not that it cannot cross at all; the passage also does not explicitly establish that atorvastatin is not a direct antioxidant. (LLM, conf=0.87)
Experimental — accuracy not yet measuredBVR-A is both a reductase and a kinase that can phosphorylate insulin receptor substrate-1.
“BVR-A, in addition to being a reductase, is a kinase that can phosphorylate insulin receptor substrate-1100.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [100]
The overview’s “HO by-products” section states that BVR-A reduces biliverdin to bilirubin and is also a serine/threonine/tyrosine kinase. It does not say that BVR-A phosphorylates insulin receptor substrate-1; instead, it describes phosphorylation of BVR-A by the insulin receptor kinase. Page numbers are unavailable in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredBoth HO-1 and BVR-A are oxidatively damaged in aMCI and AD brain.
“Both HO-1 and BVR-A are oxidatively damaged in aMCI and AD brain100.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [100]
In AD and MCI brain, BVR-A is nitrosatively modified and dysfunctional, and its loss promotes insulin resistance.
“BVR-A is nitrosatively modified and dysfunctional in AD and MCI brain100, and its impairment promotes insulin resistance101.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [100]
In 3xTg AD mice, intranasal insulin lowered brain nitrosative stress, tau phosphorylation, and Aβ oligomers and improved cognition; these effects required BVR-A activity.
“Recently, intranasal treatment of a 3 X Tg mice model of AD with insulin showed a significant reduction of brain nitrosative stress, tau phosphorylation, and Aβ oligomers coupled to improved cognition, and these effects were dependent on the activity of biliverdin reductase-A (BVR-A)99,100.”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [100]
The ‘Reconciliation of the two hypotheses’ section reports reduced nitrosative-stress markers and improved cognition after atorvastatin treatment in aged beagles, not intranasal insulin in 3xTg AD mice. Searches for intranasal insulin and the claimed mouse outcomes found no passage in our copy addressing that experiment or showing that its effects required BVR-A activity; the passages have no page numbers. (LLM, conf=0.77)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Walsh, D. M., Klyubin, I., Fadeeva, J. V., Cullen, W. K., Anwyl, R., Wolfe, M. S., Rowan, M. J., & Selkoe, D. J. (2002) · Nature · doi:10.1038/416535a · Cited by 4,291 · see citing works
Bilirubin Is an Antioxidant of Possible Physiological Importance
Stocker, R., Yamamoto, Y., McDonagh, A. F., Glazer, A. N., & Ames, B. N. (1987) · Science · doi:10.1126/science.3029864 · Cited by 3,502 · see citing works
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works
Alzheimer's Disease Neuroimaging Initiative (ADNI)
Petersen, R. C., Aisen, P. S., Beckett, L. A., Donohue, M. C., Gamst, A. C., Harvey, D. J., Jack, C. R., Jagust, W. J., Shaw, L. M., Toga, A. W., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cb3e25 · Cited by 2,572 · see citing works
THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases
Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489 · see citing works
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works
Statins and the risk of dementia
Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,748 · see citing works
Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity
Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., & Giuffrida Stella, A. M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2214 · Cited by 1,543 · see citing works
Self-citationWolozin, B., Kellman, W., Ruosseau, P., Celesia, G., & Siegel, G. (2000) · Archives of Neurology · doi:10.1001/archneur.57.10.1439 · Cited by 1,499 · see citing works
Iron accumulation in Alzheimer disease is a source of redox-generated free radicals
Smith, M. A., Harris, P. L. R., Sayre, L. M., & Perry, G. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9866 · Cited by 1,357 · see citing works
Mechanisms of Cell Protection by Heme Oxygenase-1
Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105600 · Cited by 1,241 · see citing works
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
Butterfield, D. A., Drake, J., Pocernich, C., & Castegna, A. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02173-6 · Cited by 1,114 · see citing works
Self-citationBalogun, E. A., Hoque, M., Gong, P., Killeen, E., Green, C. J., Foresti, R., Alam, J., & Motterlini, R. (2003) · Biochemical Journal · doi:10.1042/bj20021619 · Cited by 1,038 · see citing works
Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease
Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works
Butterfield, D. A., & Lauderback, C. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00794-3 · Cited by 999 · see citing works
Self-citationCarbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 959 · see citing works
Mandelkow, E., & Mandelkow, E. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01368-3 · Cited by 951 · see citing works
McCoubrey, W. K., Huang, T. J., & Maines, M. D. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00725.x · Cited by 823 · see citing works
Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works
Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010255.x · Cited by 781 · see citing works
Hensley, K., Hall, N., Subramaniam, R., Cole, P., Harris, M., Aksenov, M., Aksenova, M., Gabbita, S. P., Wu, J. F., Carney, J. M., et al. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052146.x · Cited by 779 · see citing works
Self-citationAntioxidant activity of albumin-bound bilirubin.
Stocker, R., Glazer, A. N., & Ames, B. N. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5918 · Cited by 769 · see citing works
Doré, S., Takahashi, M., Ferris, C. D., Hester, L. D., Guastella, D. B., & Snyder, S. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2445 · Cited by 699 · see citing works
Markesbery, W. R., & Lovell, M. A. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00009-8 · Cited by 680 · see citing works
Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 671 · see citing works
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase‐1 gene
Sun, J., Hoshino, H., Takaku, K., Nakajima, O., Muto, A., Suzuki, H., Tashiro, S., Takahashi, S., Shibahara, S., Alam, J., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf516 · Cited by 637 · see citing works
The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation.
Braughler, J. M., Duncan, L. A., & Chase, R. L. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67521-0 · Cited by 585 · see citing works
Castegna, A., Aksenov, M. Y., Thongboonkerd, V., Klein, J. B., Pierce, W. M. J., Booze, R. M., Markesbery, W. R., & Butterfield, D. A. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01103.x · Cited by 581 · see citing works
Self-citationCastegna, A., Aksenov, M., Aksenova, M., Thongboonkerd, V., Klein, J. B., Pierce, W. M., Booze, R., Markesbery, W. R., & Butterfield, D. A. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00914-0 · Cited by 581 · see citing works
Self-citationButterfield, D. A., Reed, T., Newman, S. F., & Sultana, R. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.037 · Cited by 564 · see citing works
Self-citationEvidence of increased oxidative damage in subjects with mild cognitive impairment
Keller, J. N., Schmitt, F. A., Scheff, S. W., Ding, Q., Chen, Q., Butterfield, D. A., & Markesbery, W. R. (2005) · Neurology · doi:10.1212/01.wnl.0000156156.13641.ba · Cited by 539 · see citing works
Self-citationOgawa, K., Sun, J., Taketani, S., Nakajima, O., Nishitani, C., Sassa, S., Hayashi, N., Yamamoto, M., Shibahara, S., Fujita, H., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.11.2835 · Cited by 532 · see citing works
Butterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526 · see citing works
Self-citationAdvanced glycation endproducts and their receptor RAGE in Alzheimer's disease
Srikanth, V., Maczurek, A., Phan, T., Steele, M., Westcott, B., Juskiw, D., & Münch, G. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.04.016 · Cited by 524 · see citing works
Rockwood, K. J., Kirkland, S., Hogan, D. B., MacKnight, C., Merry, H. R., Verreault, R., Wolfson, C. M., & McDowell, I. (2002) · Archives of Neurology · doi:10.1001/archneur.59.2.223 · Cited by 517 · see citing works
Oxidative stress in Alzheimer disease: A possibility for prevention
Bonda, D., Wang, X., Perry, G. L., Nunomura, A., Tabaton, M., Zhu, X., & Smith, M. A. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.04.005 · Cited by 481 · see citing works
Lauderback, C. M., Hackett, J. M., Huang, F. F., Keller, J. N., Szweda, L. I., Markesbery, W. R., & Butterfield, D. A. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00451.x · Cited by 464 · see citing works
Self-citationStewart, D., Killeen, E., Naquin, R., Alam, S., & Alam, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209195200 · Cited by 463 · see citing works
Pseudogenes: Pseudo-functional or key regulators in health and disease?
Pink, R. C., Wicks, K., Caley, D. P., Punch, E. K., Jacobs, L. A., & Carter, D. R. F. (2011) · RNA · doi:10.1261/rna.2658311 · Cited by 459 · see citing works
Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures
Lovell, M. A., Xie, C., & Markesbery, W. R. (2001) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00235-9 · Cited by 449 · see citing works
How does PKMζ maintain long-term memory?
Sacktor, T. C. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2949 · Cited by 431 · see citing works
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.
Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B. O., Petersen, R. B., & Perry, G. L. (1994) · PubMed Central · Cited by 425 · see citing works
Dhakshinamoorthy, S., Jain, A. K., Bloom, D. A., & Jaiswal, A. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500166200 · Cited by 414 · see citing works
Pratico, D., Lee, V. M.-Y., Trojanowski, J. Q., Rokach, J., & Fitzgerald, G. A. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.15.1777 · Cited by 405 · see citing works
Nutritional approaches to combat oxidative stress in Alzheimer’s disease
Butterfield, D. A., Castegna, A., Pocernich, C. B., Drake, J., Scapagnini, G., & Calabrese, V. (2002) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(02)00205-x · Cited by 403 · see citing works
Self-citationFujita, T., Toda, K., Karimova, A., Yan, S., Naka, Y., Yet, S., & Pinsky, D. J. (2001) · Nature Medicine · doi:10.1038/87929 · Cited by 399 · see citing works
Deane, R., Wu, Z., & Zlokovic, B. V. (2004) · Stroke · doi:10.1161/01.str.0000143452.85382.d1 · Cited by 392 · see citing works
Chapter 7 Protein Oxidation Processes in Aging Brain
Butterfield, D. A., & Stadtman, E. R. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60057-7 · Cited by 390 · see citing works
Self-citationSimvastatin is associated with a reduced incidence of dementia and Parkinson's disease
Wolozin, B. L., Wang, S. W., Li, N.-C., Lee, A. F., Lee, T. A., & Kazis, L. E. (2007) · BMC Medicine · doi:10.1186/1741-7015-5-20 · Cited by 385 · see citing works
Antioxidant Therapies for Alzheimer's Disease
Feng, Y., & Wang, X. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/472932 · Cited by 382 · see citing works
Padurariu, M., Ciobica, A., Hritcu, L., Stoica, B., Bild, W., & Stefanescu, C. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.033 · Cited by 378 · see citing works
Butterfield, D. A., Poon, H. F., St. Clair, D., Keller, J. N., Pierce, W. M., Klein, J. B., & Markesbery, W. R. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.11.002 · Cited by 377 · see citing works
Self-citationSun, J., Brand, M., Zenke, Y., Tashiro, S., Groudine, M., & Igarashi, K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308083100 · Cited by 364 · see citing works
Diabetes mellitus and Alzheimer's disease: shared pathology and treatment?
Akter, K., Lanza, E. A., Martin, S. A., Myronyuk, N., Rua, M., & Raffa, R. B. (2011) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2010.03830.x · Cited by 352 · see citing works
Akama, K. T., Albanese, C., Pestell, R. G., & Eldik, L. J. V. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5795 · Cited by 344 · see citing works
Mulder, C., Verwey, N. A., van der Flier, W. M., Bouwman, F. H., Kok, A., van Elk, E. J., Scheltens, P., & Blankenstein, M. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.130518 · Cited by 332 · see citing works
Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1
Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., Ikura, M., Asahara, T., Tokunaga, F., Iwaï, K., & Igarashi, K. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02415-06 · Cited by 330 · see citing works
Role of Oxidative Stress in the Progression of Alzheimer's Disease
Rukhsana Sultana, A., & Butterfield, D. A. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1222 · Cited by 327 · see citing works
Self-citationTranscriptional Regulation of the Heme Oxygenase-1 Gene Via the Stress Response Element Pathway
Alam, J., & Cook, J. L. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033453730 · Cited by 315 · see citing works
Antioxidant Activities of Bile Pigments
Stocker, R. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2004.6.841 · Cited by 313 · see citing works
Johnstone, E. M., Chaney, M. O., Norris, F. H., Pascual, R. V., & Little, S. H. (1991) · Molecular Brain Research · doi:10.1016/0169-328x(91)90088-f · Cited by 312 · see citing works
The Role of Bilirubin in Diabetes, Metabolic Syndrome, and Cardiovascular Diseases
Vı́tek, L. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00055 · Cited by 311 · see citing works
The Role of Oxidative Stress in Alzheimer Disease
Markesbery, W. R. (1999) · Archives of Neurology · doi:10.1001/archneur.56.12.1449 · Cited by 307 · see citing works
Horwood, J. M., Dufour, F., Laroche, S., & Davis, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04859.x · Cited by 294 · see citing works
Kanninen, K. M., Heikkinen, R., Malm, T., Rõlova, T., Kemppainen, S., Leinonen, H. M., Ylä‐Herttuala, S., Tanila, H., Levonen, A., Koistinaho, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908397106 · Cited by 293 · see citing works
Decreased plasma antioxidants in patients with Alzheimer's disease
Kim, T., Pae, C., Yoon, S.-J., Jang, W., Lee, N. J., Kim, J.-J., Lee, S., Lee, C., Paik, I.-H., & Lee, C. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1469 · Cited by 291 · see citing works
Carbon monoxide, reactive oxygen signaling, and oxidative stress
Piantadosi, C. A. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.05.013 · Cited by 281 · see citing works
Oxidative stress and β-amyloid protein in Alzheimer’s disease
Cai, Z., Zhao, B., & Ratka, A. (2011) · NeuroMolecular Medicine · doi:10.1007/s12017-011-8155-9 · Cited by 279 · see citing works
Rukhsana Sultana, A., Ravagna, A., Abdul, H. M., Calabrese, V., & Butterfield, D. A. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02899.x · Cited by 276 · see citing works
Self-citationSubramaniam, R., Roediger, F., Jordan, B., Mattson, M. P., Keller, J. N., Waeg, G., & Butterfield, D. A. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031161.x · Cited by 270 · see citing works
Self-citationCalabrese, V., Cornelius, C., Mancuso, C., Pennisi, G., Calafato, S., Bellia, F., Bates, T. E., Stella, A. M. G., Schapira, T., Dinkova‐Kostova, A. T., et al. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9775-9 · Cited by 267 · see citing works
Self-citationButterfield, D. A., & Debra Boyd-kimball, A. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00087.x · Cited by 263 · see citing works
Self-citationBach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells
Kitamuro, T., Takahashi, K., Ogawa, K., Udono‐Fujimori, R., Takeda, K., Furuyama, K., Nakayama, M., Sun, J., Fujita, H., Hida, W., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209939200 · Cited by 261 · see citing works
Rukhsana Sultana, A., Marzia Perluigi, A., & Butterfield, D. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.2021 · Cited by 259 · see citing works
Self-citationUpregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory
Suzuki, A., Fukushima, H., Mukawa, T., Toyoda, H., Wu, L.-J., Zhao, M.-G., Xu, H., Shang, Y., Endoh, K., Iwamoto, T., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-10.2011 · Cited by 250 · see citing works
Kapitulnik, J. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.002832 · Cited by 239 · see citing works
Neuropathologic Alterations in Mild Cognitive Impairment: A Review
Markesbery, W. R. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1220 · Cited by 236 · see citing works
Free Radicals: Key to Brain Aging and Heme Oxygenase as a Cellular Response to Oxidative Stress
Poon, H. F., Calabrese, V., Scapagnini, G., & Butterfield, D. A. (2004) · The Journals of Gerontology Series A · doi:10.1093/gerona/59.5.m478 · Cited by 235 · see citing works
Self-citationAPOE genotype, cholesterol level, lipid-lowering treatment, and dementia
Dufouil, C., Richard, F., Fiévet, N., Dartigues, J., Ritchie, K. A., Tzourio, C., Amouyel, P., & Alpérovitch, A. (2005) · Neurology · doi:10.1212/01.wnl.0000160114.42643.31 · Cited by 229 · see citing works
Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer’s disease
Grossman, M., Farmer, J., Leight, S., Work, M., Moore, P., Van Deerlin, V., Pratico, D., Clark, C. M., Coslett, H. B., Chatterjee, A., et al. (2005) · Annals of Neurology · doi:10.1002/ana.20477 · Cited by 228 · see citing works
Hayashi, S., Omata, Y., Sakamoto, H., Higashimoto, Y., Hara, T., Sagara, Y., & Noguchi, M. (2004) · Gene · doi:10.1016/j.gene.2004.04.002 · Cited by 227 · see citing works
Calabrese, V., Rukhsana Sultana, A., Scapagnini, G., Guagliano, E., Sapienza, M. A., Bella, R., Kański, J., Pennisi, G., Mancuso, C., Stella, A. M. G., et al. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1975 · Cited by 227 · see citing works
Self-citationSong, R., Kubo, M., Morse, D., Zhou, Z., Zhang, X., Dauber, J. H., Fabisiak, J. P., Alber, S. M., Watkins, S. C., Zuckerbraun, B. S., et al. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63646-2 · Cited by 223 · see citing works
Biomarkers of Oxidative Damage and Inflammation in Alzheimer's Disease
Galasko, D. R., & Montine, T. J. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.89 · Cited by 221 · see citing works
The role of iron in oxygen radical mediated lipid peroxidation
Minotti, G., & Aust, S. D. (1989) · Chemico-Biological Interactions · doi:10.1016/0009-2797(89)90087-2 · Cited by 217 · see citing works
Sultana, R., Perluigi, M., & Butterfield, D. A. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0517-0 · Cited by 215 · see citing works
Self-citationPremkumar, D. R., Smith, M. A., Richey, P. L., Petersen, R. B., Castellani, R. J., Kutty, R. K., Wiggert, B. O., Perry, G. L., & Kalaria, R. N. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65031399.x · Cited by 211 · see citing works
Opii, W. O., Joshi, G., Head, E., Milgram, N. W., Muggenburg, B. A., Klein, J. B., Pierce, W. M., Cotman, C. W., & Butterfield, D. A. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.012 · Cited by 202 · see citing works
Self-citationAssociation between Statin Use and Alzheimer’s Disease
ZAMRINI, E. Y., McGwin, G., & Roseman, J. M. (2004) · Neuroepidemiology · doi:10.1159/000073981 · Cited by 201 · see citing works
Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
Schipper, H. M., BENNETT, D., Liberman, A., Bienias, J. L., Schneider, J. A., Kelly, J. W., & Arvanitakis, Z. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.01.016 · Cited by 197 · see citing works
Perluigi, M., Sultana, R., Cenini, G., Di Domenico, F., Memo, M., Pierce, W. M., Coccia, R., & Butterfield, D. A. (2009) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.200800161 · Cited by 196 · see citing works
Self-citationReed, T. T., Pierce, W. M., Markesbery, W. R., & Butterfield, D. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.04.009 · Cited by 190 · see citing works
Self-citationCotman, C. W., & Head, E. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15413 · Cited by 188 · see citing works
Butterfield, D. A., Galván, V., Lange, M. L. B., Tang, H., Robinson, R. A. S., Spilman, P. R., Fombonne, J., Gorostiza, O. F., Zhang, J., Rukhsana Sultana, A., et al. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.10.035 · Cited by 188 · see citing works
Self-citationHajjar, I. M., Schumpert, J., Hirth, V., Wieland, D. M., & Eleazer, G. P. (2002) · The Journals of Gerontology Series A · doi:10.1093/gerona/57.7.m414 · Cited by 188 · see citing works
Kaide, J.-I., Zhang, F., Wei, Y., Jiang, H., Yu, C., Wang, W., Balazy, M., Abraham, N. G., & Nasjletti, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11218 · Cited by 184 · see citing works
Oxidative Damage to RNA in Aging and Neurodegenerative Disorders
Nunomura, A., Moreira, P. I., Castellani, R. J., Lee, H., Zhu, X., Smith, M. A., & Perry, G. L. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9331-x · Cited by 183 · see citing works
Takahashi, M., Doré, S., Ferris, C. D., Tomita, T., Sawa, A., Wolosker, H., Borchelt, D., Iwatsubo, T., Kim, S., Thinakaran, G., et al. (2000) · Neuron · doi:10.1016/s0896-6273(00)00125-2 · Cited by 181 · see citing works
Biliverdin, a natural product of heme catabolism, induces tolerance to cardiac allografts
Yamashita, K., McDaid, J., Öllinger, R., Tsui, T., Berberat, P. O., Usheva, A., Csizmadia, E., Smith, R. N., Soares, M. P., & Bach, F. H. (2004) · The FASEB Journal · doi:10.1096/fj.03-0839fje · Cited by 180 · see citing works
Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia
Marzia Perluigi, A., & Butterfield, D. A. (2011) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/724904 · Cited by 180 · see citing works
Self-citationKapitulnik, J., & Maines, M. D. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.12.003 · Cited by 178 · see citing works
Calabrese, V., Scapagnini, G., Colombrita, C., Ravagna, A., Pennisi, G., Stella, A. M. G., Galli, F., & Butterfield, D. A. (2003) · Amino Acids · doi:10.1007/s00726-003-0048-2 · Cited by 176 · see citing works
Self-citationScapagnini, G., Butterfield, D. A., Colombrita, C., Rukhsana Sultana, A., Pascale, A., & Calabrese, V. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2004.6.811 · Cited by 175 · see citing works
Self-citationPlasma biomarkers for mild cognitive impairment and Alzheimer's disease
Song, F., Poljak, A., Smythe, G. A., & Sachdev, P. S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.003 · Cited by 173 · see citing works
Vitamin E and Neurodegenerative Disorders Associated with Oxidative Stress
Butterfield, D. A., Castegna, A., Drake, J., Scapagnini, G., & Calabrese, V. (2002) · Nutritional Neuroscience · doi:10.1080/10284150290028954 · Cited by 170 · see citing works
Self-citationMild cognitive impairment (MCI) represents early-stage Alzheimer's disease
Morris, J. C., & Cummings, J. L. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-7306 · Cited by 167 · see citing works
Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications
Butterfield, D. A., Marzia Perluigi, A., Reed, T. T., Muharib, T., Hughes, C. P., Robinson, R. A. S., & Rukhsana Sultana, A. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4109 · Cited by 167 · see citing works
Self-citationThe heme oxygenase system and its functions in the brain.
Maines, M. D. (2000) · PubMed · Cited by 158 · see citing works
Lerner‐Marmarosh, N., Shen, J. Y., Torno, M. D., Kravets, A., Hu, Z., & Maines, M. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502173102 · Cited by 158 · see citing works
Oxidative Stress and Cell Membranes in the Pathogenesis of Alzheimer's Disease
Axelsen, P. H., Komatsu, H., & Murray, I. V. J. (2011) · Physiology · doi:10.1152/physiol.00024.2010 · Cited by 158 · see citing works
Oxidative stress and cellular stress response in diabetic nephropathy
Calabrese, V., Mancuso, C., Sapienza, M. A., Puleo, E., Calafato, S., Cornelius, C., Finocchiaro, M., Mangiameli, A., Mauro, M. D., Stella, A. M. G., et al. (2007) · Cell Stress and Chaperones · doi:10.1379/csc-270.1 · Cited by 152 · see citing works
Self-citationThe Heme Oxygenase System: Update 2005
Maines, M. D. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1761 · Cited by 146 · see citing works
Smith, M. A., Richey, P. L., Taneda, S., Kutty, R. K., Lm, S., Monnier, V. M., & Perry, G. L. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb21836.x · Cited by 146 · see citing works
Carbon Monoxide Neurotransmission Activated by CK2 Phosphorylation of Heme Oxygenase-2
Boehning, D. F., Moon, C., Sharma, S., Hurt, K. J., Hester, L. D., Ronnett, G. V., Shugar, D., & Snyder, S. H. (2003) · Neuron · doi:10.1016/s0896-6273(03)00596-8 · Cited by 142 · see citing works
Dwyer, B. E., Nishimura, R. N., & Lu, S. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00273-h · Cited by 141 · see citing works
New Insights into Biliverdin Reductase Functions: Linking Heme Metabolism to Cell Signaling
Maines, M. D. (2005) · Physiology · doi:10.1152/physiol.00029.2005 · Cited by 135 · see citing works
Gururaj Joshi, A., Hardas, S. S., Rukhsana Sultana, A., Clair, D. K. S., Vore, M. E., & Butterfield, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21158 · Cited by 134 · see citing works
Self-citationDomenico, F. D., Coccia, R., Cocciolo, A., Murphy, M. P., Cenini, G., Head, E., Butterfield, D. A., Giorgi, A., Schininà, M. E., Mancuso, C., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.04.013 · Cited by 133 · see citing works
Self-citationOwen, J. B., Rukhsana Sultana, A., Aluise, C. D., Erickson, M. A., Price, T. O., Bu, G., Banks, W. A., & Butterfield, D. A. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.013 · Cited by 130 · see citing works
Self-citationPI3 kinase signaling is involved in Aβ-induced memory loss in Drosophila
Chiang, H., Wang, L., Xie, Z., Yau, A., & Zhong, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909314107 · Cited by 127 · see citing works
Perluigi, M., Joshi, G., Sultana, R., Calabrese, V., De Marco, C., Coccia, R., Cini, C., & Butterfield, D. A. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20879 · Cited by 125 · see citing works
Self-citationBarone, E., Domenico, F. D., Rukhsana Sultana, A., Coccia, R., Mancuso, C., Marzia Perluigi, A., & Butterfield, D. A. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.03.020 · Cited by 124 · see citing works
Self-citationFrankel, D., Mehindate, K., & Schipper, H. M. (2000) · Journal of Cellular Physiology · doi:10.1002/1097-4652(200010)185:1 · Cited by 120 · see citing works
Over‐expression of heme oxygenase‐1 promotes oxidative mitochondrial damage in rat astroglia
Song, W., Su, H., Song, S., Paudel, H. K., & Schipper, H. M. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20509 · Cited by 118 · see citing works
Evaluation of heme oxygenase-1 as a systemic biological marker of sporadic AD
Schipper, H. M., Chertkow, H. M., Mehindate, K., Frankel, D., Melmed, C., & Bergman, H. (2000) · Neurology · doi:10.1212/wnl.54.6.1297 · Cited by 117 · see citing works
Mancuso, C., Navarra, P., & Preziosi, P. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06606.x · Cited by 117 · see citing works
Self-citationStructure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.
Pereira, P. J. B., Macedo‐Ribeiro, S., PÁRRAGA, A., Pérez-Luque, R., Cunningham, O., Darcy, K., Mantle, T. J., & Coll, M. (2001) · Nature Structural Biology · doi:10.1038/84948 · Cited by 117 · see citing works
Upcoming Candidate Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease
Fagan, A. M., & Perrin, R. J. (2012) · Biomarkers in Medicine · doi:10.2217/bmm.12.42 · Cited by 115 · see citing works
He, X., Lin, G. X., Chen, M. G., Zhang, J. X., & Ma, Q. (2007) · Toxicological Sciences · doi:10.1093/toxsci/kfm081 · Cited by 113 · see citing works
Protein kinase Akt/PKB phosphorylates heme oxygenase‐1 in vitro and in vivo
Salinas, M., Wang, J., de Sagarra, M. R., Martı́n, D., Rojo, A. I., Martı́n-Pérez, J., de Montellano, P. R. O., & Cuadrado, A. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.077 · Cited by 110 · see citing works
Domenico, F. D., Rukhsana Sultana, A., Hawkins, G. T., Scheff, N. N., Marzia Perluigi, A., Cini, C., & Butterfield, D. A. (2010) · Brain Research · doi:10.1016/j.brainres.2010.03.085 · Cited by 105 · see citing works
Self-citationOxidative Stress in Alzheimer Patients in Different Stages of the Disease
Zafrilla, P., Mulero, J., Graupera, J. M. X., Santo, E., Caravaca, G., & Morillas, J. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706776360978 · Cited by 105 · see citing works
A link between hyperbilirubinemia, oxidative stress and injury to neocortical synaptosomes
Brito, M. A., Brites, D. M. T. O., & Butterfield, D. A. (2004) · Brain Research · doi:10.1016/j.brainres.2004.07.063 · Cited by 104 · see citing works
Self-citationLerner‐Marmarosh, N., Miralem, T., Gibbs, P., & Maines, M. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800750105 · Cited by 103 · see citing works
Mancuso, C., Bonsignore, A., Stasio, E. D., Mordente, A., & Motterlini, R. (2003) · Biochemical Pharmacology · doi:10.1016/j.bcp.2003.08.022 · Cited by 102 · see citing works
Self-citationBilirubin as an endogenous modulator of neurotrophin redox signaling
Mancuso, C., Capone, C., Ranieri, S. C., Fusco, S., Calabrese, V., Eboli, M. L., Preziosi, P., Galeotti, T., & Pani, G. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21665 · Cited by 100 · see citing works
Self-citationThe Heme Oxygenase/Biliverdin Reductase Pathway in Drug Research and Development
Mancuso, C., & Barone, E. (2009) · Current Drug Metabolism · doi:10.2174/138920009789375405 · Cited by 99 · see citing works
Self-citationBarone, E., Domenico, F. D., Cenini, G., Rukhsana Sultana, A., Coccia, R., Preziosi, P., Marzia Perluigi, A., Mancuso, C., & Butterfield, D. A. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110092 · Cited by 98 · see citing works
Self-citationThe heme oxygenase system and cellular defense mechanisms
Maines, M. D., & Panahian, N. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-3401-0_17 · Cited by 97 · see citing works
Ewing, J. F., Weber, C. M., & Maines, M. D. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03615.x · Cited by 96 · see citing works
Barone, E., Domenico, F. D., Cenini, G., Rukhsana Sultana, A., Cini, C., Preziosi, P., Marzia Perluigi, A., Mancuso, C., & Butterfield, D. A. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.01.005 · Cited by 96 · see citing works
Self-citationPozzoli, G., Mancuso, C., Mirtella, A., Preziosi, P., Grossman, A. B., & Navarra, P. (1994) · Endocrinology · doi:10.1210/endo.135.6.7988414 · Cited by 92 · see citing works
Self-citationHyman, B. T., Elvhage, T. E., & Reiter, J. S. (1994) · PubMed Central · Cited by 92 · see citing works
Rodríguez, E., Dodge, H. H., Birzescu, M., Stoehr, G. P., & Ganguli, M. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50515.x · Cited by 90 · see citing works
Increased bilirubins and their derivatives in cerebrospinal fluid in Alzheimer’s disease
Kimpara, T., Takeda, A., Yamaguchi, T., Arai, H., Okita, N., Takase, S., Sasaki, H., & Itoyama, Y. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00128-7 · Cited by 90 · see citing works
Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicine
Mancuso, C., Siciliano, R., Barone, E., & Preziosi, P. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.004 · Cited by 88 · see citing works
Self-citationOxidative Stress in Neurodegenerative Disorders
Butterfield, D. A. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1971 · Cited by 83 · see citing works
Self-citationPurification and Characterization of Human Biliverdin Reductase
Maines, M. D., & Trakshel, G. M. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1044 · Cited by 82 · see citing works
Biliverdin inhibits activation of NF‐κB: Reversal of inhibition by human biliverdin reductase
Gibbs, P., & Maines, M. D. (2007) · International Journal of Cancer · doi:10.1002/ijc.22978 · Cited by 82 · see citing works
Heme Oxygenase-2 Is Activated by Calcium-Calmodulin
Boehning, D. F., Sedaghat, L., Sedlak, T. W., & Snyder, S. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400222200 · Cited by 82 · see citing works
Carbon monoxide produced by isolated arterioles attenuates pressure-induced vasoconstriction
Zhang, F., Kaide, J.-I., Wei, Y., Jiang, H., Yu, C., Balazy, M., Abraham, N. G., Wang, W., & Nasjletti, A. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.1.h350 · Cited by 82 · see citing works
Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease
Perry, G. L., Lee, H., Lee, H. P., Zhu, X., Smith, M. A., Rolston, R. K., Marlatt, M. W., Castellani, R. J., Nunomura, A., Casadesús, G., et al. (2010) · International Journal of Biomedical Science · doi:10.59566/ijbs.2010.6225 · Cited by 81 · see citing works
Tudor, C., Lerner‐Marmarosh, N., Engelborghs, Y., Gibbs, P., & Maines, M. D. (2008) · Biochemical Journal · doi:10.1042/bj20080018 · Cited by 78 · see citing works
Oxidative Stress, Aging, and Central Nervous System Disease in the Canine Model of Human Brain Aging
Head, E., Rofina, J., & Zicker, S. C. (2008) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/j.cvsm.2007.10.002 · Cited by 78 · see citing works
Mancuso, C., Barone, E., Guido, P., Miceli, F., Domenico, F. D., Marzia Perluigi, A., Santangelo, R., & Preziosi, P. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.062 · Cited by 77 · see citing works
Self-citationIron overload, oxidative stress, and axonal dystrophy in brain disorders
Chiueh, C. C. (2001) · Pediatric Neurology · doi:10.1016/s0887-8994(01)00266-1 · Cited by 76 · see citing works
Barone, E., Mancuso, C., Di Domenico, F., Sultana, R., Murphy, M. P., Head, E., & Butterfield, D. A. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07538.x · Cited by 75 · see citing works
Self-citationBrain sterol dysregulation in sporadic AD and MCI: relationship to heme oxygenase‐1
Hascalovici, J., Vaya, J., Khatib, S., Holcroft, C., Zukor, H., Song, W., Arvanitakis, Z., Bennett, D. A., & Schipper, H. M. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06213.x · Cited by 72 · see citing works
Hui, Y., Wang, D., Li, W., Zhang, L., Jin, J., Ma, N., Zhou, L., Nakajima, O., Zhao, W., & Gao, X. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-102061 · Cited by 71 · see citing works
Biomarkers in Alzheimer's Disease: Past, Present and Future
Gustaw‐Rothenberg, K., Lerner, A. J., Bonda, D., Lee, H., Zhu, X., Perry, G. L., & Smith, M. A. (2010) · Biomarkers in Medicine · doi:10.2217/bmm.09.86 · Cited by 71 · see citing works
Serum heme oxygenase-1 levels are increased in Parkinson’s disease but not in Alzheimer’s disease
Mateo, I., Infante, J., Sánchez-Juan, P., García‐Gorostiaga, I., RodrÃguez-RodrÃguez, E., Vázquez‐Higuera, J. L., Berciano, J., & Combarros, O. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2009.01261.x · Cited by 70 · see citing works
Cunningham, O., Gore, M. G., & Mantle, T. J. (2000) · Biochemical Journal · doi:10.1042/0264-6021:3450393 · Cited by 70 · see citing works
Circulating biomarkers of protein oxidation for Alzheimer disease: Expectations within limits
Domenico, F. D., Coccia, R., Butterfield, D. A., & Marzia Perluigi, A. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.10.001 · Cited by 67 · see citing works
Self-citationButterfield, D. A., Barone, E., Domenico, F. D., Cenini, G., Rukhsana Sultana, A., Murphy, M. P., Mancuso, C., & Head, E. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711001118 · Cited by 67 · see citing works
Self-citationCunningham, O., Gore, M. G., & Mantle, T. J. (2000) · PubMed · Cited by 66 · see citing works
Plasma F2A Isoprostane Levels in Alzheimer’s and Parkinson’s Disease
Irizarry, M. C., Yao, Y., Hyman, B. T., Growdon, J. H., & Praticò, D. (2007) · Neurodegenerative Diseases · doi:10.1159/000107699 · Cited by 66 · see citing works
Characterization of the S-denitrosylating activity of bilirubin
Barone, E., Trombino, S., Cassano, R., Sgambato, A., de Paola, B., Stasio, E. D., Picci, N., Preziosi, P., & Mancuso, C. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00680.x · Cited by 65 · see citing works
Self-citationMaines, M. D., Ewing, J. F., Huang, T., & Panahian, N. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38855-x · Cited by 64 · see citing works
Mueller, C., Zhou, W., VanMeter, A., Heiby, M., Magaki, S., Ross, M. M., Espina, V. A., Schrag, M., Dickson, C., Liotta, L. A., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1303 · Cited by 63 · see citing works
Redox cycling and lipid peroxidation: The central role of iron chelates
Bucher, J. R., Tien, M., Morehouse, L. A., & Aust, S. D. (1983) · Fundamental and Applied Toxicology · doi:10.1016/s0272-0590(83)80130-4 · Cited by 62 · see citing works
Mancuso, C., Kostoglou‐Athanassiou, I., Forsling, M. L., Grossman, A. B., Preziosi, P., Navarra, P., & Minotti, G. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00197-6 · Cited by 61 · see citing works
Self-citationBiliverdin Reductase: PKC Interaction at the Cross-Talk of MAPK and PI3K Signaling Pathways
Maines, M. D. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1805 · Cited by 61 · see citing works
Suppression of Glial HO-1 Activitiy as a Potential Neurotherapeutic Intervention in AD
Schipper, H. M., Gupta, A., & Szarek, W. A. (2009) · Current Alzheimer Research · doi:10.2174/156720509789207985 · Cited by 61 · see citing works
Torp, R., Head, E., Milgram, N. W., Hahn, F. F., Ottersen, O. P., & Cotman, C. W. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00568-0 · Cited by 60 · see citing works
Effects of Exogenous Heme on Renal Function
Rodríguez, F., Kemp, R., Balazy, M., & Nasjletti, A. (2003) · Hypertension · doi:10.1161/01.hyp.0000085785.40581.1a · Cited by 60 · see citing works
Mancuso, C., Tringali, G., Grossman, A. B., Preziosi, P., & Navarra, P. (1998) · Endocrinology · doi:10.1210/endo.139.3.5822 · Cited by 60 · see citing works
Self-citationSteiner, A. A., & Branco, L. G. S. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.2.r448 · Cited by 59 · see citing works
Reduced Expression of Heme Oxygenase-1 in Patients with Coronary Atherosclerosis
Brydun, A., Watari, Y., Yamamoto, Y., Okuhara, K., Teragawa, H., Kono, F., Chayama, K., Oshima, T., & Ozono, R. (2007) · Hypertension Research · doi:10.1291/hypres.30.341 · Cited by 57 · see citing works
Fakhrai, H., & Maines, M. D. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50627-5 · Cited by 56 · see citing works
Human Biliverdin IXα Reductase is a Zinc‐Metalloprotein
Maines, M. D., Polevoda, B. V., Huang, T., & McCoubrey, W. K. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00372.x · Cited by 56 · see citing works
Liu, N., Wang, X., McCoubrey, W. K., & Maines, M. D. (2000) · Gene · doi:10.1016/s0378-1119(99)00439-4 · Cited by 56 · see citing works
Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim
Schipper, H. M. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0436-1 · Cited by 55 · see citing works
Characterization of α1-antitrypsin as a heme oxygenase-1 suppressor in Alzheimer plasma
Maes, O. C., Kravitz, S., Mawal, Y. R., Su, H., Liberman, A., Mehindate, K., Berlin, D., Sahlas, D. J., Chertkow, H. M., & Bergman, H. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.06.009 · Cited by 54 · see citing works
Shokouhi, S., Claassen, D., Kang, H., Ding, Z., Rogers, B., Mishra, A., Riddle, W. R., & Initiative, F. T. A. D. N. (2013) · Journal of Nuclear Medicine · doi:10.2967/jnumed.112.116137 · Cited by 54 · see citing works
Mancuso, C., Ragazzoni∘, E., Tringali, G., Liberale, I., Preziosi, P., Grossman, A. B., & Navarra, P. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(99)00112-5 · Cited by 52 · see citing works
Self-citationCentral CO-heme oxygenase pathway raises body temperature by a prostaglandin-independent way
Steiner, A. A., & Branco, L. G. S. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.5.1607 · Cited by 52 · see citing works
Effects of heme oxygenase-1 expression on sterol homeostasis in rat astroglia
Vaya, J., Song, W., Khatib, S., Geng, G., & Schipper, H. M. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.022 · Cited by 52 · see citing works
Carbon monoxide as a novel mediator of the febrile response in the central nervous system
Steiner, A. A., Colombari, E., & Branco, L. G. S. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.277.2.r499 · Cited by 52 · see citing works
Repression of Heme Oxygenase-1 Expression as a Defense Strategy in Humans
Shibahara, S., Nakayama, M., Kitamuro, T., Udono‐Fujimori, R., & Takahashi, K. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322805-08 · Cited by 49 · see citing works
Cortical florbetapir-PET amyloid load in prodromal Alzheimer’s disease patients
Saint‐Aubert, L., Barbeau, E. J., Péran, P., Nemmi, F., Vervueren, C., Mirabel, H., Payoux, P., Hitzel, A., Bonneville, F., Gramada, R., et al. (2013) · EJNMMI Research · doi:10.1186/2191-219x-3-43 · Cited by 49 · see citing works
Domenico, F. D., Barone, E., Mancuso, C., Marzia Perluigi, A., Cocciolo, A., Mecocci, P., Butterfield, D. A., & Coccia, R. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-121045 · Cited by 48 · see citing works
Self-citationAntiapoptotic Action of Carbon Monoxide on Cultured Vascular Smooth Muscle Cells
Liu, X., Chapman, G. B., Peyton, K. J., Schafer, A. I., & Durante, W. (2003) · Experimental Biology and Medicine · doi:10.1177/15353702-0322805-30 · Cited by 48 · see citing works
Reductive stress in young healthy individuals at risk of Alzheimer disease
Badía, M.-C., Giraldo, E., Dası́, F., Alonso, D., Lainez, J. M., Lloret, A., & Viña, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.003 · Cited by 47 · see citing works
Lerner‐Marmarosh, N., Miralem, T., Gibbs, P., & Maines, M. D. (2007) · The FASEB Journal · doi:10.1096/fj.07-8544com · Cited by 45 · see citing works
Human Biliverdin Reductase, a Previously Unknown Activator of Protein Kinase C βII
Maines, M. D., Miralem, T., Lerner‐Marmarosh, N., Shen, J. Y., & Gibbs, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m513427200 · Cited by 41 · see citing works
Kosaka, J., Morimatsu, H., Takahashi, T., Shimizu, H., Kawanishi, S., Omori, E., Endo, Y., Tamaki, N., Morita, M., & Morita, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063606 · Cited by 41 · see citing works
Enhancement of β‐Amyloid Peptide Aβ(1–40)‐Mediated Neurotoxicity by Glutamine Synthetase
Aksenov, M. Y., Aksenova, M. V., Harris‐White, M. E., Hensley, K., Butterfield, D. A., & Carney, J. M. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65041899.x · Cited by 40 · see citing works
Self-citation
Flagged first, then by citations
1 of the 227 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954 · see citing works
Self-citationProgrammed Cell-Death by Ferroptosis: Antioxidants as Mitigators
Kajarabille, N., & Latunde-Dada, G. O. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194968 · Cited by 680 · see citing works
Butterfield, D. A., Swomley, A. M., & Sultana, R. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5027 · Cited by 526 · see citing works
Self-citationVerdile, G., Keane, K. N., Cruzat, V. F., Medic, S., Sabale, M., Rowles, J., Wijesekara, N., Martins, R. N., Fraser, P. E., & Newsholme, P. (2015) · Mediators of Inflammation · doi:10.1155/2015/105828 · Cited by 501 · see citing works
Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.010 · Cited by 402 · see citing works
Self-citationButterfield, D. A., & Boyd-Kimball, D. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170543 · Cited by 403 · see citing works
Self-citationInsulin and Insulin Resistance in Alzheimer’s Disease
Sędzikowska, A., & Szablewski, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189987 · Cited by 404 · see citing works
Metal Ions in Alzheimer’s Disease: A Key Role or Not?
Liu, Y., Nguyen, M., Robert, A., & Meunier, B. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00248 · Cited by 353 · see citing works
de la Monte, S. M. (2017) · Drugs · doi:10.1007/s40265-016-0674-0 · Cited by 331 · see citing works
The role of type 2 diabetes in neurodegeneration
Verdile, G., Fuller, S. J., & Martins, R. N. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.04.008 · Cited by 276 · see citing works
Di Domenico, F., Tramutola, A., & Butterfield, D. A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.490 · Cited by 253 · see citing works
Self-citationMancuso, C., & Santangelo, R. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2017.12.009 · Cited by 232 · see citing works
Self-citationA Novel Perspective on the Biology of Bilirubin in Health and Disease
Gazzin, S., Vı́tek, L., Watchko, J. F., Shapiro, S. M., & Tiribelli, C. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.07.004 · Cited by 215 · see citing works
Robert, A., Liu, Y., Nguyen, M., & Meunier, B. (2015) · Accounts of Chemical Research · doi:10.1021/acs.accounts.5b00119 · Cited by 212 · see citing works
Hooda, J., Shah, A. N., & Li, Z. (2014) · Nutrients · doi:10.3390/nu6031080 · Cited by 211 · see citing works
Homocysteine and age-associated disorders
Ostrakhovitch, E. A., & TABIBZADEH, S. S. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.010 · Cited by 182 · see citing works
Barone, E., Domenico, F. D., Perluigi, M., & Butterfield, D. (2021) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2021.09.006 · Cited by 155 · see citing works
Self-citationWagner, K., Wallner, M., Mölzer, C., Gazzin, S., Bulmer, A. C., Tiribelli, C., & Vı́tek, L. (2015) · Clinical Science · doi:10.1042/cs20140566 · Cited by 171 · see citing works
Fasae, K. D., Abolaji, A. O., Faloye, T. R., Odunsi, A., Oyetayo, B. O., Enya, J. I., Rotimi, J. A., Akinyemi, R., Whitworth, A. J., & Aschner, M. (2021) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2021.126779 · Cited by 160 · see citing works
Hansen, T. W. R., Wong, R. J., & Stevenson, D. K. (2020) · Physiological Reviews · doi:10.1152/physrev.00004.2019 · Cited by 148 · see citing works
Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases
Dattilo, S., Mancuso, C., Koverech, G., Mauro, P. D., Ontario, M. L., Petralia, C. C. T., Petralia, A., Maiolino, L., Serra, A., Calabrese, E. J., et al. (2015) · Immunity & Ageing · doi:10.1186/s12979-015-0046-8 · Cited by 140 · see citing works
Self-citationButterfield, D. A. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.06.006 · Cited by 126 · see citing works
Self-citationYu, L., Wang, S., Chen, X., Yang, H., Li, X., Xu, Y., & Zhu, X. (2015) · Life Sciences · doi:10.1016/j.lfs.2014.11.021 · Cited by 127 · see citing works
Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum
Ríos, J. A., Cisternas, P., Arrese, M. A., Salesa Barja, Y., & Inestrosa, N. C. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2014.07.004 · Cited by 104 · see citing works
Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes
Rochette, L., Zeller, M., Cottin, Y., & Vergely, C. (2017) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2017.11.005 · Cited by 103 · see citing works
Barone, E., Di Domenico, F., Cassano, T., Arena, A., Tramutola, A., Lavecchia, M. A., Coccia, R., Butterfield, D. A., & Perluigi, M. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.12.012 · Cited by 100 · see citing works
Self-citationCobourne-Duval, M. K., Taka, E., Mendonca, P., & Soliman, K. F. A. (2018) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2018.04.018 · Cited by 92 · see citing works
Research Progress on Alzheimer's Disease and Resveratrol
Yan, Y., Yang, H., Xie, Y., Ding, Y., Kong, D., & Yu, H. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03007-0 · Cited by 91 · see citing works
Biliverdin Reductase-A Mediates the Beneficial Effects of Intranasal Insulin in Alzheimer Disease
Barone, E., Tramutola, A., Triani, F., Calcagnini, S., Di Domenico, F., Ripoli, C., Gaetani, S., Grassi, C., Butterfield, D. A., Cassano, T., et al. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1231-5 · Cited by 86 · see citing works
Self-citationGou, L., Zhao, L., Song, W., Wang, L., Liu, J., Zhang, H., Huang, Y., Lau, C. W., Yao, X., Tian, X. Y., et al. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7005 · Cited by 86 · see citing works
Heme oxygenase in neuroprotection: from mechanisms to therapeutic implications
Chen, J. (2014) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0046 · Cited by 88 · see citing works
Matsuda, S., Nakagawa, Y., Tsuji, A., Kitagishi, Y., Nakanishi, A., & Murai, T. (2018) · Diseases · doi:10.3390/diseases6020028 · Cited by 85 · see citing works
Antognelli, C., Trapani, E., Monache, S. D., Perrelli, A., Daga, M., Pizzimenti, S., Barrera, G., Cassoni, P., Angelucci, A., Trabalzini, L., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.014 · Cited by 81 · see citing works
Barone, E., Domenico, F. D., & Butterfield, D. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.10.030 · Cited by 79 · see citing works
Self-citationDi Domenico, F., Pupo, G., Mancuso, C., Barone, E., Paolini, F., Arena, A., Blarzino, C., Schmitt, F. A., Head, E., Butterfield, D. A., et al. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-141254 · Cited by 75 · see citing works
Self-citationPentón-Rol, G., Marín-Prida, J., & McCarty, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210408123807 · Cited by 73 · see citing works
Insulin resistance: a connecting link between Alzheimer's disease and metabolic disorder
Kshirsagar, V., Thingore, C., & Juvekar, A. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-020-00622-2 · Cited by 66 · see citing works
Wang, Y., Liao, J., Luo, Y., Li, M., Su, X., Yu, B., Teng, J., Wang, H., & Lv, X. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043257 · Cited by 62 · see citing works
A Heme Oxygenase-1 Transducer Model of Degenerative and Developmental Brain Disorders
Schipper, H. M., & Song, W. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16035400 · Cited by 57 · see citing works
Loss of biliverdin reductase-A favors Tau hyper-phosphorylation in Alzheimer's disease
Sharma, N. K., Tramutola, A., Lanzillotta, C., Arena, A., Blarzino, C., Cassano, T., Butterfield, D. A., Domenico, F. D., Marzia Perluigi, A., & Barone, E. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.02.003 · Cited by 57 · see citing works
Self-citationPerspectives on Oxidative Stress in Alzheimer’s Disease and Predictions of Future Research Emphases
Butterfield, D. A. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179912 · Cited by 57 · see citing works
Self-citationDisturbance of redox homeostasis in Down Syndrome: Role of iron dysmetabolism
Barone, E., Arena, A., Head, E., Butterfield, D. A., & Marzia Perluigi, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.07.009 · Cited by 53 · see citing works
Self-citationSalerno, L., Floresta, G., Ciaffaglione, V., Gentile, D., Margani, F., Turnaturi, R., Rescifina, A., & Pittalà, V. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.027 · Cited by 54 · see citing works
Nitric Oxide Homeostasis in Neurodegenerative Diseases
Hannibal, L. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921101250 · Cited by 51 · see citing works
The Pathophysiology of Heme in the Brain
Gozzelino, R. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921103304 · Cited by 52 · see citing works
Can Co-Activation of Nrf2 and Neurotrophic Signaling Pathway Slow Alzheimer’s Disease?
Murphy, K. E., & Park, J. C. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061168 · Cited by 49 · see citing works
Regenerative effects of heme oxygenase metabolites on neuroinflammatory diseases
Lee, H., & Choi, Y. K. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010078 · Cited by 47 · see citing works
Type 2 Diabetes and Alzheimer’s Disease: The Emerging Role of Cellular Lipotoxicity
Marrano, N., Biondi, G., Borrelli, A., Rella, M., Zambetta, T., Gioia, L. D., Caporusso, M., Logroscino, G., Perrini, S., Giorgino, F., et al. (2023) · Biomolecules · doi:10.3390/biom13010183 · Cited by 44 · see citing works
Marzia Perluigi, A., Tramutola, A., Pagnotta, S. E., Barone, E., & Butterfield, D. A. (2020) · Antioxidants · doi:10.3390/antiox9090779 · Cited by 43 · see citing works
Self-citationLópez‐Pingarrón, L., Almeida, H., Soria-Aznar, M., Reyes-Gonzales, M. C., Rodríguez-Moratinos, A. B., Muñoz‐Hoyos, A., & García, J. J. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45040232 · Cited by 40 · see citing works
Increased bilirubin levels in de novo Parkinson's disease
Moccia, M., Picillo, M., Erro, R., Longo, K., Amboni, M., Santangelo, G., Palladino, R., Allocca, R., Caporale, O., Triassi, M., et al. (2015) · European Journal of Neurology · doi:10.1111/ene.12688 · Cited by 40 · see citing works
Triplett, J. C., Swomley, A. M., Cai, J., Klein, J. B., & Butterfield, D. A. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150417 · Cited by 39 · see citing works
Self-citationCimini, F. A., Arena, A., Barchetta, I., Tramutola, A., Ceccarelli, V., Lanzillotta, C., Fontana, M., Bertoccini, L., Leonetti, F., Capoccia, D., et al. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.02.021 · Cited by 39 · see citing works
Self-citationComprehensive Overview of Alzheimer’s Disease: Etiological Insights and Degradation Strategies
Singh, M. K., Shin, Y., Ju, S., Han, S., Kim, S. S., & Kang, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136901 · Cited by 41 · see citing works
Miralem, T., Lerner‐Marmarosh, N., Gibbs, P., Jenkins, J. L., Heimiller, C., & Maines, M. D. (2016) · The FASEB Journal · doi:10.1096/fj.201600330rr · Cited by 38 · see citing works
Heme Oxygenase-1 in Central Nervous System Malignancies
Sferrazzo, G., Rosa, M. D., Barone, E., Volti, G. L., Musso, N., Tibullo, D., & Barbagallo, I. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051562 · Cited by 36 · see citing works
Self-citationThe Role of Bilirubin and the Other “Yellow Players” in Neurodegenerative Diseases
Jayanti, S. D., Vı́tek, L., Tiribelli, C., & Gazzin, S. (2020) · Antioxidants · doi:10.3390/antiox9090900 · Cited by 37 · see citing works
Ammonia-induced miRNA expression changes in cultured rat astrocytes
Oenarto, J., Karababa, A., Castoldi, M., Bidmon, H. J., Görg, B., & Häussinger, D. (2016) · Scientific Reports · doi:10.1038/srep18493 · Cited by 35 · see citing works
Wang, L., Yokoyama, K. K., Lin, C., Chen, T.-Y., Hsiao, H.-W., Chiang, P.-C., & Hsu, C. (2016) · Scientific Reports · doi:10.1038/srep26358 · Cited by 34 · see citing works
Cerebrospinal fluid analysis in Alzheimer’s disease: technical issues and future developments
Lista, S., Zetterberg, H., Dubois, B., Blennow, K., & Hampel, H. J. (2014) · Journal of Neurology · doi:10.1007/s00415-014-7366-z · Cited by 33 · see citing works
Ge, X., Liu, Z., Hou, Q., Huang, L., Zhou, Y., Li, D., Huang, S., Luo, X., Lv, Y., Li, L., et al. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113683 · Cited by 32 · see citing works
Bilirubin and inflammation in neurodegenerative and other neurological diseases
Jayanti, S. D., Moretti, R., Tiribelli, C., & Gazzin, S. (2020) · Neuroimmunology and Neuroinflammation · doi:10.20517/2347-8659.2019.14 · Cited by 32 · see citing works
Kurucz, A., Bombicz, M., Kiss, R., Priksz, D., Varga, B., Hortobágyi, T., Trencsényi, G., Szabó, R., Pósa, A., Gesztelyi, R., et al. (2018) · BioMed Research International · doi:10.1155/2018/7212861 · Cited by 32 · see citing works
Huang, S., Meng, N., Liu, Z., Guo, L., Dong, L., Li, B., & Ye, Q. (2018) · Nutrients · doi:10.3390/nu10070926 · Cited by 31 · see citing works
The compensatory antioxidant response system with a focus on neuroprogressive disorders
Morris, G., Puri, B. K., Walker, A. J., Berk, M., Walder, K. R., Bortolasci, C. C., Marx, W., Carvalho, A. F., & Maes, M. H. J. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109708 · Cited by 31 · see citing works
Sung, H. Y., Choi, B., Jeong, J. H., Kong, K. A., Hwang, J., & Ahn, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153156 · Cited by 30 · see citing works
Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?
Barone, E., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.013 · Cited by 30 · see citing works
Self-citationLanzillotta, C., Tramutola, A., Lanzillotta, S., Greco, V., Pagnotta, S. E., Sanchini, C., Angelantonio, S. D., Forte, E., Rinaldo, S., Paone, A., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103221 · Cited by 29 · see citing works
Self-citationAli, T. A., Mohamed, G. G., & Farag, A. H. (2015) · International Journal of Electrochemical Science · doi:10.1016/s1452-3981(23)05014-9 · Cited by 29 · see citing works
Sun, L. V., Zhang, J., Chen, W., Chen, Y., Zhang, X., Yang, M., Xiao, M., Ma, F., Yao, Y., Ye, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13210 · Cited by 23 · see citing works
The Emerging Role of Ferroptosis in Sepsis, Opportunity or Challenge?
Huang, Q., Ding, Y., Fang, C., Wang, H., & Kong, L. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s419993 · Cited by 26 · see citing works
Bhardwaj, M., Deshmukh, R. R., Kaundal, M., & Reddy, B. V. K. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.12.037 · Cited by 26 · see citing works
Bilirubin and Redox Stress in Age-Related Brain Diseases
Llido, J. P., Jayanti, S. D., Tiribelli, C., & Gazzin, S. (2023) · Antioxidants · doi:10.3390/antiox12081525 · Cited by 25 · see citing works
Heath, L. M., Earls, J. C., Magis, A. T., Kornilov, S. A., Lovejoy, J. C., Funk, C. C., Rappaport, N., Logsdon, B. A., Mangravite, L. M., Kunkle, B. W., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-09825-2 · Cited by 24 · see citing works
Chen, L., Chang, S., Zhao, L., Li, B., Zhang, S., Yun, C., Wu, X. M., Meng, J., Li, G., Guo, S., et al. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.14095 · Cited by 24 · see citing works
Acrocomia aculeata(Jacq.) Lodd. ex Mart. Leaves Increase SIRT1 Levels and Improve Stress Resistance
Monteiro‐Alfredo, T., Matafome, P. N., Iacia, B. P., Antunes, K. Á., dos Santos, J. M., da Cunha, J. D. S. M., Oliveira, S., Oliveira, A. S., Campos, J. F., Magalhães, M., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5238650 · Cited by 23 · see citing works
Bilirubin: A Promising Therapy for Parkinson’s Disease
Jayanti, S. D., Moretti, R., Tiribelli, C., & Gazzin, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126223 · Cited by 22 · see citing works
Mumtaz, I., Ayaz, M. O., Khan, M. S., Manzoor, U., Ganayee, M. A., Bhat, A. Q., Dar, G. H., Alghamdi, B. S. A., Hashem, A. M., Dar, M. J., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.977411 · Cited by 22 · see citing works
Takemoto, J. Y., Chang, C. T., Chen, D., & Hinton, G. W. (2019) · Israel Journal of Chemistry · doi:10.1002/ijch.201800167 · Cited by 22 · see citing works
Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain
Paul, B. D., & Pieper, A. A. (2024) · Biomolecules · doi:10.3390/biom14020155 · Cited by 21 · see citing works
Lanzillotta, C., Zuliani, I., Vasavda, C., Snyder, S. H., Paul, B. D., Marzia Perluigi, A., Domenico, F. D., & Barone, E. (2020) · Antioxidants · doi:10.3390/antiox9080671 · Cited by 20 · see citing works
Self-citationLi, C., Cui, K., Zhu, X., Wang, S., Yang, Q., & Fang, G. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1453582 · Cited by 22 · see citing works
Zhou, J., Terluk, M. R., Basso, L. M., Mishra, U. R., Orchard, P. J., Cloyd, J. C., Schröder, H., & Kartha, R. V. (2020) · Biomedicines · doi:10.3390/biomedicines8080240 · Cited by 19 · see citing works
Barone, E., Cenini, G., Domenico, F. D., Noel, T. J., Wang, C., Marzia Perluigi, A., Clair, D. K. S., & Butterfield, D. A. (2015) · Journal of Neuroscience Research · doi:10.1002/jnr.23627 · Cited by 19 · see citing works
Self-citationHeme oxygenase-1 induction by hemin prevents oxidative stress-induced acute cholestasis in the rat
Martín, P. L., Ceccatto, P., Razori, M. V., Francés, D. E., Arriaga, S. M. M., Pisani, G. B., Martínez, A. I., Pozzi, E. J. S., Roma, M. G., & Basiglio, C. L. (2018) · Clinical Science · doi:10.1042/cs20180675 · Cited by 19 · see citing works
Ginseng and heme oxygenase-1: The link between an old herb and a new protective system
Carota, G., Raffaele, M., Sorrenti, V., Salerno, L., Pittalà, V., & Intagliata, S. (2019) · Fitoterapia · doi:10.1016/j.fitote.2019.104370 · Cited by 19 · see citing works
Ceccarelli, V., Barchetta, I., Cimini, F. A., Bertoccini, L., Chiappetta, C., Capoccia, D., Carletti, R., Cristofano, C. D., Silecchia, G., Fontana, M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239091 · Cited by 19 · see citing works
Self-citationButterfield, D. A., Debra Boyd-kimball, A., & Reed, T. T. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0214 · Cited by 19 · see citing works
Self-citationMounier, N. M., Wahdan, S. A., Gad, A. M., & Azab, S. S. (2021) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-021-02081-7 · Cited by 18 · see citing works
RetractedKataura, T., Saiki, S., Ishikawa, K., Akamatsu, W., Sasazawa, Y., Hattori, N., & Imoto, M. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.14997 · Cited by 17 · see citing works
RGFP966 exerts neuroprotective effect via HDAC3/Nrf2 pathway after surgical brain injury in rats
Gu, H.-P., Wu, X.-F., Gong, Y., Wu, M., Shi, M.-Y., Sun, Y.-M., Dang, B., & Chen, G. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e18160 · Cited by 16 · see citing works
Cimini, F. A., Marzia Perluigi, A., Barchetta, I., Cavallo, M. G., & Barone, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105574 · Cited by 14 · see citing works
Self-citationAssociation between serum bilirubin concentration and Parkinson's disease: a meta-analysis
Jin, J., Liu, X., Li, M., Bai, X., & Xie, A. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001300 · Cited by 13 · see citing works
Cimini, F. A., Barchetta, I., Zuliani, I., Pagnotta, S. E., Bertoccini, L., Dule, S., Zampieri, M., Reale, A., Baroni, M. G., Cavallo, M. G., et al. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119913 · Cited by 13 · see citing works
Self-citationResearch progress on the biosynthesis, activity and application of natural tetrapyrrole compounds
Hu, M., Lu, X., Qin, S., Liu, R., Wang, Q., Lu, C., & Li, W. (2024) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2024.105736 · Cited by 12 · see citing works
Bilirubin neurotoxicity: a narrative review on long lasting, insidious, and dangerous effects
Brites, D. M. T. O., & Silva, R. F. M. (2021) · Pediatric Medicine · doi:10.21037/pm-21-37 · Cited by 12 · see citing works
Kim, J., Cho, C. H., Hahn, H., Choi, S., & Cho, S. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.10.010 · Cited by 12 · see citing works
Mhillaj, E., Cuomo, V., & Mancuso, C. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000296 · Cited by 11 · see citing works
Self-citationXing, S., Shen, D., Chen, C., Wu, B., & Chi, H. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4732 · Cited by 11 · see citing works
Amyloid β perturbs elevated heme flux induced with neuronal development
Vidal, C., Daescu, K., FitzGerald, K. E., Starokadomska, A., Борисович, Б. И., & Li, Z. (2019) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.12.003 · Cited by 11 · see citing works
- Authors
- Barone, E., Di Domenico, F., Mancuso, C., & Butterfield, D. A.
- Affiliations
- University of Kentucky (US)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Butterfield, D. Allan
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 62
- Pages
- 144-159
- ISSN
- 0969-9961 (ISSN-L)
- PMC
- PMC3877707
- OpenAlex
- W2082990108
- Cited by
- 127
- References
- 227
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 15 · 2019: 12 · 2018: 10 · 2017: 8 · 2016: 8 · 2015: 18 · 2014: 11 · 2013: 1 · 2012: 1
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Funders
- NIH (AG-05119)
- Fondi Ateneo
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, heme oxygenase-1, biliverdin reductase A, biliverdin, bilirubin, carbon monoxide, ferrous iron, oxidative stress, nitrosative stress, neuroprotection, neurotoxicity, amnestic mild cognitive impairment, post-translational modification, stress response
- MeSH terms
- Alzheimer Disease, Animals, Brain, Heme Oxygenase (Decyclizing), Humans, Models, Neurological, Oxidative Stress, Oxidoreductases Acting on CH-CH Group Donors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
