Targeted pharmacological therapy restores β-cell function for diabetes remission
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A recent study identified gene signature profile changes in murine embryonic β-cells and adult β-cells following STZ treatment to identify β-cell dedifferentiation and dysfunction markers using single-cell RNA-seq.
“A recent study identified gene signature profile changes in murine embryonic β-cells and adult β-cells following STZ treatment to identify β-cell dedifferentiation and dysfunction markers using single-cell RNA-seq [45].”
From β-Cell pre-mir-21 induces dysfunction and loss of cellular identity by targeting transforming growth factor beta 2 (Tgfb2) and Smad family member 2 (Smad2) mRNAs (2021) · cites this paper as [45]
The Articles (pp. 6, 8) report scRNA-seq comparisons of β-cells from STZ-treated and healthy mice and identify markers of dysfunction and dedifferentiation. The paper also compares those cells with embryonic β-cells from a reference dataset (Articles, pp. 8–9), but it does not describe the embryonic cells as having received STZ treatment. (LLM, conf=0.88)
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- Authors
- Sachs, S., Bastidas-Ponce, A., Tritschler, S., Bakhti, M., Böttcher, A., Sánchez-Garrido, M. A., Tarquis-Medina, M., Kleinert, M., Fischer, K., Jall, S., Harger, A., Bader, E., Roscioni, S., Ussar, S., Feuchtinger, A., Yesildag, B., Neelakandhan, A., Jensen, C. B., Cornu, M., Yang, B., Finan, B., DiMarchi, R. D., Tschöp, M. H., Theis, F. J., Hofmann, S. M., Müller, T. D., & Lickert, H.
- Affiliations
- Helmholtz Munich (DE)
- University of Copenhagen (DK)
- Novo Nordisk (Denmark) (DK)
- Indiana University Bloomington (US)
- Corresponding author
- Theis, Fabian J.
- Hofmann, Susanna M.
- Müller, Timo D.
- Lickert, Heiko
- ORCID
- Sachs, Stephan
- Bastidas-Ponce, Aimée
- Tritschler, Sophie
- Bakhti, Mostafa
- Böttcher, Anika
- Tarquis-Medina, Marta
- Kleinert, Maximilian
- Fischer, Katrin
- Jall, Sigrid
- Bader, Erik
- Ussar, Siegfried
- Feuchtinger, Annette
- Yang, Bin
- Finan, Brian
- DiMarchi, Richard D.
- Tschöp, Matthias H.
- Theis, Fabian J.
- Hofmann, Susanna M.
- Müller, Timo D.
- Lickert, Heiko
- Venue
- Nature Metabolism
- Published
- 2020-02-20
- Volume
- 2
- Issue
- 2
- Pages
- 192-209
- ISSN
- 2522-5812 (ISSN-L)
- OpenAlex
- W3006783444
- Cited by
- 147
- References
- 13
- Citations by year
- 2026: 13 · 2025: 23 · 2024: 25 · 2023: 26 · 2022: 24 · 2021: 27 · 2020: 9
- FWCI
- 19.65
- Type
- journal article
- Language
- en
- Update notices
- correction (2020-04-14)
- Open access
- Licence
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Site cant be reached (submittedVersion, cc-by)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Keywords
- beta-cell dedifferentiation, diabetes remission, beta cell regeneration, insulin therapy, estrogen, ER-associated degradation, streptozotocin-induced diabetes, type 1 diabetes, type 2 diabetes
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Estrogens, Homeostasis, Humans, Hypoglycemic Agents, Insulin, Remission Induction, Streptozocin, Insulin-Secreting Cells, Mice, Glucagon-Like Peptide 1, Polypharmacology
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