Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Liskiewicz, Arkadiusz; Khalil, Ahmed; Liskiewicz, Daniela; Novikoff, Aaron; Grandl, Gerald; Maity-Kumar, Gandhari; Gutgesell, Robert M.; Bakhti, Mostafa; Bastidas-Ponce, Aimée; Czarnecki, Oliver; Makris, Konstantinos; Lickert, Heiko; Feuchtinger, Annette; Tost, Monica; Coupland, Callum; Ständer, Lisa; Akindehin, Seun; Prakash, Sneha; Abrar, Faiyaz; Castelino, Russell L.; He, Yantao; Knerr, Patrick J.; Yang, Bin; Hogendorf, Wouter F. J.; Zhang, Shiqi; Hofmann, Susanna M.; Finan, Brian; DiMarchi, Richard D.; Tschöp, Matthias H.; Douros, Jonathan D.; Müller, Timo D.

doi:10.1038/s42255-023-00931-7

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

The development of single-molecule co-agonists for the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) is considered a breakthrough in the treatment of obesity and type 2 diabetes. But although GIPR–GLP-1R co-agonism decreas…