Villeda, Saul A.

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,763

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice

Villeda, S. A., Plambeck, K. E., Middeldorp, J., Castellano, J. M., Mosher, K. I., Luo, J., Smith, L. K., Bieri, G., Lin, K., Berdnik, D., et al. (2014) · Nature Medicine

Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Cited by 1,081

Exerkines in health, resilience and disease

Chow, L. S., Gerszten, R. E., Taylor, J. M., Pedersen, B. K., van Praag, H., Trappe, S., Febbraio, M. A., Galis, Z. S., Gao, Y., Haus, J. M., et al. (2022) · Nature Reviews Endocrinology

Exercise and Physiological ResponsesAdipokines, Inflammation, and Metabolic Diseases

Cited by 927

FoxO3 Regulates Neural Stem Cell Homeostasis

Renault, V. M., Rafalski, V. A., Morgan, A. A., Salih, D. A. M., Brett, J. O., Webb, A. E., Villeda, S. A., Thekkat, P. U., Guillerey, C., Denko, N. C., et al. (2009) · Cell Stem Cell

Neurogenesis and neuroplasticity mechanismsFOXO transcription factor regulation

Cited by 586

β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis

Smith, L. K., He, Y., Park, J.-S., Bieri, G., Snethlage, C. E., Lin, K., Gontier, G., Wabl, R., Plambeck, K. E., Udeochu, J., et al. (2015) · Nature Medicine

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 500

Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain

Horowitz, A. M., Fan, X., Bieri, G., Smith, L. K., Sanchez-Diaz, C. I., Schroer, A. B., Gontier, G., Casaletto, K. B., Kramer, J. H., Williams, K. E., et al. (2020) · Science

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 496

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

Luo, J., Elwood, F., Britschgi, M., Villeda, S., Zhang, H., Ding, Z., Zhu, L., Alabsi, H., Getachew, R., Narasimhan, R., et al. (2013) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular Disturbances

Cited by 262

Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner

Deczkowska, A., Matcovitch-Natan, O., Tsitsou-Kampeli, A., Ben-Hamo, S., Dvir-Szternfeld, R., Spinrad, A., Singer, O., David, E., Winter, D. R., Smith, L. K., et al. (2017) · Nature Communications

Neuroinflammation and Neurodegeneration Mechanismsinterferon and immune responses

Cited by 260

Platelet factors attenuate inflammation and rescue cognition in ageing

Schroer, A. B., Ventura, P. B., Sucharov, J., Misra, R., Chui, M. K. K., Bieri, G., Horowitz, A. M., Smith, L. K., Encabo, K., Tenggara, I., et al. (2023) · Nature

Neuroinflammation and Neurodegeneration MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 252

Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain

Gontier, G., Iyer, M., Shea, J. M., Bieri, G., Wheatley, E. G., Ramalho-Santos, M., & Villeda, S. A. (2018) · Cell Reports

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 197

Blood-to-brain communication in aging and rejuvenation

Bieri, G., Schroer, A. B., & Villeda, S. A. (2023) · Nature Neuroscience

Genetics, Aging, and Longevity in Model OrganismsBarrier Structure and Function Studies

Cited by 156

Preclinical Assessment of Young Blood Plasma for Alzheimer Disease

Middeldorp, J., Lehallier, B., Villeda, S. A., Miedema, S. S. M., Evans, E., Czirr, E., Zhang, H., Luo, J., Stan, T., Mosher, K. I., et al. (2016) · JAMA Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 153

Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain

Wheatley, E. G., Albarran, E., White, C. W., Bieri, G., Sanchez-Diaz, C., Pratt, K., Snethlage, C. E., Ding, J. B., & Villeda, S. A. (2019) · Current Biology

Glycosylation and Glycoproteins ResearchMemory and Neural Mechanisms

Cited by 107

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

Ho, T. T., Dellorusso, P. V., Verovskaya, E. V., Bakker, S. T., Flach, J., Smith, L. K., Ventura, P. B., Lansinger, O. M., Hérault, A., Zhang, S. Y., et al. (2021) · Journal of Experimental Medicine

Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

Cited by 101

Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation

White, C. W., Fan, X., Maynard, J. C., Wheatley, E. G., Bieri, G., Couthouis, J., Burlingame, A. L., & Villeda, S. A. (2020) · Proceedings of the National Academy of Sciences

Neurogenesis and neuroplasticity mechanismsGlycosylation and Glycoproteins Research

Cited by 98

Microglia communication: parallels between aging and Alzheimer's disease

Udeochu, J. C., Shea, J. M., & Villeda, S. A. (2016) · Clinical and Experimental Neuroimmunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 87

The aged hematopoietic system promotes hippocampal‐dependent cognitive decline

Smith, L. K., Verovskaya, E., Bieri, G., Horowitz, A. M., von Ungern‐Sternberg, S. N. I., Lin, K., Seizer, P., Passegué, E., & Villeda, S. A. (2020) · Aging Cell

Neurogenesis and neuroplasticity mechanismsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 31