A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

Zhang, Jiangwei; Kim, Jinhee; Alexander, Angela; Cai, Shengli; Tripathi, Durga Nand; Dere, Ruhee; Tee, Andrew R.; Tait-Mulder, Jacqueline; Di Nardo, Alessia; Han, Juliette M.; Kwiatkowski, Erica; Dunlop, Elaine A.; Dodd, Kayleigh M.; Folkerth, Rebecca D.; Faust, Phyllis L.; Kastan, Michael B.; Sahin, Mustafa; Walker, Cheryl Lyn

doi:10.1038/ncb2822

A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We report that the tuberous sclerosis complex (TSC) signalling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). TSC1 and TSC2 were boun…