Hofmann, Susanna M.

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 1,310

Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Finan, B., Ma, T., Ottaway, N., Müller, T. D., Habegger, K. M., Heppner, K. M., Kirchner, H., Holland, J., Hembree, J., Raver, C., et al. (2013) · Science Translational Medicine

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 696

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Day, J. W., Ottaway, N., Patterson, J. T., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., et al. (2009) · Nature Chemical Biology

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 641

The central melanocortin system directly controls peripheral lipid metabolism

Nogueiras, R., Wiedmer, P., Perez-Tilve, D., Veyrat-Durebex, C., Keogh, J. M., Sutton, G. M., Pfluger, P. T., Castaneda, T. R., Neschen, S., Hofmann, S. M., et al. (2007) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 396

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Zhang, Q., Delessa, C. T., Augustin, R., Bakhti, M., Colldén, G., Drucker, D. J., Feuchtinger, A., Caceres, C. G., Grandl, G., Harger, A., et al. (2021) · Cell Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 322

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Habegger, K. M., Stemmer, K., Cheng, C., Müller, T. D., Heppner, K. M., Ottaway, N., Holland, J., Hembree, J. L., Smiley, D., Gelfanov, V., et al. (2013) · Diabetes

Fibroblast Growth Factor ResearchPancreatic function and diabetes

Cited by 245

Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans

Sachs, S., Zarini, S., Kahn, D. E., Harrison, K. A., Perreault, L., Phang, T., Newsom, S. A., Strauss, A., Kerege, A., Schoen, J. A., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 192

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Finan, B., Clemmensen, C., Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., et al. (2016) · Cell

Adipose Tissue and MetabolismAdipokines, Inflammation, and Metabolic Diseases

Cited by 191

Targeted pharmacological therapy restores β-cell function for diabetes remission

Sachs, S., Bastidas-Ponce, A., Tritschler, S., Bakhti, M., Böttcher, A., Sánchez-Garrido, M. A., Tarquis-Medina, M., Kleinert, M., Fischer, K., Jall, S., et al. (2020) · Nature Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 147

Glucagon Regulation of Energy Expenditure

Kleinert, M., Sachs, S., Habegger, K. M., Hofmann, S. M., & Müller, T. D. (2019) · International Journal of Molecular Sciences

Adipose Tissue and MetabolismPancreatic function and diabetes

Cited by 147

Lipoprotein lipase maintains microglial innate immunity in obesity.

Gao, Y., Vidal-Itriago, A., Kalsbeek, M. J., Layritz, C., García-Cáceres, C., Tom, R. Z., Eichmann, T. O., Vaz, F. M., Houtkooper, R. H., van der Wel, N., et al. (2017) · Cell Reports

Neuroinflammation and Neurodegeneration MechanismsAdipokines, Inflammation, and Metabolic Diseases

Cited by 123

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Liskiewicz, A., Khalil, A., Liskiewicz, D., Novikoff, A., Grandl, G., Maity-Kumar, G., Gutgesell, R. M., Bakhti, M., Bastidas-Ponce, A., Czarnecki, O., et al. (2023) · Nature Metabolism

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 110

Monomeric GLP-1/GIP/Glucagon Triagonism Corrects Obesity, Hepatosteatosis, and Dyslipidemia in Female Mice

Jall, S., Sachs, S., Clemmensen, C., Finan, B., Neff, F., DiMarchi, R. D., Tschöp, M. H., Müller, T. D., & Hofmann, S. M. (2017) · Molecular Metabolism

Regulation of Appetite and ObesityPharmacology and Obesity Treatment

Cited by 107

Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice

Clemmensen, C., Finan, B., Fischer, K., Tom, R. Z., Legutko, B., Sehrer, L., Heine, D., Grassl, N., Meyer, C. W., Henderson, B., et al. (2015) · EMBO Molecular Medicine

Regulation of Appetite and ObesityDiabetes Treatment and Management

Cited by 89

GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease

Sachs, S., Götz, A., Finan, B., Feuchtinger, A., DiMarchi, R. D., Döring, Y., Weber, C., Tschöp, M. H., Müller, T. D., & Hofmann, S. M. (2023) · Cardiovascular Diabetology

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 24

Fasting‐sensitive SUMO‐switch on Prox1 controls hepatic cholesterol metabolism

Alfaro, A. J., Dittner, C., Becker, J., Loft, A., Mhamane, A., Maida, A., Georgiadi, A., Tsokanos, F., Klepac, K., Molocea, C., et al. (2023) · The EMBO Reports

Cholesterol and Lipid MetabolismLiver Disease Diagnosis and Treatment

Cited by 14