Altered metabolite levels in cancer: implications for tumour biology and cancer therapy

Regulation of Ferroptotic Cancer Cell Death by GPX4

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The emerging hallmarks of cancer metabolism

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

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Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease

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Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

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Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

Figueroa, M. E., Abdel-Wahab, O., Lu, C., Ward, P. S., Patel, J., Shih, A., Li, Y., Bhagwat, N., Vasanthakumar, A., Fernandez, H. F., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.11.015 · Cited by 2,766 · see citing works

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

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The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

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IDH mutation impairs histone demethylation and results in a block to cell differentiation

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

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Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

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Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

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Reductive carboxylation supports growth in tumour cells with defective mitochondria

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Insulator dysfunction and oncogene activation in IDH mutant gliomas

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

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Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

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Gene Mutations in the Succinate Dehydrogenase Subunit SDHB Cause Susceptibility to Familial Pheochromocytoma and to Familial Paraganglioma

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Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

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NRF2 and cancer: the good, the bad and the importance of context

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

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Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability

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Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): An overview of their mechanisms of formation

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

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SDH mutations establish a hypermethylator phenotype in paraganglioma

Letouzé, E., Martinelli, C., Loriot, C., Burnichon, N., Abermil, N., Ottolenghi, C., Janin, M., Menara, M., Nguyen, A. T., Benit, P., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.04.018 · Cited by 776 · see citing works

( <i>R</i> )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Losman, J.-A., Looper, R. E., Koivunen, P., Lee, S., Schneider, R. K., McMahon, C., Cowley, G. S., Root, D. E., Ebert, B. L., & Kaelin, W. G. (2013) · Science · doi:10.1126/science.1231677 · Cited by 703 · see citing works

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

Chaneton, B., Hillmann, P., Zheng, L., Martin, A. C. L., Maddocks, O. D. K., Chokkathukalam, A., Coyle, J. E., Jankevics, A., Holding, F. P., Vousden, K. H., et al. (2012) · Nature · doi:10.1038/nature11540 · Cited by 661 · see citing works

PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells

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Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates

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Arginine deprivation and argininosuccinate synthetase expression in the treatment of cancer

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SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

Bell, E. L., Emerling, B. M., Ricoult, S. J. H., & Guarente, L. (2011) · Oncogene · doi:10.1038/onc.2011.37 · Cited by 440 · see citing works

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

Ooi, A., Wong, J.-C., Petillo, D., Roossien, D., Perrier-Trudova, V., Whitten, D., Min, B. W. H., Tan, M.-H., Zhang, Z., Yang, X. J., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.024 · Cited by 401 · see citing works

Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis

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SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

Kim, D., Fiske, B. P., Birsoy, K., Freinkman, E., Kami, K., Possemato, R. L., Chudnovsky, Y., Pacold, M. E., Chen, W. W., Cantor, J. R., et al. (2015) · Nature · doi:10.1038/nature14363 · Cited by 368 · see citing works

Hypoxia-Mediated Increases in l -2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

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The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

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A Role for the Mitochondrial Pyruvate Carrier as a Repressor of the Warburg Effect and Colon Cancer Cell Growth

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Cell-Permeating <i>α</i> -Ketoglutarate Derivatives Alleviate Pseudohypoxia in Succinate Dehydrogenase-Deficient Cells

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Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

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Mitochondrial reactive oxygen species regulate hypoxic signaling

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Comparative Metabolic Flux Profiling of Melanoma Cell Lines

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Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type I

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

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<scp>l</scp> -2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer

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Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

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The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels

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Small molecule activation of PKM2 in cancer cells induces serine auxotrophy

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The pathophysiology and treatment of hereditary tyrosinemia type 1

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Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases

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Hydroxyglutaric aciduria and malignant brain tumor: a case report and literature review

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Dicarbonyl proteome and genome damage in metabolic and vascular disease

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Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

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Long‐term therapy with NTBC and tyrosine‐restricted diet in a murine model of hereditary tyrosinemia type I

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Targeting Metabolism for Cancer Therapy

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Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

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Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

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The Influence of Metabolism on Drug Response in Cancer

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A landscape of metabolic variation across tumor types

Reznik, E., Luna, A., Aksoy, B. A., Liu, E. M., La, K., Ostrovnaya, I., Creighton, C. J., Hakimi, A. A., & Sander, C. (2018) · Cell Systems · doi:10.1016/j.cels.2017.12.014 · Cited by 172 · see citing works

Mitochondrial metabolites: undercover signalling molecules

Frezza, C. (2017) · Interface Focus · doi:10.1098/rsfs.2016.0100 · Cited by 136 · see citing works

2-Hydroxyglutarate in Cancer Cells

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Methylglyoxal-derived stress: An emerging biological factor involved in the onset and progression of cancer

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Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

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A Golgi-associated redox switch regulates catalytic activation and cooperative functioning of ST6Gal-I with B4GalT-I

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Glutathione-activated near-infrared II fluorescent probe for lung metastatic diagnosis and intraoperative imaging of tumor

Wang, Y., Zhao, G., Liu, Y., Wang, R., Xing, Y., Dou, K., & Yu, F. (2025) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2024.137005 · Cited by 16 · see citing works