Gui, Dan Y.

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

Sullivan, L. B., Gui, D. Y., Hosios, A. M., Bush, L. N., Freinkman, E., & Vander Heiden, M. G. (2015) · Cell

Cancer, Hypoxia, and MetabolismMitochondrial Function and Pathology

Cited by 1,173

Targeting Metabolism for Cancer Therapy

Luengo, A., Gui, D. Y., & Vander Heiden, M. G. (2017) · Cell Chemical Biology

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 971

Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer

Davidson, S. M., Papagiannakopoulos, T., Olenchock, B. A., Heyman, J. E., Keibler, M. A., Luengo, A., Bauer, M. R., Jha, A. K., O’Brien, J. P., Pierce, K. A., et al. (2016) · Cell Metabolism

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 737

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

Sullivan, M. R., Danai, L. V., Lewis, C. A., Chan, S. H., Gui, D. Y., Kunchok, T., Dennstedt, E. A., Vander Heiden, M. G., & Muir, A. (2019) · eLife

Cancer, Hypoxia, and MetabolismMetabolomics and Mass Spectrometry Studies

Cited by 588

Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

Lewis, C. A., Parker, S. J., Fiske, B. P., McCloskey, D., Gui, D. Y., Green, C. R., Vokes, N. I., Feist, A. M., Vander Heiden, M. G., & Metallo, C. M. (2014) · Molecular Cell

Redox biology and oxidative stressCancer, Hypoxia, and Metabolism

Cited by 562

Increased demand for NAD(+) relative to ATP drives aerobic glycolysis

Luengo, A., Li, Z., Gui, D. Y., Sullivan, L. B., Zagorulya, M., Do, B. T., Ferreira, R., Naamati, A., Ali, A., Lewis, C. A., et al. (2021) · Molecular Cell

Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and Cancer

Cited by 547

Altered metabolite levels in cancer: implications for tumour biology and cancer therapy

Sullivan, L. B., Gui, D. Y., & Heiden, M. G. V. (2016) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismCancer and biochemical research

Cited by 406

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Kim, D., Fiske, B. P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R. L., Chudnovsky, Y., Pacold, M. E., Chen, W. W., Cantor, J. R., et al. (2015) · Nature

Cancer, Hypoxia, and MetabolismGlioma Diagnosis and Treatment

Cited by 368

Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin

Gui, D. Y., Sullivan, L. B., Luengo, A., Hosios, A. M., Bush, L. N., Gitego, N., Davidson, S. M., Freinkman, E., Thomas, C. J., & Vander Heiden, M. G. (2016) · Cell Metabolism

Metabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism

Cited by 323

Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition

Muir, A., Danai, L. V., Gui, D. Y., Waingarten, C. Y., Lewis, C. A., & Vander Heiden, M. G. (2017) · eLife

Cancer, Hypoxia, and MetabolismAmino Acid Enzymes and Metabolism

Cited by 311