Dubus, Pierre

Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice

Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell

Pancreatic and Hepatic Oncology ResearchPancreatitis Pathology and Treatment

Cited by 1,224

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

Malumbres, M., Sotillo, R., Santamarı́a, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., & Barbacid, M. (2004) · Cell

Cancer-related Molecular PathwaysMicrotubule and mitosis dynamics

Cited by 793

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

Rane, S. G., Dubus, P., Mettus, R. V., Galbreath, E. J., Boden, G., Reddy, E. P., & Barbacid, M. (1999) · Nature Genetics

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 700

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

Briot, A., Deraison, C., Lacroix, M., Bonnart, C., Robin, A., Besson, C., Dubus, P., & Hovnanian, A. (2009) · Journal of Experimental Medicine

Dermatology and Skin DiseasesSkin and Cellular Biology Research

Cited by 504

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma

Puyol, M., Martín, A., Dubus, P., Mulero, F., Pizcueta, P., Khan, G., Guerra, C., Santamaría, D., & Barbacid, M. (2010) · Cancer Cell

Telomeres, Telomerase, and SenescenceCancer-related Molecular Pathways

Cited by 415

c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma

Blasco, R. B., Francoz, S., Santamaría, D., Cañamero, M., Dubus, P., Charron, J., Baccarini, M., & Barbacid, M. (2011) · Cancer Cell

Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK Pathways

Cited by 302

Wide spectrum of tumors in knock‐in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

Sotillo, R., Dubus, P., Martn, J., de la Cueva, E., Ortega, S., Malumbres, M., & Barbacid, M. (2001) · The EMBO Journal

Cancer-related Molecular PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 208

Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number

Martín, J., Hunt, S. L., Dubus, P., Sotillo, R., Néhmé-Pélluard, F., Magnuson, M. A., Parlow, A. F., Malumbres, M., Ortega, S., & Barbacid, M. (2003) · Oncogene

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 122

Loss of epidermal hypoxia-inducible factor-1α accelerates epidermal aging and affects re-epithelialization in human and mouse

Rezvani, H. R., Ali, N., Serrano-Sanchez, M., Dubus, P., Varon, C., Ged, C., Pain, C., Cario-André, M., Seneschal, J., Taïeb, A., et al. (2011) · Journal of Cell Science

Skin and Cellular Biology ResearchSkin Protection and Aging

Cited by 90

DNA methylation protects cancer cells against senescence

Chen, X., Yamaguchi, K., Rodgers, B., Goehrig, D., Vindrieux, D., Lahaye, X., Nolot, M., Ferry, L., Martin, N., Dubus, P., et al. (2024) · Nature Communications

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 17

DNA methylation protects cancer cells against senescence

Chen, X., Yamaguchi, K., Rodgers, B., Goehrig, D., Vindrieux, D., Lahaye, X., Nolot, M., Ferry, L., Lanciano, S., Martin, N., et al. (2025) · Nature Communications

Telomeres, Telomerase, and SenescenceEpigenetics and DNA Methylation

Cited by 17