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Nicotinamide metabolism regulates glioblastoma stem cell maintenance

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Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

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Metabolic requirements for cancer cell proliferation

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Brain cancer stem cells: resilience through adaptive plasticity and hierarchical heterogeneity

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Targeting metabolic reprogramming in KRAS-driven cancers

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Metabolic Reprogramming in Brain Tumors

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MERAV: a tool for comparing gene expression across human tissues and cell types

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Reprogramming of serine, glycine and one-carbon metabolism in cancer

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The complexity of the serine glycine one-carbon pathway in cancer

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Hypoxia signaling in cancer: Implications for therapeutic interventions

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Metabolic Regulation of Redox Balance in Cancer

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Formate: The Neglected Member of One-Carbon Metabolism

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Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2

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Amino acid management in cancer

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Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells

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Beyond the Warburg effect: How do cancer cells regulate one-carbon metabolism?

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Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism

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Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure

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Cancer Metabolism: Fueling More than Just Growth

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Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival

Shiota, M., Naya, M., Yamamoto, T., Hishiki, T., Tani, T., Takahashi, H., Kubo, A., Koike, D., Itoh, M., Ohmura, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03899-1 · Cited by 101 · see citing works

Metabolic Plasticity of Tumor Cell Mitochondria

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Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma

Jung, J., Zhang, Y., Celiku, O., Zhang, W., Song, H., Williams, B. J., Giles, A. J., Rich, J. N., Abounader, R., Gilbert, M. R., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0198 · Cited by 91 · see citing works

The pro-tumorigenic effects of metabolic alterations in glioblastoma including brain tumor initiating cells

Libby, C. J., Tran, A. N., Scott, S. E., Griguer, C. E., & Hjelmeland, A. B. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.01.004 · Cited by 91 · see citing works

Serine-dependent redox homeostasis regulates glioblastoma cell survival

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Systems biology of oxygen homeostasis

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Structural basis of BRCC36 function in DNA repair and immune regulation

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Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment

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Pyruvate Kinase M2 Increases Angiogenesis, Neurogenesis, and Functional Recovery Mediated by Upregulation of STAT3 and Focal Adhesion Kinase Activities After Ischemic Stroke in Adult Mice

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The role of glycine in regulated cell death

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Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma

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Au-Pt Nanoparticle Formulation as a Radiosensitizer for Radiotherapy with Dual Effects

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Distinct metabolic hallmarks of WHO classified adult glioma subtypes

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LONP1 and ClpP cooperatively regulate mitochondrial proteostasis for cancer cell survival

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Establishment of local searching methods for orbitrap-based high throughput metabolomics analysis

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Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer

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BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension

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MicroRNAs and oncogenic transcriptional regulatory networks controlling metabolic reprogramming in cancers

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The Roles of Mitochondrial Folate Metabolism in Supporting Mitochondrial DNA Synthesis, Oxidative Phosphorylation, and Cellular Function

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Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

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Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox

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Serine Supports IL-1β Production in Macrophages Through mTOR Signaling

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A Luminol-Based Self-Illuminating Nanocage as a Reactive Oxygen Species Amplifier to Enhance Deep Tumor Penetration and Synergistic Therapy

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Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

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Impact of Advanced Glycation End products (AGEs) and its receptor (RAGE) on cancer metabolic signaling pathways and its progression

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Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML

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NF-Y activates genes of metabolic pathways altered in cancer cells

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Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth

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mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis

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The sirtuin family in cancer

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Highlights from the Literature

Lawler, S. E., Hegi, M. E., Mansouri, S., & Aldape, K. D. (2015) · Neuro-Oncology · doi:10.1093/neuonc/nov134

SHMT2 Drives Ischemic Glioma Cell Survival and Sensitivity to Excess Glycine

(2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2015-075

TMIC-20. SERINE AND ONE-CARBON METABOLISM ADAPTING GLIOMA CELLS TO LOW GLUTAMINE MICROENVIRONMENT

Tanaka, K., Nagashima, H., Iwahashi, H., Hashiguchi, M., & Sasayama, T. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac209.1064

Serine-dependent redox homeostasis regulates glioblastoma cell survival

Engel, A. L., Lorenz, N. I., Klann, K., Münch, C., Depner, C., Steinbach, J. P., Ronellenfitsch, M. W., & Luger, A.-L. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-0794-x · Cited by 85 · see citing works

Overexpression of mitochondrial serine hydroxyl-methyltransferase 2 is associated with poor prognosis and promotes cell proliferation and invasion in gliomas

Wu, M., Wanggou, S., Li, X., Liu, Q., & Xie, Y. (2017) · OncoTargets and Therapy · doi:10.2147/ott.s130409 · Cited by 33 · see citing works