Wolynes, Peter G.

The Energy Landscapes and Motions of Proteins

Frauenfelder, H., Sligar, S. G., & Wolynes, P. G. (1991) · Science

Protein Structure and DynamicsHemoglobin structure and function

Cited by 3,250

Funnels, pathways, and the energy landscape of protein folding: A synthesis

Bryngelson, J. D., Onuchic, J. N., Socci, N. D., & Wolynes, P. G. (1995) · Proteins: Structure, Function, and Bioinformatics

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 2,648

THEORY OF PROTEIN FOLDING: The Energy Landscape Perspective

Onuchic, J. N., Luthey-Schulten, Z., & Wolynes, P. G. (1997) · Annual Review of Physical Chemistry

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 2,210

Toward an outline of the topography of a realistic protein-folding funnel.

Onuchic, J. N., Wolynes, P. G., Luthey-Schulten, Z., & Socci, N. D. (1995) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 523

The middle way

Laughlin, R. B., Pines, D., Schmalian, J., Stojković, B. P., & Wolynes, P. (2000) · Proceedings of the National Academy of Sciences

Theoretical and Computational PhysicsComplex Systems and Dynamics

Cited by 391

Frustration in biomolecules

Ferreiro, D. U., Komives, E. A., & Wolynes, P. G. (2014) · Quarterly Reviews of Biophysics

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 314

DynamicBind: Predicting ligand-specific protein-ligand complex structure with a deep equivariant generative model

Lu, W., Zhang, J.-X., Huang, W., Zhang, Z., Jia, X., Wang, Z., Shi, L., Li, C., Wolynes, P., & Zheng, S. (2023) · Nature Communications

Computational Drug Discovery MethodsProtein Structure and Dynamics

Cited by 243

Quantum and classical Fokker-Planck equations for a Gaussian-Markovian noise bath

Tanimura, Y., & Wolynes, P. G. (1991) · Physical Review A

Quantum Mechanics and ApplicationsAdvanced Thermodynamics and Statistical Mechanics

Cited by 224

Folding funnels and energy landscapes of larger proteins within the capillarity approximation

Wolynes, P. G. (1997) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 218

Large local energy fluctuations in water. II. Cooperative motions and fluctuations

Ohmine, I., Tanaka, H., & Wolynes, P. G. (1988) · The Journal of Chemical Physics

Material Dynamics and PropertiesSpectroscopy and Quantum Chemical Studies

Cited by 216

Deciding fate in adverse times: Sporulation and competence in Bacillus subtilis

Schultz, D., Wolynes, P. G., Jacob, E. B., & Onuchic, J. N. (2009) · Proceedings of the National Academy of Sciences

Gene Regulatory Network AnalysisBacterial Genetics and Biotechnology

Cited by 201

Frustration, specific sequence dependence, and nonlinearity in large-amplitude fluctuations of allosteric proteins

Li, W., Wolynes, P. G., & Takada, S. (2011) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 159

A second molecular biology revolution? The energy landscapes of biomolecular function

Nussinov, R., & Wolynes, P. G. (2014) · Physical Chemistry Chemical Physics

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 104

Unleashing the potential of noncanonical amino acid biosynthesis to create cells with precision tyrosine sulfation

Chen, Y., Jin, S., Zhang, M., Hu, Y., Wu, K.-L., Chung, A., Wang, S., Tian, Z., Wang, Y., Wolynes, P. G., et al. (2022) · Nature Communications

RNA and protein synthesis mechanismsClick Chemistry and Applications

Cited by 90

Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines

Wang, Q., Chen, M., Schafer, N. P., Bueno, C., Song, S. S., Hudmon, A., Wolynes, P. G., Waxham, M. N., & Cheung, M. S. (2019) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

Cited by 49

An intrinsically disordered transcription activation domain alters the DNA binding affinity and specificity of NFκB p50/RelA

Baughman, H. E. R., Narang, D., Chen, W., Villagrán Suárez, A. C., Lee, J., Bachochin, M., Gunther, T. R., Wolynes, P. G., & Komives, E. A. (2022) · Journal of Biological Chemistry

NF-κB Signaling PathwaysProtein Structure and Dynamics

Cited by 27

An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFκB p50/RelA

Baughman, H. E. R., Narang, D., Chen, W., Villagrán Suárez, A. C., Lee, J., Bachochin, M. J., Gunther, T. R., Wolynes, P. G., & Komives, E. A. (2022) · Journal of Biological Chemistry

NF-κB Signaling PathwaysProtein Structure and Dynamics

Cited by 27

Frustraevo: a web server to localize and quantify the conservation of local energetic frustration in protein families

Parra, R. G., Freiberger, M. I., Poley-Gil, M., Fernandez-Martin, M., Radusky, L. G., Ruiz-Serra, V., Wolynes, P. G., Ferreiro, D. U., & Valencia, A. (2024) · Nucleic Acids Research

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 10

Frustraevo: A Web Server To Localize And Quantify The Conservation Of Local Energetic Frustration In Protein Families

Parra, R. G., Freiberger, M. I., Poley-Gil, M., Fernandez-Martin, M., Radusky, L. G., Wolynes, P. G., Ferreiro, D. U., & Valencia, A. (2023) · Nucleic Acids Research

Protein Structure and DynamicsRNA and protein synthesis mechanisms

Cited by 10

DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins

Xu, L., Jin, S., Urem, M., Lee, S.-J., Lamers, M. H., Chen, X., Wolynes, P. G., & Wuite, G. J. L. (2025) · Nature Communications

Force Microscopy Techniques and ApplicationsDNA Repair Mechanisms

Cited by 3

DNA polymerase actively and sequentially displaces single-stranded DNA-binding proteins

Xu, L., Jin, S., Urem, M., Lee, S.-J., Lamers, M. H., Chen, X., Wolynes, P., & Wuite, G. J. L. (2025) · Nature Communications

Force Microscopy Techniques and ApplicationsDNA Repair Mechanisms

Cited by 3