Kastan, Michael B.

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 3,466

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 3,047

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,836

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Canman, C. E., Lim, D.-S., Cimprich, K. A., Taya, Y., Tamai, K., Sakaguchi, K., Appella, E., Kastan, M. B., & Siliciano, J. D. (1998) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,042

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

Zaki, M. H., Boyd, K. L., Vogel, P., Kastan, M. B., Lamkanfi, M., & Kanneganti, T.-D. (2010) · Immunity

Inflammasome and immune disordersInflammatory Bowel Disease

Cited by 989

DNA damage induces phosphorylation of the amino terminus of p53

Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B. (1997) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 818

Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members

Kim, S.-T., Lim, D.-S., Canman, C. E., & Kastan, M. B. (1999) · Journal of Biological Chemistry

DNA Repair MechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 810

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 786

The many substrates and functions of ATM.

Kastan, M. B., & Lim, D.-S. (2000) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 779

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

Maya, R., Balass, M., Kim, S.-T., Shkedy, D., Leal, J.-F. M., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., et al. (2001) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 731

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and Therapy

Cited by 717

Autophagy Links Inflammasomes to Atherosclerotic Progression

Razani, B., Feng, C., Coleman, T., Emanuel, R., Wen, H., Hwang, S., Ting, J. P., Virgin, H. W., Kastan, M. B., & Semenkovich, C. F. (2012) · Cell Metabolism

Atherosclerosis and Cardiovascular DiseasesAutophagy in Disease and Therapy

Cited by 601

The DNA Damage Response: Implications for Tumor Responses to Radiation and Chemotherapy

Goldstein, M., & Kastan, M. B. (2015) · Annual Review of Medicine

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 590

Initiating Cellular Stress Responses

Bakkenist, C. J., & Kastan, M. B. (2004) · Cell

DNA Repair MechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 544

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Berkovich, E., Monnat, R. J., & Kastan, M. B. (2007) · Nature Cell Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 477

Mitochondrial dysfunction in ataxia-telangiectasia

Valentin-Vega, Y. A., MacLean, K. H., Tait-Mulder, J., Milasta, S., Steeves, M., Dorsey, F. C., Cleveland, J. L., Green, D. R., & Kastan, M. B. (2012) · Blood

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 365

ATM: Genome stability, neuronal development, and cancer cross paths

Shiloh, Y., & Kastan, M. B. (2001) · Advances in Cancer Research

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 299

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

Zhang, J., Kim, J., Alexander, A., Cai, S., Tripathi, D. N., Dere, R., Tee, A. R., Tait-Mulder, J., Di Nardo, A., Han, J. M., et al. (2013) · Nature Cell Biology

Tuberous Sclerosis Complex ResearchPI3K/AKT/mTOR signaling in cancer

Cited by 258

Perspectives from man’s best friend: National Academy of Medicine’s Workshop on Comparative Oncology

LeBlanc, A. K., Breen, M., Choyke, P., Dewhirst, M., Fan, T. M., Gustafson, D. L., Helman, L. J., Kastan, M. B., Knapp, D. W., Levin, W. J., et al. (2016) · Science Translational Medicine

Veterinary Oncology ResearchScience, Research, and Medicine

Cited by 147

5′-3′-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage

Chen, J., & Kastan, M. B. (2010) · Genes & Development

Cancer-related Molecular PathwaysRNA Research and Splicing

Cited by 127

Identification of a DNA Damage–Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers

Chen, J., Crutchley, J., Zhang, D., Owzar, K., & Kastan, M. B. (2017) · Cancer Discovery

RNA Research and SplicingTelomeres, Telomerase, and Senescence

Cited by 93

Disappearance of the Telomere Dysfunction-Induced Stress Response in Fully Senescent Cells

Bakkenist, C. J., Drissi, R., Wu, J., Kastan, M. B., & Dome, J. S. (2004) · Cancer Research

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 68