Microglia communication: parallels between aging and Alzheimer's disease

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Microglia: a sensor for pathological events in the CNS

Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396 · see citing works

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works

Complement: a key system for immune surveillance and homeostasis

Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · cited 1× · see citing works

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · cited 10× · see citing works

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works

<i>TREM2</i> Variants in Alzheimer's Disease

Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works

Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor

Parkhurst, C. N., Yang, G., Ninan, I., Savas, J. N., Yates, J. R., Lafaille, J. J., Hempstead, B. L., Littman, D. R., & Gan, W.-B. (2013) · Cell · doi:10.1016/j.cell.2013.11.030 · Cited by 2,599 · see citing works

Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211103 · Cited by 2,558 · see citing works

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

the European Alzheimer's Disease Initiative Investigators, Lambert, J.-C., Heath, S., Even, G., Campion, D., Sleegers, K., Hiltunen, M., Combarros, O., Zelenika, D., Bullido, M. J., et al. (2009) · Nature Genetics · doi:10.1038/ng.439 · Cited by 2,234 · see citing works

Immune attack: the role of inflammation in Alzheimer disease

Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

Zhang, B., Gaiteri, C., Bodea, L.-G., Wang, Z., McElwee, J., Podtelezhnikov, A. A., Zhang, C., Xie, T., Tran, L., Dobrin, R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.030 · Cited by 1,657 · see citing works

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

Sierra, A., Encinas, J. M., Deudero, J. J. P., Chancey, J. H., Enikolopov, G., Overstreet-Wadiche, L. S., Tsirka, S. E., & Maletic-Savatic, M. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.08.014 · Cited by 1,622 · see citing works

Neural plasticity in the ageing brain

Burke, S. N., & Barnes, C. A. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1809 · Cited by 1,600 · see citing works

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Asai, H., Ikezu, S., Tsunoda, S., Medalla, M., Luebke, J., Haydar, T., Wolozin, B., Butovsky, O., Kügler, S., & Ikezu, T. (2015) · Nature Neuroscience · doi:10.1038/nn.4132 · Cited by 1,591 · see citing works

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542 · see citing works

The microglial sensome revealed by direct RNA sequencing

Hickman, S. E., Kingery, N. D., Ohsumi, T. K., Borowsky, M. L., Wang, L.-C., Means, T. K., & El Khoury, J. (2013) · Nature Neuroscience · doi:10.1038/nn.3554 · Cited by 1,511 · see citing works

Alzheimer’s disease β-amyloid peptides are released in association with exosomes

Rajendran, L., Honsho, M., Zahn, T. R., Keller, P., Geiger, K. D., Verkade, P., & Simons, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603838103 · Cited by 1,343 · see citing works

Microglial brain region-dependent diversity and selective regional sensitivities to aging

Grabert, K., Michoel, T., Karavolos, M. H., Clohisey, S., Baillie, J. K., Stevens, M. P., Freeman, T. C., Summers, K. M., & McColl, B. W. (2016) · Nature Neuroscience · doi:10.1038/nn.4222 · Cited by 1,151 · see citing works

Microglial priming in neurodegenerative disease

Perry, V. H., & Holmes, C. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.38 · Cited by 1,127 · see citing works

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease

Itagaki, S., McGeer, P. L., Akiyama, H., Zhu, S., & Selkoe, D. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90115-x · Cited by 940 · see citing works

Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J., Fredlund, E., Ringnér, M., Mörgelin, M., Bourseau-Guilmain, E., Bengzon, J., & Belting, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220998110 · Cited by 939 · see citing works

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 812 · see citing works

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

Condello, C., Yuan, P., Schain, A., & Grutzendler, J. (2015) · Nature Communications · doi:10.1038/ncomms7176 · Cited by 718 · see citing works

Microglia derived from aging mice exhibit an altered inflammatory profile

Sierra, A., Gottfried‐Blackmore, A. C., McEwen, B. S., & Bulloch, K. (2007) · Glia · doi:10.1002/glia.20468 · Cited by 688 · see citing works

The development and maintenance of resident macrophages

Perdiguero, E. G., & Geissmann, F. (2015) · Nature Immunology · doi:10.1038/ni.3341 · Cited by 634 · see citing works

CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity

Rogers, J. T., Morganti, J. M., Bachstetter, A. D., Hudson, C. E., Peters, M. M., Grimmig, B. A., Weeber, E. J., Bickford, P. C., & Gemma, C. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3667-11.2011 · Cited by 624 · see citing works

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

Holtman, I. R., Raj, D. D., Miller, J. A., Schaafsma, W., Yin, Z., Brouwer, N., Wes, P. D., Möller, T., Orre, M., Kamphuis, W., et al. (2015) · Acta Neuropathologica Communications · doi:10.1186/s40478-015-0203-5 · Cited by 619 · see citing works

Microglial dysfunction in brain aging and Alzheimer's disease

Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618 · see citing works

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 591 · see citing works

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

Initiative, T. A. D. N., Bradshaw, E. M., Chibnik, L. B., Keenan, B. T., Ottoboni, L., Raj, T., Tang, A., Rosenkrantz, L. L., Imboywa, S., Lee, M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3435 · Cited by 570 · see citing works

Acid sphingomyelinase activity triggers microparticle release from glial cells

Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., Saglietti, L., Schuchman, E. H., Furlan, R., Clementi, E., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.45 · Cited by 550 · see citing works

Sublime Microglia: Expanding Roles for the Guardians of the CNS

Salter, M. W., & Beggs, S. (2014) · Cell · doi:10.1016/j.cell.2014.06.008 · Cited by 531 · see citing works

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

Bolmont, T., Haiss, F., Eicke, D., Radde, R., Mathis, C. A., Klunk, W. E., Kohsaka, S., Jucker, M., & Calhoun, M. E. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4814-07.2008 · Cited by 526 · see citing works

Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex

Sipe, G. O., Lowery, Tremblay, M.-È., Kelly, E. A., Lamantia, C. E., & Majewska, A. K. (2016) · Nature Communications · doi:10.1038/ncomms10905 · Cited by 512 · see citing works

Age-related alterations in the dynamic behavior of microglia

Damani, M. R., Zhao, L., Fontainhas, A. M., Amaral, J., Fariss, R. N., & Wong, W. T. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00660.x · Cited by 504 · see citing works

Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Cribbs, D. H., Berchtold, N. C., Perreau, V., Coleman, P. D., Rogers, J., Tenner, A. J., & Cotman, C. W. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-179 · Cited by 499 · see citing works

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

Dinkins, M. B., Dasgupta, S., Wang, G., Zhu, G., & Bieberich, E. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.02.012 · Cited by 494 · see citing works

Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology

Krabbe, G., Halle, A., Matyash, V., Rinnenthal, J. L., Eom, G. D., Bernhardt, U., Miller, K. R., Prokop, S., Kettenmann, H., & Heppner, F. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060921 · Cited by 478 · cited 2× · see citing works

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2.

Molina, H. D., Holers, V. M., Li, B., Fung, Y., Mariathasan, S., Goellner, J. J., Strauss‐Schoenberger, J., Karr, R. W., & Chaplin, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3357 · Cited by 465 · see citing works

Microglia: actively surveying and shaping neuronal circuit structure and function

Wake, H., Moorhouse, A. J., Miyamoto, A., & Nabekura, J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.11.007 · Cited by 448 · see citing works

A Dramatic Increase of C1q Protein in the CNS during Normal Aging

Stephan, A. H., Madison, D. V., Mateos, J. M., Fraser, D. A., Lovelett, E. A., Coutellier, L., Kim, L., Tsai, H.-H., Huang, E. J., Rowitch, D. H., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1333-13.2013 · Cited by 423 · see citing works

Complement in the brain

Veerhuis, R., Nielsen, H. M., & Tenner, A. J. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.04.003 · Cited by 420 · see citing works

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.003 · Cited by 411 · see citing works

Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction

Orre, M., Kamphuis, W., Osborn, L. M., Jansen, A. H. P., Kooijman, L., Bossers, K., & Hol, E. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.004 · Cited by 394 · see citing works

Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.

(2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-27 · Cited by 393 · see citing works

Complement<i>C3</i>-Deficient Mice Fail to Display Age-Related Hippocampal Decline

Shi, Q., Colodner, K. J., Matousek, S. B., Merry, K., Hong, S., Kenison, J. E., Frost, J. L., Le, K. X., Li, S., Dodart, J.-C., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.1698-15.2015 · Cited by 368 · see citing works

Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective

Butovsky, O., Talpalar, A. E., Ben‐Yaakov, K., & Schwartz, M. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.03.005 · Cited by 368 · see citing works

Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism

Potolicchio, I., Carven, G. J., Xu, X., Stipp, C., Riese, R. J., Stern, L. J., & Santambrogio, L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2237 · Cited by 365 · see citing works

Adenosine A2A receptor mediates microglial process retraction

Orr, A. G., Orr, A. L., Traynelis, S. F., Gross, R. E., & Traynelis, S. F. (2009) · Nature Neuroscience · doi:10.1038/nn.2341 · Cited by 361 · see citing works

Factors regulating microglia activation

Kierdorf, K., & Prinz, M. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00044 · Cited by 360 · see citing works

Absence of C1q Leads to Less Neuropathology in Transgenic Mouse Models of Alzheimer's Disease

Fonseca, M. I., Zhou, J., Botto, M., & Tenner, A. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0901-04.2004 · Cited by 345 · see citing works

Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice

Crain, J. M., Nikodémová, M., & Watters, J. J. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23242 · Cited by 335 · see citing works

<i>beta</i>-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

Jiang, H., Burdick, D., Glabe, C. G., Cotman, C. W., & Tenner, A. J. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.10.5050 · Cited by 330 · see citing works

Increased interleukin-6 expression by microglia from brain of aged mice

Ye, S.-M., & Johnson, R. W. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00217-3 · Cited by 326 · see citing works

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

Maier, M., Peng, Y., Jiang, L., Seabrook, T. J., Carroll, M. C., & Lemere, C. A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0829-08.2008 · Cited by 323 · see citing works

Homeostatic and injury‐induced microglia behavior in the aging brain

Hefendehl, J. K., Neher, J. J., Sühs, R. B., Kohsaka, S., Skodras, A., & Jucker, M. (2014) · Aging Cell · doi:10.1111/acel.12149 · Cited by 319 · see citing works

Neuroinflammation in the normal aging hippocampus

Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.007 · Cited by 316 · see citing works

Role of complement in neurodegeneration and neuroinflammation

Bonifati, D. M., & Kishore, U. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.007 · Cited by 310 · see citing works

Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices

Tremblay, M., Zettel, M. L., Ison, J. R., Allen, P. D., & Majewska, A. K. (2012) · Glia · doi:10.1002/glia.22287 · Cited by 309 · see citing works

Neuroglial cells in the cerebral cortex of rats from young adulthood to old age: an electron microscope study

Vaughan, D. W., & Peters, A. (1974) · Journal of Neurocytology · doi:10.1007/bf01098730 · Cited by 301 · see citing works

Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

Cossetti, C., Iraci, N., Mercer, T. R., Leonardi, T., Alpi, E., Drago, D., Alfaro‐Cervelló, C., Saini, H. K., Davis, M. P. A., Schaeffer, J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.020 · Cited by 301 · see citing works

Age‐dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

Xu, H., Chen, M., Manivannan, A., Lois, N., & Forrester, J. V. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00351.x · Cited by 277 · see citing works

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β

Cho, S.-H., Chen, J. A., Sayed, F., Ward, M. E., Gao, F., Nguyen, T. A., Krabbe, G., Sohn, P. D., Lo, I., Minami, S., et al. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2939-14.2015 · Cited by 275 · see citing works

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

Orre, M., Kamphuis, W., Osborn, L. M., Melief, J., Kooijman, L., Huitinga, I., Klooster, J., Bossers, K., & Hol, E. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.07.008 · Cited by 269 · see citing works

CX3CR1 Protein Signaling Modulates Microglial Activation and Protects against Plaque-independent Cognitive Deficits in a Mouse Model of Alzheimer Disease

Cho, S.-H., Sun, B., Zhou, Y., Kauppinen, T. M., Halabisky, B., Wes, P., Ransohoff, R. M., & Gan, L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254268 · Cited by 268 · see citing works

Toll-Like Receptor 2 Acts as a Natural Innate Immune Receptor to Clear Amyloid β_1–42and Delay the Cognitive Decline in a Mouse Model of Alzheimer's Disease

Richard, K. L., Filali, M., Préfontaine, P., & Rivest, S. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1146-08.2008 · Cited by 261 · see citing works

Extracellular vesicles and intercellular communication within the nervous system

Zappulli, V., Friis, K. P., Fitzpatrick, Z., Maguire, C. A., & Breakefield, X. O. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81134 · Cited by 252 · see citing works

The age-related attenuation in long-term potentiation is associated with microglial activation

Griffin, R., Nally, R., Nolan, Y., McCartney, Y., Linden, J., & Lynch, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04165.x · Cited by 246 · see citing works

The role of exosomes in the processing of proteins associated with neurodegenerative diseases

Vella, L. J., Sharples, R. A., Nisbet, R. M., Cappai, R., & Hill, A. F. (2007) · European Biophysics Journal · doi:10.1007/s00249-007-0246-z · Cited by 235 · see citing works

Impaired Synaptic Function in the Microglial KARAP/DAP12-Deficient Mouse

Roumier, A., Béchade, C., Poncer, J. C., Smalla, K., Tomasello, E., Vivier, É., Gundelfinger, E. D., Triller, A., & Bessis, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2251-04.2004 · Cited by 228 · see citing works

WNT signaling in activated microglia is proinflammatory

Halleskog, C., Mulder, J., Dahlström, J., Mackie, K., Hortobágyi, T., Tanila, H., Puli, L., Färber, K., Harkany, T., & Schulte, G. (2010) · Glia · doi:10.1002/glia.21081 · Cited by 216 · see citing works

Extracellular vesicles – Their role in the packaging and spread of misfolded proteins associated with neurodegenerative diseases

Coleman, B. M., & Hill, A. F. (2015) · Seminars in Cell &amp; Developmental Biology · doi:10.1016/j.semcdb.2015.02.007 · Cited by 208 · cited 1× · see citing works

The microglial activation state regulates migration and roles of matrix-dissolving enzymes for invasion

Lively, S. S., & Schlichter, L. C. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-75 · Cited by 208 · see citing works

Amyloid β and Amylin Fibrils Induce Increases in Proinflammatory Cytokine and Chemokine Production by THP‐1 Cells and Murine Microglia

Yates, S. L., Burgess, L. H., Kocsis‐Angle, J., Antal, J. M., Dority, M. D., Embury, P. B., Piotrkowski, A. M., & Brunden, K. R. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.0741017.x · Cited by 202 · see citing works

Lipopolysaccharide-induced interleukin (IL)-4 receptor-α expression and corresponding sensitivity to the M2 promoting effects of IL-4 are impaired in microglia of aged mice

Fenn, A. M., Henry, C. J., Huang, Y., Dugan, A., & Godbout, J. P. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.10.003 · Cited by 198 · see citing works

Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia

Bahrini, I., Song, J., Díez, D., & Hanayama, R. (2015) · Scientific Reports · doi:10.1038/srep07989 · Cited by 196 · see citing works

Complement activation by neurofibrillary tangles in Alzheimer's disease

Shen, Y., Lue, L.-F., Yang, L.-B., Roher, A., Kuo, Y.-M., Strohmeyer, R., Goux, W. J., Lee, V., Johnson, G. V. W., Webster, S. D., et al. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01842-0 · Cited by 185 · see citing works

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

Koizumi, S., Ohsawa, K., Inoue, K., & Kohsaka, S. (2013) · Glia · doi:10.1002/glia.22358 · Cited by 184 · see citing works

Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia

Fu, H., Liu, B., Frost, J. L., Hong, S., Jin, M., Ostaszewski, B., Shankar, G. M., Costantino, I. M., Carroll, M. C., Mayadas, T. N., et al. (2012) · Glia · doi:10.1002/glia.22331 · Cited by 180 · see citing works

The Extracellular Matrix and Cytokines Regulate Microglial Integrin Expression and Activation

Milner, R., & Campbell, I. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.7.3850 · Cited by 179 · see citing works

CD33 modulates TREM2: convergence of Alzheimer loci

Chan, G., White, C. C., Winn, P. A., Cimpean, M., Replogle, J. M., Glick, L. R., Cuerdon, N. E., Ryan, K. J., Johnson, K. A., Schneider, J. A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4126 · Cited by 162 · see citing works

Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

Johansson, J. U., Woodling, N. S., Wang, Q., Panchal, M., Liang, X., Trueba-Saiz, A., Brown, H. D., Mhatre, S. D., Loui, T., & Andreasson, K. I. (2015) · Journal of Clinical Investigation · doi:10.1172/jci77487 · Cited by 161 · see citing works

Microglia Demonstrate Age-Dependent Interaction with Amyloid-β Fibrils

Floden, A. M., & Combs, C. K. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101014 · Cited by 160 · see citing works

C1q-induced LRP1B and GPR6 Proteins Expressed Early in Alzheimer Disease Mouse Models, Are Essential for the C1q-mediated Protection against Amyloid-β Neurotoxicity

Benoit, M. E., Hernandez, M. X., Dinh, M. L., Benavente, F., Vasquez, O., & Tenner, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.400168 · Cited by 155 · see citing works

Cytokines Associated with Amyloid Plaques in Alzheimer's Disease Brain Stimulate Human Glial and Neuronal Cell Cultures to Secrete Early Complement Proteins, But Not C1-Inhibitor

Veerhuis, R., Janssen, I., Groot, C. J. A. D., Muiswinkel, F. L. V., Hack, C. E., & Eikelenboom, P. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7199 · Cited by 154 · see citing works

Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice

Koenigsknecht-Talboo, J., Meyer-Luehmann, M., Parsadanian, M., Garcia-Alloza, M., Finn, M. B., Hyman, B. T., Bacskai, B. J., & Holtzman, D. M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4147-08.2008 · Cited by 149 · see citing works

Age- and location-related changes in microglial function

Ritzel, R. M., Patel, A. R., Pan, S., Crapser, J., Hammond, M., Jellison, E., & McCullough, L. D. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.02.016 · Cited by 134 · see citing works

DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response

Zhong, L., Chen, X.-F., Zhang, Z.-L., Wang, Z., Shi, X.-Z., Xu, K., Zhang, Y.-W., Xu, H., & Bu, G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.645986 · Cited by 133 · see citing works

Expression of complement system components during aging and amyloid deposition in APP transgenic mice

Reichwald, J., Danner, S., Wiederhold, K., & Staufenbiel, M. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-35 · Cited by 122 · see citing works

Accelerated microglial pathology is associated with <scp>A</scp> β plaques in mouse models of <scp>A</scp> lzheimer's disease

Baron, R., Babcock, A. A., Nemirovsky, A., Finsen, B., & Monsonego, A. (2014) · Aging Cell · doi:10.1111/acel.12210 · Cited by 118 · see citing works

Phagocyte dysfunction, tissue aging and degeneration

Li, W. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.006 · Cited by 114 · see citing works

Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation

Ma, W., Cojocaru, R. I., Gotoh, N., Gieser, L. M., Villasmil, R., Cogliati, T., Swaroop, A., & Wong, W. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.03.022 · Cited by 107 · see citing works

CD200 fusion protein decreases microglial activation in the hippocampus of aged rats

Cox, F., Carney, D. G., Miller, A., & Lynch, M. A. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.10.004 · Cited by 107 · see citing works

Crosstalk between Complement and Toll-Like Receptors

Song, W. (2011) · Toxicologic Pathology · doi:10.1177/0192623311428478 · Cited by 96 · see citing works

A2E accumulation influences retinal microglial activation and complement regulation

Ma, W., Coon, S., Zhao, L., Fariss, R. N., & Wong, W. T. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.010 · Cited by 92 · see citing works

Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD

Veerhuis, R. (2011) · Current Alzheimer Research · doi:10.2174/156720511794604589 · Cited by 80 · see citing works

The role of microglial mtDNA damage in age-dependent prolonged LPS-induced sickness behavior

Nakanishi, H., Hayashi, Y., & Wu, Z. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x1100010x · Cited by 30 · see citing works

Microglia in Alzheimer's disease

Sarlus, H., & Heneka, M. T. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90606 · Cited by 911 · see citing works

The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B. J. L., Möller, T., Tamm, J. A., Abdourahman, A., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.03.021 · Cited by 238 · see citing works

Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead

Novak, P., Kontsekova, E., Zilka, N., & Novak, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00798 · Cited by 87 · see citing works

Retinal and brain microglia in multiple sclerosis and neurodegeneration

Choi, S., Guo, L., & Cordeiro, M. F. (2021) · Cells · doi:10.3390/cells10061507 · Cited by 63 · see citing works

The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases

Triviño, J. J., & von Bernhardi, R. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104982 · Cited by 43 · see citing works

Cafeteria diet induces neuroplastic modifications in the nucleus accumbens mediated by microglia activation

Gutiérrez‐Martos, M., Girard, B., Mendonça‐Netto, S., Perroy, J., Valjent, E., Maldonado, R., & Martin, M. (2018) · Addiction Biology · doi:10.1111/adb.12541 · Cited by 35 · see citing works

Role of trigger receptor 2 expressed on myeloid cells in neuroinflammation－neglected multidimensional regulation of microglia

Zhang, X., Chen, X., Zhang, L., Sun, Y., Liang, Y., Li, H., & Zhang, Y. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105639 · Cited by 23 · see citing works

TREM2 expression on the microglia resolved lead exposure-induced neuroinflammation by promoting anti-inflammatory activities

Su, P., Zhang, J., Wu, J., Chen, H., Luo, W., & Hu, M. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115058 · Cited by 13 · see citing works

Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice

Xu, X., Du, L., Jiang, J., Yang, M., Wang, Z., Wang, Y., Tang, T., Fu, X., & Hao, J. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.716917 · Cited by 24 · see citing works

Continuous injection of high-dose lipopolysaccharide modulates microglia polarization via TREM2 to alter the status of septic micePreprint

Qiu, Z., Wang, H., Qu, M., Zhu, S., Zhang, H., Liao, Q., & Miao, C. (2022) · Research Square · doi:10.21203/rs.3.rs-2064325/v1

A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease

Hampel, H., Caraci, F., Cuello, A. C., Caruso, G., Nisticò, R., Corbo, M., Baldacci, F., Toschi, N., Garaci, F., Chiesa, P. A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00456 · Cited by 360 · see citing works